Elizabeth Jaffee

Professor

1992 …2019
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Research Output 1992 2019

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2019

A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell–Mediated Anticancer Activity

Ma, H. S., Poudel, B., Torres, E. R., Sidhom, J. W., Robinson, T. M., Christmas, B., Scott, B., Cruz, K., Woolman, S., Wall, V. Z., Armstrong, T. & Jaffee, E. M., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 428-442 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Antibodies
Monoclonal Antibodies
T-Lymphocytes
Tumor-Infiltrating Lymphocytes

Anti–CTLA-4 synergizes with dendritic cell–targeted vaccine to promote IL-3–dependent CD4 + effector T cell infiltration into murine pancreatic tumors

Zaidi, N., Quezada, S. A., Kuroiwa, J. M. Y., Zhang, L., Jaffee, E., Steinman, R. M. & Wang, B., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalArticle

T-cells
Interleukin-3
Infiltration
Tumors
Vaccines

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Kim, V. M., Blair, A. B., Lauer, P., Foley, K., Che, X., Soares, K., Xia, T., Muth, S. T., Kleponis, J., Armstrong, T. D., Wolfgang, C., Jaffee, E., Brockstedt, D. & Zheng, L., May 22 2019, In : Journal for immunotherapy of cancer. 7, 1, 132.

Research output: Contribution to journalArticle

Open Access
Annexin A2
Annexins
Listeria
Immunotherapy
Adenocarcinoma

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Jurcak, N. R., Rucki, A. A., Muth, S., Thompson, E., Sharma, R., Ding, D., Zhu, Q., Eshleman, J., Anders, R. A., Jaffee, E., Fujiwara, K. & Zheng, L., Sep 1 2019, In : Gastroenterology. 157, 3, p. 838-850.e6

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Neoplasms
Spinal Ganglia
Annexin A2

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Hassan, R., Alley, E., Kindler, H., Antonia, S., Jahan, T., Honarmand, S., Nair, N., Whiting, C. C., Enstrom, A., Lemmens, E., Tsujikawa, T., Kumar, S., Choe, G., Thomas, A., McDougall, K., Murphy, A. L., Jaffee, E., Coussens, L. M. & Brockstedt, D. G., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5787-5798 12 p.

Research output: Contribution to journalArticle

Listeria monocytogenes
Drug Therapy
Neoplasms
Disease-Free Survival
Pemetrexed

Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

Chan, T. A., Yarchoan, M., Jaffee, E., Swanton, C., Quezada, S. A., Stenzinger, A. & Peters, S., Jan 1 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Tumor Burden
Immunotherapy
Biomarkers
Mutation
Ligands

Differential variation analysis enables detection of tumor heterogeneity using single-cell RNA-sequencing data

Davis-Marcisak, E. F., Sherman, T. D., Orugunta, P., Stein-O'Brien, G. L., Puram, S. V., Roussos Torres, E., Hopkins, A. C., Jaffee, E., Favorov, A., Afsari, B., Goff, L. & Fertig, E., Oct 1 2019, In : Cancer Research. 79, 19, p. 5102-5112 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Neoplasms
Neoplasm Metastasis
Gene Expression
Tumor Microenvironment

Dissecting the stromal signalingandregulation of myeloid cells and memory effector T cells in pancreatic cancer

Blair, A. B., Kim, V. M., Muth, S. T., Saung, M. T., Lokker, N., Blouw, B., Armstrong, T. D., Jaffee, E. M., Tsujikawa, T., Coussens, L. M., He, J., Burkhart, R. A., Wolfgang, C. L. & Zheng, L., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5351-5363 13 p.

Research output: Contribution to journalArticle

Myeloid Cells
Pancreatic Neoplasms
Adenocarcinoma
T-Lymphocytes
Hyaluronic Acid

Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T-Cells

Jin, J., Krishnamachary, B., Barnett, J. D., Chatterjee, S., Chang, D., Mironchik, Y., Wildes, F., Jaffee, E. M., Nimmagadda, S. & Bhujwalla, Z. M., Feb 27 2019, In : ACS Applied Materials and Interfaces. 11, 8, p. 7850-7861 12 p.

