Elizabeth Thompson

Assistant Professor

20082019
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Research Output 2008 2019

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Article
2010

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

Thompson, E., Enriquez, H. L., Fu, Y. X. & Engelhard, V. H., Aug 2 2010, In : Journal of Experimental Medicine. 207, 8, p. 1791-1804 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Neoplasms
Adoptive Transfer
Antigen-Presenting Cells
Tumor-Infiltrating Lymphocytes
2015

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

Peske, J. D., Thompson, E., Gemta, L., Baylis, R. A., Fu, Y. X. & Engelhard, V. H., May 13 2015, In : Nature Communications. 6, 7114.

Research output: Contribution to journalArticle

effectors
T-cells
Lymphocytes
lymphatic system
lymphocytes
2016

Large cell neuroendocrine Carcinoma of the head and neck: A clinicopathologic series of 10 cases with an emphasis on HPV status

Thompson, E., Stelow, E. B., Mills, S. E., Westra, W. H. & Bishop, J. A., 2016, In : American Journal of Surgical Pathology. 40, 4, p. 471-478 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Large Cell Carcinoma
Neck
Head
Neoplasms

Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma

Thompson, E., Zahurak, M., Murphy, A., Cornish, T., Cuka, N., Abdelfatah, E., Yang, S. C., Duncan, M. D., Ahuja, N., Taube, J. M., Anders, R. A. & Kelly, R. J., Jan 22 2016, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Stomach
Adenocarcinoma
Ligands
T-Lymphocytes
Esophagogastric Junction

PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

Cimino-Mathews, A. M., Thompson, E., Taube, J. M., Ye, X., Lu, Y., Meeker, A. K., Xu, H., Sharma, R., Lecksell, K., Cornish, T. C., Cuka, N., Argani, P. & Emens, L. A., Jan 1 2016, In : Human Pathology. 47, 1, p. 52-63 12 p.

Research output: Contribution to journalArticle

CD80 Antigens
Tumor Microenvironment
Breast Neoplasms
Ligands
Tumor-Infiltrating Lymphocytes

The immune microenvironment of breast ductal carcinoma in situ

Thompson, E., Taube, J. M., Elwood, H., Sharma, R., Meeker, A. K., Warzecha, H. N., Argani, P., Cimino-Mathews, A. M. & Emens, L. A., Mar 1 2016, In : Modern Pathology. 29, 3, p. 249-258 10 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Tumor-Infiltrating Lymphocytes
Ligands
Breast Neoplasms
Epidermal Growth Factor

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E., Huang, L., Sharma, R., Klein, A., Zheng, L., Le, D., Laheru, D., Pandey, A., Jaffee, E. & Anders, R. A., Mar 1 2016, In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Biomarkers
Immunoprecipitation
Antibodies
Cancer Vaccines
2017

PD-L1 expression and the immune microenvironment in primary invasive lobular carcinomas of the breast

Thompson, E., Taube, J. M., Asch-Kendrick, R. J., Ogurtsova, A., Xu, H., Sharma, R., Meeker, A. K., Argani, P., Emens, L. A. & Cimino-Mathews, A. M., Nov 1 2017, In : Modern Pathology. 30, 11, p. 1551-1560 10 p.

Research output: Contribution to journalArticle

Lobular Carcinoma
Tumor-Infiltrating Lymphocytes
Breast
Breast Neoplasms
Ductal Carcinoma

Safety & clinical activity of the programmed death-ligand 1 inhibitor durvalumab in combination with Poly (ADP-Ribose) polymerase inhibitor olaparib or vascular endothelial growth factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A dose-escalation, phase I study

Lee, J. M., Cimino-Mathews, A. M., Peer, C. J., Zimmer, A., Lipkowitz, S., Annunziata, C. M., Cao, L., Harrell, M. I., Swisher, E. M., Houston, N., Botesteanu, D. A., Taube, J. M., Thompson, E., Ogurtsova, A., Xu, H., Nguyen, J., Ho, T. W., Figg, W. D. & Kohn, E. C., Jul 1 2017, In : Journal of Clinical Oncology. 35, 19, p. 2193-2202 10 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-3
Vascular Endothelial Growth Factor Receptor-1
Ligands
Safety
Neoplasms
2018

A "clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques

Hong, S. M., Noë, M., Hruban, C. A., Thompson, E., Wood, L. D. & Hruban, R. H., Jan 1 2018, (Accepted/In press) In : Advances in Anatomic Pathology.

