Elizabeth Jaffee

Professor

1992 …2019
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Research Output 1992 2019

2019

A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell–Mediated Anticancer Activity

Ma, H. S., Poudel, B., Torres, E. R., Sidhom, J. W., Robinson, T. M., Christmas, B., Scott, B., Cruz, K., Woolman, S., Wall, V. Z., Armstrong, T. & Jaffee, E. M., Mar 1 2019, In : Cancer Immunology Research. 7, 3, p. 428-442 15 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Antibodies
Monoclonal Antibodies
T-Lymphocytes
Tumor-Infiltrating Lymphocytes

Anti–CTLA-4 synergizes with dendritic cell–targeted vaccine to promote IL-3–dependent CD4 + effector T cell infiltration into murine pancreatic tumors

Zaidi, N., Quezada, S. A., Kuroiwa, J. M. Y., Zhang, L., Jaffee, E., Steinman, R. M. & Wang, B., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalArticle

T-cells
Interleukin-3
Infiltration
Tumors
Vaccines

Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Kim, V. M., Blair, A. B., Lauer, P., Foley, K., Che, X., Soares, K., Xia, T., Muth, S. T., Kleponis, J., Armstrong, T. D., Wolfgang, C., Jaffee, E., Brockstedt, D. & Zheng, L., May 22 2019, In : Journal for immunotherapy of cancer. 7, 1, 132.

Research output: Contribution to journalArticle

Open Access
Annexin A2
Annexins
Listeria
Immunotherapy
Adenocarcinoma

Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

Jurcak, N. R., Rucki, A. A., Muth, S., Thompson, E., Sharma, R., Ding, D., Zhu, Q., Eshleman, J., Anders, R. A., Jaffee, E., Fujiwara, K. & Zheng, L., Sep 1 2019, In : Gastroenterology. 157, 3, p. 838-850.e6

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Neoplasms
Spinal Ganglia
Annexin A2

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Hassan, R., Alley, E., Kindler, H., Antonia, S., Jahan, T., Honarmand, S., Nair, N., Whiting, C. C., Enstrom, A., Lemmens, E., Tsujikawa, T., Kumar, S., Choe, G., Thomas, A., McDougall, K., Murphy, A. L., Jaffee, E., Coussens, L. M. & Brockstedt, D. G., Oct 1 2019, In : Clinical Cancer Research. 25, 19, p. 5787-5798 12 p.

Research output: Contribution to journalArticle

Listeria monocytogenes
Drug Therapy
Neoplasms
Disease-Free Survival
Pemetrexed

Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C., Park, Y., Preall, J., Jaffee, E., Califano, A. & 2 others, Robson, P. & Tuveson, D. A., Aug 1 2019, In : Cancer discovery. 9, 8, p. 1102-1123 22 p.

Research output: Contribution to journalReview article

Open Access
Single-Cell Analysis
Adenocarcinoma
Antigens
Population
RNA Sequence Analysis

Current Status of Immunotherapies for Treating Pancreatic Cancer

Wu, A. A., Jaffee, E. & Lee, V., Jul 1 2019, In : Current oncology reports. 21, 7, 60.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Immunotherapy
Adenocarcinoma
Vaccines
Antigens

Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic

Chan, T. A., Yarchoan, M., Jaffee, E., Swanton, C., Quezada, S. A., Stenzinger, A. & Peters, S., Jan 1 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology. 30, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

Tumor Burden
Immunotherapy
Biomarkers
Mutation
Ligands

Differential variation analysis enables detection of tumor heterogeneity using single-cell RNA-sequencing data

Davis-Marcisak, E. F., Sherman, T. D., Orugunta, P., Stein-O'Brien, G. L., Puram, S. V., Roussos Torres, E., Hopkins, A. C., Jaffee, E., Favorov, A., Afsari, B., Goff, L. & Fertig, E., Oct 1 2019, In : Cancer Research. 79, 19, p. 5102-5112 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Neoplasms
Neoplasm Metastasis
Gene Expression
Tumor Microenvironment

Dissecting the stromal signalingandregulation of myeloid cells and memory effector T cells in pancreatic cancer

Blair, A. B., Kim, V. M., Muth, S. T., Saung, M. T., Lokker, N., Blouw, B., Armstrong, T. D., Jaffee, E. M., Tsujikawa, T., Coussens, L. M., He, J., Burkhart, R. A., Wolfgang, C. L. & Zheng, L., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5351-5363 13 p.

