Douglas Robinson

Professor

19942019
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Research Output 1994 2019

2019

Contractility kits promote assembly of the mechanoresponsive cytoskeletal network

Kothari, P., Srivastava, V., Aggarwal, V., Tchernyshyov, I., Van Eyk, J. E., Ha, T. & Robinson, D., Jan 1 2019, In : Journal of Cell Science. 132, 2, jcs226704.

Research output: Contribution to journalArticle

Myosin Type II
Actins
Physiological Feedback
Proteins
Myosin Type I

How the mechanobiome drives cell behavior, viewed through the lens of control theory

Kothari, P., Johnson, C., Sandone, C., Iglesias, P. A. & Robinson, D., Sep 2 2019, In : Journal of cell science. 132, 17

Research output: Contribution to journalReview article

Open Access
Lenses
Proteins
Myosin Type II
Actomyosin
Cell Shape

Meddlingwithmyosin'smechanobiology in cancer

Surcel, A. & Robinson, D., Jul 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15322-15323 2 p.

Research output: Contribution to journalComment/debate

Open Access

Myosin IIB assembly state determines its mechanosensitive dynamics

Schiffhauer, E. S., Ren, Y., Iglesias, V. A., Kothari, P., Iglesias, P. A. & Robinson, D., Mar 1 2019, In : Journal of Cell Biology. 218, 3, p. 895-908 14 p.

Research output: Contribution to journalArticle

Open Access
Nonmuscle Myosin Type IIB
Myosin Type II
NIH 3T3 Cells
Dictyostelium
Cell Shape

Targeting mechanoresponsive proteins in pancreatic cancer: 4-hydroxyacetophenone blocks dissemination and invasion by activating MYH14

Surcel, A., Schiffhauer, E. S., Thomas, D. G., Zhu, Q., DiNapoli, K. T., Herbig, M., Otto, O., West-Foyle, H., Jacobi, A., Krater, M., Plak, K., Guck, J., Jaffee, E., Iglesias, P. A., Anders, R. A. & Robinson, D., Sep 15 2019, In : Cancer Research. 79, 18, p. 4665-4678 14 p.

Research output: Contribution to journalArticle

Protein Transport
Pancreatic Neoplasms
Filamins
Actinin
Proteins
2018

14-3-3 proteins tune non-muscle myosin II assembly

West-Foyle, H., Kothari, P., Osborne, J. & Robinson, D., Jan 1 2018, In : Journal of Biological Chemistry. 293, 18, p. 6751-6761 11 p.

Research output: Contribution to journalArticle

Myosin Type II
14-3-3 Proteins
Dictyostelium
Neoplasms
Phosphorylation

Micropipette Aspiration of Oocytes to Assess Cortical Tension

Evans, J. P. & Robinson, D., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 163-171 9 p. (Methods in Molecular Biology; vol. 1818).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oocyte Retrieval
Mechanics
Oocytes
Biophysics
Zygote

Recent advances in cytokinesis: Understanding the molecular underpinnings [version 1; referees: 2 approved]

Liu, Y. & Robinson, D., Jan 1 2018, In : F1000Research. 7, 1849.

Research output: Contribution to journalReview article

Cytokinesis
Tissue

Spectrin is a mechanoresponsive protein shaping fusogenic synapse architecture during myoblast fusion

Duan, R., Kim, J. H., Shilagardi, K., Schiffhauer, E. S., Lee, D. M., Son, S., Li, S., Thomas, C., Luo, T., Fletcher, D. A., Robinson, D. & Chen, E. H., Jun 1 2018, In : Nature Cell Biology. 20, 6, p. 688-698 11 p.

Research output: Contribution to journalArticle

Spectrin
Myoblasts
Synapses
Cell Fusion
Proteins
2017

Cigarette smoke disrupts monolayer integrity by altering epithelial cell-cell adhesion and cortical tension

Nishida, K., Brune, K. A., Putcha, N., Mandke, P., O’Neal, W. K., Shade, D., Srivastava, V., Wang, M., Lam, H., An, S., Drummond, M. B., Hansel, N., Robinson, D. & Sidhaye, V., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L581-L591

Research output: Contribution to journalArticle

Cell Adhesion
Smoke
Tobacco Products
Epithelial Cells
Chronic Obstructive Pulmonary Disease

Entosis Is Induced by Glucose Starvation

Hamann, J. C., Surcel, A., Chen, R., Teragawa, C., Albeck, J. G., Robinson, D. & Overholtzer, M., Jul 5 2017, In : Cell Reports. 20, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

Entosis
AMP-Activated Protein Kinases
Starvation
Nutrients
Glucose

Mechanochemical Signaling Directs Cell-Shape Change

Schiffhauer, E. S. & Robinson, D., Jan 24 2017, In : Biophysical Journal. 112, 2, p. 207-214 8 p.

