Research Output 1992 2017

2017

A STING Agonist Given with OX40 Receptor and PD-L1 Modulators Primes Immunity and Reduces Tumor Growth in Tolerized Mice

Foote, J. B., Kok, M., Leatherman, J. M., Armstrong, T. D., Marcinkowski, B. C., Ojalvo, L. S., Kanne, D. B., Jaffee, E. M., Dubensky, T. W. & Emens, L. A. Jun 1 2017 In : Cancer Immunology Research. 5, 6, p. 468-479 12 p.

Research output: Contribution to journalArticle

OX40 Receptor
Interferons
Immunity
T-Lymphocytes
Genes
Annexins
Tenascin
Hedgehogs
Adenocarcinoma
Neoplasms

Heterogeneous stromal signaling within the tumor microenvironment controls the metastasis of pancreatic cancer

Rucki, A. A., Foley, K., Zhang, P., Xiao, Q., Kleponis, J., Wu, A. A., Sharma, R., Mo, G., Liu, A., Van Eyk, J., Jaffee, E. M. & Zheng, L. Jan 1 2017 In : Cancer Research. 77, 1, p. 41-52 12 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Hedgehogs

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A. D., Le, D. T., Jaffee, E. M., Azad, N. S., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. A. & Goggins, M. 2017 In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma
Maximum Tolerated Dose

Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

Tsujikawa, T. , Kumar, S. , Borkar, R. N. , Azimi, V. , Thibault, G. , Chang, Y. H. , Balter, A. , Kawashima, R. , Choe, G. , Sauer, D. , El Rassi, E. , Clayburgh, D. R. , Kulesz-Martin, M. F. , Lutz, E. R. , Zheng, L. , Jaffee, E. M. , Leyshock, P. , Margolin, A. A. , Mori, M. , Gray, J. W. & 2 others Flint, P. W. & Coussens, L. M. Apr 4 2017 In : Cell Reports. 19, 1, p. 203-217 15 p.

Research output: Contribution to journalArticle

Immunohistochemistry
Neoplasms
Library Catalogs
Cell Count
Biological Markers

Strategies for increasing pancreatic tumor immunogenicity

Johnson, B. A., Yarchoan, M., Lee, V., Laheru, D. A. & Jaffee, E. M. Apr 1 2017 In : Clinical Cancer Research. 23, 7, p. 1656-1669 14 p.

Research output: Contribution to journalReview article

Adenocarcinoma
Neoplasms
Immunotherapy
Drug Combinations
Standard of Care

Targeting neoantigens to augment antitumour immunity

Yarchoan, M., Johnson, B. A., Lutz, E. R., Laheru, D. A. & Jaffee, E. M. Apr 1 2017 In : Nature Reviews Cancer. 17, 4, p. 209-222 14 p.

Research output: Contribution to journalReview article

Immunity
Neoplasms
Immunotherapy
Immune Tolerance
Mutant Proteins
2016

A U.S. "Cancer Moonshot" to accelerate cancer research

Singer, D. S., Jacks, T. & Jaffee, E. Sep 9 2016 In : Science. 353, 6304, p. 1105-1106 2 p.

Research output: Contribution to journalReview article

Neoplasms

Cancer-associated fibroblasts in pancreatic cancer are reprogrammed by tumor-induced alterations in genomic DNA methylation

Xiao, Q., Zhou, D., Rucki, A. A., Williams, J., Zhou, J., Mo, G., Murphy, A., Fujiwara, K., Kleponis, J., Salman, B., Wolfgang, C. L., Anders, R. A., Zheng, S., Jaffee, E. M. & Zheng, L. Sep 15 2016 In : Cancer Research. 76, 18, p. 5395-5404 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Pancreatic Neoplasms
Fibroblasts
Neoplasms
Adenocarcinoma

De novo DNA methylation by DNA methyltransferase 3a controls early effector CD8+ T-cell fate decisions following activation

Ladle, B. H., Li, K. P., Phillips, M. J., Pucsek, A. B., Haile, A., Powell, J. D., Jaffee, E. M., Hildeman, D. A. & Gamper, C. J. Sep 20 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10631-10636 6 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
T-Lymphocytes
DNA
Wild Animals