Research output: Contribution to journalArticle

T-cells
Biomimetics
Fibroblasts
Cell membranes
Nanoparticles

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

Llosa, N. J., Luber, B., Siegel, N., Awan, A. H., Oke, T., Zhu, Q., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Jaffee, E. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., Pardoll, D. M., Wang, H., Housseau, F. & Anders, R. A., Jan 1 2019, In : Cancer Immunology Research. 7, 10, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Colorectal Neoplasms
Mucins
Microsatellite Repeats
Neoplasms

MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity

Yarchoan, M., Mohan, A. A., Dennison, L., Vithayathil, T., Ruggieri, A., Lesinski, G. B., Armstrong, T. D., Azad, N. S. & Jaffee, E. M., Oct 2019, In : PloS one. 14, 10, e0224600.

Research output: Contribution to journalArticle

Open Access
Regulatory B-Lymphocytes
Mitogen-Activated Protein Kinase Kinases
Tumors
Immunity
immunity

Multiple immune-suppressive mechanisms in fibrolamellar carcinoma

Kim, A., Gani, F., Layman, A. J., Besharati, S., Zhu, Q., Succaria, F., Engle, E. L., Bhaijee, F., Goggins, M. B., Llosa, N., Pawlik, T. M., Yarchoan, M., Jaffee, E., Simons, H. C., Taube, J. M. & Anders, R. A., May 1 2019, In : Cancer Immunology Research. 7, 5, p. 805-812 8 p.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Cytotoxic T-Lymphocytes
Myeloid Cells

PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers

Yarchoan, M., Albacker, L. A., Hopkins, A. C., Montesion, M., Murugesan, K., Vithayathil, T. T., Zaidi, N., Azad, N., Laheru, D., Frampton, G. M. & Jaffee, E., Mar 21 2019, In : JCI Insight. 4, 6, 126908.

Research output: Contribution to journalArticle

Open Access
Tumor Burden
Biomarkers
Neoplasms
Therapeutics

Peptide-based PET quantifies target engagement of PD-L1 therapeutics

Kumar, D., Lisok, A., Dahmane, E., McCoy, M., Shelake, S., Chatterjee, S., Allaj, V., Sysa-Shah, P., Wharram, B., Lesniak, W., Tully, E., Gabrielson, E., Jaffee, E., Poirier, J. T., Rudin, C. M., Gobburu, J. V. S., Pomper, M. G. & Nimmagadda, S., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 616-630 15 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Ligands
Peptides
Antibodies
Therapeutics
Adenocarcinoma
Cell Death
Ligands
Survival
Biomarkers

Recent developments and therapeutic strategies against hepatocellular carcinoma

Yarchoan, M., Agarwal, P., Villanueva, A., Rao, S., Dawson, L. A., Llovet, J. M., Finn, R. S., Groopman, J. D., El-Serag, H. B., Monga, S. P., Wang, X. W., Karin, M., Schwartz, R. E., Tanabe, K. K., Roberts, L. R., Gunaratne, P. H., Tsung, A., Brown, K. A., Lawrence, T. S., Salem, R. & 13 others, Singal, A. G., Kim, A. K., Rabiee, A., Resar, L., Hoshida, Y., He, A. R., Ghoshal, K., Ryan, P. B., Jaffee, E. M., Guha, C., Mishra, L., Norman Coleman, C. & Ahmed, M. M., Sep 1 2019, In : Cancer Research. 79, 17, p. 4326-4330 5 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Genomics
Liver Transplantation
Cause of Death
Neoplasms

Results from a phase IIb, randomized, multicenter study of GVAX pancreas and CRS-207 compared with chemotherapy in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE study)

Le, D., Picozzi, V. J., Ko, A. H., Wainberg, Z. A., Kindler, H., Wang-Gillam, A., Oberstein, P., Morse, M. A., Zeh, H. J., Weekes, C., Reid, T., Borazanci, E., Crocenzi, T., LoConte, N. K., Musher, B., Laheru, D., Murphy, A., Whiting, C., Nair, N., Enstrom, A. & 3 others, Ferber, S., Brockstedt, D. G. & Jaffee, E., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5493-5502 10 p.

Research output: Contribution to journalArticle

Multicenter Studies
Pancreas
Adenocarcinoma
Drug Therapy
Cyclophosphamide

Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14

Surcel, A., Schiffhauer, E. S., Thomas, D. G., Zhu, Q., DiNapoli, K. T., Herbig, M., Otto, O., West-Foyle, H., Jacobi, A., Krater, M., Plak, K., Guck, J., Jaffee, E., Iglesias, P. A., Anders, R. A. & Robinson, D., Sep 15 2019, In : Cancer Research. 79, 18, p. 4665-4678 14 p.

