Eric Spear

Research Associate

20002019
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Endoplasmic Reticulum Medicine & Life Sciences
Quality Control Medicine & Life Sciences
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Endoplasmic Reticulum-Associated Degradation Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Cathepsin A Medicine & Life Sciences
Protein Transport Medicine & Life Sciences
Proteins Medicine & Life Sciences

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Research Output 2000 2019

A humanized yeast system to analyze cleavage of prelamin A by ZMPSTE24

Spear, E., Alford, R. F., Babatz, T. D., Wood, K. M., Mossberg, O. W., Odinammadu, K., Shilagardi, K., Gray, J. J. & Michaelis, S. D., Jan 1 2019, (Accepted/In press) In : Methods.

Research output: Contribution to journalArticle

Yeast
Yeasts
Processing
Lamin Type A
Aging of materials

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin a cleavage activity and/or protein stability

Spear, E., Hsu, E. T., Nie, L., Carpenter, E. P., Hrycyna, C. A. & Michaelis, S. D., Jul 1 2018, In : DMM Disease Models and Mechanisms. 11, 7, Y.

Research output: Contribution to journalArticle

Protein Stability
Missense Mutation
Proteins
Membrane Proteins
Yeast

Degradation signals for ubiquitin-proteasome dependent cytosolic protein quality control (CytoQC) in yeast

Maurer, M. J., Spear, E., Yu, A. T., Lee, E. J., Shahzad, S. & Michaelis, S. D., Jul 1 2016, In : G3: Genes, Genomes, Genetics. 6, 7, p. 1853-1866 14 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Quality Control
Yeasts
Ubiquitin-Protein Ligases

Erratum for the report: "Mapping the cellular response to small molecules using chemogenomic fitness signatures" (Science (2014) (208-211))

Lee, A. Y., St.Onge, R. P., Proctor, M. J., Wallace, I. M., Nile, A. H., Spagnuolo, P. A., Jitkova, Y., Gronda, M., Wu, Y., Kim, M. K., Cheung-Ong, K., Torres, N. P., Spear, E., Han, M. K. L., Schlecht, U., Suresh, S., Duby, G., Heisler, L. E., Surendra, A., Fung, E. & 19 othersUrbanus, M. L., Gebbia, M., Lissina, E., Miranda, M., Chiang, J. H., Aparicio, A. M., Zeghouf, M., Davis, R. W., Cherfils, J., Boutry, M., Kaiser, C. A., Cummins, C. L., Trimble, W. S., Brown, G. W., Schimmer, A. D., Bankaitis, V. A., Nislow, C., Bader, G. D. & Giaever, G., 2014, In : Science. 344, 6186, 1255771.

Research output: Contribution to journalArticle

Mapping the cellular response to small molecules using chemogenomic fitness signatures

Lee, A. Y., St.Onge, R. P., Proctor, M. J., Wallace, I. M., Nile, A. H., Spagnuolo, P. A., Jitkova, Y., Gronda, M., Wu, Y., Kim, M. K., Cheung-Ong, K., Torres, N. P., Spear, E., Han, M. K. L., Schlecht, U., Suresh, S., Duby, G., Heisler, L. E., Surendra, A., Fung, E. & 19 othersUrbanus, M. L., Gebbia, M., Lissina, E., Miranda, M., Chiang, J. H., Aparicio, A. M., Zeghouf, M., Davis, R. W., Cherfils, J., Boutry, M., Kaiser, C. A., Cummins, C. L., Trimble, W. S., Brown, G. W., Schimmer, A. D., Bankaitis, V. A., Nislow, C., Bader, G. D. & Giaever, G., 2014, In : Science. 344, 6180, p. 208-211 4 p.

Research output: Contribution to journalArticle

Fitness
Gene
Signature
Molecules
Fundamental