Research output: Contribution to journalArticle

Myeloid Cells
Pancreatic Neoplasms
Adenocarcinoma
T-Lymphocytes
Hyaluronic Acid

Equity and diversity in academic medicine: A perspective from the JCI editors

Smith Resar, L. M., Jaffee, E., Armanios, M., Jackson, S., Azad, N., Horton, M., Kaplan, M. J., Laiho, M., Maus, M. V., Sumner, C., Wheelan, S. & Wills-Karp, M., Oct 1 2019, In : Journal of Clinical Investigation. 129, 10

Research output: Contribution to journalComment/debate

Open Access
Medicine

Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T-Cells

Jin, J., Krishnamachary, B., Barnett, J. D., Chatterjee, S., Chang, D., Mironchik, Y., Wildes, F., Jaffee, E. M., Nimmagadda, S. & Bhujwalla, Z. M., Feb 27 2019, In : ACS Applied Materials and Interfaces. 11, 8, p. 7850-7861 12 p.

Research output: Contribution to journalArticle

T-cells
Biomimetics
Fibroblasts
Cell membranes
Nanoparticles

Immune cells track hard-to-target brain tumours

Zaidi, N. & Jaffee, E. M., Jan 10 2019, In : Nature. 565, 7738, p. 170-171 2 p.

Research output: Contribution to journalComment/debate

Brain Neoplasms
Immunotherapy
Vaccines
Clinical Trials
Therapeutics

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

Llosa, N. J., Luber, B., Siegel, N., Awan, A. H., Oke, T., Zhu, Q., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Jaffee, E. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., Pardoll, D. M., Wang, H., Housseau, F. & Anders, R. A., Jan 1 2019, In : Cancer Immunology Research. 7, 10, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Colorectal Neoplasms
Mucins
Microsatellite Repeats
Neoplasms

Immunotherapy transforms cancer treatment

Zaidi, N. & Jaffee, E., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI126046.

Research output: Contribution to journalComment/debate

Immunotherapy
Neoplasms
Therapeutics

MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity

Yarchoan, M., Mohan, A. A., Dennison, L., Vithayathil, T., Ruggieri, A., Lesinski, G. B., Armstrong, T. D., Azad, N. S. & Jaffee, E. M., Oct 2019, In : PloS one. 14, 10, e0224600.

Research output: Contribution to journalArticle

Open Access
Regulatory B-Lymphocytes
Mitogen-Activated Protein Kinase Kinases
Tumors
Immunity
immunity

Multiple immune-suppressive mechanisms in fibrolamellar carcinoma

Kim, A., Gani, F., Layman, A. J., Besharati, S., Zhu, Q., Succaria, F., Engle, E. L., Bhaijee, F., Goggins, M. B., Llosa, N., Pawlik, T. M., Yarchoan, M., Jaffee, E., Simons, H. C., Taube, J. M. & Anders, R. A., May 1 2019, In : Cancer Immunology Research. 7, 5, p. 805-812 8 p.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Tumor-Infiltrating Lymphocytes
Cytotoxic T-Lymphocytes
Myeloid Cells

PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers

Yarchoan, M., Albacker, L. A., Hopkins, A. C., Montesion, M., Murugesan, K., Vithayathil, T. T., Zaidi, N., Azad, N., Laheru, D., Frampton, G. M. & Jaffee, E., Mar 21 2019, In : JCI Insight. 4, 6, 126908.

