1988 …2019
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Research Output 1988 2019

2019

Current pediatric administered activity guidelines for 99mTc-DMSA SPECT based on patient weight do not provide the same task-based image quality

Li, Y., O'Reilly, S., Plyku, D., Treves, S. T., Fahey, F., Du, Y., Cao, X., Sexton-Stallone, B., Brown, J., Sgouros, G., Bolch, W. E. & Frey, E. C., Jan 1 2019, (Accepted/In press) In : Medical physics.

Research output: Contribution to journalArticle

Technetium Tc 99m Dimercaptosuccinic Acid
Single-Photon Emission-Computed Tomography
ROC Curve
Guidelines
Pediatrics

Incorporating CT prior information in the robust fuzzy C-means algorithm for QSPECT image segmentation

Chen, J., Jha, A. K. & Frey, E. C., Jan 1 2019, Medical Imaging 2019: Image Processing. Angelini, E. D., Angelini, E. D., Angelini, E. D. & Landman, B. A. (eds.). SPIE, 109491W. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10949).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Medical image processing
fuzzy systems
Nuclear medicine
Copying
nuclear medicine
2018

A projection image database to investigate factors affecting image quality in weight-based dosing: Application to pediatric renal SPECT

Li, Y., O'Reilly, S., Plyku, D., Treves, S. T., Du, Y., Fahey, F., Cao, X., Jha, A. K., Sgouros, G., Bolch, W. E. & Frey, E., Jul 9 2018, In : Physics in Medicine and Biology. 63, 14, 145004.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Databases
Pediatrics
Kidney
Weights and Measures

Measuring PET spatial resolution using a cylinder phantom positioned at an oblique angle

Lodge, M., Leal, J. P., Rahmim, A., Sunderland, J. J. & Frey, E., Nov 1 2018, In : Journal of Nuclear Medicine. 59, 11, p. 1768-1775 8 p.

Research output: Contribution to journalArticle

Clinical Protocols
Isotopes
Computer-Assisted Image Processing
Electrons
Equipment and Supplies

Short coherence dynamic Fizeau interferometer with internal path matching for radius of curvature measurement

North Morris, M. & Frey, E., Jan 1 2018, Interferometry XIX. Creath, K., Burke, J., Davies, A. D., North Morris, M. B. & Creath, K. (eds.). SPIE, Vol. 10749. 1074910

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fizeau Interferometer
Radius of curvature
Interferometers
interferometers
curvature

The effect of attenuation map, scatter energy window width, and volume of interest on the calibration factor calculation in quantitative 177Lu SPECT imaging: Simulation and phantom study

Karimi Ghodoosi, E., D'Alessandria, C., Li, Y., Bartel, A., Köhner, M., Höllriegl, V., Navab, N., Eiber, M., Li, W. B., Frey, E. & Ziegler, S., Dec 1 2018, In : Physica Medica. 56, p. 74-80 7 p.

Research output: Contribution to journalArticle

Imaging Phantoms
Single-Photon Emission-Computed Tomography
Calibration
attenuation
Water
2017

A comparison of resampling schemes for estimating model observer performance with small ensembles

Elshahaby, F. E. A., Jha, A. K., Ghaly, M. & Frey, E., Aug 22 2017, In : Physics in Medicine and Biology. 62, 18, p. 7300-7320 21 p.

Research output: Contribution to journalArticle

ROC Curve
Area Under Curve
Sample Size

Dose Estimation in Pediatric Nuclear Medicine

Fahey, F. H., Goodkind, A. B., Plyku, D., Khamwan, K., O'Reilly, S. E., Cao, X., Frey, E., Li, Y., Bolch, W. E., Sgouros, G. & Treves, S. T., Mar 1 2017, In : Seminars in Nuclear Medicine. 47, 2, p. 118-125 8 p.

Research output: Contribution to journalReview article

Nuclear Medicine
Pediatrics
Radiopharmaceuticals
Radiation
Radiometry

No-gold-standard evaluation of image-acquisition methods using patient data

Jha, A. K. & Frey, E., 2017, Medical Imaging 2017: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 10136. 101360L

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Image acquisition
Gold
acquisition
gold
evaluation

Practical no-gold-standard evaluation framework for quantitative imaging methods: Application to lesion segmentation in positron emission tomography

Jha, A. K., Mena, E., Caffo, B. S., Ashrafinia, S., Rahmim, A., Frey, E. & Subramaniam, R. M., Jan 1 2017, In : Journal of Medical Imaging. 4, 1, 011011.

