Research Output 1999 2018

2018

A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis

Leung-Theung-Long, S., Coupet, C. A., Gouanvic, M., Schmitt, D., Ray, A., Hoffmann, C., Schultz, H., Tyagi, S., Soni, H., Converse, P. J., Arias, L., Kleinpeter, P., Sansas, B., Mdluli, K., Vilaplana, C., Cardona, P. J., Nuermberger, E., Marchand, J. B., Silvestre, N. & Inchauspé, G. May 1 2018 In : PloS one. 13, 5, e0196815

Research output: Contribution to journalArticle

Vaccinia
Vaccinium
Mycobacterium tuberculosis
Combination Drug Therapy
drug therapy

Long-acting formulations for the treatment of latent tuberculous infection: Opportunities and challenges

Swindells, S., Siccardi, M., Barrett, S. E., Olsen, D. B., Grobler, J. A., Podany, A. T., Nuermberger, E., Kim, P., Barry, C. E., Owen, A., Hazuda, D. & Flexner, C. Feb 1 2018 In : International Journal of Tuberculosis and Lung Disease. 22, 2, p. 125-132 8 p.

Research output: Contribution to journalReview article

Tuberculosis
Infection
HIV
Drug Compounding
Virus Diseases

Verapamil increases the bioavailability and efficacy of bedaquiline but not clofazimine in a murine model of tuberculosis

Xu, J., Tasneen, R., Peloquin, C. A., Almeida, D. V., Li, S. Y., Barnes-Boyle, K., Lu, Y. & Nuermberger, E. Jan 1 2018 In : Antimicrobial Agents and Chemotherapy. 62, 1, e01692

Research output: Contribution to journalArticle

bedaquiline
Clofazimine
Verapamil
Mycobacterium tuberculosis
Biological Availability
2017

Bactericidal and sterilizing activity of a novel regimen with bedaquiline, pretomanid, moxifloxacin, and pyrazinamide in a murine model of tuberculosis

Li, S. Y., Tasneen, R., Tyagi, S., Soni, H., Converse, P. J., Mdluli, K. & Nuermberger, E. L. Sep 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 9, e00913-17

Research output: Contribution to journalArticle

bedaquiline
Pyrazinamide
Tuberculosis
Drug Combinations
Recurrence

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

Islam, M. M., Hameed, H. M. A., Mugweru, J., Chhotaray, C., Wang, C., Tan, Y., Liu, J., Li, X., Tan, S., Ojima, I., Yew, W. W., Nuermberger, E., Lamichhane, G. & Zhang, T. Jan 20 2017 In : Journal of Genetics and Genomics. 44, 1, p. 21-37 17 p.

Research output: Contribution to journalReview article

Drug Resistance
Tuberculosis
Pharmaceutical Preparations
Multidrug-Resistant Tuberculosis
Mycobacterium tuberculosis

Immunodeficiency and intermittent dosing promote acquired rifamycin monoresistance in murine tuberculosis

Park, S. W., Tasneen, R., Converse, P. J. & Nuermberger, E. L. Nov 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 11, e01502-17

Research output: Contribution to journalArticle

rifapentine
Isoniazid
Tuberculosis
Rifampin
Nude Mice

In vitro and in vivo activity of biapenem against drug-susceptible and rifampicin-resistant Mycobacterium tuberculosis

Kaushik, A., Ammerman, N. C., Tasneen, R., Story-Roller, E., Dooley, K. E., Dorman, S. E., Nuermberger, E. L. & Lamichhane, G. Aug 1 2017 In : Journal of Antimicrobial Chemotherapy. 72, 8, p. 2320-2325 6 p., dkx152

Research output: Contribution to journalArticle

biapenem
Rifampin
Mycobacterium tuberculosis
Pharmaceutical Preparations
In Vitro Techniques

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1

Gopal, P., Tasneen, R., Yee, M., Lanoix, J. P., Sarathy, J., Rasic, G., Li, L., Dartois, V., Nuermberger, E. & Dick, T. Jul 14 2017 In : ACS Infectious Diseases. 3, 7, p. 492-501 10 p.