Research output: Contribution to journalArticle

Open Access
Tumor Burden
Biomarkers
Neoplasms
Therapeutics

Peptide-based PET quantifies target engagement of PD-L1 therapeutics

Kumar, D., Lisok, A., Dahmane, E., McCoy, M., Shelake, S., Chatterjee, S., Allaj, V., Sysa-Shah, P., Wharram, B., Lesniak, W., Tully, E., Gabrielson, E., Jaffee, E., Poirier, J. T., Rudin, C. M., Gobburu, J. V. S., Pomper, M. G. & Nimmagadda, S., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 616-630 15 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Ligands
Peptides
Antibodies
Therapeutics
Adenocarcinoma
Cell Death
Ligands
Survival
Biomarkers

Recent developments and therapeutic strategies against hepatocellular carcinoma

Yarchoan, M., Agarwal, P., Villanueva, A., Rao, S., Dawson, L. A., Llovet, J. M., Finn, R. S., Groopman, J. D., El-Serag, H. B., Monga, S. P., Wang, X. W., Karin, M., Schwartz, R. E., Tanabe, K. K., Roberts, L. R., Gunaratne, P. H., Tsung, A., Brown, K. A., Lawrence, T. S., Salem, R. & 13 others, Singal, A. G., Kim, A. K., Rabiee, A., Resar, L., Hoshida, Y., He, A. R., Ghoshal, K., Ryan, P. B., Jaffee, E. M., Guha, C., Mishra, L., Norman Coleman, C. & Ahmed, M. M., Sep 1 2019, In : Cancer Research. 79, 17, p. 4326-4330 5 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Genomics
Liver Transplantation
Cause of Death
Neoplasms

Results from a phase IIb, randomized, multicenter study of GVAX pancreas and CRS-207 compared with chemotherapy in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE study)

Le, D., Picozzi, V. J., Ko, A. H., Wainberg, Z. A., Kindler, H., Wang-Gillam, A., Oberstein, P., Morse, M. A., Zeh, H. J., Weekes, C., Reid, T., Borazanci, E., Crocenzi, T., LoConte, N. K., Musher, B., Laheru, D., Murphy, A., Whiting, C., Nair, N., Enstrom, A. & 3 others, Ferber, S., Brockstedt, D. G. & Jaffee, E., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5493-5502 10 p.

Research output: Contribution to journalArticle

Multicenter Studies
Pancreas
Adenocarcinoma
Drug Therapy
Cyclophosphamide

Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14

Surcel, A., Schiffhauer, E. S., Thomas, D. G., Zhu, Q., DiNapoli, K. T., Herbig, M., Otto, O., West-Foyle, H., Jacobi, A., Krater, M., Plak, K., Guck, J., Jaffee, E., Iglesias, P. A., Anders, R. A. & Robinson, D., Sep 15 2019, In : Cancer Research. 79, 18, p. 4665-4678 14 p.

Research output: Contribution to journalArticle

Protein Transport
Pancreatic Neoplasms
Filamins
Actinin
Proteins
2018

Cancers. Emerging strategies for combination checkpoint modulators in cancer immunotherapy

Popovic, A., Jaffee, E. & Zaidi, N., Aug 1 2018, In : Journal of Clinical Investigation. 128, 8, p. 3209-3218 10 p.

Research output: Contribution to journalReview article

Immunotherapy
T-Lymphocytes
Tumor Burden
Neoplasms
Immunosuppressive Agents

Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer

Kinkead, H. L., Hopkins, A., Lutz, E., Wu, A. A., Yarchoan, M., Cruz, K., Woolman, S., Vithayathil, T., Glickman, L. H., Ndubaku, C. O., McWhirter, S. M., Dubensky, T. W., Armstrong, T. D., Jaffee, E. & Zaidi, N., Oct 18 2018, In : JCI insight. 3, 20

Research output: Contribution to journalArticle

Open Access
Pancreatic Neoplasms
Immunity
Vaccines
Neoplasms
T-Lymphocytes

Entinostat converts immune-resistant breast and pancreatic cancers into checkpoint-responsive tumors by reprogramming tumor-infiltrating MDSCs

