Research Output 1999 2017

Filter
Article
2017

Bactericidal and sterilizing activity of a novel regimen with bedaquiline, pretomanid, moxifloxacin, and pyrazinamide in a murine model of tuberculosis

Li, S. Y., Tasneen, R., Tyagi, S., Soni, H., Converse, P. J., Mdluli, K. & Nuermberger, E. L. Sep 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 9, e00913-17

Research output: Research - peer-reviewArticle

bedaquiline
Pyrazinamide
Tuberculosis
moxifloxacin
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis

Kaushik, A., Ammerman, N. C., Tasneen, R., Story-Roller, E., Dooley, K. E., Dorman, S. E., Nuermberger, E. L. & Lamichhane, G. Aug 1 2017 In : Journal of Antimicrobial Chemotherapy. 72, 8, p. 2320-2325 6 p., dkx152

Research output: Research - peer-reviewArticle

biapenem
Rifampin
Mycobacterium tuberculosis
Pharmaceutical Preparations
In Vitro Techniques

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1

Gopal, P., Tasneen, R., Yee, M., Lanoix, J. P., Sarathy, J., Rasic, G., Li, L., Dartois, V., Nuermberger, E. & Dick, T. Jul 14 2017 In : ACS Infectious Diseases. 3, 7, p. 492-501 10 p.

Research output: Research - peer-reviewArticle

aspartate 4-decarboxylase
Missense Mutation
Mycobacterium tuberculosis
pyrazinoic acid
Pyrazinamide

New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response

Bartelink, I. H., Zhang, N., Keizer, R. J., Strydom, N., Converse, P. J., Dooley, K. E., Nuermberger, E. L. & Savic, R. M. 2017 (Accepted/In press) In : Clinical and Translational Science.

Research output: Research - peer-reviewArticle

Tuberculosis
Confidence Intervals
Therapeutics
Rifampin
Pharmacokinetics

Primary clofazimine and bedaquiline resistance among isolates from patients with multidrug-resistant tuberculosis

Xu, J., Wang, B., Hu, M., Huo, F., Guo, S., Jing, W., Nuermberger, E. & Lu, Y. Jun 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 6, e00239-17

Research output: Research - peer-reviewArticle

bedaquiline
Clofazimine
Multidrug-Resistant Tuberculosis
Mutation
Pharmaceutical Preparations

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model

Kendall, E. A., Shrestha, S., Cohen, T., Nuermberger, E., Dooley, K. E., Gonzalez-Angulo, L., Churchyard, G. J., Nahid, P., Rich, M. L., Bansbach, C., Forissier, T., Lienhardt, C. & Dowdy, D. W. Jan 1 2017 In : PLoS Medicine. 14, 1, e1002202

Research output: Research - peer-reviewArticle

Tuberculosis
Pharmaceutical Preparations
Rifampin
Uncertainty
Mortality

Pyrazinoic acid inhibits a bifunctional enzyme in Mycobacterium tuberculosis

Njire, M., Wang, N., Wang, B., Tan, Y., Cai, X., Liu, Y., Mugweru, J., Guo, J., Hameed, H. M. A., Tan, S., Liu, J., Yew, W. W., Nuermberger, E., Lamichhane, G., Liu, J. & Zhang, T. Jul 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 7, e00070-17

Research output: Research - peer-reviewArticle

Pyrazinamide
Mycobacterium tuberculosis
Enzymes
pyrazinoic acid
Pharmaceutical Preparations
2016

A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground

Srivastava, S., Deshpande, D., Pasipanodya, J. G., Thomas, T., Swaminathan, S., Nuermberger, E. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S75-S79

Research output: Research - peer-reviewArticle

Tuberculosis
Pharmaceutical Preparations
Therapeutics
Drug Combinations
Pharmacokinetics

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way

Deshpande, D., Srivastava, S., Nuermberger, E., Pasipanodya, J. G., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S95-S101

Research output: Research - peer-reviewArticle

Linezolid
Multidrug-Resistant Tuberculosis
Pharmaceutical Preparations
fropenem
moxifloxacin

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo

Deshpande, D., Srivastava, S., Nuermberger, E., Pasipanodya, J. G., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S88-S94

Research output: Research - peer-reviewArticle

Linezolid
Tuberculosis
Therapeutics
moxifloxacin
Mycobacterium tuberculosis

Contribution of oxazolidinones to the efficacy of novel regimens containing bedaquiline and pretomanid in a mouse model of tuberculosis

Tasneen, R., Betoudji, F., Tyagi, S., Li, S. Y., Williams, K., Converse, P. J., Dartois, V., Yang, T., Mendel, C. M., Mdluli, K. E. & Nuermberger, E. L. Jan 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 270-277 8 p.