Research output: Contribution to journalArticle

aspartate 4-decarboxylase
Missense Mutation
Pyrazinamide
Mycobacterium tuberculosis
Mutation

New Paradigm for Translational Modeling to Predict Long-term Tuberculosis Treatment Response

Bartelink, I. H., Zhang, N., Keizer, R. J., Strydom, N., Converse, P. J., Dooley, K. E., Nuermberger, E. L. & Savic, R. M. 2017 (Accepted/In press) In : Clinical and Translational Science.

Research output: Contribution to journalArticle

Tuberculosis
rifapentine
Pharmacokinetics
Confidence Intervals
Rifampin

Preclinical Efficacy Testing of New Drug Candidates

Nuermberger, E. L. Jun 1 2017 In : Microbiology spectrum. 5, 3

Research output: Contribution to journalReview article

chemotherapy
drug
Latent Tuberculosis
Drug Therapy
Drug Combinations

Primary clofazimine and bedaquiline resistance among isolates from patients with multidrug-resistant tuberculosis

Xu, J., Wang, B., Hu, M., Huo, F., Guo, S., Jing, W., Nuermberger, E. & Lu, Y. Jun 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 6, e00239-17

Research output: Contribution to journalArticle

bedaquiline
Clofazimine
Multidrug-Resistant Tuberculosis
Mutation
Extensively Drug-Resistant Tuberculosis

Priority-Setting for Novel Drug Regimens to Treat Tuberculosis: An Epidemiologic Model

Kendall, E. A., Shrestha, S., Cohen, T., Nuermberger, E., Dooley, K. E., Gonzalez-Angulo, L., Churchyard, G. J., Nahid, P., Rich, M. L., Bansbach, C., Forissier, T., Lienhardt, C. & Dowdy, D. W. Jan 1 2017 In : PLoS Medicine. 14, 1, e1002202

Research output: Contribution to journalArticle

Rifampin
Tuberculosis
Uncertainty
Pharmaceutical Preparations
Mortality

Pyrazinoic acid inhibits a bifunctional enzyme in Mycobacterium tuberculosis

Njire, M., Wang, N., Wang, B., Tan, Y., Cai, X., Liu, Y., Mugweru, J., Guo, J., Hameed, H. M. A., Tan, S., Liu, J., Yew, W. W., Nuermberger, E., Lamichhane, G., Liu, J. & Zhang, T. Jul 1 2017 In : Antimicrobial Agents and Chemotherapy. 61, 7, e00070-17

Research output: Contribution to journalArticle

Pyrazinamide
Mycobacterium tuberculosis
Enzymes
Alleles
Pharmaceutical Preparations

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Dheda, K. , Gumbo, T. , Maartens, G. , Dooley, K. E. , McNerney, R. , Murray, M. , Furin, J. , Nardell, E. A. , London, L. , Lessem, E. , Theron, G. , van Helden, P. , Niemann, S. , Merker, M. , Dowdy, D. , Van Rie, A. , Siu, G. K. H. , Pasipanodya, J. G. , Rodrigues, C. , Clark, T. G. & 22 others Sirgel, F. A., Esmail, A., Lin, H. H., Atre, S. R., Schaaf, H. S., Chang, K. C., Lange, C., Nahid, P., Udwadia, Z. F., Horsburgh, C. R., Churchyard, G. J., Menzies, D., Hesseling, A. C., Nuermberger, E., McIlleron, H., Fennelly, K. P., Goemaere, E., Jaramillo, E., Low, M., Jara, C. M., Padayatchi, N. & Warren, R. M. Apr 1 2017 In : The Lancet Respiratory Medicine. 5, 4, p. 291-360 70 p.