Christmas, B. J., Rafie, C. I., Hopkins, A. C., Scott, B. A., Ma, H. S., Cruz, K. A., Woolman, S., Armstrong, T. D., Connolly, R., Azad, N., Jaffee, E. & Roussos Torres, E., Dec 1 2018, In : Cancer immunology research. 6, 12, p. 1561-1577 17 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Breast Neoplasms
Tumor Microenvironment
Neoplasms
Tumor-Infiltrating Lymphocytes

Histopathological and immunophenotypic features of ipilimumab-associated colitis compared to ulcerative colitis

Adler, B., Pezhouh, M. K., Kim, A., Luan, L., Zhu, Q., Gani, F., Yarchoan, M., Chen, J., Voltaggio, L., Parian, A., Lazarev, M., Lauwers, G. Y., Pawlik, T. M., Montgomery, E. A., Jaffee, E., Le, D., Taube, J. M. & Anders, R. A., Jan 1 2018, (Accepted/In press) In : Journal of Internal Medicine.

Research output: Contribution to journalArticle

Colitis
Ulcerative Colitis
ipilimumab
Biopsy
Inflammatory Bowel Diseases

Immune modulation therapy and imaging: Workshop report

Shields, A. F., Jacobs, P. M., Sznol, M., Graham, M. M., Germain, R. N., Lum, L. G., Jaffee, E., De Vries, E. G. E., Nimmagadda, S., Van Den Abbeele, A. D., Leung, D. K., Wu, A. M., Sharon, E. & Shankar, L. K., Mar 1 2018, In : Journal of Nuclear Medicine. 59, 3, p. 410-417 8 p.

Research output: Contribution to journalArticle

Immunotherapy
Education
Therapeutics
Immunoglobulin Fragments
Tumor Microenvironment

Next-generation algorithms for neoantigen selection

Hopkins, A. & Jaffee, E., Mar 1 2018, In : Nature Reviews Gastroenterology and Hepatology. 15, 3, p. 135-136 2 p.

Research output: Contribution to journalShort survey

Targeting myeloid-inflamed tumor with anti-CSF-1R antibody expands CD137+ effector T-cells in the murine model of pancreatic cancer

Saung, M. T., Muth, S., Ding, D., Thomas, D. L., Blair, A. B., Tsujikawa, T., Coussens, L., Jaffee, E. M. & Zheng, L., Nov 13 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 1 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
T-Lymphocytes
Antibodies
Adenocarcinoma
Neoplasms

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins, A. C., Yarchoan, M., Durham, J. N., Yusko, E. C., Rytlewski, J. A., Robins, H. S., Laheru, D. A., Le, D. T., Lutz, E. R. & Jaffee, E. M., Jul 12 2018, In : JCI insight. 3, 13

Research output: Contribution to journalArticle

Open Access
T-Cell Antigen Receptor
Immunotherapy
Adenocarcinoma
Survival
Pancreatic Neoplasms

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A., Wheelan, S., Yegnasubramanian, S. & Jaffee, E., Dec 1 2018, In : PLoS One. 13, 12, e0208602.

Research output: Contribution to journalArticle

Macrophages
macrophages
Polarization
DNA methylation
DNA Methylation

Vaccine therapy and immunotherapy for pancreatic cancer

Zheng, L. & Jaffee, E., Apr 11 2018, Pancreatic Cancer. Springer New York, p. 1461-1505 45 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Active Immunotherapy
Pancreatic Neoplasms
Immunotherapy
Neoplasms
Clinical Trials
2017

A blueprint to advance colorectal cancer immunotherapies

Le, D., Hubbard-Lucey, V. M., Morse, M. A., Heery, C. R., Dwyer, A., Marsilje, T. H., Brodsky, A. N., Chan, E., Deming, D. A., Diaz, L. A., Fridman, W. H., Goldberg, R. M., Hamilton, S. R., Housseau, F., Jaffee, E., Kang, S. P., Krishnamurthi, S. S., Lieu, C. H., Messersmith, W., Sears, C. L. & 10 others, Segal, N. H., Yang, A., Moss, R. A., Cha, E., O'Donnell-Tormey, J., Roach, N., Davis, A. Q., McAbee, K., Worrall, S. & Benson, A. B., Nov 1 2017, In : Cancer immunology research. 5, 11, p. 942-949 8 p.

