Research Output 1995 2017

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2017

TAX1BP1 restrains virus-induced apoptosis by facilitating itch-mediated degradation of the mitochondrial adaptor MAVS

Choi, Y. B., Shembade, N., Parvatiyar, K., Balachandran, S. & Harhaj, E. W. 2017 In : Molecular and Cellular Biology. 37, 1, e00422-16

Research output: Contribution to journalArticle

Apoptosis
Viruses
RNA Virus Infections
Proteins
Sendai virus
2016

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

Han, K. J., Foster, D., Harhaj, E. W., Dzieciatkowska, M., Hansen, K. & Liu, C. W. Apr 1 2016 In : Human Molecular Genetics. 25, 7, p. 1392-1405 14 p., ddw021

Research output: Contribution to journalArticle

Motor Neurons
Ubiquitin
Small Nuclear Ribonucleoproteins
Cytoplasm
Spinal Muscular Atrophy

SHARPINing the knowledge of TCR signal control

Bowman, M., Pan, F. & Harhaj, E. W. Feb 1 2016 In : Nature Immunology. 17, 3, p. 221-222 2 p.

Research output: Contribution to journalArticle

2015

Aryl hydrocarbon receptor interacting protein targets IRF7 to suppress antiviral signaling and the induction of type I interferon

Zhou, Q., Lavorgna, A., Bowman, M., Hiscott, J. & Harhaj, E. W. Jun 5 2015 In : Journal of Biological Chemistry. 290, 23, p. 14729-14739 11 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factor-7
Receptor-Interacting Protein Serine-Threonine Kinases
Aryl Hydrocarbon Receptors
Interferon Type I
Antiviral Agents
Ubiquitination
Ubiquitin
Proteins
TNF Receptor-Associated Factor 6
Autoimmune Diseases

Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB

Jain, P., Lavorgna, A., Sehgal, M., Gao, L., Ginwala, R., Sagar, D., Harhaj, E. W. & Khan, Z. K. Feb 27 2015 In : Retrovirology. 12, 1, 23

Research output: Contribution to journalArticle

Deltaretrovirus Infections
MEF2 Transcription Factors
Human T-lymphotropic virus 1
Taxes
T-Lymphocytes

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways

Hyun, J., Ramos, J. C., Toomey, N., Balachandran, S., Lavorgna, A., Harhaj, E. & Barber, G. N. 2015 In : Journal of Virology. 89, 9, p. 4880-4893 14 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Taxes
Viruses
T-Lymphocytes
taxes
2014

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation

Lavorgna, A., Matsuoka, M. & Harhaj, E. W. Oct 1 2014 In : PLoS Pathogens. 10, 10

Research output: Contribution to journalArticle

Deltaretrovirus
Taxes
T-Lymphocytes
Adult T Cell Leukemia Lymphoma
Genes

Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

Choi, Y. B. & Harhaj, E. W. Dec 5 2014 In : Frontiers in Biology. 9, 6, p. 423-436 14 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Oncogenic Viruses
Reactive Oxygen Species
Mitochondria
oncogenic viruses
TNF Receptor-Associated Factor 6
Deltaretrovirus
Taxes
Cell Survival
Ubiquitin

Regulation of HTLV-1 tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway

Lavorgna, A. & Harhaj, E. W. Oct 23 2014 In : Viruses. 6, 10, p. 3925-3943 19 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Taxes
Proteasome Endopeptidase Complex
Ubiquitin
T-Lymphocytes
2013
Deltaretrovirus
HSP90 Heat-Shock Proteins
Oncogene Proteins
Taxes
taxes

Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation?

