Edward Lakatta

Professor

1971 …2020

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2020

Increased Drp1 acetylation by lipid overload induces cardiomyocyte death and heart dysfunction

Hu, Q., Zhang, H., Cortés, N. G., Wu, D., Wang, P., Zhang, J., Mattison, J. A., Smith, E., Bettcher, L. F., Wang, M., Lakatta, E. G., Sheu, S. S. & Wang, W., Feb 14 2020, In : Circulation research. p. 456-470 15 p.

Research output: Contribution to journalArticle

2019

Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice

Axsom, J. E., Nanavati, A. P., Rutishauser, C. A., Bonin, J. E., Moen, J. M. & Lakatta, E. G., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalArticle

Open Access

Age-related changes of the retinal microvasculature

Orlov, N. V., Coletta, C., van Asten, F., Qian, Y., Ding, J., AlGhatrif, M., Lakatta, E., Chew, E., Wong, W., Swaroop, A., Fiorillo, E., Delitala, A., Marongiu, M., Goldberg, I. G. & Schlessinger, D., May 1 2019, In : PloS one. 14, 5, e0215916.

Research output: Contribution to journalArticle

Open Access

Aging, MicroRNAs, and Heart Failure

Florio, M. C., Magenta, A., Beji, S., Lakatta, E. G. & Capogrossi, M. C., Jan 1 2019, (Accepted/In press) In : Current Problems in Cardiology.

Research output: Contribution to journalArticle

Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats

Fedorova, O. V., Fadeev, A. V., Grigorova, Y. N., Marshall, C. A., Zernetkina, V., Kolodkin, N. I., Agalakova, N. I., Konradi, A. O., Lakatta, E. G. & Bagrov, A. Y., Nov 1 2019, In : Journal of cardiovascular pharmacology. 74, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease

Monfredi, O. & Lakatta, E. G., Sep 1 2019, In : Cardiovascular research. 115, 11, p. 1576-1595 20 p.

Research output: Contribution to journalArticle

Open Access

Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Ushakumary, M. G., Wang, M., Harikrishnan, V., Titus, A. S., Zhang, J., Liu, L., Monticone, R., Wang, Y., Mattison, J. A., De Cabo, R., Lakatta, E. G. & Kailasam, S., Jan 1 2019, In : PloS one. 14, 12, e0225911.

Research output: Contribution to journalArticle

Open Access

Impact of Stiffer Arteries on the Response to Antihypertensive Treatment: A Longitudinal Study of the SardiNIA Cohort

Lakatta, E. G., AlunniFegatelli, D., Morrell, C. H., Fiorillo, E., Orru, M., Delitala, A., Marongiu, M., Schlessinger, D., Cucca, F. & Scuteri, A., Jan 1 2019, (Accepted/In press) In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticle

Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension

Zhang, Y., Wei, W., Shilova, V., Petrashevskaya, N. N., Zernetkina, V. I., Grigorova, Y. N., Marshall, C. A., Fenner, R. C., Lehrmann, E., Wood, W. H., Becker, K. G., Lakatta, E. G., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2019, In : Journal of the American Heart Association. 8, 20, p. e012138

Research output: Contribution to journalArticle

Open Access

Overexpression of a neuronal type adenylyl cyclase (type 8) in sinoatrial node markedly impacts heart rate and rhythm

Moen, J. M., Matt, M. G., Ramirez, C., Tarasov, K. V., Chakir, K., Tarasova, Y. S., Lukyanenko, Y., Tsutsui, K., Monfredi, O., Morrell, C. H., Tagirova, S., Yaniv, Y., Huynh, T., Pacak, K., Ahmet, I. & Lakatta, E. G., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 00615.

Research output: Contribution to journalArticle

Open Access
Open Access

To help aging populations, classify organismal senescence

Calimport, S. R. G., Bentley, B. L., Stewart, C. E., Pawelec, G., Scuteri, A., Vinciguerra, M., Slack, C., Chen, D., Harries, L. W., Marchant, G., Alexander Fleming, G., Conboy, M., Antebi, A., Small, G. W., Gil, J., Lakatta, E. G., Richardson, A., Rosen, C., Nikolich, K., Wyss-Coray, T. & 5 others, Steinman, L., Montine, T., de Magalhães, J. P., Campisi, J. & Church, G., Nov 1 2019, In : Science. 366, 6465, p. 576-578 3 p.

