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Research Output 1988 2019

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Article
2019

Current pediatric administered activity guidelines for 99mTc-DMSA SPECT based on patient weight do not provide the same task-based image quality

Li, Y., O'Reilly, S., Plyku, D., Treves, S. T., Fahey, F., Du, Y., Cao, X., Sexton-Stallone, B., Brown, J., Sgouros, G., Bolch, W. E. & Frey, E. C., Jan 1 2019, (Accepted/In press) In : Medical physics.

Research output: Contribution to journalArticle

Technetium Tc 99m Dimercaptosuccinic Acid
Single-Photon Emission-Computed Tomography
ROC Curve
Guidelines
Pediatrics
2018

A projection image database to investigate factors affecting image quality in weight-based dosing: Application to pediatric renal SPECT

Li, Y., O'Reilly, S., Plyku, D., Treves, S. T., Du, Y., Fahey, F., Cao, X., Jha, A. K., Sgouros, G., Bolch, W. E. & Frey, E., Jul 9 2018, In : Physics in Medicine and Biology. 63, 14, 145004.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Databases
Pediatrics
Kidney
Weights and Measures

Measuring PET spatial resolution using a cylinder phantom positioned at an oblique angle

Lodge, M., Leal, J. P., Rahmim, A., Sunderland, J. J. & Frey, E., Nov 1 2018, In : Journal of Nuclear Medicine. 59, 11, p. 1768-1775 8 p.

Research output: Contribution to journalArticle

Clinical Protocols
Isotopes
Computer-Assisted Image Processing
Electrons
Equipment and Supplies

The effect of attenuation map, scatter energy window width, and volume of interest on the calibration factor calculation in quantitative 177Lu SPECT imaging: Simulation and phantom study

Karimi Ghodoosi, E., D'Alessandria, C., Li, Y., Bartel, A., Köhner, M., Höllriegl, V., Navab, N., Eiber, M., Li, W. B., Frey, E. & Ziegler, S., Dec 1 2018, In : Physica Medica. 56, p. 74-80 7 p.

Research output: Contribution to journalArticle

Imaging Phantoms
Single-Photon Emission-Computed Tomography
Calibration
attenuation
Water
2017

A comparison of resampling schemes for estimating model observer performance with small ensembles

Elshahaby, F. E. A., Jha, A. K., Ghaly, M. & Frey, E., Aug 22 2017, In : Physics in Medicine and Biology. 62, 18, p. 7300-7320 21 p.

Research output: Contribution to journalArticle

ROC Curve
Area Under Curve
Sample Size

Practical no-gold-standard evaluation framework for quantitative imaging methods: Application to lesion segmentation in positron emission tomography

Jha, A. K., Mena, E., Caffo, B. S., Ashrafinia, S., Rahmim, A., Frey, E. & Subramaniam, R. M., Jan 1 2017, In : Journal of Medical Imaging. 4, 1, 011011.

Research output: Contribution to journalArticle

Positron emission tomography
Gold
Positron-Emission Tomography
Imaging techniques
Uncertainty

Simplifying volumes-of-interest (VOIs) definition in quantitative SPECT: Beyond manual definition of 3D whole-organ VOIs

Vicente, E. M., Lodge, M., Rowe, S., Wahl, R. L. & Frey, E., May 1 2017, In : Medical Physics. 44, 5, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

Organ Size
Single-Photon Emission-Computed Tomography
Noise
Liver
Kidney

Use of quantitative SPECT/CT reconstruction in 99mTc-sestamibi imaging of patients with renal masses

Jones, K. M., Solnes, L., Rowe, S., Gorin, M., Sheikhbahaei, S., Fung, G., Frey, E., Allaf, M. E., Du, Y. & Javadi, M. S. S., Dec 6 2017, (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Kidney
Single-Photon Emission-Computed Tomography
Neoplasms
Biomarkers

Use of Sub-Ensembles and Multi-Template Observers to Evaluate Detection Task Performance for Data That are Not Multivariate Normal

Li, X., Jha, A. K., Ghaly, M., Elshahaby, F. E. A., Links, J. M. & Frey, E., Apr 1 2017, In : IEEE Transactions on Medical Imaging. 36, 4, p. 917-929 13 p., 7795176.

Research output: Contribution to journalArticle

Task Performance and Analysis
Area Under Curve
Statistics
Medical imaging
Image quality
2016

A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods

Jha, A. K., Caffo, B. S. & Frey, E., Mar 15 2016, In : Physics in Medicine and Biology. 61, 7, p. 2780-2801 22 p.

