Eric H Kossoff

Professor

19982019

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2019

Autism and developmental disability caused by KCNQ3 gain-of-function variants

Sands, T. T., Miceli, F., Lesca, G., Beck, A. E., Sadleir, L. G., Arrington, D. K., Schönewolf-Greulich, B., Moutton, S., Lauritano, A., Nappi, P., Soldovieri, M. V., Scheffer, I. E., Mefford, H. C., Stong, N., Heinzen, E. L., Goldstein, D. B., Perez, A. G., Kossoff, E. H., Stocco, A., Sullivan, J. A. & 15 others, Shashi, V., Gerard, B., Francannet, C., Bisgaard, A. M., Tümer, Z., Willems, M., Rivier, F., Vitobello, A., Thakkar, K., Rajan, D. S., Barkovich, A. J., Weckhuysen, S., Cooper, E. C., Taglialatela, M. & Cilio, M. R., Aug 2019, In : Annals of neurology. 86, 2, p. 181-192 12 p.

Research output: Contribution to journalArticle

Cerebral Ketones Detected by 3T MR Spectroscopy in Patients with High-Grade Glioma on an Atkins-Based Diet

Berrington, A., Schreck, K. C., Barron, B. J., Blair, L., Lin, D. D. M., Hartman, A. L., Kossoff, E., Easter, L., Whitlow, C. T., Jung, Y., Hsu, F. C., Cervenka, M. C., Blakeley, J. O., Barker, P. B. & Strowd, R. E., Nov 1 2019, In : AJNR. American journal of neuroradiology. 40, 11, p. 1908-1915 8 p.

Research output: Contribution to journalArticle

Open Access

Highlights From the Annual Meeting of the American Epilepsy Society 2018

Jobst, B. C., Ben-Menachem, E., Chapman, K. E., Fu, A., Goldman, A., Hirsch, L. J., Jehi, L. E., Kossoff, E. H., Plueger, M., Rho, J. M., Schevon, C. A., Shinnar, S., Sperling, M. R., Simeone, T. A., Wagner, J. L. & Lado, F., May 1 2019, In : Epilepsy Currents. 19, 3, p. 152-158 7 p.

Research output: Contribution to journalArticle

Open Access

How often is antiseizure drug-free ketogenic diet therapy achieved?

Shah, L. M., Turner, Z., Bessone, S. K., Winesett, S. P., Stanfield, A. & Kossoff, E. H., Apr 1 2019, In : Epilepsy and Behavior. 93, p. 29-31 3 p.

Research output: Contribution to journalArticle

Immediate outcomes in early life epilepsy: A contemporary account

Berg, A. T., Wusthoff, C., Shellhaas, R. A., Loddenkemper, T., Grinspan, Z. M., Saneto, R. P., Knupp, K. G., Patel, A., Sullivan, J. E., Kossoff, E. H., Chu, C. J., Massey, S., Valencia, I., Keator, C., Wirrell, E. C., Coryell, J., Millichap, J. J. & Gaillard, W. D., Aug 1 2019, In : Epilepsy and Behavior. 97, p. 44-50 7 p.

Research output: Contribution to journalArticle

Ketogenic dietary therapies for epilepsy and beyond

deCampo, D. M. & Kossoff, E. H., Jul 1 2019, In : Current opinion in clinical nutrition and metabolic care. 22, 4, p. 264-268 5 p.

Research output: Contribution to journalArticle

Ketogenic Dietary Therapy Controversies for Its Second Century

Kossoff, E. & Cervenka, M., Jan 1 2019, (Accepted/In press) In : Epilepsy Currents.

Research output: Contribution to journalArticle

Open Access

Quantitative analysis of phenotypic elements augments traditional electroclinical classification of common familial epilepsies

Epi4K Consortium, Nov 1 2019, In : Epilepsia. 60, 11, p. 2194-2203 10 p.

Research output: Contribution to journalArticle

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day

Sánchez Fernández, I., Gaínza-Lein, M., Abend, N. S., Amengual-Gual, M., Anderson, A., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Clark, J., Farias-Moeller, R., Davis Gaillard, W., Glauser, T. A., Goldstein, J., Goodkin, H. P., Guerriero, R. M., Hecox, K., Jackson, M., Kapur, K., Kelley, S. A. & 21 others, Kossoff, E. H. W., Lai, Y. C., McDonough, T. L., Mikati, M. A., Morgan, L. A., Novotny, E. J., Ostendorf, A. P., Payne, E. T., Peariso, K., Piantino, J., Riviello, J. J., Sannagowdara, K., Stafstrom, C. E., Tasker, R. C., Tchapyjnikov, D., Topjian, A. A., Vasquez, A., Wainwright, M. S., Wilfong, A., Williams, K. & Loddenkemper, T., Aug 2019, In : Seizure. 70, p. 90-96 7 p.

