Elena MacFarlane

Assistant Professor

20022019
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Fingerprint Dive into the research topics where Elena MacFarlane is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Transforming Growth Factors Medicine & Life Sciences
Calcineurin Medicine & Life Sciences
Loeys-Dietz Syndrome Medicine & Life Sciences
Thoracic Aortic Aneurysm Medicine & Life Sciences
Aortic Aneurysm Medicine & Life Sciences
Thymocytes Medicine & Life Sciences
Marfan Syndrome Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences

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Research Output 2002 2019

Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis

Kim, D. H., Beckett, J. D., Nagpal, V., Seman-Senderos, M. A., Gould, R. A., Creamer, T. J., MacFarlane, E., Chen, Y., Bedja, D., Butcher, J. T., Mitzner, W. A., Rouf, R., Hata, S., Warren, D. & Dietz, H. C., Jul 17 2019, In : Science translational medicine. 11, 501, eaau2814.

Research output: Contribution to journalArticle

Calpain
Transforming Growth Factors
Fibrosis
Myofibroblasts
Therapeutics

Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

Shin, J. Y., Beckett, J. D., Bagirzadeh, R., Creamer, T. J., Shah, A., McMahan, Z., Paik, J., Sampedro, M. M., MacFarlane, E., Beer, M. A., Warren, D., Wigley, F. & Dietz, H. C., Jan 1 2019, In : Science translational medicine. 11, 497, eaaw0790.

Research output: Contribution to journalArticle

Systemic Scleroderma
Epigenomics
Fibrosis
Skin
Autocrine Communication

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

MacFarlane, E., Parker, S. J., Shin, J. Y., Ziegler, S. G., Creamer, T. J., Bagirzadeh, R., Bedja, D., Chen, Y., Calderon, J. F., Weissler, K., Frischmeyer-Guerrerio, P. A., Lindsay, M. E., Habashi, J. & Dietz, H. C., Feb 1 2019, In : Journal of Clinical Investigation. 129, 2, p. 659-675 17 p.

Research output: Contribution to journalArticle

Loeys-Dietz Syndrome
Aortic Aneurysm
Transforming Growth Factors
Vascular Smooth Muscle
Smooth Muscle Myocytes

Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome

Habashi, J., MacFarlane, E., Bagirzadeh, R., Bowen, C., Huso, N., Chen, Y., Bedja, D., Creamer, T. J., Rykiel, G., Manning, M., Huso, D. & Dietz, H. C., May 1 2019, In : Science translational medicine. 11, 490

Research output: Contribution to journalArticle

Marfan Syndrome
Extracellular Signal-Regulated MAP Kinases
Oxytocin
Dissection
Pregnancy

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation

van der Pluijm, I., Burger, J., van Heijningen, P. M., IJpma, A., van Vliet, N., Milanese, C., Schoonderwoerd, K., Sluiter, W., Ringuette, L. J., Dekkers, D. H. W., Que, I., Kaijzel, E. L., Te Riet, L., MacFarlane, E., Das, D., van der Linden, R., Vermeij, M., Demmers, J. A., Mastroberardino, P. G., Davis, E. C. & 4 others, Yanagisawa, H., Dietz, H. C., Kanaar, R. & Essers, J., Nov 1 2018, In : Cardiovascular Research. 114, 13, p. 1776-1793 18 p.

Research output: Contribution to journalArticle

Aorta
Respiration
Vascular Smooth Muscle
Smooth Muscle Myocytes
Oxygen Consumption