Duncan Sousa

Research Associate

20042020

Research output per year

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Research Output

2020

Comparative analysis of the capsid structures of AAVrh.10, AAVrh.39, and AAV8

Mietzsch, M., Barnes, C., Hull, J. A., Chipman, P., Xie, J., Bhattacharya, N., Sousa, D., McKenna, R., Gao, G. & Agbandje-McKenna, M., Mar 1 2020, In : Journal of virology. 94, 6, e01769-19.

Research output: Contribution to journalArticle

2019

Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue

Guenther, C. M., Brun, M. J., Bennett, A. D., Ho, M. L., Chen, W., Zhu, B., Lam, M., Yamagami, M., Kwon, S., Bhattacharya, N., Sousa, D., Evans, A. C., Voss, J., Sevick-Muraca, E. M., Agbandje-McKenna, M. & Suh, J., Jan 1 2019, In : Molecular Therapy.

Research output: Contribution to journalArticle

Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2

Bennett, A., Keravala, A., Makal, V., Kurian, J., Belbellaa, B., Aeran, R., Tseng, Y. S., Sousa, D., Spear, J., Gasmi, M. & Agbandje-McKenna, M., Jan 1 2019, (Accepted/In press) In : Journal of Structural Biology. 107433.

Research output: Contribution to journalArticle

Yeast R2TP Interacts with Extended Termini of Client Protein Nop58p

Yu, G., Zhao, Y., Tian, S., Rai, J., He, H., Spear, J., Sousa, D., Fan, J., Yu, H. G., Stagg, S. M. & Li, H., Dec 1 2019, In : Scientific reports. 9, 1, 20228.

Research output: Contribution to journalArticle

Open Access
2018

Atomic resolution structures of human bufaviruses determined by cryo-electron microscopy

Ilyas, M., Mietzsch, M., Kailasan, S., Väisänen, E., Luo, M., Chipman, P., Smith, J. K., Kurian, J., Sousa, D., McKenna, R., Söderlund-Venermo, M. & Agbandje-McKenna, M., Jan 1 2018, In : Viruses. 10, 1, 22.

Research output: Contribution to journalArticle

Atomic structure of a rationally engineered gene delivery vector, AAV2.5

Burg, M., Rosebrough, C., Drouin, L. M., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., Jude Samulski, R. & Agbandje-McKenna, M., Jan 1 2018, (Accepted/In press) In : Journal of Structural Biology.

Research output: Contribution to journalArticle

2017

Mechanism of ribosome rescue by ArfA and RF2

Demo, G., Svidritskiy, E., Madireddy, R., Diaz-Avalos, R., Grant, T., Grigorieff, N., Sousa, D. & Korostelev, A. A., Mar 16 2017, In : eLife. 6, e23687.

Research output: Contribution to journalArticle

Structural insights into human bocaparvoviruses

Mietzsch, M., Kailasan, S., Garrison, J., Ilyas, M., Chipman, P., Kantola, K., Janssen, M. E., Spear, J., Sousa, D., McKenna, R., Brown, K., Söderlund-Venermo, M., Baker, T. & Agbandje-McKenna, M., Jun 1 2017, In : Journal of Virology. 91, 11, e00261-17.

Research output: Contribution to journalArticle

The 2.8 Å Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide

Xie, Q., Spear, J. M., Noble, A. J., Sousa, D., Meyer, N. L., Davulcu, O., Zhang, F., Linhardt, R. J., Stagg, S. M. & Chapman, M. S., Jun 16 2017, In : Molecular Therapy - Methods and Clinical Development. 5, p. 1-12 12 p.

Research output: Contribution to journalArticle

2015

The influence of frame alignment with dose compensation on the quality of single particle reconstructions

Spear, J. M., Noble, A. J., Xie, Q., Sousa, D. R., Chapman, M. S. & Stagg, S. M., Nov 2015, In : Journal of Structural Biology. 192, 2, p. 196-203 8 p.

Research output: Contribution to journalArticle

2014

The structure of Sinorhizobium meliloti phage ΦM12, which has a novel T=19l triangulation number and is the founder of a new group of T4-superfamily phages

Stroupe, M. E., Brewer, T. E., Sousa, D. R. & Jones, K. M., Feb 1 2014, In : Virology. 450-451, p. 205-212 8 p.

Research output: Contribution to journalArticle

2013

Cryo-EM structures of the actin:tropomyosin filament reveal the mechanism for the transition from C- to M-State

Sousa, D. R., Stagg, S. M. & Stroupe, M. E., Nov 15 2013, In : Journal of molecular biology. 425, 22, p. 4544-4555 12 p.

Research output: Contribution to journalArticle

2011

Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind co-operatively to actin and regulate myosin

East, D. A., Sousa, D., Martin, S. R., Edwards, T. A., Lehman, W. & Mulvihill, D. P., Sep 1 2011, In : Biochemical Journal. 438, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

2010

Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands

Sousa, D., Cammarato, A., Jang, K., Graceffa, P., Tobacman, L. S., Li, X. & Lehman, W., Aug 4 2010, In : Biophysical journal. 99, 3, p. 862-868 7 p.

Research output: Contribution to journalArticle

2007

Ab initio resolution measurement for single particle structures

Sousa, D. & Grigorieff, N., Jan 1 2007, In : Journal of Structural Biology. 157, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

2004

Three-dimensional structure of C complex spliceosomes by electron microscopy

Jurica, M. S., Sousa, D., Moore, M. J. & Grigorieff, N., Mar 1 2004, In : Nature Structural and Molecular Biology. 11, 3, p. 265-269 5 p.

Research output: Contribution to journalArticle