Research output: Contribution to journalArticle

Positron emission tomography
Gold
Positron-Emission Tomography
Imaging techniques
Uncertainty

Simplifying volumes-of-interest (VOIs) definition in quantitative SPECT: Beyond manual definition of 3D whole-organ VOIs

Vicente, E. M., Lodge, M., Rowe, S., Wahl, R. L. & Frey, E., May 1 2017, In : Medical Physics. 44, 5, p. 1707-1717 11 p.

Research output: Contribution to journalArticle

Organ Size
Single-Photon Emission-Computed Tomography
Noise
Liver
Kidney

Use of quantitative SPECT/CT reconstruction in 99mTc-sestamibi imaging of patients with renal masses

Jones, K. M., Solnes, L., Rowe, S., Gorin, M., Sheikhbahaei, S., Fung, G., Frey, E., Allaf, M. E., Du, Y. & Javadi, M. S. S., Dec 6 2017, (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Kidney
Single-Photon Emission-Computed Tomography
Neoplasms
Biomarkers

Use of Sub-Ensembles and Multi-Template Observers to Evaluate Detection Task Performance for Data That are Not Multivariate Normal

Li, X., Jha, A. K., Ghaly, M., Elshahaby, F. E. A., Links, J. M. & Frey, E., Apr 1 2017, In : IEEE Transactions on Medical Imaging. 36, 4, p. 917-929 13 p., 7795176.

Research output: Contribution to journalArticle

Task Performance and Analysis
Area Under Curve
Statistics
Medical imaging
Image quality
2016

A no-gold-standard technique for objective assessment of quantitative nuclear-medicine imaging methods

Jha, A. K., Caffo, B. S. & Frey, E., Mar 15 2016, In : Physics in Medicine and Biology. 61, 7, p. 2780-2801 22 p.

Research output: Contribution to journalArticle

Nuclear Medicine
Gold
Noise
Organ Size
Task Performance and Analysis

Applying the J-optimal channelized quadratic observer to SPECT myocardial perfusion defect detection

Kupinski, M. K., Clarkson, E., Ghaly, M. & Frey, E., 2016, Medical Imaging 2016: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 9787. 978708

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single-Photon Emission-Computed Tomography
Area Under Curve
Perfusion
defects
Statistics

A risk index for pediatric patients undergoing diagnostic imaging with 99mTc-dimercaptosuccinic acid that accounts for body habitus

O'Reilly, S. E., Plyku, D., Sgouros, G., Fahey, F. H., Ted Treves, S., Frey, E. & Bolch, W. E., Mar 1 2016, In : Physics in Medicine and Biology. 61, 6, p. 2319-2332 14 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Dimercaptosuccinic Acid
Diagnostic Imaging
Pediatrics
Kidney
Newborn Infant
Single-Photon Emission-Computed Tomography
Perfusion
ROC Curve
Area Under Curve
Noise
Single-Photon Emission-Computed Tomography
ROC Curve
Perfusion
Joints
Monte Carlo Method

Comparison of quantitative Y-90 SPECT and non-time-of-flight PET imaging in post-therapy radioembolization of liver cancer

Yue, J., Mauxion, T., Reyes, D. K., Lodge, M., Hobbs, R., Rong, X., Dong, Y., Herman, J. M., Wahl, R. L., Geschwind, J. F. H. & Frey, E., Oct 1 2016, In : Medical Physics. 43, 10, p. 5779-5790 12 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Single-Photon Emission-Computed Tomography
Liver
Calibration
Yttrium

Development of a defect model for renal pediatric SPECT imaging research

Li, Y., O'Reilly, S., Plyku, D., Cao, X., Fahey, F., Bolch, W. E., Treves, S. T., Sgouros, G. & Frey, E., Oct 3 2016, 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 7582174

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pediatrics
Single-Photon Emission-Computed Tomography
Nuclear medicine
nuclear medicine
Nuclear Medicine
Single-Photon Emission-Computed Tomography
Perfusion
Statistics
Myocardial Perfusion Imaging
Normal Distribution
2015
Single-Photon Emission-Computed Tomography
Theoretical Models
Perfusion
ROC Curve
Computer-Assisted Image Processing

Estimating ROI activity concentration with photon-processing and photon-counting SPECT imaging systems

Jha, A. K. & Frey, E., 2015, Medical Imaging 2015: Physics of Medical Imaging. SPIE, Vol. 9412. 94120R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single photon emission computed tomography
Single-Photon Emission-Computed Tomography
Photons
Imaging systems
counting

Estimation of dynamic time activity curves from dynamic cardiac SPECT imaging

Hossain, J., Du, Y., Links, J. M., Rahmim, A., Karakatsanis, N., Akhbardeh, A., Lyons, J. & Frey, E., Apr 21 2015, In : Physics in Medicine and Biology. 60, 8, p. 3193-3208 16 p., 3193.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Myocardium
Perfusion
Organ Size
Cardiovascular Diseases

Factors affecting the repeatability of gamma camera calibration for quantitative imaging applications using a sealed source

Anizan, N., Wang, H., Zhou, X. C., Wahl, R. L. & Frey, E., Feb 7 2015, In : Physics in Medicine and Biology. 60, 3, p. 1325-1337 13 p.