Research output: Contribution to journalArticle

2018

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Tsutsui, K., Monfredi, O. J., Sirenko-Tagirova, S. G., Maltseva, L. A., Bychkov, R., Kim, M. S., Ziman, B. D., Tarasov, K. V., Tarasova, Y. S., Zhang, J., Wang, M., Maltsev, A. V., Brennan, J. A., Efimov, I. R., Stern, M. D., Maltsev, V. A. & Lakatta, E., Jun 12 2018, In : Science Signaling. 11, 534, eaap7608.

Research output: Contribution to journalArticle

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Delitala, A. P., Steri, M., Fiorillo, E., Marongiu, M., Lakatta, E., Schlessinger, D. & Cucca, F., Nov 1 2018, In : Cytokine. 111, p. 189-193 5 p.

Research output: Contribution to journalArticle

Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension

Chirinos, J. A., Sardana, M., Syed, A. A., Koppula, M. R., Varakantam, S., Vasim, I., Oldland, H. G., Phan, T. S., Drummen, N. E. A., Vermeer, C., Townsend, R. R., Akers, S. R., Wei, W., Lakatta, E. & Fedorova, O. V., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia

Fedorova, O. V., Ishkaraeva, V. V., Grigorova, Y. N., Reznik, V. A., Kolodkin, N. I., Zazerskaya, I. E., Zernetkina, V., Agalakova, N. I., Tapilskaya, N. I., Adair, C. D., Lakatta, E. & Bagrov, A. Y., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2377.

Research output: Contribution to journalArticle

Association of arginine vasopressin with low atrial natriuretic peptide levels, left ventricular remodelling, and outcomes in adults with and without heart failure

Chirinos, J. A., Sardana, M., Oldland, G., Ansari, B., Lee, J., Hussain, A., Mustafa, A., Akers, S. R., Wei, W., Lakatta, E. G. & Fedorova, O. V., Oct 2018, In : ESC Heart Failure. 5, 5, p. 911-919 9 p.

Research output: Contribution to journalArticle

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4

Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B. & Lakatta, E., Jun 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 6, e005896.

Research output: Contribution to journalArticle

Calorie restriction curbs proinflammation that accompanies arterial aging, preserving a youthful phenotype

Wang, M., Zhang, L., Zhu, W., Zhang, J., Kim, S. H., Wang, Y., Ni, L., Telljohann, R., Monticone, R. E., McGraw, K., Liu, L., de Cabo, R. & Lakatta, E., Sep 1 2018, In : Journal of the American Heart Association. 7, 18, e009112.

Research output: Contribution to journalArticle

Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium

Metabolic syndrome, Arteries REsearch (MARE) Consortium, Jan 1 2018, In : Journal of hypertension. 36, 12, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

Dietary sodium restriction reduces arterial stiffness, vascular TGF-β-dependent fibrosis and marinobufagenin in young normotensive rats

Grigorova, Y. N., Wei, W., Petrashevskaya, N., Zernetkina, V., Juhasz, O., Fenner, R., Gilbert, C., Lakatta, E., Shapiro, J. I., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2018, In : International Journal of Molecular Sciences. 19, 10, 3168.

Research output: Contribution to journalArticle

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, Oct 1 2018, In : Nature genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalArticle

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node

Kim, M. S., Maltsev, A. V., Monfredi, O., Maltseva, L. A., Wirth, A., Florio, M. C., Tsutsui, K., Riordon, D. R., Parsons, S. P., Tagirova, S., Ziman, B. D., Stern, M. D., Lakatta, E. & Maltsev, V. A., Sep 1 2018, In : Cell Calcium. 74, p. 168-179 12 p.