Research output: Research - peer-reviewArticle

bedaquiline
Oxazolidinones
Tuberculosis
2-nitro-6-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo(2,1-b)(1,3)oxazine
Linezolid

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children with Tuberculosis: Bread Crumb Trails in Random Forests

Swaminathan, S., Pasipanodya, J. G., Ramachandran, G., Kumar, A. K. H., Srivastava, S., Deshpande, D., Nuermberger, E. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S63-S74

Research output: Research - peer-reviewArticle

Bread
Tuberculosis
Pharmaceutical Preparations
Therapeutics
Forests

High systemic exposure of pyrazinoic acid has limited antituberculosis activity in murine and rabbit models of tuberculosis

Lanoix, J. P., Tasneen, R., O'Brien, P., Sarathy, J., Safi, H., Pinn, M., Alland, D., Dartois, V. & Nuermberger, E. Jul 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 7, p. 4197-4205 9 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Rabbits
pyrazinoic acid
Pyrazinamide
Lung

Linezolid for Infants and Toddlers with Disseminated Tuberculosis: First Steps

Deshpande, D., Srivastava, S., Pasipanodya, J. G., Bush, S. J., Nuermberger, E., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S80-S87

Research output: Research - peer-reviewArticle

Linezolid
Tuberculosis
Area Under Curve
Mycobacterium tuberculosis
Microbial Sensitivity Tests

Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9

Ordonez, A. A., Tasneen, R., Pokkali, S., Xu, Z., Converse, P. J., Klunk, M. H., Mollura, D. J., Nuermberger, E. L. & Jain, S. K. Jul 1 2016 In : DMM Disease Models and Mechanisms. 9, 7, p. 779-788 10 p.

Research output: Research - peer-reviewArticle

Matrix Metalloproteinase 9
Pulmonary Tuberculosis
Tuberculosis
Cavitation
Lung

Mutations in pepQ confer low-level resistance to bedaquiline and clofazimine in Mycobacterium tuberculosis

Almeida, D., Ioerger, T., Tyagi, S., Li, S. Y., Mdluli, K., Andries, K., Grosset, J., Sacchettini, J. & Nuermberger, E. Aug 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4590-4599 10 p.

Research output: Research - peer-reviewArticle

bedaquiline
Clofazimine
Mycobacterium tuberculosis
Mutation
Therapeutics

MYCOBACT-18 - Qualification des souris C3HeB/FeJ pour le traitement expérimental de la tuberculose

Lanoix, J. P., Schmit, J. L. & Nuermberger, E. Jun 1 2016 In : Medecine et Maladies Infectieuses. 46, 4, p. 84 1 p.

Research output: Research - peer-reviewArticle

Optimal Clinical Doses of Faropenem, Linezolid, and Moxifloxacin in Children with Disseminated Tuberculosis: Goldilocks

Srivastava, S., Deshpande, D., Pasipanodya, J., Nuermberger, E., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S102-S109

Research output: Research - peer-reviewArticle

Linezolid
Tuberculosis
fropenem
moxifloxacin
Microbial Sensitivity Tests

Selective inactivity of pyrazinamide against tuberculosis in C3HeB/FeJ mice is best explained by neutral pH of caseum

Lanoix, J. P., Ioerger, T., Ormond, A., Kaya, F., Sacchettini, J., Dartois, V. & Nuermberger, E. Feb 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 2, p. 735-743 9 p.

Research output: Research - peer-reviewArticle

Pyrazinamide
Tuberculosis
Lung
Pharmaceutical Preparations
Bacillus

Sterilizing activity of pyrazinamide in combination with first-line drugs in a C3HeB/FeJ mouse model of tuberculosis

Lanoix, J. P., Betoudji, F. & Nuermberger, E. Feb 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 2, p. 1091-1096 6 p.