Research output: Contribution to journalArticle

Protein Transport
Pancreatic Neoplasms
Filamins
Actinin
Proteins
2018

Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Kinkead, H. L., Hopkins, A., Lutz, E., Wu, A. A., Yarchoan, M., Cruz, K., Woolman, S., Vithayathil, T., Glickman, L. H., Ndubaku, C. O., McWhirter, S. M., Dubensky, T. W., Armstrong, T. D., Jaffee, E. & Zaidi, N., Oct 18 2018, In : JCI insight. 3, 20

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Immunity
Vaccines
Neoplasms
T-Lymphocytes

Entinostat converts immune-resistant breast and pancreatic cancers into checkpoint-responsive tumors by reprogramming tumor-infiltrating MDSCs

Christmas, B. J., Rafie, C. I., Hopkins, A. C., Scott, B. A., Ma, H. S., Cruz, K. A., Woolman, S., Armstrong, T. D., Connolly, R., Azad, N., Jaffee, E. & Roussos Torres, E., Dec 1 2018, In : Cancer immunology research. 6, 12, p. 1561-1577 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Breast Neoplasms
Tumor Microenvironment
Neoplasms
Tumor-Infiltrating Lymphocytes

Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis

Adler, B., Pezhouh, M. K., Kim, A., Luan, L., Zhu, Q., Gani, F., Yarchoan, M., Chen, J., Voltaggio, L., Parian, A., Lazarev, M., Lauwers, G. Y., Pawlik, T. M., Montgomery, E. A., Jaffee, E., Le, D., Taube, J. M. & Anders, R. A., Jan 1 2018, (Accepted/In press) In : Journal of Internal Medicine.

Research output: Contribution to journalArticle

Colitis
Ulcerative Colitis
ipilimumab
Biopsy
Inflammatory Bowel Diseases

Immune modulation therapy and imaging: Workshop report

Shields, A. F., Jacobs, P. M., Sznol, M., Graham, M. M., Germain, R. N., Lum, L. G., Jaffee, E., De Vries, E. G. E., Nimmagadda, S., Van Den Abbeele, A. D., Leung, D. K., Wu, A. M., Sharon, E. & Shankar, L. K., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 410-417 8 p.

Research output: Contribution to journalArticle

Immunotherapy
Education
Therapeutics
Immunoglobulin Fragments
Tumor Microenvironment

Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

Saung, M. T., Muth, S., Ding, D., Thomas, D. L., Blair, A. B., Tsujikawa, T., Coussens, L., Jaffee, E. M. & Zheng, L., Nov 13 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 1 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
T-Lymphocytes
Antibodies
Adenocarcinoma
Neoplasms

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins, A. C., Yarchoan, M., Durham, J. N., Yusko, E. C., Rytlewski, J. A., Robins, H. S., Laheru, D. A., Le, D. T., Lutz, E. R. & Jaffee, E. M., Jul 12 2018, In : JCI insight. 3, 13

Research output: Contribution to journalArticle

Open Access
T-Cell Antigen Receptor
Immunotherapy
Adenocarcinoma
Survival
Pancreatic Neoplasms

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A., Wheelan, S., Yegnasubramanian, S. & Jaffee, E., Dec 1 2018, In : PLoS One. 13, 12, e0208602.

Research output: Contribution to journalArticle

Macrophages
macrophages
Polarization
DNA methylation
DNA Methylation
2017

A blueprint to advance colorectal cancer immunotherapies

Le, D., Hubbard-Lucey, V. M., Morse, M. A., Heery, C. R., Dwyer, A., Marsilje, T. H., Brodsky, A. N., Chan, E., Deming, D. A., Diaz, L. A., Fridman, W. H., Goldberg, R. M., Hamilton, S. R., Housseau, F., Jaffee, E., Kang, S. P., Krishnamurthi, S. S., Lieu, C. H., Messersmith, W., Sears, C. L. & 10 others, Segal, N. H., Yang, A., Moss, R. A., Cha, E., O'Donnell-Tormey, J., Roach, N., Davis, A. Q., McAbee, K., Worrall, S. & Benson, A. B., Nov 1 2017, In : Cancer immunology research. 5, 11, p. 942-949 8 p.

Research output: Contribution to journalArticle

Immunotherapy
Colorectal Neoplasms
Microsatellite Repeats
T-Lymphocytes
Biomarkers

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Foote, J. B., Kok, M., Leatherman, J. M., Armstrong, T. D., Marcinkowski, B. C., Ojalvo, L. S., Kanne, D. B., Jaffee, E., Dubensky, T. W. & Emens, L. A., Jun 1 2017, In : Cancer immunology research. 5, 6, p. 468-479 12 p.

