Edward Lakatta

Professor

1971 …2020

Research output per year

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Research Output

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Review article
2018

Dual activation of phosphodiesterases 3 and 4 regulates basal spontaneous beating rate of cardiac pacemaker cells: Role of compartmentalization?

Vinogradova, T. M., Kobrinsky, E. & Lakatta, E., Oct 9 2018, In : Frontiers in Physiology. 9, OCT, 1301.

Research output: Contribution to journalReview article

Unique Ca2+-cycling protein abundance and regulation sustains local Ca2+ releases and spontaneous firing of rabbit sinoatrial node cells

Vinogradova, T. M., Sirenko, S. T. & Lakatta, E., Aug 1 2018, In : International Journal of Molecular Sciences. 19, 8, 2173.

Research output: Contribution to journalReview article

2017

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E., Jan 1 2017, In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

2016

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Di Germanio, C., Bernier, M., Csiszar, A., Ungvari, Z., Lakatta, E. & De Cabo, R., May 13 2016, In : Circulation Research. 118, 10, p. 1626-1642 17 p.

Research output: Contribution to journalReview article

2015

The Conundrum of Arterial Stiffness, Elevated Blood Pressure, and Aging

AlGhatrif, M. & Lakatta, E. G., Jan 1 2015, In : Current hypertension reports. 17, 2

Research output: Contribution to journalReview article

2014

Modern perspectives on numerical modeling of cardiac pacemaker cell

Maltsev, V. A., Yaniv, Y., Maltsev, A. V., Stern, M. D. & Lakatta, E. G., 2014, In : Journal of Pharmacological Sciences. 125, 1, p. 6-38 33 p.

Research output: Contribution to journalReview article

Proinflammation: The key to arterial aging

Wang, M., Jiang, L., Monticone, R. E. & Lakatta, E. G., Feb 1 2014, In : Trends in Endocrinology and Metabolism. 25, 2, p. 72-79 8 p.

Research output: Contribution to journalReview article

Proinflammation of aging central arteries: A mini-review

Wang, M., Monticone, R. E. & Lakatta, E. G., Nov 7 2014, In : Gerontology. 60, 6, p. 519-529 11 p.

Research output: Contribution to journalReview article

2013

Milk fat globule epidermal growth factor VIII signaling in arterial wall remodeling

Wang, M., Wang, H. H. & Lakatta, E. G., Jan 1 2013, In : Current Vascular Pharmacology. 11, 5, p. 768-776 9 p.

Research output: Contribution to journalReview article

Modern concepts concerning the origin of the heartbeat

Monfredi, O., Maltsev, V. A. & Lakatta, E. G., Mar 11 2013, In : Physiology. 28, 2, p. 74-92 19 p.

Research output: Contribution to journalReview article

2012

Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure

Strait, J. B. & Lakatta, E. G., Jan 1 2012, In : Heart Failure Clinics. 8, 1, p. 143-164 22 p.

Research output: Contribution to journalReview article

2011

β2 AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation

Talan, M. I., Ahmet, I., Xiao, R. P. & Lakatta, E. G., Oct 1 2011, In : Journal of Molecular and Cellular Cardiology. 51, 4, p. 529-533 5 p.

Research output: Contribution to journalReview article

2010

A Coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker

Lakatta, E. G., Maltsev, V. A. & Vinogradova, T. M., Mar 1 2010, In : Circulation research. 106, 4, p. 659-673 15 p.

Research output: Contribution to journalReview article

Arterial aging: A journey into subclinical arterial disease

Wang, M., Monticone, R. E. & Lakatta, E. G., Mar 1 2010, In : Current opinion in nephrology and hypertension. 19, 2, p. 201-207 7 p.

Research output: Contribution to journalReview article

Modulation of sarcoplasmic reticulum Ca2+ cycling in systolic and diastolic heart failure associated with aging

Janczewski, A. M. & Lakatta, E. G., Sep 1 2010, In : Heart Failure Reviews. 15, 5, p. 431-445 15 p.

Research output: Contribution to journalReview article

2009

Arterial Aging and Subclinical Arterial Disease are Fundamentally Intertwined at Macroscopic and Molecular Levels

Lakatta, E. G., Wang, M. & Najjar, S. S., May 1 2009, In : Medical Clinics of North America. 93, 3, p. 583-604 22 p.