Lavorgna, A. & Harhaj, E. W. Mar 2013 In : Future Virology. 8, 3, p. 223-227 5 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Taxes
Ubiquitin

RING Finger Protein 11 Targets TBK1/IKKi Kinases to Inhibit Antiviral Signaling

Charoenthongtrakul, S., Gao, L., Parvatiyar, K., Lee, D. & Harhaj, E. W. Jan 15 2013 In : PLoS One. 8, 1, e53717

Research output: Contribution to journalArticle

virus replication
Antiviral Agents
Phosphotransferases
Proteins
interferon-beta
2012
Ubiquitin-Specific Proteases
Deltaretrovirus
Cell Nucleus Active Transport
Taxes
RNA Interference
Ubiquitin-Specific Proteases
Deltaretrovirus
Cell Nucleus Active Transport
Taxes
RNA Interference

EBV LMP1: New and shared pathways to NF-κB activation

Lavorgna, A. & Harhaj, E. W. Feb 14 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 7, p. 2188-2189 2 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4

Regulation of NF-κB by deubiquitinases

Harhaj, E. W. & Dixit, V. M. Mar 2012 In : Immunological Reviews. 246, 1, p. 107-124 18 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Ubiquitin
Polyubiquitin
Ubiquitin-Protein Ligases
Ubiquitination

Regulation of NF-κB signaling by the A20 deubiquitinase

Shembade, N. & Harhaj, E. W. Mar 2012 In : Cellular and Molecular Immunology. 9, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Autoimmune Diseases
Phosphotransferases
Inflammation
Polyubiquitin

The NLRP4-DTX4 axis: A key suppressor of TBK1 and innate antiviral signaling

Charoenthongtrakul, S., Gao, L. & Harhaj, E. W. Nov 2012 In : Cellular and Molecular Immunology. 9, 6, p. 431-433 3 p.

Research output: Contribution to journalArticle

2011

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling

Gao, L., Coope, H., Grant, S., Averil, M., Ley, S. C. & Harhaj, E. W. Oct 21 2011 In : Journal of Biological Chemistry. 286, 42, p. 36592-36602 11 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Antiviral Agents
Viruses
Infection
Proteins

Deubiquitinases in the regulation of NF-κB signaling

Harhaj, E. W. & Dixit, V. M. Jan 2011 In : Cell Research. 21, 1, p. 22-39 18 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Ubiquitin-Protein Ligases
Down-Regulation
Neoplasms
NF-kappa B

Human T cell leukemia virus type 1 tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

Charoenthongtrakul, S., Zhou, Q., Shembade, N., Harhaj, N. S. & Harhaj, E. W. Jul 2011 In : Journal of Virology. 85, 14, p. 6955-6962 8 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Taxes
Antiviral Agents
taxes
Interferons

IKKi: A novel regulator of Act1, IL-17 signaling and pulmonary inflammation

Shembade, N. & Harhaj, E. W. Nov 2011 In : Cellular and Molecular Immunology. 8, 6, p. 447-449 3 p.

Research output: Contribution to journalArticle

Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway

Shembade, N. & Harhaj, E. W. Oct 2011 In : Future Virology. 6, 10, p. 1165-1168 4 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Oncogene Proteins
Taxes
Proteasome Endopeptidase Complex
Ubiquitin

Regulation of inflammatory and antiviral signaling by A20

Parvatiyar, K. & Harhaj, E. W. Mar 2011 In : Microbes and Infection. 13, 3, p. 209-215 7 p.

Research output: Contribution to journalArticle

Antiviral Agents
Homeostasis
Enzymes

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1

Shembade, N., Pujari, R., Harhaj, N. S., Abbott, D. W. & Harhaj, E. W. Sep 2011 In : Nature Immunology. 12, 9, p. 834-843 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Transcription Factors
Phosphotransferases
Phosphorylation
Cytokines
2010

A20 inhibition of NFκB and inflammation: Targeting E2:E3 ubiquitin enzyme complexes

Shembade, N. & Harhaj, E. W. Jul 1 2010 In : Cell cycle (Georgetown, Tex.). 9, 13, p. 2481-2482 2 p.