Research output: Contribution to journalArticle

Immunotherapy
Colorectal Neoplasms
Microsatellite Repeats
T-Lymphocytes
Biomarkers

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Foote, J. B., Kok, M., Leatherman, J. M., Armstrong, T. D., Marcinkowski, B. C., Ojalvo, L. S., Kanne, D. B., Jaffee, E., Dubensky, T. W. & Emens, L. A., Jun 1 2017, In : Cancer immunology research. 5, 6, p. 468-479 12 p.

Research output: Contribution to journalArticle

OX40 Receptor
Interferons
Immunity
T-Lymphocytes
Growth

Characterization of the immune microenvironment in hepatocellular carcinoma

Yarchoan, M., Xing, D., Luan, L., Xu, H., Sharma, R. B., Popovic, A., Pawlik, T. M., Kim, A., Zhu, Q., Jaffee, E., Taube, J. M. & Anders, R. A., Dec 1 2017, In : Clinical Cancer Research. 23, 23, p. 7333-7339 7 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Neoplasms
Liver
CD8-Positive T-Lymphocytes
Tumor-Infiltrating Lymphocytes

Dual inhibition of Hedgehog and c-Met pathways for pancreatic cancer treatment

Rucki, A. A., Xiao, Q., Muth, S., Chen, J., Che, X., Kleponis, J., Sharma, R., Anders, R. A., Jaffee, E. & Zheng, L., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2399-2409 11 p.

Research output: Contribution to journalArticle

Hedgehogs
Pancreatic Neoplasms
Adenocarcinoma
gemcitabine
Tumor Burden

Future cancer research priorities in the USA: a Lancet Oncology Commission

Jaffee, E., Dang, C. V., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S., Bluestone, J. A., Brawley, O., Butte, A. J., Coit, D. G., Davidson, N. E., Davis, M., DePinho, R. A., Diasio, R. B., Draetta, G., Frazier, A. L., Futreal, A. & 34 others, Gambhir, S. S., Ganz, P. A., Garraway, L., Gerson, S., Gupta, S., Heath, J., Hoffman, R. I., Hudis, C., Hughes-Halbert, C., Ibrahim, R., Jadvar, H., Kavanagh, B., Kittles, R., Le, Q. T., Lippman, S. M., Mankoff, D., Mardis, E. R., Mayer, D. K., McMasters, K., Meropol, N. J., Mitchell, B., Naredi, P., Ornish, D., Pawlik, T. M., Peppercorn, J., Pomper, M. G., Raghavan, D., Ritchie, C., Schwarz, S. W., Sullivan, R., Wahl, R., Wolchok, J. D., Wong, S. L. & Yung, A., Nov 1 2017, In : The Lancet Oncology. 18, 11, p. e653-e706

Research output: Contribution to journalReview article

Research
Neoplasms
Precision Medicine
Radiation Oncology
National Cancer Institute (U.S.)

Hedgehog signaling stimulates Tenascin C to promote invasion of pancreatic ductal adenocarcinoma cells through Annexin A2

Foley, K., Muth, S., Jaffee, E. & Zheng, L., Feb 4 2017, (Accepted/In press) In : Cell Adhesion and Migration. p. 1-10 10 p.