Research output: Contribution to journalReview article

Using New Tools to Define the Genetic Underpinnings of Risky Traits Associated With Coronary Artery Disease: The SardiNIA Study

Strait, J. B., Uda, M., Lakatta, E. G. & Najjar, S. S., Apr 1 2009, In : Trends in Cardiovascular Medicine. 19, 3, p. 69-75 7 p.

Research output: Contribution to journalReview article

2008

Arterial-ventricular coupling: Mechanistic insights into cardiovascular performance at rest and during exercise

Chantler, P. D., Lakatta, E. G. & Najjar, S. S., Oct 2008, In : Journal of applied physiology. 105, 4, p. 1342-1351 10 p.

Research output: Contribution to journalReview article

Inflammation and endothelial dysfunction during aging: Role of NF-κB

Csiszar, A., Wang, M., Lakatta, E. G. & Ungvari, Z., Oct 1 2008, In : Journal of applied physiology. 105, 4, p. 1333-1341 9 p.

Research output: Contribution to journalReview article

2007

Central arterial aging and the epidemic of systolic hypertension and atherosclerosis

Lakatta, E. G., Sep 1 2007, In : Journal of the American Society of Hypertension. 1, 5, p. 302-340 39 p.

Research output: Contribution to journalReview article

Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Maltsev, V. A. & Lakatta, E. G., Oct 1 2007, In : Heart Lung and Circulation. 16, 5, p. 335-348 14 p.

Research output: Contribution to journalReview article

2006

Subtype-specific α1- and β-adrenoceptor signaling in the heart

Xiao, R. P., Zhu, W., Zheng, M., Cao, C., Zhang, Y., Lakatta, E. G. & Han, Q., Jun 1 2006, In : Trends in Pharmacological Sciences. 27, 6, p. 330-337 8 p.

Research output: Contribution to journalReview article

The emergence of a general theory of the initiation and strength of the heartbeat

Maltsev, V. A., Vinogradovad, T. M. & Lakatta, E. G., Oct 30 2006, In : Journal of Pharmacological Sciences. 100, 5, p. 338-369 32 p.

Research output: Contribution to journalReview article

2005

Protection in the aged heart: Preventing the heart-break of old age?

Juhaszova, M., Rabuel, C., Zorov, D. B., Lakatta, E. G. & Sollott, S. J., May 1 2005, In : Cardiovascular research. 66, 2, p. 233-244 12 p.

Research output: Contribution to journalReview article

The future of aging therapies

Hadley, E. C., Lakatta, E. G., Morrison-Bogorad, M., Warner, H. R. & Hodes, R. J., Feb 25 2005, In : Cell. 120, 4, p. 557-567 11 p.

Research output: Contribution to journalReview article

2004

Cross-talk of opioid peptide receptor and β-adrenergic receptor signalling in the heart

Pepe, S., Van Den Brink, O. W. V., Lakatta, E. G. & Xiao, R. P., Aug 15 2004, In : Cardiovascular research. 63, 3, p. 414-422 9 p.

Research output: Contribution to journalReview article

Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications

Xiao, R. P., Zhu, W., Zheng, M., Chakir, K., Bond, R., Lakatta, E. G. & Cheng, H., Jul 1 2004, In : Trends in Pharmacological Sciences. 25, 7, p. 358-365 8 p.

Research output: Contribution to journalReview article

2003

Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease

Lakatta, E. G. & Levy, D., Jan 7 2003, In : Circulation. 107, 1, p. 139-146 8 p.

Research output: Contribution to journalReview article

Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II: The aging heart in health: Links to heart disease

Lakatta, E. G. & Levy, D., Jan 21 2003, In : Circulation. 107, 2, p. 346-354 9 p.

Research output: Contribution to journalReview article

2002

Age-associated cardiovascular changes in health: Impact on cardiovascular disease in older persons

Lakatta, E. G., Feb 27 2002, In : Heart Failure Reviews. 7, 1, p. 29-49 21 p.

Research output: Contribution to journalReview article

Cardiovascular ageing in health sets the stage for cardiovascular disease

Lakatta, E. G., Jan 1 2002, In : Heart Lung and Circulation. 11, 2, p. 76-91 16 p.

Research output: Contribution to journalReview article

The "heartbreak" of older age.

Lakatta, E. G. & Sollott, S. J., Nov 2002, In : Molecular interventions. 2, 7, p. 431-446 16 p.