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

Lee, D., Lyu, H., Chung, Y. H., Kim, J. A., Mathews, P., Jaffee, E., Zheng, L., Yu, E., Lee, Y. J. & Ryu, S. H. Jun 21 2016 In : World Journal of Gastroenterology. 22, 23, p. 5393-5399 7 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Mutation
Genotype
Chronic Hepatitis B

Leveraging premalignant biology for immune-based cancer prevention

Spira, A., Disis, M. L., Schiller, J. T., Vilar, E., Rebbeck, T. R., Bejar, R., Ideker, T., Arts, J., Yurgelun, M. B., Mesirov, J. P., Rao, A., Garber, J., Jaffee, E. M. & Lippman, S. M. Sep 27 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 39, p. 10750-10758 9 p.

Research output: Contribution to journalArticle

Neoplasms
Genetic Processes
Immune Evasion
Hereditary Nonpolyposis Colorectal Neoplasms
Cancer Vaccines

Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients with Unresectable Pancreatic Cancer

Wild, A. T., Herman, J. M., Dholakia, A. S., Moningi, S., Lu, Y., Rosati, L. M., Hacker-Prietz, A., Assadi, R. K., Saeed, A. M., Pawlik, T. M., Jaffee, E. M., Laheru, D. A., Tran, P. T., Weiss, M. J., Wolfgang, C. L., Ford, E., Grossman, S. A., Ye, X. & Ellsworth, S. G. 2016 In : International Journal of Radiation Oncology, Biology, Physics. 94, 3, p. 571-579 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Lymphocytes
Radiation
radiation therapy
therapy

Mesothelin immunotherapy for cancer: Ready for prime time?

Hassan, R., Thomas, A., Alewine, C., Le, D. T., Jaffee, E. M. & Pastan, I. Dec 1 2016 In : Journal of Clinical Oncology. 34, 34, p. 4171-4179 9 p.

Research output: Contribution to journalArticle

Immunotherapy
Antibodies
Neoplasms
Mesothelioma
Cell- and Tissue-Based Therapy

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E. D., Huang, L., Sharma, R., Klein, A. P., Zheng, L., Le, D. T., Laheru, D. A., Pandey, A., Jaffee, E. M. & Anders, R. A. Mar 1 2016 In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Biological Markers
Antibodies
Immunoprecipitation
Serum
2015

Current progress in immunotherapy for pancreatic cancer

Foley, K., Kim, V., Jaffee, E. & Zheng, L. 2015 In : Cancer Letters.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Immunotherapy
Neoplasms
T-Lymphocytes
Vaccines

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J. N., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D. A., Jaffee, E. M., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. T. & Caturegli, P. Jan 1 2015 In : International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Thyroglobulin
Immunotherapy
Antibodies
Neoplasms
Epitopes

Galectin-3 shapes antitumor immune responses by suppressing CD8 T Cells via LAG-3 and Inhibiting Expansion of Plasmacytoid Dendritic Cells

Kouo, T., Huang, L., Pucsek, A. B., Cao, M., Solt, S., Armstrong, T. & Jaffee, E. Apr 1 2015 In : Cancer immunology research. 3, 4, p. 412-423 12 p.

Research output: Contribution to journalArticle

Galectin 3
Dendritic Cells
T-Lymphocytes
T-Cell Antigen Receptor
Adenocarcinoma

Immune therapy in GI malignancies: A review

Wang, J., Reiss, K. A., Khatri, R., Jaffee, E. & Laheru, D. Jun 1 2015 In : Journal of Clinical Oncology. 33, 16, p. 1745-1753 9 p.