Research output: Contribution to journalArticle

2018

A Serendipitous Case for Shorter Steroid Course in Infantile Spasms

Gill, R. E., Morrow, C. & Kossoff, E. H., Jan 1 2018, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

Child Life Services in an Epilepsy Monitoring Unit

Lowenstein, D. B., Cervenka, M., Mitchell, L., Stewart, N., Kossoff, E. H. & Kelley, S. A., Apr 1 2018, (Accepted/In press) In : Clinical Pediatrics.

Research output: Contribution to journalArticle

Comparative effectiveness of levetiracetam vs phenobarbital for infantile epilepsy

Grinspan, Z. M., Shellhaas, R. A., Coryell, J., Sullivan, J. E., Wirrell, E. C., Mytinger, J. R., Gaillard, W. D., Kossoff, E. H., Valencia, I., Knupp, K. G., Wusthoff, C., Keator, C., Ryan, N., Loddenkemper, T., Chu, C. J., Novotny, E. J., Millichap, J. & Berg, A. T., Apr 1 2018, In : JAMA Pediatrics. 172, 4, p. 352-360 9 p.

Research output: Contribution to journalArticle

Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis

Fitzgerald, K., Vizthum, D., Henry-Barron, B., Schweitzer, A., Cassard, S., Kossoff, E. H., Hartman, A. L., Kapogiannis, D., Sullivan, P., Baer, D. J., Mattson, M. P., Appel, L. & Mowry, E. M., Jul 1 2018, In : Multiple Sclerosis and Related Disorders. 23, p. 33-39 7 p.

Research output: Contribution to journalArticle

Evaluation of the Utility of a Dietary Therapy Second Opinion Clinic

Lackey, A. R., Turner, Z., Haney, C. A., Stanfield, A. C. & Kossoff, E. H., Mar 1 2018, In : Journal of Child Neurology. 33, 4, p. 290-296 7 p.

Research output: Contribution to journalArticle

How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey

for the Pediatric Epilepsy Research Consortium, Aug 1 2018, In : Epilepsy Research. 144, p. 14-19 6 p.

Research output: Contribution to journalArticle

Impact of the modified Atkins diet on cardiovascular health in adults with epilepsy

McDonald, T., Ratchford, E., Henry-Barron, B. J., Kossoff, E. H. & Cervenka, M., Feb 1 2018, In : Epilepsy and Behavior. 79, p. 82-86 5 p.

Research output: Contribution to journalArticle

Improving compliance in adults with epilepsy on a modified Atkins diet: A randomized trial

McDonald, T., Henry-Barron, B. J., Felton, E. A., Gutierrez, E. G., Barnett, J., Fisher, R., Lwin, M. Y., Jan, A., Vizthum, D., Kossoff, E. H. & Cervenka, M., Aug 1 2018, In : Seizure. 60, p. 132-138 7 p.

Research output: Contribution to journalArticle

Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group

The Charlie Foundation, Matthew's Friends & the Practice Committee of the Child Neurology Society, Jan 1 2018, In : Epilepsia Open. 3, 2, p. 175-192 18 p.

Research output: Contribution to journalArticle

Open Access

Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children

Gonzalez-Giraldo, E., Stafstrom, C., Stanfield, A. C. & Kossoff, E. H., Oct 1 2018, In : Pediatric Neurology. 87, p. 30-35 6 p.

Research output: Contribution to journalArticle

2017

Application of rare variant transmission disequilibrium tests to epileptic encephalopathy trio sequence data

Epi4K Consortium, Epilepsy Phenome Genome Project & EuroEPINOMICS-RES Consortium, Jun 1 2017, In : European Journal of Human Genetics. 25, 7, p. 894-899 6 p.

Research output: Contribution to journalArticle

Complications During Ketogenic Diet Initiation: Prevalence, Treatment, and Influence on Seizure Outcomes

Lin, A., Turner, Z., Doerrer, S. C., Stanfield, A. & Kossoff, E. H., Mar 1 2017, In : Pediatric Neurology. 68, p. 35-39 5 p.