Research output: Contribution to journalArticle

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Lyashkov, A. E., Beahr, J., Lakatta, E., Yaniv, Y. & Maltsev, V. A., Mar 13 2018, In : Biophysical Journal. 114, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten, J., Brody, J. A., Jamshidi, Y., Swenson, B. R., Butler, A. M., Campbell, H., Del Greco, F. M., Evans, D. S., Gibson, Q., Gudbjartsson, D. F., Kerr, K. F., Krijthe, B. P., Lyytikäinen, L. P., Müller, C., Müller-Nurasyid, M., Nolte, I. M., Padmanabhan, S., Ritchie, M. D., Robino, A., Smith, A. V. & 106 others, Steri, M., Tanaka, T., Teumer, A., Trompet, S., Ulivi, S., Verweij, N., Yin, X., Arnar, D. O., Asselbergs, F. W., Bader, J. S., Barnard, J., Bis, J., Blankenberg, S., Boerwinkle, E., Bradford, Y., Buckley, B. M., Chung, M. K., Crawford, D., den Hoed, M., Denny, J. C., Dominiczak, A. F., Ehret, G. B., Eijgelsheim, M., Ellinor, P. T., Felix, S. B., Franco, O. H., Franke, L., Harris, T. B., Holm, H., Ilaria, G., Iorio, A., Kähönen, M., Kolcic, I., Kors, J. A., Lakatta, E. G., Launer, L. J., Lin, H., Lin, H. J., Loos, R. J. F., Lubitz, S. A., Macfarlane, P. W., Magnani, J. W., Leach, I. M., Meitinger, T., Mitchell, B. D., Munzel, T., Papanicolaou, G. J., Peters, A., Pfeufer, A., Pramstaller, P. P., Raitakari, O. T., Rotter, J. I., Rudan, I., Samani, N. J., Schlessinger, D., Silva Aldana, C. T., Sinner, M. F., Smith, J. D., Snieder, H., Soliman, E. Z., Spector, T. D., Stott, D. J., Strauch, K., Tarasov, K. V., Thorsteinsdottir, U., Uitterlinden, A. G., Van Wagoner, D. R., Völker, U., Völzke, H., Waldenberger, M., Jan Westra, H., Wild, P. S., Zeller, T., Alonso, A., Avery, C. L., Bandinelli, S., Benjamin, E. J., Cucca, F., Dörr, M., Ferrucci, L., Gasparini, P., Gudnason, V., Hayward, C., Heckbert, S. R., Hicks, A. A., Jukema, J. W., Kääb, S., Lehtimäki, T., Liu, Y., Munroe, P. B., Parsa, A., Polasek, O., Psaty, B. M., Roden, D. M., Schnabel, R. B., Sinagra, G., Stefansson, K., Stricker, B. H., van der Harst, P., van Duijn, C. M., Wilson, J. F., Gharib, S. A., de Bakker, P. I. W., Isaacs, A., Arking, D. E. & Sotoodehnia, N., Dec 1 2018, In : Nature communications. 9, 1, 2904.

Research output: Contribution to journalArticle

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall

Pintus, G., Giordo, R., Wang, Y., Zhu, W., Kim, S. H., Zhang, L., Ni, L., Zhang, J., Telljohann, R., McGraw, K. R., Monticone, R. E., Ferris, C., Liu, L., Wang, M. & Lakatta, E. G., Jun 1 2018, In : Oncotarget. 9, 43, p. 27117-27132 16 p.

Research output: Contribution to journalArticle

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an in vivo human study

Gallo, D., Bijari, P. B., Morbiducci, U., Qiao, Y., Xie, Y. J., Etesami, M., Habets, D., Lakatta, E., Wasserman, B. A. & Steinman, D. A., Oct 10 2018, In : Journal of the Royal Society, Interface. 15, 147

Research output: Contribution to journalArticle

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J. & Berry, J. D., Feb 1 2017, In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Contribution to journalArticle

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E., Maltsev, V. A. & Monfredi, O., Jul 1 2017, In : PLoS One. 12, 7, e0179419.

Research output: Contribution to journalArticle

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2017, In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. G. & Alghatrif, M., Feb 1 2017, In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E. M., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E., McDermott, M. M. & Ferrucci, L., Sep 1 2017, In : Journal of the American Heart Association. 6, 9, e006604.