Research output: Contribution to journalArticle

Gamma Cameras
Calibration
Noise
Nuclear Medicine
Single-Photon Emission-Computed Tomography

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification: An IAEA phantom study

Zimmerman, B. E., Grošev, D., Buvat, I., Coca Pérez, M. A., Frey, E., Green, A., Krisanachinda, A., Lassmann, M., Ljungberg, M., Pozzo, L., Quadir, K. A., Terán Gretter, M. A., Van Staden, J. & Poli, G. L., Dec 4 2015, (Accepted/In press) In : Zeitschrift fur Medizinische Physik.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
X Ray Computed Tomography
Radioisotopes
Technology
Equipment and Supplies

Objective evaluation of reconstruction methods for quantitative SPECT imaging in the absence of ground truth

Jha, A. K., Song, N., Caffo, B. S. & Frey, E., 2015, Medical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 9416. 94161K

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single photon emission computed tomography
ground truth
Single-Photon Emission-Computed Tomography
tomography
Imaging techniques
Clinical Protocols
Single-Photon Emission-Computed Tomography
Isotopes
Perfusion
Monte Carlo Method

Optimization and evaluation of reconstruction-based compensation methods and reconstruction parameters for Tc-99m MIBI parathyroid SPECT

Ekjeen, T., Tocharoenchai, C., Pusuwan, P., Fung, G. S. K., Ghaly, M., Du, Y. & Frey, E., Mar 1 2015, In : Physica Medica. 31, 2, p. 159-166 8 p.

Research output: Contribution to journalArticle

Technetium Tc 99m Sestamibi
Single-Photon Emission-Computed Tomography
optimization
evaluation
attenuation

Optimization of energy window and evaluation of scatter compensation methods in MPS using the ideal observer with model mismatch

Ghaly, M., Links, J. M. & Frey, E., 2015, Medical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 9416. 94160N

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single-Photon Emission-Computed Tomography
optimization
evaluation
Perfusion
Image processing
Single photon emission computed tomography
Single-Photon Emission-Computed Tomography
Perfusion
Image processing
Imaging systems

Repeatability of radiotracer uptake in normal abdominal organs with 111In-pentetreotide quantitative SPECT/CT

Rowe, S., Vicente, E., Anizan, N., Wang, H., Leal, J. P., Lodge, M., Frey, E. & Wahl, R. L., Jul 1 2015, In : Journal of Nuclear Medicine. 56, 7, p. 985-988 4 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Kidney
Liver
Fluorodeoxyglucose F18
Single Photon Emission Computed Tomography Computed Tomography

Singular value decomposition for photon-processing nuclear imaging systems and applications for reconstruction and computing null functions

Jha, A. K., Barrett, H. H., Frey, E., Clarkson, E., Caucci, L. & Kupinski, M. A., Sep 21 2015, In : Physics in Medicine and Biology. 60, 18, p. 7359-7385 27 p.

Research output: Contribution to journalArticle

Photons
Single-Photon Emission-Computed Tomography
Information Systems

The effect of signal variability on the histograms of anthropomorphic channel outputs: Factors resulting in non-normally distributed data

Elshahaby, F. E. A., Ghaly, M., Jha, A. K. & Frey, E., 2015, Medical Imaging 2015: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 9416. 94160P

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nuclear Medicine
histograms
Nuclear medicine
Computer-Assisted Image Processing
output
2014

Design of a digital phantom population for myocardial perfusion SPECT imaging research

Ghaly, M., Du, Y., Fung, G. S. K., Tsui, B., Links, J. M. & Frey, E., Jun 21 2014, In : Physics in Medicine and Biology. 59, 12, p. 2935-2953 19 p.