Research output: Contribution to journalReview article

Extensively Drug-Resistant Tuberculosis
Epidemiology
Tuberculosis
Multidrug-Resistant Tuberculosis
Linezolid
2016

A Combination Regimen Design Program Based on Pharmacodynamic Target Setting for Childhood Tuberculosis: Design Rules for the Playground

Srivastava, S., Deshpande, D., Pasipanodya, J. G., Thomas, T., Swaminathan, S., Nuermberger, E. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S75-S79

Research output: Contribution to journalArticle

Tuberculosis
Pharmaceutical Preparations
Drug Combinations
Pharmacokinetics
Clinical Trials

A Faropenem, Linezolid, and Moxifloxacin Regimen for Both Drug-Susceptible and Multidrug-Resistant Tuberculosis in Children: FLAME Path on the Milky Way

Deshpande, D., Srivastava, S., Nuermberger, E., Pasipanodya, J. G., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S95-S101

Research output: Contribution to journalArticle

Linezolid
Multidrug-Resistant Tuberculosis
Pharmaceutical Preparations
Stem Cells
Pediatrics

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

Irwin, S. M., Prideaux, B., Lyon, E. R., Zimmerman, M. D., Brooks, E. J., Schrupp, C. A., Chen, C., Reichlen, M. J., Asay, B. C., Voskuil, M. I., Nuermberger, E. L., Andries, K., Lyons, M. A., Dartois, V. & Lenaerts, A. J. Apr 8 2016 In : ACS Infectious Diseases. 2, 4, p. 251-267 17 p.

Research output: Contribution to journalArticle

bedaquiline
Pyrazinamide
Mycobacterium tuberculosis
Tuberculosis
Lung

Concentration-Dependent Synergy and Antagonism of Linezolid and Moxifloxacin in the Treatment of Childhood Tuberculosis: The Dynamic Duo

Deshpande, D., Srivastava, S., Nuermberger, E., Pasipanodya, J. G., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S88-S94

Research output: Contribution to journalArticle

Linezolid
Tuberculosis
Mycobacterium tuberculosis
Therapeutics
Appointments and Schedules

Contribution of oxazolidinones to the efficacy of novel regimens containing bedaquiline and pretomanid in a mouse model of tuberculosis

Tasneen, R., Betoudji, F., Tyagi, S., Li, S. Y., Williams, K., Converse, P. J., Dartois, V., Yang, T., Mendel, C. M., Mdluli, K. E. & Nuermberger, E. L. Jan 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 270-277 8 p.

Research output: Contribution to journalArticle

bedaquiline
Linezolid
Oxazolidinones
Tuberculosis
Pyrazinamide

Drug Concentration Thresholds Predictive of Therapy Failure and Death in Children with Tuberculosis: Bread Crumb Trails in Random Forests

Swaminathan, S., Pasipanodya, J. G., Ramachandran, G., Kumar, A. K. H., Srivastava, S., Deshpande, D., Nuermberger, E. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S63-S74

Research output: Contribution to journalArticle

Bread
Tuberculosis
Rifampin
Pyrazinamide
Pharmaceutical Preparations
Linezolid
Tuberculosis
Multidrug-Resistant Tuberculosis
Mitochondrial Proteins
Pharmaceutical Preparations

High systemic exposure of pyrazinoic acid has limited antituberculosis activity in murine and rabbit models of tuberculosis

Lanoix, J. P., Tasneen, R., O'Brien, P., Sarathy, J., Safi, H., Pinn, M., Alland, D., Dartois, V. & Nuermberger, E. Jul 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 7, p. 4197-4205 9 p.

Research output: Contribution to journalArticle

Pyrazinamide
Tuberculosis
Rabbits
pyrazinoic acid
amidase

Linezolid for Infants and Toddlers with Disseminated Tuberculosis: First Steps

Deshpande, D., Srivastava, S., Pasipanodya, J. G., Bush, S. J., Nuermberger, E., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S80-S87

Research output: Contribution to journalArticle

Linezolid
Tuberculosis
Area Under Curve
Mycobacterium tuberculosis
Microbial Sensitivity Tests

Mouse model of pulmonary cavitary tuberculosis and expression of matrix metalloproteinase-9