Research output: Contribution to journalArticle

OX40 Receptor
Interferons
Immunity
T-Lymphocytes
Growth

Characterization of the immune microenvironment in hepatocellular carcinoma

Yarchoan, M., Xing, D., Luan, L., Xu, H., Sharma, R. B., Popovic, A., Pawlik, T. M., Kim, A., Zhu, Q., Jaffee, E., Taube, J. M. & Anders, R. A., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7333-7339 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Neoplasms
Liver
CD8-Positive T-Lymphocytes
Tumor-Infiltrating Lymphocytes

Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment

Rucki, A. A., Xiao, Q., Muth, S., Chen, J., Che, X., Kleponis, J., Sharma, R., Anders, R. A., Jaffee, E. & Zheng, L., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2399-2409 11 p.

Research output: Contribution to journalArticle

Hedgehogs
Pancreatic Neoplasms
Adenocarcinoma
gemcitabine
Tumor Burden

Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2

Foley, K., Muth, S., Jaffee, E. & Zheng, L., Feb 4 2017, (Accepted/In press) In : Cell Adhesion and Migration. p. 1-10 10 p.

Research output: Contribution to journalArticle

Annexins
Tenascin
Adenocarcinoma
Stromal Cells
Neoplasms

Heterogeneous stromal signaling within the tumor microenvironment controls the metastasis of pancreatic cancer

Rucki, A. A., Foley, K., Zhang, P., Xiao, Q., Kleponis, J., Wu, A. A., Sharma, R., Mo, G., Liu, A., Van Eyk, J., Jaffee, E. & Zheng, L., Jan 1 2017, In : Cancer Research. 77, 1, p. 41-52 12 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Insulin-Like Growth Factor I

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D., Liu, Y., von Eyben, R., Hsu, C. C., Hu, C., Rosati, L. M., Parekh, A., Ng, K., Hacker-Prietz, A., Zheng, L., Pawlik, T. M., Laheru, D., Jaffee, E., Weiss, M. J., Le, D., Hruban, R. H., De Jesus-Acosta, A., Wolfgang, C., Narang, A., Chang, D. T. & 2 others, Koong, A. C. & Herman, J. M., Jan 1 2017, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A., Le, D., Jaffee, E., Azad, N., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. & Goggins, M. S., 2017, In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T., Kumar, S., Borkar, R. N., Azimi, V., Thibault, G., Chang, Y. H., Balter, A., Kawashima, R., Choe, G., Sauer, D., El Rassi, E., Clayburgh, D. R., Kulesz-Martin, M. F., Lutz, E. R., Zheng, L., Jaffee, E., Leyshock, P., Margolin, A. A., Mori, M., Gray, J. W. & 2 others, Flint, P. W. & Coussens, L. M., Apr 4 2017, In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Contribution to journalArticle

Tumors
Immunohistochemistry
Tissue
Biomarkers
Papillomaviridae
Lymphocyte Count
Cell Death
Lymphopenia
Neoplasms
Drug-Related Side Effects and Adverse Reactions

Report on the third FDA–AACR oncology dose-finding workshop

Emens, L. A., Bruno, R., Rubin, E. H., Jaffee, E. & McKee, A. E., Dec 1 2017, In : Cancer immunology research. 5, 12, p. 1058-1061 4 p.

Research output: Contribution to journalArticle

Education
Practice Guidelines
Patient Selection
Biomarkers
Therapeutics

Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective

Ryan, J. F., Groot, V. P., Rosati, L. M., Hacker-Prietz, A., Narang, A., McNutt, T., Jackson, J. F., Le, D., Jaffee, E., Zheng, L., Laheru, D., He, J., Pawlik, T. M., Weiss, M. J., Wolfgang, C. & Herman, J. M., Oct 23 2017, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Radiotherapy
Recurrence
Maintenance Chemotherapy
Disease-Free Survival

Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer

Murphy, A., Foley, K., Rucki, A. A., Xia, T., Jaffee, E., Huang, C. Y. & Zheng, L., Jan 1 2017, In : Oncotarget. 8, 63, p. 106405-106414 10 p.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Pancreatic Neoplasms
Adenocarcinoma
Survival

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: A report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer

Zloza, A., Karolina Palucka, A., Coussens, L. M., Gotwals, P. J., Headley, M. B., Jaffee, E., Lund, A. W., Sharpe, A. H., Sznol, M., Wainwright, D. A., Wong, K. K. & Bosenberg, M. W., Sep 19 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 77.

