Research Output 1992 2017

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2017

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Foote, J. B., Kok, M., Leatherman, J. M., Armstrong, T. D., Marcinkowski, B. C., Ojalvo, L. S., Kanne, D. B., Jaffee, E. M., Dubensky, T. W. & Emens, L. A. Jun 1 2017 In : Cancer Immunology Research. 5, 6, p. 468-479 12 p.

Research output: Research - peer-reviewArticle

OX40 Receptor
Interferons
Immunity
T-Lymphocytes
Growth

Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2

Foley, K., Muth, S., Jaffee, E. & Zheng, L. Feb 4 2017 (Accepted/In press) In : Cell Adhesion and Migration. p. 1-10 10 p.

Research output: Research - peer-reviewArticle

Annexins
Tenascin
Adenocarcinoma
Neoplasms
Stromal Cells

Heterogeneous stromal signaling within the tumor microenvironment controls the metastasis of pancreatic cancer

Rucki, A. A., Foley, K., Zhang, P., Xiao, Q., Kleponis, J., Wu, A. A., Sharma, R., Mo, G., Liu, A., Van Eyk, J., Jaffee, E. M. & Zheng, L. Jan 1 2017 In : Cancer Research. 77, 1, p. 41-52 12 p.

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Insulin-Like Growth Factor I

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A. D., Le, D. T., Jaffee, E. M., Azad, N. S., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. A. & Goggins, M. 2017 In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Research - peer-reviewArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
olaparib

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T. , Kumar, S. , Borkar, R. N. , Azimi, V. , Thibault, G. , Chang, Y. H. , Balter, A. , Kawashima, R. , Choe, G. , Sauer, D. , El Rassi, E. , Clayburgh, D. R. , Kulesz-Martin, M. F. , Lutz, E. R. , Zheng, L. , Jaffee, E. M. , Leyshock, P. , Margolin, A. A. , Mori, M. , Gray, J. W. & 2 others Flint, P. W. & Coussens, L. M. Apr 4 2017 In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Research - peer-reviewArticle

Immunohistochemistry
Neoplasms
Tumors
Tissue
Cell Count

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: A report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

Zloza, A., Karolina Palucka, A., Coussens, L. M., Gotwals, P. J., Headley, M. B., Jaffee, E. M., Lund, A. W., Sharpe, A. H., Sznol, M., Wainwright, D. A., Wong, K. K. & Bosenberg, M. W. Sep 19 2017 In : Journal for ImmunoTherapy of Cancer. 5, 1, 77

Research output: Research - peer-reviewArticle

Allergy and Immunology
Immunotherapy
Education
Neoplasms
Direction compound
2016

Cancer-associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation

Xiao, Q., Zhou, D., Rucki, A. A., Williams, J., Zhou, J., Mo, G., Murphy, A., Fujiwara, K., Kleponis, J., Salman, B., Wolfgang, C. L., Anders, R. A., Zheng, S., Jaffee, E. M. & Zheng, L. Sep 15 2016 In : Cancer Research. 76, 18, p. 5395-5404 10 p.

Research output: Research - peer-reviewArticle

DNA Methylation
Pancreatic Neoplasms
Adenocarcinoma
Neoplasms
Cancer-Associated Fibroblasts

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B. H., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J. D., Jaffee, E. M., Hildeman, D. A. & Gamper, C. J. Sep 20 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Research - peer-reviewArticle

DNA Methylation
T-Lymphocytes
DNA methyltransferase 3A
Wild Animals
Methyltransferases

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

Lee, D., Lyu, H., Chung, Y. H., Kim, J. A., Mathews, P., Jaffee, E., Zheng, L., Yu, E., Lee, Y. J. & Ryu, S. H. Jun 21 2016 In : World Journal of Gastroenterology. 22, 23, p. 5393-5399 7 p.

Research output: Research - peer-reviewArticle

Hepatitis B virus
Hepatocellular Carcinoma
Mutation
Genotype
Chronic Hepatitis B

Leveraging premalignant biology for immune-based cancer prevention

Spira, A., Disis, M. L., Schiller, J. T., Vilar, E., Rebbeck, T. R., Bejar, R., Ideker, T., Arts, J., Yurgelun, M. B., Mesirov, J. P., Rao, A., Garber, J., Jaffee, E. M. & Lippman, S. M. Sep 27 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10750-10758 9 p.