Ordonez, A. A., Tasneen, R., Pokkali, S., Xu, Z., Converse, P. J., Klunk, M. H., Mollura, D. J., Nuermberger, E. L. & Jain, S. K. Jul 1 2016 In : DMM Disease Models and Mechanisms. 9, 7, p. 779-788 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 9
Pulmonary Tuberculosis
Cavitation
Tuberculosis
Matrix Metalloproteinases

Mutations in pepQ confer low-level resistance to bedaquiline and clofazimine in Mycobacterium tuberculosis

Almeida, D., Ioerger, T., Tyagi, S., Li, S. Y., Mdluli, K., Andries, K., Grosset, J., Sacchettini, J. & Nuermberger, E. Aug 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4590-4599 10 p.

Research output: Contribution to journalArticle

bedaquiline
Clofazimine
Mycobacterium tuberculosis
Mutation
Multidrug-Resistant Tuberculosis

MYCOBACT-18 - Qualification des souris C3HeB/FeJ pour le traitement expérimental de la tuberculose

Lanoix, J. P., Schmit, J. L. & Nuermberger, E. Jun 1 2016 In : Medecine et Maladies Infectieuses. 46, 4, p. 84 1 p.

Research output: Contribution to journalArticle

Tuberculosis

Optimal Clinical Doses of Faropenem, Linezolid, and Moxifloxacin in Children with Disseminated Tuberculosis: Goldilocks

Srivastava, S., Deshpande, D., Pasipanodya, J., Nuermberger, E., Swaminathan, S. & Gumbo, T. Nov 1 2016 In : Clinical Infectious Diseases. 63, p. S102-S109

Research output: Contribution to journalArticle

Linezolid
Tuberculosis
Microbial Sensitivity Tests
Area Under Curve
Pharmaceutical Preparations

Selective inactivity of pyrazinamide against tuberculosis in C3HeB/FeJ mice is best explained by neutral pH of caseum

Lanoix, J. P., Ioerger, T., Ormond, A., Kaya, F., Sacchettini, J., Dartois, V. & Nuermberger, E. Feb 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 2, p. 735-743 9 p.

Research output: Contribution to journalArticle

Pyrazinamide
Tuberculosis
Lung
Pharmaceutical Preparations
Bacillus

Sterilizing activity of pyrazinamide in combination with first-line drugs in a C3HeB/FeJ mouse model of tuberculosis

Lanoix, J. P., Betoudji, F. & Nuermberger, E. Feb 1 2016 In : Antimicrobial Agents and Chemotherapy. 60, 2, p. 1091-1096 6 p.

Research output: Contribution to journalArticle

Pyrazinamide
Tuberculosis
Pharmaceutical Preparations
Recurrence
Ethambutol
National Institute of Allergy and Infectious Diseases (U.S.)
Critical Pathways
Tuberculosis
Pharmacology
Education
2015

A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections

Locher, C. P., Jones, S. M., Hanzelka, B. L., Perola, E., Shoen, C. M., Cynamon, M. H., Ngwane, A. H., Wiid, I. J., Van Helden, P. D., Betoudji, F., Nuermberger, E. L. & Thomson, J. A. Mar 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 3, p. 1455-1465 11 p.

Research output: Contribution to journalArticle

Tuberculosis
Prodrugs
Infection
Pharmaceutical Preparations
Mycobacterium tuberculosis

Assessing the Landscape of Tools and Approaches for Novel Tuberculosis Regimen Development

Nuermberger, E. & Hanna, D. Jun 15 2015 In : Journal of Infectious Diseases. 211, p. S81-S82

Research output: Contribution to journalArticle

Antitubercular Agents
Multidrug-Resistant Tuberculosis
Tuberculosis
Animal Models
Pharmacokinetics

Correlations between the hollow fiber model of tuberculosis and therapeutic events in tuberculosis patients: Learn and confirm

Gumbo, T., Pasipanodya, J. G., Nuermberger, E., Romero, K. & Hanna, D. 2015 In : Clinical Infectious Diseases. 61, p. S18-S24

Research output: Contribution to journalArticle

Tuberculosis
Pharmacokinetics
Therapeutics
Meta-Analysis
Appointments and Schedules