Research output: Contribution to journalArticle

Annexins
Tenascin
Adenocarcinoma
Stromal Cells
Neoplasms

Heterogeneous stromal signaling within the tumor microenvironment controls the metastasis of pancreatic cancer

Rucki, A. A., Foley, K., Zhang, P., Xiao, Q., Kleponis, J., Wu, A. A., Sharma, R., Mo, G., Liu, A., Van Eyk, J., Jaffee, E. & Zheng, L., Jan 1 2017, In : Cancer Research. 77, 1, p. 41-52 12 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Insulin-Like Growth Factor I

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D., Liu, Y., von Eyben, R., Hsu, C. C., Hu, C., Rosati, L. M., Parekh, A., Ng, K., Hacker-Prietz, A., Zheng, L., Pawlik, T. M., Laheru, D., Jaffee, E., Weiss, M. J., Le, D., Hruban, R. H., De Jesus-Acosta, A., Wolfgang, C., Narang, A., Chang, D. T. & 2 others, Koong, A. C. & Herman, J. M., Jan 1 2017, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A., Le, D., Jaffee, E., Azad, N., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. & Goggins, M. S., 2017, In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma

Proteins (mesothelin)

Lutz, E., Le, D. & Jaffee, E., Jan 1 2017, Cancer Therapeutic Targets. Springer New York, Vol. 1-2. p. 441-450 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Proteins
Pancreatic Neoplasms
Ovarian Neoplasms
T-cells
Mesothelioma

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T., Kumar, S., Borkar, R. N., Azimi, V., Thibault, G., Chang, Y. H., Balter, A., Kawashima, R., Choe, G., Sauer, D., El Rassi, E., Clayburgh, D. R., Kulesz-Martin, M. F., Lutz, E. R., Zheng, L., Jaffee, E., Leyshock, P., Margolin, A. A., Mori, M., Gray, J. W. & 2 others, Flint, P. W. & Coussens, L. M., Apr 4 2017, In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Contribution to journalArticle

Tumors
Immunohistochemistry
Tissue
Biomarkers
Papillomaviridae
Lymphocyte Count
Cell Death
Lymphopenia
Neoplasms
Drug-Related Side Effects and Adverse Reactions

Report on the third FDA–AACR oncology dose-finding workshop

Emens, L. A., Bruno, R., Rubin, E. H., Jaffee, E. & McKee, A. E., Dec 1 2017, In : Cancer immunology research. 5, 12, p. 1058-1061 4 p.

Research output: Contribution to journalArticle

Education
Practice Guidelines
Patient Selection
Biomarkers
Therapeutics

Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective

Ryan, J. F., Groot, V. P., Rosati, L. M., Hacker-Prietz, A., Narang, A., McNutt, T., Jackson, J. F., Le, D., Jaffee, E., Zheng, L., Laheru, D., He, J., Pawlik, T. M., Weiss, M. J., Wolfgang, C. & Herman, J. M., Oct 23 2017, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Radiotherapy
Recurrence
Maintenance Chemotherapy
Disease-Free Survival

Strategies for increasing pancreatic tumor immunogenicity

Johnson, B. A., Yarchoan, M., Lee, V., Laheru, D. & Jaffee, E., Apr 1 2017, In : Clinical Cancer Research. 23, 7, p. 1656-1669 14 p.

Research output: Contribution to journalReview article

Adenocarcinoma
Immunotherapy
Neoplasms
Drug Combinations
Standard of Care

Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer

Murphy, A., Foley, K., Rucki, A. A., Xia, T., Jaffee, E., Huang, C. Y. & Zheng, L., Jan 1 2017, In : Oncotarget. 8, 63, p. 106405-106414 10 p.

Research output: Contribution to journalArticle

Annexin A2
Annexins
Pancreatic Neoplasms
Adenocarcinoma
Survival

Targeting neoantigens to augment antitumour immunity

Yarchoan, M., Johnson, B. A., Lutz, E. R., Laheru, D. & Jaffee, E., Apr 1 2017, In : Nature Reviews Cancer. 17, 4, p. 209-222 14 p.

Research output: Contribution to journalReview article

Immunity
Neoplasms
Immunotherapy
Immune Tolerance
Mutant Proteins