Research output: Research - peer-reviewArticle

Neoplasms
Genetic Phenomena
Immune Evasion
Hereditary Nonpolyposis Colorectal Neoplasms
Cancer Vaccines

Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients with Unresectable Pancreatic Cancer

Wild, A. T., Herman, J. M., Dholakia, A. S., Moningi, S., Lu, Y., Rosati, L. M., Hacker-Prietz, A., Assadi, R. K., Saeed, A. M., Pawlik, T. M., Jaffee, E. M., Laheru, D. A., Tran, P. T., Weiss, M. J., Wolfgang, C. L., Ford, E., Grossman, S. A., Ye, X. & Ellsworth, S. G. 2016 In : International Journal of Radiation Oncology, Biology, Physics. 94, 3, p. 571-579 9 p.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
Radiotherapy
Lymphocytes
Therapeutics
lymphocytes

Mesothelin immunotherapy for cancer: Ready for prime time?

Hassan, R., Thomas, A., Alewine, C., Le, D. T., Jaffee, E. M. & Pastan, I. Dec 1 2016 In : Journal of Clinical Oncology. 34, 34, p. 4171-4179 9 p.

Research output: Research - peer-reviewArticle

Immunotherapy
Neoplasms
mesothelin
Antibodies
Cell- and Tissue-Based Therapy

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E. D., Huang, L., Sharma, R., Klein, A. P., Zheng, L., Le, D. T., Laheru, D. A., Pandey, A., Jaffee, E. M. & Anders, R. A. Mar 1 2016 In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
Biomarkers
Antibodies
Immunoprecipitation
Serum
2015

Current progress in immunotherapy for pancreatic cancer

Foley, K., Kim, V., Jaffee, E. & Zheng, L. 2015 (Accepted/In press) In : Cancer Letters.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
Immunotherapy
Neoplasms
Vaccines
T-Lymphocytes

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J. N., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D. A., Jaffee, E. M., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. T. & Caturegli, P. Jan 1 2015 In : International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Research - peer-reviewArticle

Thyroglobulin
Immunotherapy
Survival
Antibodies
ipilimumab

Galectin-3 shapes antitumor immune responses by suppressing CD8 T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

Kouo, T., Huang, L., Pucsek, A. B., Cao, M., Solt, S., Armstrong, T. & Jaffee, E. Apr 1 2015 In : Cancer immunology research. 3, 4, p. 412-423 12 p.

Research output: Research - peer-reviewArticle

Galectin 3
Dendritic Cells
T-Lymphocytes
T-Cell Antigen Receptor
Adenocarcinoma

Immune therapy in GI malignancies: A review

Wang, J., Reiss, K. A., Khatri, R., Jaffee, E. & Laheru, D. Jun 1 2015 In : Journal of Clinical Oncology. 33, 16, p. 1745-1753 9 p.

Research output: Research - peer-reviewArticle

Neoplasms
Therapeutics
Immunotherapy
Oncogenes
Immune System
Vaccines
Antigens
Neoplasms
Early Detection of Cancer
Carcinogenesis

PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors

Soares, K. C., Rucki, A. A., Wu, A. A., Olino, K., Xiao, Q., Chai, Y., Wamwea, A., Bigelow, E., Lutz, E., Liu, L., Yao, S., Anders, R. A., Laheru, D., Wolfgang, C. L., Edil, B. H., Schulick, R. D., Jaffee, E. M. & Zheng, L. Jan 14 2015 In : Journal of Immunotherapy. 38, 1, p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Active Immunotherapy
T-Lymphocytes
Neoplasms
Adenocarcinoma
Therapeutics

Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer

Le, D. T. , Wang-Gillam, A. , Picozzi, V. , Greten, T. F. , Crocenzi, T. , Springett, G. , Morse, M. , Zeh, H. , Cohen, D. , Fine, R. L. , Onners, B. , Uram, J. N. , Laheru, D. A. , Lutz, E. R. , Solt, S. , Murphy, A. L. , Skoble, J. , Lemmens, E. , Grous, J. , Dubensky, T. & 2 others Brockstedt, D. G. & Jaffee, E. M. Apr 20 2015 In : Journal of Clinical Oncology. 33, 12, p. 1325-1333 9 p.