Research output: Contribution to journalArticle

Mammalian γ2 AMPK regulates intrinsic heart rate

Yavari, A., Bellahcene, M., Bucchi, A., Sirenko, S., Pinter, K., Herring, N., Jung, J. J., Tarasov, K. V., Sharpe, E. J., Wolfien, M., Czibik, G., Steeples, V., Ghaffari, S., Nguyen, C., Stockenhuber, A., Clair, J. R. S., Rimmbach, C., Okamoto, Y., Yang, D., Wang, M. & 44 others, Ziman, B. D., Moen, J. M., Riordon, D. R., Ramirez, C., Paina, M., Lee, J., Zhang, J., Ahmet, I., Matt, M. G., Tarasova, Y. S., Baban, DI., Sahgal, N., Lockstone, H., Puliyadi, R., De Bono, J., Siggs, O. M., Gomes, J., Muskett, H., Maguire, M. L., Beglov, Y., Kelly, M., Dos Santos, P. P. N., Bright, N. J., Woods, A., Gehmlich, K., Isackson, H., Douglas, G., Ferguson, D. J. P., Schneider, J. E., Tinker, A., Wolkenhauer, O., Channon, K. M., Cornall, R. J., Sternick, E. B., Paterson, D. J., Redwood, C. S., Carling, D., Proenza, C., David, R., Baruscotti, M., DIfrancesco, D., Lakatta, E. G., Watkins, H. & Ashrafian, H., Dec 1 2017, In : Nature communications. 8, 1, 1258.

Research output: Contribution to journalArticle

Prognostic utility of morning blood pressure surge for 20-year all- cause and cardiovascular mortalities: Results of a community-based study

Cheng, H. M., Wu, C. L., Sung, S. H., Lee, J. C., Kario, K., Chiang, C. E., Huang, C. J., Hsu, P. F., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., Dec 1 2017, In : Journal of the American Heart Association. 6, 12, e007667.

Research output: Contribution to journalArticle

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. & Maltsev, V. A., Sep 1 2017, In : PLoS One. 12, 9, e0185222.

Research output: Contribution to journalArticle

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E., Raman, S. V., Harrington, R. A. & Heitner, J. F., Jan 1 2017, In : PLoS One. 12, 1, e0169108.

Research output: Contribution to journalArticle

2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L. P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S. J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S. T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H. J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., Sep 27 2016, In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticle

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H. S., Yang, A., Islam, C., Lakatta, E. G. & Lin, L., Jan 5 2016, In : Scientific reports. 6, 18822.

Research output: Contribution to journalArticle

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E., Fedorova, O. V. & Bagrov, A. Y., May 1 2016, In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. & Lin, L., Sep 19 2016, In : Journal of Visualized Experiments. 2016, 115, e53777.

Research output: Contribution to journalArticle

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. & Lakatta, E., Sep 1 2016, In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Contribution to journalArticle

Camkii-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local ca2+ releases

Li, Y., Sirenko, S., Riordon, D. R., Yang, D., Spurgeon, H., Lakatta, E. & Vinogradova, T. M., Sep 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H532-H544

Research output: Contribution to journalArticle

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo

Yaniv, Y., Ahmet, I., Tsutsui, K., Behar, J., Moen, J. M., Okamoto, Y., Guiriba, T. R., Liu, J., Bychkov, R. & Lakatta, E., Aug 1 2016, In : Aging Cell. 15, 4, p. 716-724 9 p.

Research output: Contribution to journalArticle

Electrochemical Na+ and Ca2+gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Sirenko, S. G., Maltsev, V. A., Yaniv, Y., Bychkov, R., Yaeger, D., Vinogradova, T., Spurgeon, H. A. & Lakatta, E., Jul 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H251-H267

Research output: Contribution to journalArticle

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study

Scuteri, A., Morrell, C. H., Orru', M., Alghatrif, M., Saba, P. S., Terracciano, A., Ferreli, L. A. P., Loi, F., Marongiu, M., Pilia, M. G., Delitala, A., Tarasov, K. V., Schlessinger, D., Ganau, A., Cucca, F. & Lakatta, E. G., Aug 15 2016, In : International Journal of Cardiology. 217, p. 92-98 7 p.

Research output: Contribution to journalArticle

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

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E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. 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R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature communications. 7, 10023.

Research output: Contribution to journalArticle

High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives

Hsu, P. F., Cheng, H. M., Wu, C. H., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2016, In : American Journal of Hypertension. 29, 7, p. 806-813 8 p.

Research output: Contribution to journalArticle