Research output: Research - peer-reviewArticle

Pyrazinamide
Tuberculosis
Pharmaceutical Preparations
Recurrence
Ethambutol
National Institute of Allergy and Infectious Diseases (U.S.)
Critical Pathways
Tuberculosis
Pharmacology
Education
2015

A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections

Locher, C. P., Jones, S. M., Hanzelka, B. L., Perola, E., Shoen, C. M., Cynamon, M. H., Ngwane, A. H., Wiid, I. J., Van Helden, P. D., Betoudji, F., Nuermberger, E. L. & Thomson, J. A. Mar 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 3, p. 1455-1465 11 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Infection
Pharmaceutical Preparations
VXc-486
Prodrugs

Assessing the Landscape of Tools and Approaches for Novel Tuberculosis Regimen Development

Nuermberger, E. & Hanna, D. Jun 15 2015 In : Journal of Infectious Diseases. 211, p. S81-S82

Research output: Research - peer-reviewArticle

Correlations between the hollow fiber model of tuberculosis and therapeutic events in tuberculosis patients: Learn and confirm

Gumbo, T., Pasipanodya, J. G., Nuermberger, E., Romero, K. & Hanna, D. 2015 In : Clinical Infectious Diseases. 61, p. S18-S24

Research output: Research - peer-reviewArticle

Tuberculosis
Therapeutics
Pharmacokinetics
Meta-Analysis
Appointments and Schedules

Daily rifapentine for treatment of pulmonary tuberculosis: A randomized, dose-ranging trial

Dorman, S. E., Savic, R. M., Goldberg, S., Stout, J. E., Schluger, N., Muzanyi, G., Johnson, J. L., Nahid, P., Hecker, E. J., Heilig, C. M., Bozeman, L., Feng, P. J. I., Moro, R. N., MacKenzie, W., Dooley, K. E., Nuermberger, E. L., Vernon, A. & Weiner, M. Feb 1 2015 In : American Journal of Respiratory and Critical Care Medicine. 191, 3, p. 333-343 11 p.

Research output: Research - peer-reviewArticle

rifapentine
Pulmonary Tuberculosis
Therapeutics
Rifampin
Sputum

Efficacy of rifampin plus clofazimine in a murine model of Mycobacterium ulcerans disease

Converse, P. J., Tyagi, S., Xing, Y., Li, S. Y., Kishi, Y., Adamson, J., Nuermberger, E. L. & Grosset, J. H. Jun 4 2015 In : PLoS Neglected Tropical Diseases. 9, 6, e0003823

Research output: Research - peer-reviewArticle

Mycobacterium ulcerans
Clofazimine
Rifampin
Streptomycin
Clarithromycin

Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models

Li, S. Y., Irwin, S. M., Converse, P. J., Mdluli, K. E., Lenaerts, A. J. & Nuermberger, E. L. Jul 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 4026-4030 5 p.

Research output: Research - peer-reviewArticle

Tuberculosis
moxifloxacin
Ethambutol
Isoniazid
Recurrence

Extensively drug-resistant tuberculosis in a young child after travel to India

Salazar-Austin, N., Ordonez, A. A., Hsu, A. J., Benson, J. E., Mahesh, M., Menachery, E., Razeq, J. H., Salfinger, M., Starke, J. R., Milstone, A. M., Parrish, N., Nuermberger, E. L. & Jain, S. K. Dec 1 2015 In : Lancet Infectious Diseases. 15, 12, p. 1485-1491 7 p.

Research output: Research - peer-reviewArticle

Extensively Drug-Resistant Tuberculosis
India
Tuberculosis
Therapeutics
Pharmaceutical Preparations

Forecasting accuracy of the hollow fiber model of tuberculosis for clinical therapeutic outcomes

Gumbo, T., Pasipanodya, J. G., Romero, K., Hanna, D. & Nuermberger, E. 2015 In : Clinical Infectious Diseases. 61, p. S25-S31

Research output: Research - peer-reviewArticle

Tuberculosis
Therapeutics
Confidence Intervals
Pharmaceutical Preparations
Clinical Studies

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

Lanoix, J. P., Lenaerts, A. J. & Nuermberger, E. L. Jun 1 2015 In : DMM Disease Models and Mechanisms. 8, 6, p. 603-610 8 p.