Research output: Contribution to journalArticle

Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Perfusion
Research
Population
Computer-Assisted Image Processing
Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Therapeutics
Kidney

Evaluation of simultaneous 201Tl/99mTc dual-isotope cardiac SPECT imaging with model-based crosstalk compensation using canine studies

Du, Y., Links, J. M., Becker, L., Dipaula, A. F., Frank, T., Schuleri, K. H., Lardo, A. C. & Frey, E., 2014, In : Journal of Nuclear Cardiology. 21, 2, p. 329-340 12 p.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Isotopes
Canidae
Technetium Tc 99m Sestamibi
Dogs
Gamma Cameras
Calibration
Radioisotopes
Single-Photon Emission-Computed Tomography
Body Image
Myocardial Perfusion Imaging
Single-Photon Emission-Computed Tomography
Radioisotopes
Radionuclide Imaging
Cicatrix
2013

A collimator optimization method for quantitative imaging: Application to Y-90 bremsstrahlung SPECT

Rong, X. & Frey, E., Aug 2013, In : Medical Physics. 40, 8, 082504.

Research output: Contribution to journalArticle

Single-Photon Emission-Computed Tomography
Microspheres
Photons
Radioisotopes
Anatomy

Compensation for spill-in and spill-out partial volume effects in cardiac PET imaging

Du, Y., Madar, I., Stumpf, M. J., Rong, X., Fung, G. S. K. & Frey, E., Feb 2013, In : Journal of Nuclear Cardiology. 20, 1, p. 84-98 15 p.

Research output: Contribution to journalArticle

Myocardium
Perfusion
Dogs
Direction compound

Evaluation of image quality using Channelized Hotelling observer for pediatric diagnostic imaging of 99mTc-dimercaptosuccinic acid

Lee, T-S., Bolch, W. E., Wayson, M. B., Treves, S. T., Sgouros, G. & Frey, E., 2013, IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 6829167

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Technetium Tc 99m Dimercaptosuccinic Acid
Diagnostic Imaging
Pediatrics
cut-off
acids

Improved dose-volume histogram estimates for radiopharmaceutical therapy by optimizing quantitative SPECT reconstruction parameters

Cheng, L., Hobbs, R., Segars, P. W., Sgouros, G. & Frey, E., Jun 7 2013, In : Physics in Medicine and Biology. 58, 11, p. 3631-3647 17 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Single-Photon Emission-Computed Tomography
Noise
Artifacts
Kidney

MIRD pamphlet No. 24: Guidelines for quantitative 131I SPECT in dosimetry applications

Dewaraja, Y. K., Ljungberg, M., Green, A. J., Zanzonico, P. B., Frey, E. C., Bolch, W. E., Brill, A. B., Dunphy, M., Fisher, D. R., Howell, R. W., Meredith, R. F., Sgouros, G. & Wessels, B. W., Dec 1 2013, In : Journal of Nuclear Medicine. 54, 12, p. 2182-2188 7 p.

Research output: Contribution to journalArticle

Pamphlets
Single-Photon Emission-Computed Tomography
Radioisotopes
Guidelines
Therapeutics

Model mismatch and the ideal observer in SPECT

Ghaly, M., Links, J. M., Du, Y. & Frey, E., 2013, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 8673. 86730K

Research output: Chapter in Book/Report/Conference proceedingConference contribution

SPECT
Observer
acquisition
Model
human performance
Single-Photon Emission-Computed Tomography
Area Under Curve
Microspheres
Yttrium
Monte Carlo Method

Radiobiologic optimization of combination radiopharmaceutical therapy applied to myeloablative treatment of non-hodgkin lymphoma

Hobbs, R., Wahl, R. L., Frey, E., Kasamon, Y., Song, H., Huang, P., Jones, R. J. & Sgouros, G., Sep 1 2013, In : Journal of Nuclear Medicine. 54, 9, p. 1535-1542 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Non-Hodgkin's Lymphoma
Therapeutics
Neoplasms
Radioisotopes

Task-based evaluation of motion compensated reconstructed images using 4D channelized Hotelling observer in dual gated SPECT

Lee, T-S., Feng, T., Frey, E. & Tsui, B., 2013, IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 6829067

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single-Photon Emission-Computed Tomography
evaluation
Noise
ROC Curve
Computer-Assisted Image Processing
2012

4D mathematical observer models for the task-based evaluation of gated myocardial perfusion SPECT images

Lee, T-S., Frey, E. & Tsui, B., 2012, IEEE Nuclear Science Symposium Conference Record. p. 2257-2260 4 p. 6551513

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Single-Photon Emission-Computed Tomography
Theoretical Models
Perfusion
evaluation
defects

Accuracy and precision of radioactivity quantification in nuclear medicine images

Frey, E., Humm, J. L. & Ljungberg, M., May 2012, In : Seminars in Nuclear Medicine. 42, 3, p. 208-218 11 p.

Research output: Contribution to journalArticle

Nuclear Medicine
Radioactivity
Positron-Emission Tomography
Neoplasms
Single-Photon Emission-Computed Tomography