Research output: Contribution to journalArticle

Inflammation

Anchors away for ubiquitin chains

Parvatiyar, K. & Harhaj, E. W. Jun 4 2010 In : Science. 328, 5983, p. 1244-1245 2 p.

Research output: Contribution to journalArticle

Ubiquitin
Infection

Inhibition of nf-kb signaling by a20 through disruption of ubiquitin enzyme complexes

Shembade, N., Ma, A. & Harhaj, E. W. Feb 26 2010 In : Science. 327, 5969, p. 1135-1139 5 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Enzymes
TNF Receptor-Associated Factor 2
Ubiquitin-Specific Proteases

Role of the proteasome in the downregulation of transcription factors NFκB and C/EBP in macrophages from tumor hosts

Perry, G., Iragavarapu-Charyulu, V., Harhaj, E. W. & Torroella-Kouri, M. Mar 2010 In : Oncology Reports. 23, 3, p. 875-881 7 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Proteasome Endopeptidase Complex
Transcription Factors
Down-Regulation
Macrophages

TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases

Parvatiyar, K., Barber, G. N. & Harhaj, E. W. May 14 2010 In : Journal of Biological Chemistry. 285, 20, p. 14999-15009 11 p.

Research output: Contribution to journalArticle

Antiviral Agents
Phosphotransferases
Fibroblasts
TNF Receptor-Associated Factor 3
Phosphorylation
2009

ITCH K63-Ubiquitinates the NOD2 Binding Protein, RIP2, to Influence Inflammatory Signaling Pathways

Tao, M., Scacheri, P. C., Marinis, J. M., Harhaj, E. W., Matesic, L. E. & Abbott, D. W. Aug 11 2009 In : Current Biology. 19, 15, p. 1255-1263 9 p.

Research output: Contribution to journalArticle

Crohn disease
cytokines
pathogenesis
Carrier Proteins
Supravalvular Aortic Stenosis

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S. & Harhaj, E. W. Mar 4 2009 In : The EMBO journal. 28, 5, p. 513-522 10 p.

Research output: Contribution to journalArticle

Ubiquitin
Down-Regulation
Tumor Necrosis Factor-alpha
Enzymes
Transforming Growth Factor beta
2008

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

Shembade, N., Harhaj, N. S., Parvatiyar, K., Copeland, N. G., Jenkins, N. A., Matesic, L. E. & Harhaj, E. W. Mar 2008 In : Nature Immunology. 9, 3, p. 254-262 9 p.

Research output: Contribution to journalArticle

Ubiquitin-Protein Ligases
Ubiquitin
Enzymes
Human T-lymphotropic virus 1
Tumor Necrosis Factor Receptors
2007
Human T-lymphotropic virus 1
Oncogene Proteins
Taxes
Ubiquitin
Phosphotransferases

Deregulated expression of CD40 ligand in HTLV-I infection: Distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients

Harhaj, N. S., Janic, B., Ramos, J. C., Harrington, W. J. & Harhaj, E. W. May 25 2007 In : Virology. 362, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

HTLV-I Infections
Adult T Cell Leukemia Lymphoma
CD40 Ligand
Transformed Cell Line
Human T-lymphotropic virus 1

Essential role for TAX1BP1 in the termination of TNF-α-, IL-1- and LPS-mediated NF-κB and JNK signaling

Shembade, N., Harhaj, N. S., Liebl, D. J. & Harhaj, E. W. Sep 5 2007 In : The EMBO journal. 26, 17, p. 3910-3922 13 p.