Research output: Contribution to journalArticle

Early-life epilepsies and the emerging role of genetic testing

Berg, A. T., Coryell, J., Saneto, R. P., Grinspan, Z. M., Alexander, J. J., Kekis, M., Sullivan, J. E., Wirrell, E. C., Shellhaas, R. A., Mytinger, J. R., Gaillard, W. D., Kossoff, E. H., Valencia, I., Knupp, K. G., Wusthoff, C., Keator, C., Dobyns, W. B., Ryan, N., Loddenkemper, T., Chu, C. J. & 2 others, Novotny, E. J. & Koh, S., Sep 1 2017, In : JAMA Pediatrics. 171, 9, p. 863-871 9 p.

Research output: Contribution to journalArticle

Impact of Child Life Services on Children and Families Admitted to Start the Ketogenic Diet

Kossoff, E. H., Sutter, L., Doerrer, S. C., Haney, C. A. & Turner, Z., Aug 1 2017, In : Journal of Child Neurology. 32, 9, p. 828-833 6 p.

Research output: Contribution to journalArticle

Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus

Shellhaas, R. A., Berg, A. T., Grinspan, Z. M., Wusthoff, C. J., Millichap, J. J., Loddenkemper, T., Coryell, J., Saneto, R. P., Chu, C. J., Joshi, S. M., Sullivan, J. E., Knupp, K. G., Kossoff, E. H., Keator, C., Wirrell, E. C., Mytinger, J. R., Valencia, I., Massey, S. & Gaillard, W. D., Oct 1 2017, In : Pediatric Neurology. 75, p. 73-79 7 p.

Research output: Contribution to journalArticle

Is there a role for diet monotherapy in adult epilepsy?

Cervenka, M., Henry-Barron, B. J. & Kossoff, E. H., 2017, In : Epilepsy and Behavior Case Reports. 7, p. 6-9 4 p.

Research output: Contribution to journalArticle

Ketogenic diet therapy for epilepsy during pregnancy: A case series

van der Louw, E. J. T. M., McDonald, T., Henry-Barron, B. J., Olieman, J. F., Duvekot, J. J., Vermeulen, M. J., Bannink, N., Williams, M., Neuteboom, R. F., Kossoff, E. H., Catsman-Berrevoets, C. E. & Cervenka, M., Feb 1 2017, In : Seizure. 45, p. 198-201 4 p.

Research output: Contribution to journalArticle

Pediatric Headache and Seizures

Oakley, C. & Kossoff, E. H., Nov 1 2017, In : Seminars in Pediatric Neurology. 24, 4, p. 310-319 10 p.

Research output: Contribution to journalArticle

Phase I/II multicenter ketogenic diet study for adult superrefractory status epilepticus

Cervenka, M., Hocker, S., Koenig, M., Bar, B., Henry-Barron, B., Kossoff, E. H., Hartman, A. L., Probasco, J. C., Benavides, D. R., Venkatesan, A., Hagen, E. C., Dittrich, D., Stern, T., Radzik, B., Depew, M., Caserta, F. M., Nyquist, P. A., Kaplan, P. W. & Geocadin, R., Mar 7 2017, In : Neurology. 88, 10, p. 938-943 6 p.

Research output: Contribution to journalArticle

Phenotypic analysis of 303 multiplex families with common epilepsies

The Epi4K Consortium, Aug 1 2017, In : Brain. 140, 8, p. 2144-2156 13 p.

Research output: Contribution to journalArticle

Ultra-rare genetic variation in common epilepsies: a case-control sequencing study