Research output: Contribution to journalArticle

Microscopy
Pathology
Anatomy
Light
Exocrine Pancreas
Breast Neoplasms
Neoplasms
Neoplasm Metastasis
Chromogranins
Synaptophysin

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., Dimaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 1 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

Organoids
Pancreatic Neoplasms
Drug Therapy
Therapeutics
Precision Medicine

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: A proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E., Forde, P., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., Gabrielson, E., Askin, F. B., Niknafs, N., Smith, K., Velez, M. J., Sauter, J. L., Isbell, J. M., Jones, D. R., Battafarano, R. J., Yang, S. C. & 10 others, Danilova, L. V., Wolchok, J. D., Topalian, S., Velculescu, V. E., Pardoll, A. M., Brahmer, J., Hellmann, M. D., Chaft, J. E., Cimino-Mathews, A. M. & Taube, J. M., Jan 1 2018, In : Annals of Oncology. 29, 8, p. 1853-1860 8 p.

Research output: Contribution to journalArticle

Residual Neoplasm
Non-Small Cell Lung Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Neoadjuvant Therapy
Pancreatic Neoplasms
Pediatrics
Neoplasms
Fine Needle Biopsy
PubMed
Tumor Microenvironment
Macrophages
Neoplasms
Ovarian epithelial cancer
Recurrence
2019

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer

Yarchoan, M., Huang, C. Y., Zhu, Q., Ferguson, A. K., Durham, J. N., Anders, R. A., Thompson, E. D., Rozich, N. S., Thomas, D. L., Nauroth, J. M., Rodriguez, C., Osipov, A., De Jesus-Acosta, A., Le, D. T., Murphy, A. G., Laheru, D., Donehower, R. C., Jaffee, E. M., Zheng, L. & Azad, N. S., Jan 1 2019, (Accepted/In press) In : Cancer medicine.

Research output: Contribution to journalArticle

Open Access
DNA Mismatch Repair
Cyclophosphamide
Colorectal Neoplasms
Colon
Carcinoembryonic Antigen

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Jurcak, N. R., Rucki, A. A., Muth, S., Thompson, E., Sharma, R., Ding, D., Zhu, Q., Eshleman, J., Anders, R. A., Jaffee, E., Fujiwara, K. & Zheng, L., Sep 1 2019, In : Gastroenterology. 157, 3, p. 838-850.e6

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Neoplasms
Spinal Ganglia
Annexin A2

Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture

Matsushita, Y., Smith, B., Delannoy, M., Trujillo, M. A., Chianchiano, P., McMillan, R., Kamiyama, H., Liang, H., Thompson, E. D., Hruban, R. H., Matsui, W., Wood, L. D., Roberts, N. J. & Eshleman, J. R., Oct 1 2019, In : Pancreas. 48, 9, p. 1225-1231 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Organoids
Pancreatic Ducts
Microvilli

Cross Validation of the Monoclonal Antibody Das-1 in Identification of High-Risk Mucinous Pancreatic Cystic Lesions

Das, K. K., Geng, X., Brown, J. W., Morales-Oyarvide, V., Huynh, T., Pergolini, I., Pitman, M. B., Ferrone, C., Al Efishat, M., Haviland, D., Thompson, E., Wolfgang, C., O'Broin-Lennon, A. M., Allen, P., Lillemoe, K. D., Fields, R. C., Hawkins, W. G., Liu, J., Castillo, C. F. D., Das, K. M. & 1 others, Mino-Kenudson, M., Sep 1 2019, In : Gastroenterology. 157, 3, p. 720-730.e2

Research output: Contribution to journalArticle

Monoclonal Antibodies
Cyst Fluid
Enzyme-Linked Immunosorbent Assay
Neoplasms
Sensitivity and Specificity
Biopsy
Muscles
Myenteric Plexus
Surgical Instruments
Interstitial Cells of Cajal

Feasibility of Using Hydrogel Spacers for Borderline-Resectable and Locally Advanced Pancreatic Tumors

Kerdsirichairat, T., Narang, A. K., Thompson, E., Kim, S. H., Rao, A., Ding, K. & Shin, E. J., Oct 1 2019, In : Gastroenterology. 157, 4, p. 933-935 3 p.