Research output: Contribution to journalArticle

Neoplasms
Immunotherapy
Oncogenes
Immune System
Inflammation
Vaccines
Antigens
Neoplasms
Early Detection of Cancer
Carcinogenesis

PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors

Soares, K. C., Rucki, A. A., Wu, A. A., Olino, K., Xiao, Q., Chai, Y., Wamwea, A., Bigelow, E., Lutz, E., Liu, L., Yao, S., Anders, R. A., Laheru, D., Wolfgang, C. L., Edil, B. H., Schulick, R. D., Jaffee, E. M. & Zheng, L. Jan 14 2015 In : Journal of Immunotherapy. 38, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Active Immunotherapy
T-Lymphocytes
Neoplasms
Adenocarcinoma
CTLA-4 Antigen

Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer

Le, D. T. , Wang-Gillam, A. , Picozzi, V. , Greten, T. F. , Crocenzi, T. , Springett, G. , Morse, M. , Zeh, H. , Cohen, D. , Fine, R. L. , Onners, B. , Uram, J. N. , Laheru, D. A. , Lutz, E. R. , Solt, S. , Murphy, A. L. , Skoble, J. , Lemmens, E. , Grous, J. , Dubensky, T. & 2 others Brockstedt, D. G. & Jaffee, E. M. Apr 20 2015 In : Journal of Clinical Oncology. 33, 12, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

Listeria monocytogenes
Pancreatic Neoplasms
Cyclophosphamide
Pancreas
Vaccines

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Foley, K., Rucki, A. A., Xiao, Q., Zhou, D., Leubner, A., Mo, G., Kleponis, J., Wu, A. A., Sharma, R., Jiang, Q., Anders, R. A., Iacobuzio-Donahue, C. A., Hajjar, K. A., Maitra, A., Jaffee, E. M. & Zheng, L. Aug 4 2015 In : Science Signaling. 8, 388, ra77

Research output: Contribution to journalArticle

Autocrine Communication
Semaphorins
Annexins
Pancreatic Neoplasms
Adenocarcinoma

Special conference on tumor immunology and immunotherapy: A new chapter

Byrne, K. T., Vonderheide, R. H., Jaffee, E. M. & Armstrong, T. D. Jun 1 2015 In : Cancer immunology research. 3, 6, p. 590-597 8 p.

Research output: Contribution to journalArticle

Allergy and Immunology
Immunotherapy
Neoplasms
Tumor Microenvironment
Antibodies

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

Soares, K. C., Rucki, A. A., Kim, V., Foley, K., Solt, S., Wolfgang, C. L., Jaffee, E. M. & Zheng, L. 2015 In : Oncotarget. 6, 40, p. 43005-43015 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Transforming Growth Factor beta
Vaccines
Neoplasms
Adenocarcinoma

The prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapy

Bever, K. M., Sugar, E. A., Bigelow, E., Sharma, R., Laheru, D., Wolfgang, C. L., Jaffee, E. M., Anders, R. A., De Jesus-Acosta, A. & Zheng, L. Apr 1 2015 In : HPB. 17, 4, p. 292-298 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Adenocarcinoma
Pancreatic Stellate Cells
Tissue Preservation
Active Immunotherapy
2014

A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer

Chen, G. , Gupta, R. , Petrik, S. , Laiko, M. , Leatherman, J. M. , Asquith, J. M. , Daphtary, M. M. , Garrett-Mayer, E. , Davidson, N. E. , Hirt, K. , Berg, M. , Uram, J. N. , Dauses, T. , Fetting, J. , Duus, E. M. , Atay-Rosenthal, S. , Ye, X. , Wolff, A. C. , Stearns, V. , Jaffee, E. M. & 1 others Emens, L. A. Oct 1 2014 In : Cancer immunology research. 2, 10, p. 949-961 13 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Feasibility Studies
Granulocyte-Macrophage Colony-Stimulating Factor
Cyclophosphamide
Vaccination

A listeria vaccine and depletion of t-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice

Keenan, B. P., Saenger, Y., Kafrouni, M. I., Leubner, A., Lauer, P., Maitra, A., Rucki, A. A., Gunderson, A. J., Coussens, L. M., Brockstedt, D. G., Dubensky, T. W., Hassan, R., Armstrong, T. D. & Jaffee, E. M. 2014 In : Gastroenterology. 146, 7

Research output: Contribution to journalArticle

Listeria
Carcinoma in Situ
Pancreatic Neoplasms
Immunity
Vaccines
Apoptosis
T-Lymphocytes
Neoplasms
Clonal Deletion
Cell Death