Research output: Research - peer-reviewArticle

Listeria monocytogenes
Pancreatic Neoplasms
Cyclophosphamide
Pancreas
Vaccines

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Foley, K., Rucki, A. A., Xiao, Q., Zhou, D., Leubner, A., Mo, G., Kleponis, J., Wu, A. A., Sharma, R., Jiang, Q., Anders, R. A., Iacobuzio-Donahue, C. A., Hajjar, K. A., Maitra, A., Jaffee, E. M. & Zheng, L. Aug 4 2015 In : Science Signaling. 8, 388, ra77

Research output: Research - peer-reviewArticle

Autocrine Communication
Semaphorins
Annexins
Pancreatic Neoplasms
Adenocarcinoma

Special conference on tumor immunology and immunotherapy: A new chapter

Byrne, K. T., Vonderheide, R. H., Jaffee, E. M. & Armstrong, T. D. Jun 1 2015 In : Cancer immunology research. 3, 6, p. 590-597 8 p.

Research output: Research - peer-reviewArticle

Allergy and Immunology
Immunotherapy
Neoplasms
Therapeutics
pembrolizumab

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Soares, K. C., Rucki, A. A., Kim, V., Foley, K., Solt, S., Wolfgang, C. L., Jaffee, E. M. & Zheng, L. 2015 In : Oncotarget. 6, 40, p. 43005-43015 11 p.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Transforming Growth Factor beta
Vaccines
Neoplasms
Therapeutics

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

Bever, K. M., Sugar, E. A., Bigelow, E., Sharma, R., Laheru, D., Wolfgang, C. L., Jaffee, E. M., Anders, R. A., De Jesus-Acosta, A. & Zheng, L. Apr 1 2015 In : HPB. 17, 4, p. 292-298 7 p.

Research output: Research - peer-reviewArticle

Pancreatic Neoplasms
Adenocarcinoma
Therapeutics
Pancreatic Stellate Cells
Tissue Preservation
2014

A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer

Chen, G. , Gupta, R. , Petrik, S. , Laiko, M. , Leatherman, J. M. , Asquith, J. M. , Daphtary, M. M. , Garrett-Mayer, E. , Davidson, N. E. , Hirt, K. , Berg, M. , Uram, J. N. , Dauses, T. , Fetting, J. , Duus, E. M. , Atay-Rosenthal, S. , Ye, X. , Wolff, A. C. , Stearns, V. , Jaffee, E. M. & 1 others Emens, L. A. Oct 1 2014 In : Cancer immunology research. 2, 10, p. 949-961 13 p.

Research output: Research - peer-reviewArticle

Cancer Vaccines
Feasibility Studies
Granulocyte-Macrophage Colony-Stimulating Factor
Cyclophosphamide
Vaccination

A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

Keenan, B. P., Saenger, Y., Kafrouni, M. I., Leubner, A., Lauer, P., Maitra, A., Rucki, A. A., Gunderson, A. J., Coussens, L. M., Brockstedt, D. G., Dubensky, T. W., Hassan, R., Armstrong, T. D. & Jaffee, E. M. 2014 In : Gastroenterology. 146, 7

Research output: Research - peer-reviewArticle

Listeria
Carcinoma in Situ
Pancreatic Neoplasms
Immunity
Vaccines
Apoptosis
T-Lymphocytes
Neoplasms
Clonal Deletion
Cell Death

A preclinical murine model of hepatic metastases

Soares, K. C., Foley, K., Olino, K., Leubner, A., Mayo, S. C., Jain, A., Schulick, R. D., Jaffee, E., Yoshimura, K., Edil, B. & Zheng, L. Sep 27 2014 In : Journal of Visualized Experiments. 91, e51677

Research output: Research - peer-reviewArticle

Neoplasm Metastasis
Liver
Neoplasms
Tumors
Immunology
Cancer Vaccines
Feasibility Studies
Granulocyte-Macrophage Colony-Stimulating Factor
Colonic Neoplasms
Colorectal Neoplasms

Cancer immunoprevention - The next frontier

Smit, M. A. D., Jaffee, E. M. & Lutz, E. R. Nov 1 2014 In : Cancer Prevention Research. 7, 11, p. 1072-1080 9 p.