Daily rifapentine for treatment of pulmonary tuberculosis: A randomized, dose-ranging trial

Dorman, S. E., Savic, R. M., Goldberg, S., Stout, J. E., Schluger, N., Muzanyi, G., Johnson, J. L., Nahid, P., Hecker, E. J., Heilig, C. M., Bozeman, L., Feng, P. J. I., Moro, R. N., MacKenzie, W., Dooley, K. E., Nuermberger, E. L., Vernon, A. & Weiner, M. Feb 1 2015 In : American Journal of Respiratory and Critical Care Medicine. 191, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

rifapentine
Pulmonary Tuberculosis
Rifampin
Sputum
Therapeutics

Efficacy of rifampin plus clofazimine in a murine model of Mycobacterium ulcerans disease

Converse, P. J., Tyagi, S., Xing, Y., Li, S. Y., Kishi, Y., Adamson, J., Nuermberger, E. L. & Grosset, J. H. Jun 4 2015 In : PLoS Neglected Tropical Diseases. 9, 6, e0003823

Research output: Contribution to journalArticle

Mycobacterium ulcerans
Clofazimine
Rifampin
Streptomycin
Clarithromycin
Latent Tuberculosis
Multidrug-Resistant Tuberculosis
Anti-Infective Agents
Drug Therapy
Therapeutics

Evaluation of moxifloxacin-containing regimens in pathologically distinct murine tuberculosis models

Li, S. Y., Irwin, S. M., Converse, P. J., Mdluli, K. E., Lenaerts, A. J. & Nuermberger, E. L. Jul 1 2015 In : Antimicrobial Agents and Chemotherapy. 59, 7, p. 4026-4030 5 p.

Research output: Contribution to journalArticle

Tuberculosis
Ethambutol
Isoniazid
Pyrazinamide
Recurrence
Antitubercular Agents
Multidrug-Resistant Tuberculosis
Medication Adherence
Drug-Related Side Effects and Adverse Reactions

Extensively drug-resistant tuberculosis in a young child after travel to India

Salazar-Austin, N., Ordonez, A. A., Hsu, A. J., Benson, J. E., Mahesh, M., Menachery, E., Razeq, J. H., Salfinger, M., Starke, J. R., Milstone, A. M., Parrish, N., Nuermberger, E. L. & Jain, S. K. Dec 1 2015 In : Lancet Infectious Diseases. 15, 12, p. 1485-1491 7 p.

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
India
Tuberculosis
Teaching Rounds
Multidrug-Resistant Tuberculosis

Forecasting accuracy of the hollow fiber model of tuberculosis for clinical therapeutic outcomes

Gumbo, T., Pasipanodya, J. G., Romero, K., Hanna, D. & Nuermberger, E. 2015 In : Clinical Infectious Diseases. 61, p. S25-S31

Research output: Contribution to journalArticle

Tuberculosis
Confidence Intervals
Pharmaceutical Preparations
Therapeutics
Gold

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

Lanoix, J. P., Lenaerts, A. J. & Nuermberger, E. L. Jun 1 2015 In : DMM Disease Models and Mechanisms. 8, 6, p. 603-610 8 p.

Research output: Contribution to journalArticle

Linezolid
Disease Progression
Tuberculosis
Pyrazinamide
rifapentine

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

Via, L. E. , Savic, R. , Weiner, D. M. , Zimmerman, M. D. , Prideaux, B. , Irwin, S. M. , Lyon, E. , O'Brien, P. , Gopal, P. , Eum, S. , Lee, M. , Lanoix, J. P. , Dutta, N. K. , Shim, T. S. , Cho, J. S. , Kim, W. , Karakousis, P. C. , Lenaerts, A. , Nuermberger, E. , Barry, C. E. & 1 others Dartois, V. May 8 2015 In : ACS Infectious Diseases. 1, 5, p. 203-214 12 p.