Research output: Contribution to journalArticle

Nuclear Medicine
Gold
Noise
Organ Size
Task Performance and Analysis

A risk index for pediatric patients undergoing diagnostic imaging with 99mTc-dimercaptosuccinic acid that accounts for body habitus

O'Reilly, S. E., Plyku, D., Sgouros, G., Fahey, F. H., Ted Treves, S., Frey, E. & Bolch, W. E., Mar 1 2016, In : Physics in Medicine and Biology. 61, 6, p. 2319-2332 14 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Dimercaptosuccinic Acid
Diagnostic Imaging
Pediatrics
Kidney
Newborn Infant
Single-Photon Emission-Computed Tomography
Perfusion
ROC Curve
Area Under Curve
Noise
Single-Photon Emission-Computed Tomography
ROC Curve
Perfusion
Joints
Monte Carlo Method

Comparison of quantitative Y-90 SPECT and non-time-of-flight PET imaging in post-therapy radioembolization of liver cancer

Yue, J., Mauxion, T., Reyes, D. K., Lodge, M., Hobbs, R., Rong, X., Dong, Y., Herman, J. M., Wahl, R. L., Geschwind, J. F. H. & Frey, E., Oct 1 2016, In : Medical Physics. 43, 10, p. 5779-5790 12 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Single-Photon Emission-Computed Tomography
Liver
Calibration
Yttrium
Single-Photon Emission-Computed Tomography
Perfusion
Statistics
Myocardial Perfusion Imaging
Normal Distribution
2015
Single-Photon Emission-Computed Tomography
Theoretical Models
Perfusion
ROC Curve
Computer-Assisted Image Processing

Estimation of dynamic time activity curves from dynamic cardiac SPECT imaging

Hossain, J., Du, Y., Links, J. M., Rahmim, A., Karakatsanis, N., Akhbardeh, A., Lyons, J. & Frey, E., Apr 21 2015, In : Physics in Medicine and Biology. 60, 8, p. 3193-3208 16 p., 3193.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Myocardium
Perfusion
Organ Size
Cardiovascular Diseases

Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

Anizan, N., Wang, H., Zhou, X. C., Wahl, R. L. & Frey, E., Feb 7 2015, In : Physics in Medicine and Biology. 60, 3, p. 1325-1337 13 p.

Research output: Contribution to journalArticle

Gamma Cameras
Calibration
Noise
Nuclear Medicine
Single-Photon Emission-Computed Tomography

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study

Zimmerman, B. E., Grošev, D., Buvat, I., Coca Pérez, M. A., Frey, E., Green, A., Krisanachinda, A., Lassmann, M., Ljungberg, M., Pozzo, L., Quadir, K. A., Terán Gretter, M. A., Van Staden, J. & Poli, G. L., Dec 4 2015, (Accepted/In press) In : Zeitschrift fur Medizinische Physik.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
X Ray Computed Tomography
Radioisotopes
Technology
Equipment and Supplies
Clinical Protocols
Single-Photon Emission-Computed Tomography
Isotopes
Perfusion
Monte Carlo Method

Optimization and evaluation of reconstruction-based compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT

Ekjeen, T., Tocharoenchai, C., Pusuwan, P., Fung, G. S. K., Ghaly, M., Du, Y. & Frey, E., Mar 1 2015, In : Physica Medica. 31, 2, p. 159-166 8 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Single-Photon Emission-Computed Tomography
optimization
evaluation
attenuation
Single photon emission computed tomography
Single-Photon Emission-Computed Tomography
Perfusion
Image processing
Imaging systems

Repeatability of radiotracer uptake in normal abdominal organs with 111In-pentetreotide quantitative SPECT/CT

Rowe, S., Vicente, E., Anizan, N., Wang, H., Leal, J. P., Lodge, M., Frey, E. & Wahl, R. L., Jul 1 2015, In : Journal of Nuclear Medicine. 56, 7, p. 985-988 4 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Kidney
Liver
Fluorodeoxyglucose F18
Single Photon Emission Computed Tomography Computed Tomography

Singular value decomposition for photon-processing nuclear imaging systems and applications for reconstruction and computing null functions

Jha, A. K., Barrett, H. H., Frey, E., Clarkson, E., Caucci, L. & Kupinski, M. A., Sep 21 2015, In : Physics in Medicine and Biology. 60, 18, p. 7359-7385 27 p.