Allen, A. S., Bellows, S. T., Berkovic, S. F., Bridgers, J., Burgess, R., Cavalleri, G., Chung, S. K., Cossette, P., Delanty, N., Dlugos, D., Epstein, M. P., Freyer, C., Goldstein, D. B., Heinzen, E. L., Hildebrand, M. S., Johnson, M. R., Kuzniecky, R., Lowenstein, D. H., Marson, A. G., Mayeux, R. & 66 others, Mebane, C., Mefford, H. C., O'Brien, T. J., Ottman, R., Petrou, S., Petrovski, S., Pickrell, W. O., Radtke, R. A., Rees, M. I., Regan, B. M., Ren, Z., Scheffer, I. E., Sills, G. J., Thomas, R. H., Wang, Q., Abou-Khalil, B., Alldredge, B. K., Amrom, D., Andermann, E., Andermann, F., Bautista, J. F., Bluvstein, J., Boro, A., Cascino, G. D., Consalvo, D., Crumrine, P., Devinsky, O., Fiol, M., Fountain, N. B., French, J., Friedman, D., Geller, E. B., Glauser, T., Glynn, S., Haas, K., Haut, S. R., Hayward, J., Helmers, S. L., Joshi, S., Kanner, A., Kirsch, H. E., Knowlton, R. C., Kossoff, E. H., Kuperman, R., Motika, P. V., Novotny, E. J., Paolicchi, J. M., Parent, J. M., Park, K., Poduri, A., Sadleir, L. G., Shellhaas, R. A., Sherr, E. H., Shih, J. J., Shinnar, S., Singh, R. K., Sirven, J., Smith, M. C., Sullivan, J., Thio, L. L., Venkat, A., Vining, E. P. G., Von Allmen, G. K., Weisenberg, J. L., Widdess-Walsh, P. & Winawer, M. R., Feb 1 2017, In : The Lancet Neurology. 16, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

2016

Diet Redux: Outcomes from Reattempting Dietary Therapy for Epilepsy

Kossoff, E. H., Doerrer, S. C., Winesett, S. P., Turner, Z., Henry, B. J., Bessone, S., Stanfield, A. & Cervenka, M. K. C., Jul 1 2016, In : Journal of Child Neurology. 31, 8, p. 1052-1056 5 p.

Research output: Contribution to journalArticle

Establishing an Adult Epilepsy Diet Center: Experience, efficacy and challenges

Cervenka, M., Henry, B. J., Felton, E. A., Patton, K. & Kossoff, E. H., May 1 2016, In : Epilepsy and Behavior. 58, p. 61-68 8 p.

Research output: Contribution to journalArticle

Hepatic Dysfunction as a Complication of Combined Valproate and Ketogenic Diet

Stevens, C. E., Turner, Z. & Kossoff, E. H., Jan 1 2016, In : Pediatric Neurology. 54, p. 82-84 3 p.

Research output: Contribution to journalArticle

Leveraging a Sturge-Weber Gene Discovery: An Agenda for Future Research

Comi, A. M., Sahin, M., Hammill, A., Kaplan, E. H., Juhász, C., North, P., Ball, K. L., Levin, A. V., Cohen, B., Morris, J., Lo, W., Roach, E. S., Abreu, N., Acosta, M., Ball, K. L., Berrocal, A., Bischoff, J., Brodie, J., Burkhart, C., Cohen, B. & 44 others, Comi, A. M., Dymerska, G., Eckstein, D., Enriquez-Algeciras, M., Ewen, J., Fisher, B., Freedman, S., Germain-Lee, E., Geronemus, R., Gold, M., Gopal-Srivastava, R., Hammill, A., Hebert, A., Huang, L., Jampel, H., Juhász, C., Kaplan, E. H., Kaseka, M., Kirkorian, Y., Kossoff, E., Levin, A. V., Lin, D., Lo, W., Loeb, J., Marathe, K., Marchuk, D., Mead, A., Mellis, S., Morris, J., Murray, T., North, P., Phung, T., Pinto, A., Puttgen, K. B., Ratner, N., Reeve, J., Roach, S., Sahin, M., Swindell, C., Tseng, H., Tune, M., Wetzel-Strong, S., White, M. & Whittemore, V., May 1 2016, In : Pediatric Neurology. 58, p. 12-24 13 p.

Research output: Contribution to journalArticle

Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort

Knupp, K. G., Leister, E., Coryell, J., Nickels, K. C., Ryan, N., Juarez-Colunga, E., Gaillard, W. D., Mytinger, J. R., Berg, A. T., Millichap, J., Nordli, D. R., Joshi, S., Shellhaas, R. A., Loddenkemper, T., Dlugos, D., Wirrell, E., Sullivan, J., Hartman, A. L., Kossoff, E. H., Grinspan, Z. M. & 1 others, Kelley, S. A., 2016, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

Response to treatment in a prospective national infantile spasms cohort

Knupp, K. G., Coryell, J., Nickels, K. C., Ryan, N., Leister, E., Loddenkemper, T., Grinspan, Z., Hartman, A. L., Kossoff, E. H., Gaillard, W. D., Mytinger, J. R., Joshi, S., Shellhaas, R. A., Sullivan, J., Dlugos, D., Hamikawa, L., Berg, A. T., Millichap, J., Nordli, D. R. & Wirrell, E., Mar 1 2016, In : Annals of Neurology. 79, 3, p. 475-484 10 p.