Research output: Research - peer-reviewArticle

Disease Progression
Tuberculosis
Pharmaceutical Preparations
Pyrazinamide
Linezolid

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

Via, L. E. , Savic, R. , Weiner, D. M. , Zimmerman, M. D. , Prideaux, B. , Irwin, S. M. , Lyon, E. , O'Brien, P. , Gopal, P. , Eum, S. , Lee, M. , Lanoix, J. P. , Dutta, N. K. , Shim, T. S. , Cho, J. S. , Kim, W. , Karakousis, P. C. , Lenaerts, A. , Nuermberger, E. , Barry, C. E. & 1 others Dartois, V. May 8 2015 In : ACS Infectious Diseases. 1, 5, p. 203-214 12 p.

Research output: Research - peer-reviewArticle

Pyrazinamide
Therapeutics
pyrazinoic acid
In Vitro Techniques
Tuberculosis

Nonclinical Models for Antituberculosis Drug Development: A Landscape Analysis

Gumbo, T., Lenaerts, A. J., Hanna, D., Romero, K. & Nuermberger, E. Jun 15 2015 In : Journal of Infectious Diseases. 211, p. S83-S95

Research output: Research - peer-reviewArticle

Pharmaceutical Preparations
Drug Combinations
Tuberculosis
Animal Models
In Vitro Techniques

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Irwin, S. M., Driver, E., Lyon, E., Schrupp, C., Ryan, G., Gonzalez-Juarrero, M., Basaraba, R. J., Nuermberger, E. L. & Lenaerts, A. J. Jun 1 2015 In : DMM Disease Models and Mechanisms. 8, 6, p. 591-602 12 p.

Research output: Research - peer-reviewArticle

Aerosols
Mycobacterium tuberculosis
Infection
Pharmaceutical Preparations
Animal Models

Primary HIV infection presenting as limbic encephalitis and rhabdomyolysis

Ferrada, M. A., Xie, Y. & Nuermberger, E. Oct 24 2015 In : International Journal of STD and AIDS. 26, 11, p. 835-836 2 p.

Research output: Research - peer-reviewArticle

Limbic Encephalitis
Rhabdomyolysis
HIV Infections
Counseling
Therapeutics

Shortening Tuberculosis Treatment with Fluoroquinolones: Lost in Translation?

Lanoix, J. P., Chaisson, R. E. & Nuermberger, E. L. Nov 4 2015 In : Clinical Infectious Diseases. 62, 4, p. 484-490 7 p.

Research output: Research - peer-reviewArticle

Fluoroquinolones
Tuberculosis
Pharmacokinetics
Clinical Trials

Systematic analysis of hollow fiber model of tuberculosis experiments

Pasipanodya, J. G., Nuermberger, E., Romero, K., Hanna, D. & Gumbo, T. 2015 In : Clinical Infectious Diseases. 61, p. S10-S17

Research output: Research - peer-reviewArticle

Tuberculosis
Drug Resistance
Pharmacokinetics
Aptitude
Pharmaceutical Preparations

Targeting DnaN for tuberculosis therapy using novel griselimycins

Kling, A. , Lukat, P. , Almeida, D. V. , Bauer, A. , Fontaine, E. , Sordello, S. , Zaburannyi, N. , Herrmann, J. , Wenzel, S. C. , König, C. , Ammerman, N. C. , Barrio, M. B. , Borchers, K. , Bordon-Pallier, F. , Brönstrup, M. , Courtemanche, G. , Gerlitz, M. , Geslin, M. , Hammann, P. , Heinz, D. W. & 12 others Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Tyagi, S., Fraisse, L., Grosset, J. H., Lagrange, S. & Müller, R. Jun 5 2015 In : Science. 348, 6239, p. 1106-1112 7 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Therapeutics
griselimycin
Streptomyces
Mycobacterium tuberculosis
2014

Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.