Research output: Contribution to journalReview article

Cell Shape
Mechanical Stress
Aptitude
Cytokinesis
Actins

Parallel Compression Is a Fast Low-Cost Assay for the High-Throughput Screening of Mechanosensory Cytoskeletal Proteins in Cells

Miao, C., Schiffhauer, E. S., Okeke, E. I., Robinson, D. & Luo, T., Aug 30 2017, In : ACS Applied Materials and Interfaces. 9, 34, p. 28168-28179 12 p.

Research output: Contribution to journalArticle

Cytoskeletal Proteins
Assays
Screening
Myosin Type II
Throughput

The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis

Thomas, D. G. & Robinson, D., Mar 10 2017, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

Actinin
Neoplasm Metastasis
Neoplasms
Actins
Microfilament Proteins
2016
Nocodazole
Dictyostelium
RNA-Binding Proteins
Cytokinesis
Microtubules

Cell blebbing in confined microfluidic environments

Ibo, M., Srivastava, V., Robinson, D. & Gagnon, Z. R., Oct 1 2016, In : PLoS One. 11, 10, e0163866.

Research output: Contribution to journalArticle

Myosin Type II
Microfluidics
Blister
pseudopodia
myosin

Cortical mechanics and myosin-II abnormalities associated with postovulatory aging: Implications for functional defects in aged eggs

Mackenzie, A. C. L., Kyle, D. D., McGinnis, L. A., Lee, H. J., Aldana, N., Robinson, D. & Evans, J. P., Jun 16 2016, In : Molecular Human Reproduction. 22, 6, p. 397-409 13 p., gaw019.

Research output: Contribution to journalArticle

Myosin Type II
Mechanics
Eggs
Spermatozoa
Myosin-Light-Chain Kinase

Cytokinesis: Robust cell shape regulation

Srivastava, V., Iglesias, P. A. & Robinson, D., May 1 2016, In : Seminars in Cell and Developmental Biology. 53, p. 39-44 6 p.

Research output: Contribution to journalArticle

Cytokinesis
Cell Shape
Cell Division
Dictyostelium
Cell Survival

Cytokinesis from nanometers to micrometers and microseconds to minutes

Kothari, P., Schiffhauer, E. S. & Robinson, D., 2016, (Accepted/In press) In : Methods in Cell Biology.

Research output: Contribution to journalArticle

Cytokinesis
Cell Shape
Mechanics
Fluorescence Recovery After Photobleaching
Mechanical Stress

Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs

Christianson, M. S., Gerolstein, A. L., Lee, H. J., Monseur, B. C., Robinson, D. & Evans, J. P., Mar 1 2016, In : Molecular Reproduction and Development. 83, 3, p. 188-189 2 p.

Research output: Contribution to journalArticle

Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization

Bai, H., Zhu, Q., Surcel, A., Luo, T., Ren, Y., Guan, B., Liu, Y., Wu, N., Joseph, N. E., Wang, T-L., Zhang, N., Pan, D., Alpini, G., Robinson, D. & Anders, R. A., 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G396-G411

Research output: Contribution to journalArticle

Adherens Junctions
Actin Cytoskeleton
Actomyosin
Liver
Elasticity
2015

Cell shape regulation through mechanosensory feedback control

Mohan, K., Luo, T., Robinson, D. & Iglesias, P. A., Aug 6 2015, In : Journal of the Royal Society Interface. 12, 109, 20150512.

Research output: Contribution to journalArticle

Cell Shape
Feedback control
Dictyostelium
Feedback
Myosin Type II

Kinetic Monte Carlo simulations of the assembly of filamentous biomacromolecules by the dimer addition mechanism

Luo, T. & Robinson, D., 2015, In : RSC Advances. 5, 6, p. 3922-3929 8 p.

Research output: Contribution to journalArticle

Dimers
Kinetics
Agglomeration
Oligomers
Masks
Myosin Type II
Myosin-Light-Chain Kinase
Metaphase
Eggs
Zinc

Mechanical stress and network structure drive protein dynamics during cytokinesis

Srivastava, V. & Robinson, D., Mar 2 2015, In : Current Biology. 25, 5, p. 663-670 8 p.