Research output: Contribution to journalArticle

Allergy and Immunology
Immunotherapy
Education
Neoplasms
Direction compound
2016

Cancer-associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation

Xiao, Q., Zhou, D., Rucki, A. A., Williams, J., Zhou, J., Mo, G., Murphy, A., Fujiwara, K., Kleponis, J., Salman, B., Wolfgang, C., Anders, R. A., Zheng, S., Jaffee, E. & Zheng, L., Sep 15 2016, In : Cancer Research. 76, 18, p. 5395-5404 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Pancreatic Neoplasms
Adenocarcinoma
Methylation
Neoplasms

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J., Jaffee, E., Hildeman, D. A. & Gamper, C., Sep 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Contribution to journalArticle

DNA Methylation
T-Lymphocytes
Wild Animals
DNA methyltransferase 3A
Methyltransferases

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

Lee, D., Lyu, H., Chung, Y. H., Kim, J. A., Mathews, P., Jaffee, E., Zheng, L., Yu, E., Lee, Y. J. & Ryu, S. H., Jun 21 2016, In : World Journal of Gastroenterology. 22, 23, p. 5393-5399 7 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Mutation
Genotype
Chronic Hepatitis B

Leveraging premalignant biology for immune-based cancer prevention

Spira, A., Disis, M. L., Schiller, J. T., Vilar, E., Rebbeck, T. R., Bejar, R., Ideker, T., Arts, J., Yurgelun, M. B., Mesirov, J. P., Rao, A., Garber, J., Jaffee, E. & Lippman, S. M., Sep 27 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10750-10758 9 p.

Research output: Contribution to journalArticle

Neoplasms
Genetic Phenomena
Immune Evasion
Hereditary Nonpolyposis Colorectal Neoplasms
Cancer Vaccines

Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients with Unresectable Pancreatic Cancer

Wild, A. T., Herman, J. M., Dholakia, A. S., Moningi, S., Lu, Y., Rosati, L. M., Hacker-Prietz, A., Assadi, R. K., Saeed, A. M., Pawlik, T. M., Jaffee, E., Laheru, D., Tran, P. T., Weiss, M. J., Wolfgang, C., Ford, E., Grossman, S. A., Ye, X. & Ellsworth, S. G., 2016, In : International Journal of Radiation Oncology, Biology, Physics. 94, 3, p. 571-579 9 p.

Research output: Contribution to journalArticle

lymphocytes
Pancreatic Neoplasms
radiation therapy
Radiotherapy
cancer

Mesothelin immunotherapy for cancer: Ready for prime time?

Hassan, R., Thomas, A., Alewine, C., Le, D., Jaffee, E. & Pastan, I., Dec 1 2016, In : Journal of Clinical Oncology. 34, 34, p. 4171-4179 9 p.

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Cell- and Tissue-Based Therapy
Antibodies
Phase II Clinical Trials

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E., Huang, L., Sharma, R., Klein, A., Zheng, L., Le, D., Laheru, D., Pandey, A., Jaffee, E. & Anders, R. A., Mar 1 2016, In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Biomarkers
Immunoprecipitation
Antibodies
Cancer Vaccines
2015

Current progress in immunotherapy for pancreatic cancer

Foley, K., Kim, V., Jaffee, E. & Zheng, L., 2015, (Accepted/In press) In : Cancer Letters.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Immunotherapy
Vaccines
T-Lymphocytes
Tumor Microenvironment

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D., Jaffee, E., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. & Caturegli, P. P., Jan 1 2015, In : International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Thyroglobulin
Immunotherapy
Survival
Antibodies
Epitopes

Galectin-3 shapes antitumor immune responses by suppressing CD8 T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

Kouo, T., Huang, L., Pucsek, A. B., Cao, M., Solt, S., Armstrong, T. D. & Jaffee, E., Apr 1 2015, In : Cancer immunology research. 3, 4, p. 412-423 12 p.

Research output: Contribution to journalArticle

Galectin 3
Dendritic Cells
T-Lymphocytes
T-Cell Antigen Receptor
Adenocarcinoma

Immune therapy in GI malignancies: A review

Wang, J., Reiss, K. A., Khatri, R., Jaffee, E. & Laheru, D., Jun 1 2015, In : Journal of Clinical Oncology. 33, 16, p. 1745-1753 9 p.

Research output: Contribution to journalArticle

Neoplasms
Immunotherapy
Therapeutics
Oncogenes
Immune System