Research output: Contribution to journalReview article

2001

Discovering altered genomic expression patterns in heart: Transcriptome determination by serial analysis of gene expression

Anisimov, S. V., Lakatta, E. G. & Boheler, K. R., Oct 6 2001, In : European Journal of Heart Failure. 3, 3, p. 271-281 11 p.

Research output: Contribution to journalReview article

2000

Pivotal research in cardiovascular syndromes in the elderly

McKay, C. R., Rich, M. W., Vlietstra, R. E., Kitzman, D. W., Fleg, J. L., Krumholz, H. M., Lakatta, E. G., Cooke, J. P., Cannon, C. P., Ezekowitz, M. D., Frolich, E. D., Jalife, J., Kass, D. A., Kottke, B. A., Muller, J. E., Saltin, B., Shen, W. K. & Somers, V. K., Jan 1 2000, In : American Journal of Geriatric Cardiology. 9, 5, p. 243-251 9 p.

Research output: Contribution to journalReview article

1999

Cardiovascular aging research: The next horizons

Lakatta, E. G., May 1999, In : Journal of the American Geriatrics Society. 47, 5, p. 613-625 13 p.

Research output: Contribution to journalReview article

Recent advances in cardiac β2-adrenergic signal transduction

Xiao, R. P., Cheng, H., Zhou, Y. Y., Kuschel, M. & Lakatta, E. G., Nov 26 1999, In : Circulation research. 85, 11, p. 1092-1100 9 p.

Research output: Contribution to journalReview article

Open Access
1998

Age-associated alterations in calcium current and its modulation in cardiac myocytes

Zhou, Y. Y., Lakatta, E. G. & Xiao, R. P., Sep 22 1998, In : Drugs and Aging. 13, 2, p. 159-171 13 p.

Research output: Contribution to journalReview article

Cardiovascular aging: Perspectives from humans to rodents

Lakatta, E. G., Nov 1 1998, In : American Journal of Geriatric Cardiology. 7, 6, p. 32-45 14 p.

Research output: Contribution to journalReview article

Physio-pharmacological evaluation of myocardial performance: An integrative approach

Shah, A. M., Sollott, S. J. & Lakatta, E. G., Jul 1 1998, In : Cardiovascular research. 39, 1, p. 148-154 7 p.

Research output: Contribution to journalReview article

The role of the tumor suppressor gene p53 in cardiomyocyte apoptosis

Crow, M. T., Long, X., Guglielmi, M. B., Asai, T. & Lakatta, E. G., Jan 1 1998, In : Heart Failure Reviews. 3, 1, p. 45-61 17 p.

Research output: Contribution to journalReview article

1996

Excitation contraction coupling in heart: New insights from Ca2+ sparks

Cheng, H., Lederer, M. R., Xiao, R. P., Gómez, A. M., Zhou, Y. Y., Ziman, B., Spurgeon, H., Lakatta, E. G. & Lederer, W. J., Aug 1996, In : Cell Calcium. 20, 2, p. 129-140 12 p.

Research output: Contribution to journalReview article

1994

Cardiovascular reserve capacity in healthy older humans

Lakatta, E. G., Aug 1994, In : Aging Clinical and Experimental Research. 6, 4, p. 213-223 11 p.

Research output: Contribution to journalReview article

1993

Cardiovascular regulatory mechanisms in advanced age

Lakatta, E. G., Jan 1 1993, In : Physiological reviews. 73, 2, p. 413-465 53 p.

Research output: Contribution to journalReview article

Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans

Lakatta, E. G., Jan 1 1993, In : Circulation. 87, 2, p. 631-636 6 p.

Research output: Contribution to journalReview article

Open Access

Hypertension in the elderly: Age- and disease-related complications and therapeutic implications

Lakatta, E. G., Cohen, J. D., Fleg, J. L., Frohlich, E. D. & Gradman, A. H., Aug 1 1993, In : Cardiovascular Drugs and Therapy. 7, 4, p. 643-653 11 p.

Research output: Contribution to journalReview article

Spontaneous Myocardial Calcium Oscillations: Are They Linked to Ventricular Fibrillation?

LAKATTA, EDWARD. G. & GUARNIERI, THOMAS., Aug 1993, In : Journal of cardiovascular electrophysiology. 4, 4, p. 473-489 17 p.

Research output: Contribution to journalReview article

1992

Excitation-contraction coupling in the heart: The state of the question

Stern, M. D. & Lakatta, E. G., Jan 1 1992, In : FASEB Journal. 6, 12, p. 3092-3100 9 p.

Research output: Contribution to journalReview article