A preclinical murine model of hepatic metastases

Soares, K. C., Foley, K., Olino, K., Leubner, A., Mayo, S. C., Jain, A., Schulick, R. D., Jaffee, E., Yoshimura, K., Edil, B. & Zheng, L. Sep 27 2014 In : Journal of Visualized Experiments. 91, e51677

Research output: Contribution to journalArticle

Anthralin
Neoplasm Metastasis
Liver
Neoplasms
Contraception Behavior
Cancer Vaccines
Feasibility Studies
Granulocyte-Macrophage Colony-Stimulating Factor
Colonic Neoplasms
Colorectal Neoplasms

Cancer immunoprevention - The next frontier

Smit, M. A. D., Jaffee, E. M. & Lutz, E. R. Nov 1 2014 In : Cancer Prevention Research. 7, 11, p. 1072-1080 9 p.

Research output: Contribution to journalArticle

Neoplasms
Immune Tolerance
Recurrence
Steam
Residual Neoplasm

Can we predict mutant neoepitopes in human cancers for patient-specific vaccine therapy?

Lutz, E. R. & Jaffee, E. M. Jun 1 2014 In : Cancer immunology research. 2, 6, p. 518-521 4 p.

Research output: Contribution to journalReview article

Active Immunotherapy
Neoplasms

Fusion protein of mutant B7-DC and Fc enhances the antitumor immune effect of GM-CSF-secreting whole-cell vaccine

Kojima, M., Murata, S., Mekata, E., Takebayashi, K., Jaffee, E. M. & Tani, T. 2014 In : Journal of Immunotherapy. 37, 3, p. 147-154 8 p.

Research output: Contribution to journalArticle

Mutant Proteins
Granulocyte-Macrophage Colony-Stimulating Factor
Dendritic Cells
Vaccines
Neoplasms

Immunobiology of radiotherapy: New paradigms

Ahmed, M. M., Guha, C., Hodge, J. W. & Jaffee, E. 2014 In : Radiation Research. 182, 2, p. 123-125 3 p.

Research output: Contribution to journalArticle

Radiotherapy

Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation

Lutz, E. R., Wu, A. A., Bigelow, E., Sharma, R., Mo, G., Soares, K., Solt, S., Dorman, A., Wamwea, A., Yager, A., Laheru, D., Wolfgang, C. L., Wang, J., Hruban, R. H., Anders, R. A., Jaffee, E. M. & Zheng, L. Jul 1 2014 In : Cancer immunology research. 2, 7, p. 616-631 16 p.

Research output: Contribution to journalArticle

Immunotherapy
Vaccines
Neoplasms
Adenocarcinoma
Tumor Microenvironment

Oncogenic kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia

McAllister, F., Bailey, J. M., Alsina, J., Nirschl, C. J., Sharma, R., Fan, H., Rattigan, Y., Roeser, J. C., Lankapalli, R. H., Zhang, H., Jaffee, E. M., Drake, C. G., Housseau, F., Maitra, A., Kolls, J. K., Sears, C. L., Pardoll, D. M. & Leach, S. D. May 12 2014 In : Cancer Cell. 25, 5, p. 621-637 17 p.

Research output: Contribution to journalArticle

Interleukin-17
Neoplasms
Interleukin-17 Receptor
Epithelial Cells
Inflammation

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Zhou, W. , Jubb, A. M. , Lyle, K. , Xiao, Q. , Ong, C. C. , Desai, R. , Fu, L. , Gnad, F. , Song, Q. , Haverty, P. M. , Aust, D. , Grützmann, R. , Romero, M. , Totpal, K. , Neve, R. M. , Yan, Y. , Forrest, W. F. , Wang, Y. , Raja, R. , Pilarsky, C. & 8 others De Jesus-Acosta, A., Belvin, M., Friedman, L. S., Merchant, M., Jaffee, E. M., Zheng, L., Koeppen, H. & Hoeflich, K. P. Dec 1 2014 In : Journal of Pathology. 234, 4, p. 502-513 12 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Pancreatic Neoplasms
Cell Movement
Adenocarcinoma
Intercellular Signaling Peptides and Proteins