Research output: Contribution to journalArticle

Mechanical Stress
mechanical stress
Cytokinesis
cytokinesis
Myosin Type II

Mechanical Tension Drives Cell Membrane Fusion

Kim, J. H., Ren, Y., Ng, W. P., Li, S., Son, S., Kee, Y. S., Zhang, S., Zhang, G., Fletcher, D. A., Robinson, D. & Chen, E. H., Mar 9 2015, In : Developmental Cell. 32, 5, p. 561-573 13 p.

Research output: Contribution to journalArticle

Membrane Fusion
Cell Fusion
Myosin Type II
Cell membranes
Fusion reactions

Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton

Schiffhauer, E. S., Luo, T., Mohan, K., Srivastava, V., Qian, X., Griffis, E. R., Iglesias, P. A. & Robinson, D., Nov 20 2015, (Accepted/In press) In : Current Biology.

Research output: Contribution to journalArticle

Filamins
Myosin Type II
Actinin
microfilaments
Actin Cytoskeleton

Pharmacological activation of myosin ii paralogs to correct cell mechanics defects

Surcel, A., Ng, W. P., West-Foyle, H., Zhu, Q., Ren, Y., Avery, L. B., Krenc, A. K., Meyers, D. J., Rock, R. S., Anders, R. A., Meyers, C. L. & Robinson, D., Feb 3 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1428-1433 6 p.

Research output: Contribution to journalArticle

Myosins
Mechanics
Pharmacology
Myosin Type II
Nonmuscle Myosin Type IIB
2014

Competition between human cells by entosis

Sun, Q., Luo, T., Ren, Y., Florey, O., Shirasawa, S., Sasazuki, T., Robinson, D. & Overholtzer, M., Nov 5 2014, In : Cell Research. 24, 11, p. 1299-1310 12 p.

Research output: Contribution to journalArticle

Entosis
Cell-in-Cell Formation
Neoplasms
Cell Death
Actomyosin

Mimicking the mechanical properties of the cell cortex by the self-assembly of an actin cortex in vesicles

Luo, T., Srivastava, V., Ren, Y. & Robinson, D., 2014, In : Applied Physics Letters. 104, 15, 153701.

Research output: Contribution to journalArticle

cortexes
self assembly
mechanical properties
cells
emulsions
2013

A summer academic research experience for disadvantaged youth

Kabacoff, C., Srivastava, V. & Robinson, D., Sep 4 2013, In : CBE Life Sciences Education. 12, 3, p. 410-418 9 p.

Research output: Contribution to journalArticle

internship
Vulnerable Populations
Internship and Residency
Students
Research

Cytokinesis

Srivastava, V. & Robinson, D., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 622-626 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biochemistry
Cytokinesis
Mechanics
Cells
Biological Phenomena

Micropipette aspiration for studying cellular mechanosensory responses and mechanics

Kee, Y. S. & Robinson, D., 2013, Methods in Molecular Biology. Vol. 983. p. 367-382 16 p. (Methods in Molecular Biology; vol. 983).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mechanics
Mechanical Stress
Dictyostelium

Molecular mechanisms of cellular mechanosensing

Luo, T., Mohan, K., Iglesias, P. A. & Robinson, D., Nov 2013, In : Nature Materials. 12, 11, p. 1064-1071 8 p.

Research output: Contribution to journalArticle

Myosins
Actins
Filamins
Myosin Type II
Proteins

Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy

Kryzak, C. A., Moraine, M. M., Kyle, D. D., Lee, H. J., Cubeñas-Potts, C., Robinson, D. & Evans, J. P., 2013, In : Biology of Reproduction. 89, 2, 44.

Research output: Contribution to journalArticle

Meiotic Prophase I
Aptitude
Fertilization
Oocytes
Spermatozoa
2012

A mechanosensory system governs myosin II accumulation in dividing cells

Kee, Y. S., Ren, Y., Dorfman, D., Iijima, M., Firtel, R., Iglesias, P. A. & Robinson, D., Apr 15 2012, In : Molecular Biology of the Cell. 23, 8, p. 1510-1523 14 p.

Research output: Contribution to journalArticle

Myosin Type II
Mechanical Stress
Spindle Apparatus
Asymmetric Cell Division
Contractile Proteins

A novel role for aquaporin-5 in enhancing microtubule organization and stability

Sidhaye, V., Chau, E., Srivastava, V., Sirimalle, S., Balabhadrapatruni, C., Aggarwal, N. R., D'Alessio, F., Robinson, D. & King, L. S., Jun 8 2012, In : PLoS One. 7, 6, e38717.

Research output: Contribution to journalArticle

Aquaporin 5
aquaporins
Microtubules
microtubules
Permeability

Bringing the physical sciences into your cell biology research

Robinson, D. & Iglesias, P. A., Nov 1 2012, In : Molecular Biology of the Cell. 23, 21, p. 4167-4170 4 p.