Research output: Research - peer-reviewArticle

Neoplasms
Immune Tolerance
Recurrence
Steam
Residual Neoplasm

Fusion protein of mutant B7-DC and Fc enhances the antitumor immune effect of GM-CSF-secreting whole-cell vaccine

Kojima, M., Murata, S., Mekata, E., Takebayashi, K., Jaffee, E. M. & Tani, T. 2014 In : Journal of Immunotherapy. 37, 3, p. 147-154 8 p.

Research output: Research - peer-reviewArticle

Mutant Proteins
Granulocyte-Macrophage Colony-Stimulating Factor
Dendritic Cells
Vaccines
Neoplasms

Immunobiology of radiotherapy: New paradigms

Ahmed, M. M., Guha, C., Hodge, J. W. & Jaffee, E. 2014 In : Radiation Research. 182, 2, p. 123-125 3 p.

Research output: Research - peer-reviewArticle

Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation

Lutz, E. R., Wu, A. A., Bigelow, E., Sharma, R., Mo, G., Soares, K., Solt, S., Dorman, A., Wamwea, A., Yager, A., Laheru, D., Wolfgang, C. L., Wang, J., Hruban, R. H., Anders, R. A., Jaffee, E. M. & Zheng, L. Jul 1 2014 In : Cancer immunology research. 2, 7, p. 616-631 16 p.

Research output: Research - peer-reviewArticle

Immunotherapy
Adenocarcinoma
Vaccines
Neoplasms
Tumor Microenvironment

Oncogenic kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., Jaffee, E. M., Drake, C. G., Housseau, F., Maitra, A., Kolls, J. K., Sears, C. L., Pardoll, D. M. & Leach, S. D. May 12 2014 In : Cancer Cell. 25, 5, p. 621-637 17 p.

Research output: Research - peer-reviewArticle

Interleukin-17
Neoplasms
Interleukin-17 Receptors
Chronic Pancreatitis
Epithelial Cells

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Zhou, W. , Jubb, A. M. , Lyle, K. , Xiao, Q. , Ong, C. C. , Desai, R. , Fu, L. , Gnad, F. , Song, Q. , Haverty, P. M. , Aust, D. , Grützmann, R. , Romero, M. , Totpal, K. , Neve, R. M. , Yan, Y. , Forrest, W. F. , Wang, Y. , Raja, R. , Pilarsky, C. & 8 others De Jesus-Acosta, A., Belvin, M., Friedman, L. S., Merchant, M., Jaffee, E. M., Zheng, L., Koeppen, H. & Hoeflich, K. P. Dec 1 2014 In : Journal of Pathology. 234, 4, p. 502-513 12 p.

Research output: Research - peer-reviewArticle

p21-Activated Kinases
Pancreatic Neoplasms
Cell Movement
Adenocarcinoma
Therapeutics

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

Lutz, E. R., Kinkead, H., Jaffee, E. M. & Zheng, L. Nov 2 2014 In : OncoImmunology. 3, 11, p. e962401-1-e962401-3

Research output: Research - peer-reviewArticle

Tumor Microenvironment
Pancreatic Neoplasms
Immunotherapy
Neoplasms
Allergy and Immunology

Specificity delivers: Therapeutic role of tumor antigen-specific antibodies in pancreatic cancer

Jhaveri, D. T., Zheng, L. & Jaffee, E. M. Oct 1 2014 In : Seminars in Oncology. 41, 5, p. 559-575 17 p.

Research output: Research - peer-reviewArticle

Neoplasm Antigens
Pancreatic Neoplasms
Adenocarcinoma
Antibodies
Therapeutics
2013

Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma

Mathews, P., Lee, D., Chung, Y. H., Kim, J. A., Lee, J. H., Jin, Y. J., Park, W., Lyu, H., Jaffee, E., Zheng, L., Yu, E. & Lee, Y. J. Apr 2013 In : Annals of Surgical Oncology. 20, 4, p. 1216-1222 7 p.