Priming the pancreatic cancer tumor microenvironment for checkpoint-inhibitor immunotherapy

Lutz, E. R., Kinkead, H., Jaffee, E. M. & Zheng, L. Nov 2 2014 In : OncoImmunology. 3, 11, p. e962401-1-e962401-3

Research output: Contribution to journalArticle

Tumor Microenvironment
Pancreatic Neoplasms
Immunotherapy
Neoplasms
Allergy and Immunology

Specificity delivers: Therapeutic role of tumor antigen-specific antibodies in pancreatic cancer

Jhaveri, D. T., Zheng, L. & Jaffee, E. M. Oct 1 2014 In : Seminars in Oncology. 41, 5, p. 559-575 17 p.

Research output: Contribution to journalArticle

Neoplasm Antigens
Pancreatic Neoplasms
Adenocarcinoma
Antibodies
Biological Markers
2013

Cancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition

Prendergast, G. C. & Jaffee, E. M. Jul 2013 Elsevier Inc.655 p.

Research output: Book/ReportBook

Immunotherapy
Neoplasms
Combination Drug Therapy

Carcinoma of the Pancreas

Mauro, L. A., Herman, J. M., Jaffee, E. M. & Laheru, D. A. Oct 22 2013 Abeloff's Clinical Oncology: Fifth Edition. Elsevier Inc., p. 1397-1415.e7

Research output: Chapter in Book/Report/Conference proceedingChapter

Pancreas
Carcinoma

Development of a cytokine-modified allogeneic whole cell pancreatic cancer vaccine

Laheru, D., Biedrzycki, B. & Jaffee, E. M. 2013 Methods in Molecular Biology. Humana Press Inc., Vol. 980, p. 175-203 29 p. (Methods in Molecular Biology; vol. 980)

Research output: Chapter in Book/Report/Conference proceedingChapter

Cancer Vaccines
Pancreatic Neoplasms
Cytokines

Effects of genomic changes in hepatitis B virus on postoperative recurrence and survival in patients with hepatocellular carcinoma

Mathews, P., Lee, D., Chung, Y. H., Kim, J. A., Lee, J. H., Jin, Y. J., Park, W., Lyu, H., Jaffee, E., Zheng, L., Yu, E. & Lee, Y. J. Apr 2013 In : Annals of Surgical Oncology. 20, 4, p. 1216-1222 7 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Recurrence
Neoplasms
Serum
Granulocyte-Macrophage Colony-Stimulating Factor
Pancreatic Neoplasms
Genes
Neoplasms
CTLA-4 Antigen

Harnessing immune responses in the tumor microenvironment: All signals needed

Le, D. T. & Jaffee, E. M. Nov 15 2013 In : Clinical Cancer Research. 19, 22, p. 6061-6063 3 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunotherapy
Adenocarcinoma
B-Lymphocytes
Monoclonal Antibodies

Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.

Bigelow, E., Bever, K. M., Xu, H., Yager, A., Wu, A., Taube, J., Chen, L., Jaffee, E. M., Anders, R. A. & Zheng, L. 2013 In : Journal of Visualized Experiments. 71

Research output: Contribution to journalArticle

Paraffin
Adenocarcinoma
Staining and Labeling
Neoplasms
Tumors

Immunotherapy and Cancer Therapeutics: A Rich Partnership

Chen, G., Jaffee, E. M. & Emens, L. A. Jul 2013 Cancer Immunotherapy: Immune Suppression and Tumor Growth: Second Edition. Elsevier Inc., p. 415-432 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunotherapy
Neoplasms
Drug Therapy
Radiation Effects
Standard of Care
Cancer
Immunotherapy
Neoplasms
Contraception Behavior
Vaccine

Introduction

Prendergast, G. C. & Jaffee, E. M. Jul 2013 In : Unknown Journal. p. 1-8 8 p.

Research output: Contribution to journalArticle

Neoplasms
Immune System
Immune Tolerance
Cellular Microenvironment
Tumor Microenvironment