Research output: Contribution to journalArticle

The impact of the modified Atkins diet on lipid profiles in adults with epilepsy

Cervenka, M., Patton, K., Eloyan, A., Henry, B. & Kossoff, E. H., 2016, In : Nutritional Neuroscience. 19, 3, p. 131-137 7 p.

Research output: Contribution to journalArticle

The molecular and phenotypic spectrum of IQSEC2-related epilepsy

Zerem, A., Haginoya, K., Lev, D., Blumkin, L., Kivity, S., Linder, I., Shoubridge, C., Palmer, E. E., Field, M., Boyle, J., Chitayat, D., Gaillard, W. D., Kossoff, E. H., Willems, M., Geneviève, D., Tran-Mau-Them, F., Epstein, O., Heyman, E., Dugan, S., Masurel-Paulet, A. & 9 others, Piton, A., Kleefstra, T., Pfundt, R., Sato, R., Tzschach, A., Matsumoto, N., Saitsu, H., Leshinsky-Silver, E. & Lerman-Sagie, T., 2016, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalArticle

Use of dietary therapies amongst patients with GLUT1 deficiency syndrome

Kass, H. R., Winesett, S. P., Bessone, S. K., Turner, Z. & Kossoff, E. H., Feb 1 2016, In : Seizure. 35, p. 83-87 5 p.

Research output: Contribution to journalArticle

2015

Anticonvulsant Efficacy in Sturge-Weber Syndrome

Kaplan, E. H., Kossoff, E. H., Bachur, C. D., Gholston, M., Hahn, J., Widlus, M. & Comi, A. M. S., Oct 30 2015, (Accepted/In press) In : Pediatric Neurology.

Research output: Contribution to journalArticle

Commentary: Breaking down the barriers to using dietary therapy for refractory epilepsy

Kossoff, E. H., Sep 1 2015, In : Epilepsia. 56, 9, p. 1335-1336 2 p.

Research output: Contribution to journalArticle

Delivery of epilepsy care to adults with intellectual and developmental disabilities

Devinsky, O., Asato, M., Camfield, P., Geller, E., Kanner, A. M., Keller, S., Kerr, M., Kossoff, E. H., Lau, H., Kothare, S., Singh, B. K. & Wirrell, E., Oct 27 2015, In : Neurology. 85, 17, p. 1512-1521 10 p.

Research output: Contribution to journalArticle

Glycemic modulation in neuro-oncology: Experience and future directions using a modified Atkins diet for high-grade brain tumors

Strowd, R. E., Cervenka, M., Henry, B. J., Kossoff, E. H., Hartman, A. L. & Blakeley, J., Jan 1 2015, In : Neuro-Oncology Practice. 2, 3, p. 127-136 10 p.

Research output: Contribution to journalArticle

Incidental rolandic spikes: Long-term outcomes and impact of treatment

McNally, M. A. & Kossoff, E. H., Feb 1 2015, In : Epilepsy and Behavior. 43, p. 135-138 4 p.

Research output: Contribution to journalArticle

Phenotypic and imaging features of FLNA-negative patients with bilateral periventricular nodular heterotopia and epilepsy

for the EPGP Investigators, Oct 1 2015, In : Epilepsy and Behavior. 51, p. 321-327 7 p.

Research output: Contribution to journalArticle

The ketogenic diet in pharmacoresistant childhood epilepsy

Winesett, S. P., Bessone, S. K. & Kossoff, E. H. W., Jun 1 2015, In : Expert Review of Neurotherapeutics. 15, 6, p. 621-628 8 p.

Research output: Contribution to journalArticle

What are the minimum requirements for ketogenic diet services in resource-limited regions? Recommendations from the International League Against Epilepsy Task Force for Dietary Therapy

Kossoff, E. H., Al-Macki, N., Cervenka, M., Kim, H. D., Liao, J., Megaw, K., Nathan, J. K., Raimann, X., Rivera, R., Wiemer-Kruel, A., Williams, E. & Zupec-Kania, B. A., Sep 1 2015, In : Epilepsia. 56, 9, p. 1337-1342 6 p.

Research output: Contribution to journalArticle