Research output: Contribution to journalArticle

Interleukin-1
Lipopolysaccharides
Carrier Proteins
Tumor Necrosis Factor-alpha
Cape Verde

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma

Ramos, J. C., Ruiz, P., Ratner, L., Reis, I. M., Brites, C., Pedroso, C., Byrne, G. E., Toomey, N. L., Andela, V., Harhaj, E. W., Lossos, I. S. & Harrington, W. J. Apr 1 2007 In : Blood. 109, 7, p. 3060-3068 9 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Adult T Cell Leukemia Lymphoma
Antiviral Agents
Neoplasms
T-cells

The human T-cell leukemia virus type 1 tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation

Shembade, N., Harhaj, N. S., Yamamoto, M., Akira, S. & Harhaj, E. W. Dec 2007 In : Journal of Virology. 81, 24, p. 13735-13742 8 p.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
Deltaretrovirus
Oncogene Proteins
Taxes
taxes
2006

Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

Kamanaka, M., Kim, S. T., Wan, Y. Y., Sutterwala, F. S., Lara-Tejero, M., Galán, J. E., Harhaj, E. & Flavell, R. A. Dec 2006 In : Immunity. 25, 6, p. 941-952 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Lymphocytes
Fluorescence
Proteins
Regulatory T-Lymphocytes

Regulation of human T-cell leukemia virus type 1 gene expression by Sp1 and Sp3 interaction with TRE-1 repeat III

Yao, J., Grant, C., Harhaj, E., Nonnemacher, M., Alefantis, T., Martin, J., Jain, P. & Wigdahl, B. May 2006 In : DNA and Cell Biology. 25, 5, p. 262-276 15 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Taxes
Gene Expression
Terminal Repeat Sequences
Binding Sites
2005

Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappa B pathway

Harhaj, E. W., Harhaj, N. S., Grant, C., Mostoller, K., Alefantis, T., Sun, S. C. & Wigdahl, B. Mar 1 2005 In : Virology. 333, 1, p. 145-158 14 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
NF-kappa B
Taxes
Gene Expression
T-Lymphocytes

Mechanisms of persistent NF-κB activation by HTLV-I tax

Harhaj, E. W. & Harhaj, N. S. Feb 2005 In : IUBMB Life. 57, 2, p. 83-91 9 p.

Research output: Contribution to journalArticle

T-cells
Human T-lymphotropic virus 1
Taxes
Taxation
Bulimia

Secretion of the human T cell leukemia virus type I transactivator protein tax

Alefantis, T., Mostoller, K., Jain, P., Harhaj, E., Grant, C. & Wigdahl, B. Apr 29 2005 In : Journal of Biological Chemistry. 280, 17, p. 17353-17362 10 p.

Research output: Contribution to journalArticle

tax Gene Products
Human T-lymphotropic virus 1
Trans-Activators
Taxes
Taxation
2004

Regulation of the NF-κB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

Liao, G., Zhang, M., Harhaj, E. W. & Sun, S. C. Jun 18 2004 In : Journal of Biological Chemistry. 279, 25, p. 26243-26250 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Phosphotransferases
4-Aminobutyrate Transaminase
Cape Verde
Proteasome Endopeptidase Complex
2003

Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax

Alefantis, T., Barmak, K., Harhaj, E. W., Grant, C. & Wigdahl, B. Jun 13 2003 In : Journal of Biological Chemistry. 278, 24, p. 21814-21822 9 p.

Research output: Contribution to journalArticle

tax Gene Products
Nuclear Export Signals
Human T-lymphotropic virus 1
Trans-Activators
Taxes

Human T cell leukemia virus type I-induced disease: Pathways to cancer and neurodegeneration

Barmak, K., Harhaj, E., Grant, C., Alefantis, T. & Wigdahl, B. Mar 30 2003 In : Virology. 308, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Neoplasms
Infection
Tropical Spastic Paraparesis
Adult T Cell Leukemia Lymphoma
Tropical Spastic Paraparesis
T-Cell Leukemia
Spinal Cord Diseases
Central Nervous System
Human T-lymphotropic virus 1
2001

NF-κB-inducing kinase regulates the processing of NF-κB2 p100

Xiao, G., Harhaj, E. W. & Sun, S. C. 2001 In : Molecular Cell. 7, 2, p. 401-409 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Genes
Protein Precursors
Ubiquitination
Knockout Mice