Research output: Research - peer-reviewArticle

Hepatitis B virus
Hepatocellular Carcinoma
Recurrence
Survival
Neoplasms
Granulocyte-Macrophage Colony-Stimulating Factor
Pancreatic Neoplasms
Genes
Neoplasms
ipilimumab

Harnessing immune responses in the tumor microenvironment: All signals needed

Le, D. T. & Jaffee, E. M. Nov 15 2013 In : Clinical Cancer Research. 19, 22, p. 6061-6063 3 p.

Research output: Research - peer-reviewArticle

gemcitabine
Tumor Microenvironment
Immunotherapy
Adenocarcinoma
B-Lymphocytes

Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.

Bigelow, E., Bever, K. M., Xu, H., Yager, A., Wu, A., Taube, J., Chen, L., Jaffee, E. M., Anders, R. A. & Zheng, L. 2013 In : Journal of Visualized Experiments. 71

Research output: Research - peer-reviewArticle

Paraffin
Adenocarcinoma
Staining and Labeling
Neoplasms
Tumors
Cancer
Suppression
Tolerance
Immunotherapy
Neoplasms

Introduction

Prendergast, G. C. & Jaffee, E. M. Jul 2013 In : Unknown Journal. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Neoplasms
cancer
immune system
Immune System
Therapeutics
Cancer Vaccines
Lymphocyte Count
Adenocarcinoma
Survival
Lymphocytes
Pancreaticoduodenectomy
Adenocarcinoma
Radiation
Recurrence
Therapeutics
Cancer Vaccines
Neoplasms
Tumor Microenvironment
Castration
Biotechnology

Peptidases released by necrotic cells control CD8+ T cell cross-priming

Gamrekelashvili, J., Kapanadze, T., Han, M., Wissing, J., Ma, C., Jaensch, L., Manns, M. P., Armstrong, T., Jaffee, E., White, A. O., Citrin, D. E., Korangy, F. & Greten, T. F. Nov 1 2013 In : Journal of Clinical Investigation. 123, 11, p. 4755-4768 14 p.

Research output: Research - peer-reviewArticle

Cross-Priming
Peptide Hydrolases
T-Lymphocytes
Necrosis
thimet oligopeptidase

Personalized chemotherapy profiling using cancer cell lines from selectable mice

Kamiyama, H. , Rauenzahn, S. , Shim, J. S. , Karikari, C. A. , Feldmann, G. , Hua, L. , Kamiyama, M. , Schuler, F. W. , Lin, M. T. , Beaty, R. M. , Karanam, B. , Liang, H. , Mullendore, M. E. , Mo, G. , Hidalgo, M. , Jaffee, E. , Hruban, R. H. , Jinnah, H. A. , Roden, R. B. S. , Jimeno, A. & 3 others Liu, J. O., Maitra, A. & Eshleman, J. R. Mar 1 2013 In : Clinical Cancer Research. 19, 5, p. 1139-1146 8 p.

Research output: Research - peer-reviewArticle

Drug Therapy
Cell Line
Neoplasms
Pharmaceutical Preparations
Hypoxanthine

Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma

Zheng, L., Xue, J., Jaffee, E. M. & Habtezion, A. Jun 2013 In : Gastroenterology. 144, 6, p. 1230-1240 11 p.

Research output: Research - peer-reviewArticle

Pancreatitis
Adenocarcinoma
Therapeutics
Chronic Pancreatitis
Immunosuppressive Agents

Synergistic effects of A1896, T1653 and T1762/A1764 mutations in genotype C2 hepatitis B virus on development of hepatocellular carcinoma

Lyu, H., Lee, D., Chung, Y. H., Kim, J. A., Lee, J. H., Jin, Y. J., Park, W., Mathews, P., Jaffee, E., Zheng, L., Yu, E. & Lee, Y. J. Mar 2013 In : Journal of Viral Hepatitis. 20, 3, p. 219-224 6 p.

Research output: Research - peer-reviewArticle

Hepatitis B virus
Hepatocellular Carcinoma
Genotype
Mutation
Chronic Hepatitis B