Research output: Contribution to journalArticle

Photons
Single-Photon Emission-Computed Tomography
Information Systems
2014

Design of a digital phantom population for myocardial perfusion SPECT imaging research

Ghaly, M., Du, Y., Fung, G. S. K., Tsui, B., Links, J. M. & Frey, E., Jun 21 2014, In : Physics in Medicine and Biology. 59, 12, p. 2935-2953 19 p.

Research output: Contribution to journalArticle

Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Perfusion
Research
Population
Computer-Assisted Image Processing
Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Therapeutics
Kidney

Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies

Du, Y., Links, J. M., Becker, L., Dipaula, A. F., Frank, T., Schuleri, K. H., Lardo, A. C. & Frey, E., 2014, In : Journal of Nuclear Cardiology. 21, 2, p. 329-340 12 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Isotopes
Canidae
Technetium Tc 99m Sestamibi
Dogs
Gamma Cameras
Calibration
Radioisotopes
Single-Photon Emission-Computed Tomography
Body Image
Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Radioisotopes
Radionuclide Imaging
Cicatrix
2013

A collimator optimization method for quantitative imaging: Application to Y-90 bremsstrahlung SPECT

Rong, X. & Frey, E., Aug 2013, In : Medical Physics. 40, 8, 082504.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Microspheres
Photons
Radioisotopes
Anatomy

Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging

Du, Y., Madar, I., Stumpf, M. J., Rong, X., Fung, G. S. K. & Frey, E., Feb 2013, In : Journal of Nuclear Cardiology. 20, 1, p. 84-98 15 p.

Research output: Contribution to journalArticle

Myocardium
Perfusion
Dogs
Direction compound

Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters

Cheng, L., Hobbs, R., Segars, P. W., Sgouros, G. & Frey, E., Jun 7 2013, In : Physics in Medicine and Biology. 58, 11, p. 3631-3647 17 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Noise
Artifacts
Kidney

MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications

Dewaraja, Y. K., Ljungberg, M., Green, A. J., Zanzonico, P. B., Frey, E. C., Bolch, W. E., Brill, A. B., Dunphy, M., Fisher, D. R., Howell, R. W., Meredith, R. F., Sgouros, G. & Wessels, B. W., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2182-2188 7 p.

Research output: Contribution to journalArticle

Pamphlets
Single-Photon Emission-Computed Tomography
Radioisotopes
Guidelines
Therapeutics
Single-Photon Emission-Computed Tomography
Area Under Curve
Microspheres
Yttrium
Monte Carlo Method

Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-hodgkin lymphoma

Hobbs, R., Wahl, R. L., Frey, E., Kasamon, Y., Song, H., Huang, P., Jones, R. J. & Sgouros, G., Sep 1 2013, In : Journal of Nuclear Medicine. 54, 9, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Non-Hodgkin's Lymphoma
Therapeutics
Neoplasms
Radioisotopes
2012

Accuracy and precision of radioactivity quantification in nuclear medicine images

Frey, E., Humm, J. L. & Ljungberg, M., May 2012, In : Seminars in Nuclear Medicine. 42, 3, p. 208-218 11 p.

Research output: Contribution to journalArticle

Nuclear Medicine
Radioactivity
Positron-Emission Tomography
Neoplasms
Single-Photon Emission-Computed Tomography
Single-Photon Emission-Computed Tomography
Microspheres
Photons
Imaging Phantoms
Yttrium

Development and evaluation of an improved quantitative 90Y bremsstrahlung SPECT method

Rong, X., Du, Y., Ljungberg, M., Rault, E., Vandenberghe, S. & Frey, E., May 2012, In : Medical Physics. 39, 5, p. 2346-2358 13 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Photons
Radioisotopes
Yttrium
Monte Carlo Method

Internal photon and electron dosimetry of the newborn patient-a hybrid computational phantom study

Wayson, M., Lee, C., Sgouros, G., Treves, S. T., Frey, E. & Bolch, W. E., Mar 7 2012, In : Physics in Medicine and Biology. 57, 5, p. 1433-1457 25 p.

Research output: Contribution to journalArticle

Photons
Newborn Infant
Electrons
Radioisotopes
Nuclear Medicine

MIRD pamphlet no. 23: Quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy

Dewaraja, Y. K., Frey, E., Sgouros, G., Brill, A. B., Roberson, P., Zanzonico, P. B. & Ljungberg, M., Aug 1 2012, In : Journal of Nuclear Medicine. 53, 8, p. 1310-1325 16 p.