Converse, P. J., Xing, Y., Kim, K. H., Tyagi, S., Li, S. Y., Almeida, D. V., Nuermberger, E. L., Grosset, J. H. & Kishi, Y. 2014 In : PLoS Neglected Tropical Diseases. 8, 1

Research output: Research - peer-reviewArticle

Mycobacterium ulcerans
Rifampin
Thin Layer Chromatography
Anti-Bacterial Agents
mycolactone

Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas

Irwin, S. M., Gruppo, V., Brooks, E., Gilliland, J., Scherman, M., Reichlen, M. J., Leistikow, R., Kramnik, I., Nuermberger, E. L., Voskuil, M. I. & Lenaerts, A. J. 2014 In : Antimicrobial Agents and Chemotherapy. 58, 7, p. 4026-4034 9 p.

Research output: Research - peer-reviewArticle

Clofazimine
Granuloma
Tuberculosis
Pharmaceutical Preparations
Lung

Minding the gaps in tuberculosis research

Ekins, S., Nuermberger, E. L. & Freundlich, J. S. 2014 In : Drug Discovery Today. 19, 9, p. 1279-1282 4 p.

Research output: Research - peer-reviewArticle

Population pharmacokinetics of rifapentine and desacetyl rifapentine in healthy volunteers: Nonlinearities in clearance and bioavailability

Savic, R. M., Lu, Y., Bliven-Sizemore, E., Weiner, M., Nuermberger, E., Burman, W., Dorman, S. E. & Dooley, K. E. 2014 In : Antimicrobial Agents and Chemotherapy. 58, 6, p. 3035-3042 8 p.

Research output: Research - peer-reviewArticle

rifapentine
Biological Availability
Healthy Volunteers
Pharmacokinetics
Population

Principes de conception de futurs schémas thérapeutiques pour traiter la tuberculose multirésistante

Brigden, G., Nyang'wa, B. T., du Cros, P., Varaine, F., Hughes, J., Rich, M., Horsburgh, C. R., Mitnick, C. D., Nuermberger, E., McIlleron, H., Phillips, P. P. J. & Balasegaram, M. 2014 In : Bulletin of the World Health Organization. 92, 1, p. 68-74 7 p.

Research output: Research - peer-reviewArticle

Multidrug-Resistant Tuberculosis
Pharmaceutical Preparations
Therapeutics
bedaquiline
Extensively Drug-Resistant Tuberculosis
2013

Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

Almeida, D. V., Converse, P. J., Li, S. Y., Tyagi, S., Nuermberger, E. L. & Grosset, J. H. Feb 2013 In : PLoS Neglected Tropical Diseases. 7, 2, e2085

Research output: Research - peer-reviewArticle

rifapentine
Mycobacterium ulcerans
Streptomycin
Therapeutics
Rifampin

Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis

Ahmad, Z., Tyagi, S., Minkowski, A., Peloquin, C. A., Grosset, J. H. & Nuermberger, E. L. Jul 1 2013 In : American Journal of Respiratory and Critical Care Medicine. 188, 1, p. 97-102 6 p.

Research output: Research - peer-reviewArticle

Pyrazinamide
Levofloxacin
Tuberculosis
moxifloxacin
Fluoroquinolones

Pipeline of drugs for related diseases: Tuberculosis

Dooley, K. E., Nuermberger, E. L. & Diacon, A. H. Nov 2013 In : Current Opinion in HIV and AIDS. 8, 6, p. 579-585 7 p.

Research output: Research - peer-reviewArticle

Tuberculosis
Pharmaceutical Preparations
Therapeutics
Multidrug-Resistant Tuberculosis
rifapentine

Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen

Dutta, N. K., Alsultan, A., Gniadek, T. J., Belchis, D. A., Pinn, M. L., Mdluli, K. E., Nuermberger, E. L., Peloquin, C. A. & Karakousis, P. C. Aug 2013 In : Antimicrobial Agents and Chemotherapy. 57, 8, p. 3910-3916 7 p.

Research output: Research - peer-reviewArticle

Pyrazinamide
Guinea Pigs
Tuberculosis
rifamycin SV
Therapeutics

Rapid, Serial, Non-invasive Assessment of Drug Efficacy in Mice with Autoluminescent Mycobacterium ulcerans Infection

Zhang, T., Li, S. Y., Converse, P. J., Grosset, J. H. & Nuermberger, E. L. 2013 In : PLoS Neglected Tropical Diseases. 7, 12, e2598

Research output: Research - peer-reviewArticle

Mycobacterium ulcerans
Buruli Ulcer
Pharmaceutical Preparations
Drug Evaluation
Streptomycin