Research output: Contribution to journalArticle

Hydrogel
Neoplasms

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

Llosa, N. J., Luber, B., Siegel, N., Awan, A. H., Oke, T., Zhu, Q., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Jaffee, E. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., Pardoll, D. M., Wang, H., Housseau, F. & Anders, R. A., Jan 1 2019, In : Cancer Immunology Research. 7, 10, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Colorectal Neoplasms
Mucins
Microsatellite Repeats
Neoplasms

Intraductal Papillary Mucinous Neoplasms Arise From Multiple Independent Clones, Each With Distinct Mutations

Fischer, C. G., Beleva Guthrie, V., Braxton, A. M., Zheng, L., Wang, P., Song, Q., Griffin, J. F., Chianchiano, P. E., Hosoda, W., Niknafs, N., Springer, S., Dal Molin, M., Masica, D., Scharpf, R. B., Thompson, E. D., He, J., Wolfgang, C. L., Hruban, R. H., Roberts, N. J., Lennon, A. M. & 3 others, Jiao, Y., Karchin, R. & Wood, L. D., Oct 1 2019, In : Gastroenterology. 157, 4, p. 1123-1137.e22

Research output: Contribution to journalArticle

Clone Cells
Mutation
Neoplasms
Carcinogenesis
Pancreatic Neoplasms

Intratumoral adaptive immunosuppression and type 17 immunity in mismatch repair proficient colorectal tumors

Llosa, N. J., Luber, B., Tam, A. J., Smith, K. N., Siegel, N., Awan, A. H., Fan, H., Oke, T., Zhang, J., Domingue, J., Engle, E. L., Roberts, C. A., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Taube, J. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A. & 4 others, Pardoll, D. M., Wang, H., Anders, R. A. & Housseau, F., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5250-5259 10 p.

Research output: Contribution to journalArticle

Open Access
DNA Mismatch Repair
Immunosuppression
Colorectal Neoplasms
Immunity
Immunotherapy

Pancreatic Nerve Sheath Tumors: a Single Institutional Series and Systematic Review of the Literature

Javed, A. A., Wright, M. J., Hasanain, A., Chang, K., Burkhart, R., Hruban, R. H., Thompson, E., Fishman, E. K., Cameron, J. L., He, J., Wolfgang, C. & Weiss, M. J., Jan 1 2019, In : Journal of Gastrointestinal Surgery.

Research output: Contribution to journalArticle

Nerve Sheath Neoplasms
Diagnostic Errors
Neoplasms
Lost to Follow-Up
Databases

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access
Oncogenes
T-Lymphocytes
Biomarkers
DNA Mismatch Repair
Neoplasms

Prevalence of Germline Mutations Associated With Cancer Risk in Patients With Intraductal Papillary Mucinous Neoplasms

Skaro, M., Nanda, N., Gauthier, C., Felsenstein, M., Jiang, Z., Qiu, M., Shindo, K., Yu, J., Hutchings, D., Javed, A. A., Beckman, R., He, J., Wolfgang, C., Thompson, E., Hruban, R. H., Klein, A., Goggins, M. S., Wood, L. D. & Roberts, N., May 1 2019, In : Gastroenterology. 156, 6, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Neoplasms
Pancreatic Neoplasms
Mutation
Confidence Intervals

Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions

Kuboki, Y., Fischer, C. G., Beleva Guthrie, V., Huang, W., Yu, J., Chianchiano, P., Hosoda, W., Zhang, H., Zheng, L., Shao, X., Thompson, E. D., Waters, K., Poling, J., He, J., Weiss, M. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H., Roberts, N. J., Karchin, R. & 1 others, Wood, L. D., Jan 1 2019, (Accepted/In press) In : Journal of Pathology.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Pancreatic Neoplasms
Neoplasms
Mutation
Genes

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Jan 1 2019, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Cadherins
Veins
Keratin-19

Why is pancreatic cancer so deadly? The pathologist's view

Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S. M., Noë, M., Brosens, L. A. A., Jongepier, M., Offerhaus, G. J. A. & Wood, L. D., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
Pathologists