Emily Barron-Casella

Research output

Research output per year 1977 2021 2023

• 48 Article
• 5 Comment/debate
• 3 Letter
• 1 Review article

Research output per year

Research output per year

Search results

• 2023

  Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 27 2023, In: Nature. 616, 7958, p. 755-763 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Hematopoiesis 100%
  • Hematopoietic Stem Cells 90%
  • Stem Cells 67%
  • Mutation 34%
  • Alleles 22%

• Author Correction: Clonal haematopoiesis and risk of chronic liver disease (Nature, (2023), 616, 7958, (747-754), 10.1038/s41586-023-05857-4)

  NHLBI TOPMed Hematology Working Group, Jul 20 2023, In: Nature. 619, 7970, p. E47

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Hematopoiesis 100%
  • Liver Diseases 77%
  • Chronic Disease 67%

• Clonal haematopoiesis and risk of chronic liver disease

  NHLBI TOPMed Hematology Working Group, Apr 27 2023, In: Nature. 616, 7958, p. 747-754 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoiesis 100%
  • Liver Diseases 77%
  • Chronic Disease 67%
  • Inflammation 36%
  • Odds Ratio 29%

• Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

  NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sep 2023, In: EBioMedicine. 95, 104758.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenome 100%
  • DNA Methylation 79%
  • Immunoglobulin E 74%
  • Asthma 62%
  • Quantitative Trait Loci 22%
• 2022

  A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Dec 1 2022, In: Nature Methods.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Precision Medicine 92%
  • Lipid 59%
  • Genes 34%
  • Genome 19%

• Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

  TOPMed Anthropometry Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mar 2022, In: Nature genetics. 54, 3, p. 263-273 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multifactorial Inheritance 100%
  • Linkage Disequilibrium 92%
  • Single Nucleotide Polymorphism 67%
  • Body Mass Index 58%
  • Genome 54%

• Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Lipids Working Group, 2022, (Accepted/In press) In: Nature genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Meta-Analysis 64%
  • Whole Exome Sequencing 34%
  • Precision Medicine 30%
  • Lipids 18%

• Whole genome sequence analysis of blood lipid levels in >66,000 individuals

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2022, In: Nature communications. 13, 1, 5995.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • genome 100%
  • lipids 75%
  • blood 73%
  • Sequence Analysis 71%
  • Lipid 52%
• 2021

  A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Oct 2021, In: Nature genetics. 53, 10, p. 1504-1516 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HIV 100%
  • HLA-B Antigens 61%
  • Population 56%
  • Hispanic Americans 46%
  • Genome-Wide Association Study 25%

• Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (Nature, (2020), 586, 7831, (763-768), 10.1038/s41586-020-2819-2)

  NHLBI Trans-Omics for Precision Medicine Consortium, Mar 25 2021, In: Nature. 591, 7851, p. E27

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Hematopoiesis 100%
  • Genome 62%
  • Medical Oncology 54%
  • Computational Biology 43%
  • Neoplasms 14%

• Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (Nature Genetics, (2021), 53, 10, (1504-1516), 10.1038/s41588-021-00935-7)

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2021, In: Nature genetics. 53, 12, p. 1722 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Seoul 100%
  • HIV 53%
  • Republic of Korea 46%
  • Population 30%
  • Bioengineering 25%

• Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & FinnGen, Dec 1 2021, In: Nature communications. 12, 1, 2182.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chromosomes 100%
  • lipids 80%
  • Chromosomes 64%
  • blood 62%
  • Lipid 56%

• Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

  NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), Dec 2021, In: Genome Medicine. 13, 1, 66.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Epithelium 51%
  • Viruses 33%
  • Gene Expression 30%
  • Genes 27%

• Genome sequencing unveils a regulatory landscape of platelet reactivity

  NHLBI Trans-Omics for Precision (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3626.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sequencing 100%
  • genome 95%
  • loci 82%
  • platelets 79%
  • reactivity 73%

• Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease

  Lance, E. I., Faulcon, L. M., Fu, Z., Yang, J., Whyte-Stewart, D., Strouse, J. J., Barron-Casella, E., Jones, K., Van Eyk, J. E., Casella, J. F. & Everett, A. D., Sep 2021, In: Proteomics - Clinical Applications. 15, 5, 2100003.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurogranin 100%
  • Sickle Cell Anemia 64%
  • Proteomics 53%
  • Plasma 36%
  • Cerebral Infarction 27%

• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Feb 11 2021, In: Nature. 590, 7845, p. 290-299 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • National Heart, Lung, and Blood Institute (U.S.) 100%
  • Precision Medicine 79%
  • Genome 49%
  • Genotype 21%
  • Catalogs 18%
  19 Scopus citations

• Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3506.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • stratification 98%
  • Economic Inflation 96%
  • Hemoglobin 79%
  • sequencing 58%

• Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

  TOPMed Sleep Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2021, In: Genome Medicine. 13, 1, 136.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • National Heart, Lung, and Blood Institute (U.S.) 100%
  • Sleep Apnea Syndromes 79%
  • Precision Medicine 79%
  • Genome-Wide Association Study 76%
  • Oxyhemoglobins 48%
• 2020

  Brain-derived neurotrophic factor levels in pediatric sickle cell disease

  Lance, E. I., Barron-Casella, E., Everett, A. D. & Casella, J. F., Feb 1 2020, In: Pediatric Blood and Cancer. 67, 2, e28076.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sickle Cell Anemia 100%
  • Brain-Derived Neurotrophic Factor 96%
  • Cerebral Infarction 65%
  • Pediatrics 58%
  • Child 26%
  2 Scopus citations

• Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

  NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Sep 1 2020, In: Nature genetics. 52, 9, p. 969-983 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Computer Simulation 81%
  • Intergenic DNA 55%
  • Precision Medicine 46%
  • LDL Cholesterol 38%
  4 Scopus citations

• Inherited causes of clonal haematopoiesis in 97,691 whole genomes

  NHLBI Trans-Omics for Precision Medicine Consortium, Oct 29 2020, In: Nature. 586, 7831, p. 763-768 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoiesis 100%
  • Genome 62%
  • Hematopoietic Stem Cells 45%
  • National Heart, Lung, and Blood Institute (U.S.) 20%
  • Genetic Loci 18%
  30 Scopus citations

• Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w)

  NHLBI TOPMed Lipids Working Group, Dec 1 2020, In: Nature communications. 11, 1, 1715.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • lipoproteins 100%
  • genome 89%
  • Lipoprotein(a) 84%
  • Lipoprotein 75%
  • Communication 62%
• 2019

  Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

  National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2019, In: CHEST. 156, 6, p. 1068-1079 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Protein Domains 86%
  • Cysteine 81%
  • Asthma 66%
  • Lung 46%
  3 Scopus citations
• 2018

  Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

  NHLBI TOPMed Lipids Working Group, Dec 1 2018, In: Nature communications. 9, 1, 3391.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Low-Density Lipoprotein Cholesterol 100%
  • sequencing 85%
  • genome 82%
  • cholesterol 80%
  • Whole Genome Sequencing 73%
  62 Scopus citations

• Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

  Zekavat, S. M., Ruotsalainen, S., Handsaker, R. E., Alver, M., Bloom, J., Poterba, T., Seed, C., Ernst, J., Chaffin, M., Engreitz, J., Peloso, G. M., Manichaikul, A., Yang, C., Ryan, K. A., Fu, M., Johnson, W. C., Tsai, M., Budoff, M., Ramachandran, V. S., Cupples, L. A., & 323 othersRotter, J. I., Rich, S. S., Post, W., Mitchell, B. D., Correa, A., Metspalu, A., Wilson, J. G., Salomaa, V., Kellis, M., Daly, M. J., Neale, B. M., McCarroll, S., Surakka, I., Esko, T., Ganna, A., Ripatti, S., Kathiresan, S., Natarajan, P., Abe, N., Abecasis, G., Albert, C., Allred, N. P., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Beaty, T., Becker, D., Becker, L., Beer, R., Begum, F., Beitelshees, A., Benjamin, E., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Boerwinkle, E., Borecki, I., Bowler, R., Brody, J., Broeckel, U., Broome, J., Bunting, K., Burchard, E., Cardwell, J., Carty, C., Casaburi, R., Casella, J., Chang, C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Chen, Y. D. I., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Cornell, E., Crandall, C., Crapo, J., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., Das, S., David, S., Davis, C., Daya, M., Andrade, M. D., Debaun, M., Deka, R., Demeo, D., Devine, S., Do, R., Duan, Q., Duggirala, R., Durda, P., Dutcher, S., Eaton, C., Ekunwe, L., Ellinor, P., Emery, L., Farber, C., Farnam, L., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, Y., Gass, M., Gelb, B., Geng, X., Germer, S., Gignoux, C., Gladwin, M., Glahn, D., Gogarten, S., Gong, D. W., Goring, H., Gu, C. C., Guan, Y., Guo, X., Haessler, J., Hall, M., Harris, D., Hawley, N., He, J., Heavner, B., Heckbert, S., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hixson, J., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Huston, H., Hwu, C. M., Irvin, M. R., Jackson, R., Jain, D., Jaquish, C., Jhun, M. A., Johnsen, J., Johnson, A., Johnston, R., Jones, K., Kang, H. M., Kaplan, R., Kardia, S., Kaufman, L., Kelly, S., Kenny, E., Kessler, M., Khan, A., Kinney, G., Konkle, B., Kooperberg, C., Kramer, H., Krauter, S., Lange, C., Lange, E., Lange, L., Laurie, C., Laurie, C., Leboff, M., Lee, S. S., Lee, W. J., Lefaive, J., Levine, D., Levy, D., Lewis, J., Li, Y., Lin, H., Lin, K. H., Liu, S., Liu, Y., Loos, R., Lubitz, S., Lunetta, K., Luo, J., Mahaney, M., Make, B., Manson, J. A., Margolin, L., Martin, L., Mathai, S., Mathias, R., McArdle, P., McDonald, M. L., McFarland, S., McGarvey, S., Mei, H., Meyers, D. A., Mikulla, J., Min, N., Minear, M., Minster, R. L., Montasser, M. E., Musani, S., Mwasongwe, S., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Nekhai, S., Nickerson, D., North, K., O'connell, J., O'connor, T., Ochs-Balcom, H., Pankow, J., Papanicolaou, G., Parker, M., Parsa, A., Penchev, S., Peralta, J. M., Perez, M., Perry, J., Peters, U., Peyser, P., Phillips, L., Phillips, S., Pollin, T., Becker, J. P., Boorgula, M. P., Preuss, M., Prokopenko, D., Psaty, B., Qasba, P., Qiao, D., Qin, Z., Rafaels, N., Raffield, L., Rao, D. C., Rasmussen-Torvik, L., Ratan, A., Redline, S., Reed, R., Regan, E., Reiner, A., Rice, K., Roden, D., Roselli, C., Ruczinski, I., Russell, P., Ruuska, S., Sakornsakolpat, P., Salimi, S., Salzberg, S., Sandow, K., Sankaran, V., Scheller, C., Schmidt, E., Schwander, K., Schwartz, D., Sciurba, F., Seidman, C., Sheehan, V., Shetty, A., Shetty, A., Sheu, W. H. H., Shoemaker, M. B., Silver, B., Silverman, E., Smith, J., Smith, J., Smith, N., Smith, T., Smoller, S., Snively, B., Sofer, T., Sotoodehnia, N., Stilp, A., Streeten, E., Sung, Y. J., Sylvia, J., Szpiro, A., Sztalryd, C., Taliun, D., Tang, H., Taub, M., Taylor, K., Taylor, S., Telen, M., Thornton, T. A., Tinker, L., Tirschwell, D., Tiwari, H., Tracy, R., Vaidya, D., Vandehaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wan, E., Wang, F. F., Watson, K., Weeks, D. E., Weir, B., Weiss, S., Weng, L. C., Willer, C., Williams, K., Williams, L. K., Wilson, C., Wong, Q., Xu, H., Yanek, L., Yang, I., Yang, R., Zaghloul, N., Zhang, Y., Zhao, S. X., Zhao, W., Zheng, X., Zhi, D., Zhou, X., Zody, M. & Zoellner, S., Dec 1 2018, In: Nature communications. 9, 1, 2606.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • lipoproteins 100%
  • genome 89%
  • Lipoprotein(a) 84%
  • Lipoprotein 75%
  • Cholesterol 61%
  30 Scopus citations

• Erratum to: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w)

  NHLBI TOPMed Lipids Working Group, Dec 1 2018, In: Nature communications. 9, 1, 3493.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • document markup languages 100%
  • lipoproteins 81%
  • genome 72%
  • Lipoprotein(a) 68%
  • Lipoprotein 61%
• 2017