Research output: Contribution to journalArticle

Pamphlets
Single-Photon Emission-Computed Tomography
Radioisotopes
Diagnostic Imaging
Therapeutics

Three-dimensional radiobiological dosimetry of kidneys for treatment planning in peptide receptor radionuclide therapy

Baechler, S., Hobbs, R., Boubaker, A., Buchegger, F., He, B., Frey, E. & Sgouros, G., Oct 2012, In : Medical Physics. 39, 10, p. 6118-6128 11 p.

Research output: Contribution to journalArticle

Peptide Receptors
Radioisotopes
Kidney
Single-Photon Emission-Computed Tomography
Therapeutics

Tumor dosimetry and response for 153Sm-ethylenediamine tetramethylene phosphonic acid therapy of high-risk osteosarcoma

Senthamizhchelvan, S., Hobbs, R., Song, H., Frey, E., Zhang, Z., Armour, E., Wahl, R. L., Loeb, D. M. & Sgouros, G., Feb 1 2012, In : Journal of Nuclear Medicine. 53, 2, p. 215-224 10 p.

Research output: Contribution to journalArticle

ethylenediamine
Osteosarcoma
Neoplasms
Therapeutics
phosphonic acid
2011

An approach for balancing diagnostic image quality with cancer risk: Application to pediatric diagnostic imaging of 99mTc- dimercaptosuccinic acid

Sgouros, G., Frey, E., Bolch, W. E., Wayson, M. B., Abadia, A. F. & Treves, S. T., Dec 1 2011, In : Journal of Nuclear Medicine. 52, 12, p. 1923-1929 7 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Dimercaptosuccinic Acid
Diagnostic Imaging
Pediatrics
Neoplasms
Body Weight

A treatment planning method for sequentially combining radiopharmaceutical therapy and external radiation therapy

Hobbs, R., McNutt, T., Baechler, S., He, B., Esaias, C. E., Frey, E., Loeb, D. M., Wahl, R. L., Shokek, O. & Sgouros, G., Jul 15 2011, In : International Journal of Radiation Oncology, Biology, Physics. 80, 4, p. 1256-1262 7 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
planning
radiation therapy
therapy
Radiotherapy

Development and evaluation of a model-based downscatter compensation method for quantitative I-131 SPECT

Song, N., Du, Y., He, B. & Frey, E., Jun 2011, In : Medical Physics. 38, 6, p. 3193-3204 12 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Photons
Radioisotopes
Beta Particles
Therapeutics

EQPlanar: A maximum-likelihood method for accurate organ activity estimation from whole body planar projections

Song, N., He, B., Wahl, R. L. & Frey, E., Sep 7 2011, In : Physics in Medicine and Biology. 56, 17, p. 5503-5524 22 p.

Research output: Contribution to journalArticle

Organ Size
Single-Photon Emission-Computed Tomography
Patient Simulation
Whole Body Imaging
Injections
Labyrinth Vestibule
Implanted Electrodes
Prostheses and Implants
Brain
Research

Material separation in x-ray CT with energy resolved photon-counting detectors

Wang, X., Meier, D., Taguchi, K., Wagenaar, D. J., Patt, B. E. & Frey, E., Mar 2011, In : Medical Physics. 38, 3, p. 1534-1546 13 p.

Research output: Contribution to journalArticle

Photons
Tomography
X-Rays
Contrast Media
Bone and Bones

MicroCT with energy-resolved photon-counting detectors

Wang, X., Meier, D., Mikkelsen, S., Maehlum, G. E., Wagenaar, D. J., Tsui, B., Patt, B. E. & Frey, E., May 7 2011, In : Physics in Medicine and Biology. 56, 9, p. 2791-2816 26 p.

Research output: Contribution to journalArticle

X-Ray Microtomography
Photons
X-Rays
Radiation
Polymethyl Methacrylate

Modeling the performance of a photon counting x-ray detector for CT: Energy response and pulse pileup effects

Taguchi, K., Zhang, M., Frey, E., Wang, X., Iwanczyk, J. S., Nygard, E., Hartsough, N. E., Tsui, B. & Barber, W. C., Feb 2011, In : Medical Physics. 38, 2, p. 1089-1102 14 p.

Research output: Contribution to journalArticle

Photons
Tomography
X-Rays
X-Ray Computed Tomography Scanners
Calibration