Research output: Contribution to journalArticle

Pyrazinamide
Therapeutics
Tuberculosis
Pharmacokinetics
Essential Drugs

Nonclinical Models for Antituberculosis Drug Development: A Landscape Analysis

Gumbo, T., Lenaerts, A. J., Hanna, D., Romero, K. & Nuermberger, E. Jun 15 2015 In : Journal of Infectious Diseases. 211, p. S83-S95

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Drug Combinations
Tuberculosis
Animal Models
Forensic Anthropology

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Irwin, S. M., Driver, E., Lyon, E., Schrupp, C., Ryan, G., Gonzalez-Juarrero, M., Basaraba, R. J., Nuermberger, E. L. & Lenaerts, A. J. Jun 1 2015 In : DMM Disease Models and Mechanisms. 8, 6, p. 591-602 12 p.

Research output: Contribution to journalArticle

Aerosols
Mycobacterium tuberculosis
Animals
Animal Models
Infection

Primary HIV infection presenting as limbic encephalitis and rhabdomyolysis

Ferrada, M. A., Xie, Y. & Nuermberger, E. Oct 24 2015 In : International Journal of STD and AIDS. 26, 11, p. 835-836 2 p.

Research output: Contribution to journalArticle

Limbic Encephalitis
Rhabdomyolysis
HIV Infections
Counseling
Therapeutics

Shortening Tuberculosis Treatment with Fluoroquinolones: Lost in Translation?

Lanoix, J. P., Chaisson, R. E. & Nuermberger, E. L. Nov 4 2015 In : Clinical Infectious Diseases. 62, 4, p. 484-490 7 p.

Research output: Contribution to journalArticle

Fluoroquinolones
Tuberculosis
Pharmacokinetics
Clinical Trials

Systematic analysis of hollow fiber model of tuberculosis experiments

Pasipanodya, J. G., Nuermberger, E., Romero, K., Hanna, D. & Gumbo, T. 2015 In : Clinical Infectious Diseases. 61, p. S10-S17

Research output: Contribution to journalArticle

Tuberculosis
Drug Resistance
Aptitude
Pharmacokinetics
Mycobacterium tuberculosis

Targeting DnaN for tuberculosis therapy using novel griselimycins

Kling, A. , Lukat, P. , Almeida, D. V. , Bauer, A. , Fontaine, E. , Sordello, S. , Zaburannyi, N. , Herrmann, J. , Wenzel, S. C. , König, C. , Ammerman, N. C. , Barrio, M. B. , Borchers, K. , Bordon-Pallier, F. , Brönstrup, M. , Courtemanche, G. , Gerlitz, M. , Geslin, M. , Hammann, P. , Heinz, D. W. & 12 others Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Tyagi, S., Fraisse, L., Grosset, J. H., Lagrange, S. & Müller, R. Jun 5 2015 In : Science. 348, 6239, p. 1106-1112 7 p.

Research output: Contribution to journalArticle

Tuberculosis
Streptomyces
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
Gene Amplification
2014

Accelerated detection of mycolactone production and response to antibiotic treatment in a mouse model of Mycobacterium ulcerans disease.

Converse, P. J., Xing, Y., Kim, K. H., Tyagi, S., Li, S. Y., Almeida, D. V., Nuermberger, E. L., Grosset, J. H. & Kishi, Y. 2014 In : PLoS Neglected Tropical Diseases. 8, 1

Research output: Contribution to journalArticle

Mycobacterium ulcerans
Rifampin
Thin Layer Chromatography
Anti-Bacterial Agents
Clarithromycin

Limited activity of clofazimine as a single drug in a mouse model of tuberculosis exhibiting caseous necrotic granulomas

Irwin, S. M., Gruppo, V., Brooks, E., Gilliland, J., Scherman, M., Reichlen, M. J., Leistikow, R., Kramnik, I., Nuermberger, E. L., Voskuil, M. I. & Lenaerts, A. J. 2014 In : Antimicrobial Agents and Chemotherapy. 58, 7, p. 4026-4034 9 p.

Research output: Contribution to journalArticle

Clofazimine
Granuloma
Tuberculosis
Pharmaceutical Preparations
Lung