  Genome-wide association study to identify variants associated with acute severe vaso-occlusive pain in sickle cell anemia

  Chaturvedi, S., Bhatnagar, P., Bean, C. J., Steinberg, M. H., Milton, J. N., Casella, J. F., Barron-Casella, E., Arking, D. E. & DeBaun, M. R., Aug 3 2017, In: Blood. 130, 5, p. 686-688 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  8 Scopus citations

• Identification of Aptamers That Bind to Sickle Hemoglobin and Inhibit Its Polymerization

  Purvis, S. H., Keefer, J. R., Fortenberry, Y. M., Barron-Casella, E. A. & Casella, J. F., Dec 2017, In: Nucleic Acid Therapeutics. 27, 6, p. 354-364 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Sickle Hemoglobin 100%
  • Hemoglobin 66%
  • Polymerization Reaction 42%
  • Sickle Cell Anemia 26%
  • Deoxygenation 16%
  5 Scopus citations
• 2014

  Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease

  Lance, E. I., Casella, J. F., Everett, A. D. & Barron-Casella, E., Dec 1 2014, In: Proteomics - Clinical Applications. 8, 11-12, p. 813-827 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Sickle Cell Anemia 100%
  • Proteomics 84%
  • Biological Marker 82%
  • Platelet-Derived Growth Factor 79%
  • Biomarkers 59%
  9 Scopus citations
• 2013

  Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia

  Bean, C. J., Boulet, S. L., Yang, G., Payne, A. B., Ghaji, N., Pyle, M. E., Hooper, W. C., Bhatnagar, P., Keefer, J., Barron-Casella, E. A., Casella, J. F. & Debaun, M. R., Oct 2013, In: British journal of haematology. 163, 2, p. 268-276 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Chest Syndrome 100%
  • beta-Globins 81%
  • Sickle Cell Anemia 71%
  • Globins 65%
  • Haplotypes 61%
  12 Scopus citations

• Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

  Bhatnagar, P., Keefer, J. R., Casella, J. F., Barron-Casella, E. A., Bean, C. J., Hooper, C. W., Payne, A. B., Arking, D. E. & Debaun, M. R., Oct 2013, In: Pediatric Blood and Cancer. 60, 10, p. E125-E127

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fetal Hemoglobin 100%
  • Sickle Cell Anemia 82%
  • Pain 43%
  • Incidence 36%
  • Child 32%
  8 Scopus citations

• Genome-Wide Meta-Analysis of Systolic Blood Pressure in Children with Sickle Cell Disease

  Bhatnagar, P., Barron-Casella, E., Bean, C. J., Milton, J. N., Baldwin, C. T., Steinberg, M. H., DeBaun, M., Casella, J. F. & Arking, D. E., Sep 12 2013, In: PloS one. 8, 9, e74193.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sickle cell anemia 100%
  • Blood Pressure 85%
  • systolic blood pressure 85%
  • meta-analysis 77%
  • Sickle Cell Anemia 74%
  17 Scopus citations

• Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia

  Faulcon, L. M., Fu, Z., Dulloor, P., Barron-Casella, E., Savage, W., Jennings, J. M., Van Eyk, J. E., Debaun, M., Casella, J. F. & Everett, A., Aug 2013, In: British journal of haematology. 162, 3, p. 421-424 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Scopus citations
• 2012

  A genome-wide association study of total Bilirubin and Cholelithiasis risk in sickle cell anemia

  Milton, J. N., Sebastiani, P., Solovieff, N., Hartley, S. W., Bhatnagar, P., Arking, D. E., Dworkis, D. A., Casella, J. F., Barron-Casella, E., Bean, C. J., Hooper, W. C., DeBaun, M. R., Garrett, M. E., Soldano, K., Telen, M. J., Ashley-Koch, A., Gladwin, M. T., Baldwin, C. T., Steinberg, M. H. & Klings, E. S., Apr 27 2012, In: PloS one. 7, 4, e34741.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cholelithiasis 100%
  • Sickle Cell Anemia 88%
  • Genome-Wide Association Study 84%
  • Bilirubin 79%
  • Single Nucleotide Polymorphism 40%
  38 Scopus citations

• Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

  Bean, C. J., Boulet, S. L., Ellingsen, D., Pyle, M. E., Barron-Casella, E. A., Casella, J. F., Payne, A. B., Driggers, J., Trau, H. A., Yang, G., Jones, K., Ofori-Acquah, S. F., Hooper, W. C. & DeBaun, M. R., Nov 1 2012, In: Blood. 120, 18, p. 3822-3828 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Chest Syndrome 100%
  • Heme Oxygenase-1 76%
  • Sickle Cell Anemia 71%
  • Heme 60%
  • Alleles 47%
  55 Scopus citations

• Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia

  Thangarajh, M., Yang, G., Fuchs, D., Ponisio, M. R., Mckinstry, R. C., Jaju, A., Noetzel, M. J., Casella, J. F., Barron-Casella, E., Hooper, W. C., Boulet, S. L., Bean, C. J., Pyle, M. E., Payne, A. B., Driggers, J., Trau, H. A., Vendt, B. A., Rodeghier, M. & Debaun, M. R., Nov 2012, In: British journal of haematology. 159, 3, p. 352-359 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glucosephosphate Dehydrogenase 100%
  • Magnetic Resonance Angiography 92%
  • Sickle Cell Anemia 88%
  • Cerebral Infarction 86%
  • Mutation 45%
  48 Scopus citations

• Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African Americans

  Bae, H. T., Baldwin, C. T., Sebastiani, P., Telen, M. J., Ashley-Koch, A., Garrett, M., Hooper, W. C., Bean, C. J., DeBaun, M. R., Arking, D. E., Bhatnagar, P., Casella, J. F., Keefer, J. R., Barron-Casella, E., Gordeuk, V., Kato, G. J., Minniti, C., Taylor, J., Campbell, A., Luchtman-Jones, L., & 4 othersHoppe, C., Gladwin, M. T., Zhang, Y. & Steinberg, M. H., Aug 30 2012, In: Blood. 120, 9, p. 1961-1962 2 p.

  Research output: Contribution to journal › Letter › peer-review
  55 Scopus citations
• 2011

  Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity

  An, P., Barron-Casella, E. A., Strunk, R. C., Hamilton, R. G., Casella, J. F. & DeBaun, M. R., Jun 2011, In: Journal of Allergy and Clinical Immunology. 127, 6, p. 1440-1446 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sickle Cell Anemia 100%
  • Immunoglobulin E 84%
  • Asthma 71%
  • Morbidity 54%
  • Child 39%
  40 Scopus citations

• Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients

  Bhatnagar, P., Purvis, S., Barron-Casella, E., DeBaun, M. R., Casella, J. F., Arking, D. E. & Keefer, J. R., Apr 2011, In: Journal of Human Genetics. 56, 4, p. 316-323 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Glucagon-Like Peptide-2 Receptor 87%
  • Single Nucleotide Polymorphism 40%
  • Sickle Cell Anemia 34%
  • Fetal Hemoglobin 21%
  53 Scopus citations

• Plasma glial fibrillary acidic protein levels in children with sickle cell disease

  Savage, W. J., Barron-Casella, E., Fu, Z., Dulloor, P., Williams, L., Crain, B. J., White, D. A., Jennings, J. M., Van Eyk, J. E., Debaun, M. R., Everett, A. & Casella, J. F., May 2011, In: American journal of hematology. 86, 5, p. 427-429 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  23 Scopus citations
• 2010

  Hemoglobin depletion from plasma: Considerations for proteomic discovery in Sickle Cell disease and other hemolytic processes

  Williams, L. M., Fu, Z., Dulloor, P., Yen, T., Barron-Casella, E., Savage, W., Van Eyk, J. E., Casella, J. F. & Everett, A., Dec 2010, In: Proteomics - Clinical Applications. 4, 12, p. 926-930 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nickel nitrilotriacetic acid 100%
  • Haemolytic 74%
  • Sickle Cell Anemia 70%
  • Hemoglobin 60%
  • Proteomics 59%
  10 Scopus citations
• 2007

  The role of peroxisomal ABC transporters in the mouse adrenal gland: The loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