Research output: Contribution to journalArticle

Natural Science Disciplines
Cell Biology
Research Personnel
Biological Science Disciplines
Research

Cytokinesis mechanics and mechanosensing

West-Foyle, H. & Robinson, D., Oct 2012, In : Cytoskeleton. 69, 10, p. 700-709 10 p.

Research output: Contribution to journalArticle

Cytokinesis
Mechanics
Myosin Type II
Proteins

Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression

Poirier, C. C., Ng, W. P., Robinson, D. & Iglesias, P. A., Apr 2012, In : PLoS Computational Biology. 8, 4, e1002467.

Research output: Contribution to journalArticle

Myosin Type II
Cytokinesis
cytokinesis
Deconvolution
deconvolution

Separation anxiety: Stress, tension and cytokinesis

Mohan, K., Iglesias, P. A. & Robinson, D., Jul 15 2012, In : Experimental Cell Research. 318, 12, p. 1428-1434 7 p.

Research output: Contribution to journalArticle

Separation Anxiety
Cytokinesis
Mechanical Phenomena
Biochemical Phenomena
Stem Cells

Understanding how dividing cells change shape

Robinson, D., Kee, Y. S., Luo, T. & Surcel, A., 2012, Comprehensive Biophysics. Elsevier Inc., Vol. 7. p. 48-72 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Integrated control
Molecular mechanics
Cytokinesis
Cell Shape
Physiology

Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation

Luo, T., Mohan, K., Srivastava, V., Ren, Y., Iglesias, P. A. & Robinson, D., Jan 18 2012, In : Biophysical Journal. 102, 2, p. 238-247 10 p.

Research output: Contribution to journalArticle

Myosin Type II
Myosins
Actin Cytoskeleton
Actins
Mechanical Stress

α-Catenin and IQGAP Regulate Myosin Localization to Control Epithelial Tube Morphogenesils in Dictyostelium

Dickinson, D. J., Robinson, D., Nelson, W. J. & Weis, W. I., Sep 11 2012, In : Developmental Cell. 23, 3, p. 533-546 14 p.

Research output: Contribution to journalArticle

Myosin Type II
Catenins
Dictyostelium
Myosins
Morphogenesis
2011

Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation

Wang, Y., Steimle, P. A., Ren, Y., Ross, C. A., Robinson, D., Egelhoff, T. T., Sesaki, H. & Iijima, M., Jul 1 2011, In : Molecular Biology of the Cell. 22, 13, p. 2270-2281 12 p.

Research output: Contribution to journalArticle

Myosin Type II
Dictyostelium
Cytokinesis
Chemotaxis
Protein Phosphatase 2

The spatial and mechanical challenges of female meiosis

Evans, J. P. & Robinson, D., Oct 2011, In : Molecular Reproduction and Development. 78, 10-11, p. 769-777 9 p.

Research output: Contribution to journalArticle

Meiosis
Polar Bodies
Mechanics
Oocytes
Cytokinesis
2010

14-3-3, an integrator of cell mechanics and cytokinesis

Robinson, D., Nov 2010, In : Small GTPases. 1, 3

Research output: Contribution to journalArticle

14-3-3 Proteins
Cytokinesis
Mechanics
Myosin Type II
Amoeba

14-3-3 coordinates microtubules, rac, and myosin II to control cell mechanics and cytokinesis

Zhou, Q., Kee, Y. S., Poirier, C. C., Jelinek, C., Osborne, J., Divi, S., Surcel, A., Will, M. E., Eggert, U. S., Müller-Taubenberger, A., Iglesias, P. A., Cotter, R. J. & Robinson, D., Nov 9 2010, In : Current Biology. 20, 21, p. 1881-1889 9 p.

Research output: Contribution to journalArticle

Myosin Type II
Cytokinesis
cytokinesis
myosin
Mechanics

Automated characterization of cell shape changes during amoeboid motility by skeletonization

Xiong, Y., Kabacoff, C., Franca-Koh, J., Devreotes, P. N., Robinson, D. & Iglesias, P. A., Mar 24 2010, In : BMC Systems Biology. 4, 33.

Research output: Contribution to journalArticle

Skeletonization
Motility
Cell Shape
Cell Migration
Retraction

Cooperative interactions between myosin II and cortexillin I mediated by actin filaments during cellular deformation

Luo, T. & Robinson, D., 2010, IFMBE Proceedings. Vol. 32 IFMBE. p. 74-76 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Myosin Type II
Actins
Proteins