  Lu, J. F., Barron-Casella, E., Deering, R., Heinzer, A. K., Moser, A. B., DeMesy Bentley, K. L., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., Pujol, A., Smith, K. D. & Powers, J. M., Mar 2007, In: Laboratory Investigation. 87, 3, p. 261-272 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • ATP-Binding Cassette Transporters 100%
  • Adrenal Glands 89%
  • Knockout Mice 57%
  • Oxidative Stress 46%
  • Hemizygote 34%
  26 Scopus citations
• 1999

  Construction of a human platelet alloantigen-1a epitope(s) within murine glycoprotein IIIa: Identification of residues critical to the conformation of the antibody binding site(s)

  Barron-Casella, E. A., Nebbia, G., Rogers, O. C., King, K. E., Kickler, T. S. & Casella, J. F., May 1 1999, In: Blood. 93, 9, p. 2959-2967 9 p.

  Research output: Contribution to journal › Article › peer-review

  • human 1a alloantigen 100%
  • Human Platelet Antigens 93%
  • Antibody Binding Sites 86%
  • Epitope 60%
  • Glycoprotein 54%
  11 Scopus citations
• 1998

  Identification of a human heavy chain antibody fragment directed against human platelet alloantigen 1a by phage display library

  Okamoto, N., Kennedy, S. D., Barron-Casella, E. A., Casella, J. F., Inoko, H. & Kickler, T. S., 1998, In: Tissue Antigens. 51, 2, p. 156-163 8 p.

  Research output: Contribution to journal › Article › peer-review

  • human 1a alloantigen 100%
  • Human Platelet Antigens 93%
  • Forensic Anthropology 76%
  • Immunoglobulin Fragments 75%
  • Bacteriophages 58%
  11 Scopus citations
• 1996

  Cap Z, a calcium insensitive capping protein in resting and activated platelets

  Nachmias, V. T., Golla, R., Casella, J. F. & Barron-Casella, E., Jan 15 1996, In: FEBS Letters. 378, 3, p. 258-262 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Filament 100%
  • Blood Platelets 78%
  • Calcium(0) 77%
  • Thrombin 72%
  • Calcium 69%
  34 Scopus citations
• 1995

  Quantitation of cap Z in conventional actin preparations and methods for further purification of actin

  Casella, J. F., Barron‐Casella, E. A. & Torres, M. A., 1995, In: Cell Motility and the Cytoskeleton. 30, 2, p. 164-170 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Actins 100%
  • Viscosity 25%
  • Actin Cytoskeleton 23%
  • Antibodies 13%
  • Proteins 8%
  24 Scopus citations

• Sequence analysis and chromosomal localization of human Cap Z: Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families

  Barron-Casella, E. A., Torres, M. A., Scherer, S. W., Heng, H. H. Q., Tsui, L. C. & Casella, J. F., Sep 15 1995, In: Journal of Biological Chemistry. 270, 37, p. 21472-21479 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dictyostelium severin protein 100%
  • Profilins 86%
  • Gelsolin 84%
  • Chickens 56%
  • Sequence Analysis 54%
  54 Scopus citations
• 1994

  Expression and purification of functional recombinant epitopes for the platelet antigens, Pl^A1 and Pl^A2

  Barron-Casella, E. A., Kickler, T. S., Rogers, O. C. & Casella, J. F., Aug 15 1994, In: Blood. 84, 4, p. 1157-1163 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Integrin beta3 100%
  • Epitope 72%
  • Epitopes 61%
  • Antigen 59%
  • Blood Platelets 55%
  16 Scopus citations
• 1992

  Conservation of the mammalian RNA polymerase II largest-subunit C-terminal domain

  Barron-Casella, E. & Corden, J. L., Nov 1992, In: Journal of Molecular Evolution. 35, 5, p. 405-410 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA polymerase II largest subunit 100%
  • RNA 63%
  • DNA-directed RNA polymerase 62%
  • amino acid 56%
  • Amino Acid Sequence 37%
  21 Scopus citations
• 1989

  DNA recognition element required for PUF-I mediated cell-type-specific transcription of the rat prolactin gene

  Sharp, Z. D., Helsel, S., Cao, Z., Barron, E. A. & Sanchez, Y., Apr 11 1989, In: Nucleic acids research. 17, 7, p. 2705-2722 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prolactin 100%
  • transcription factor UBF 85%
  • DNA 56%
  • TATA Box 43%
  • Genes 40%
  13 Scopus citations