Douglas Gladstone

Associate Professor

19992019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1999 2019

Filter
Article
2019

Allogeneic Haploidentical Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide in Chronic Lymphocytic Leukemia

Paul, S., Tsai, H. L., Lowery, P., Fuchs, E. J., Luznik, L., Bolaños-Meade, J., Swinnen, L. J., Shanbhag, S., Wagner-Johnston, N., Varadhan, R., Ambinder, R. F., Jones, R. J. & Gladstone, D. E., Jan 1 2019, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Cyclophosphamide
Transplantation
Bone Marrow
Graft vs Host Disease
Open Access
Graft vs Host Disease
Cyclophosphamide
Transplantation
Mortality
Incidence
Peripheral Blood Stem Cell Transplantation
Cytokines
Transplantation
Odds Ratio
Confidence Intervals
Methotrexate
Lymphoma
Central Nervous System
Rituximab
White Matter
2018
Bone Marrow Transplantation
Fever
Transplants
Unrelated Donors
Cyclophosphamide
Bone Marrow Transplantation
Cyclophosphamide
Tissue Donors
Confidence Intervals
Transplants
Homologous Transplantation
Graft vs Host Disease
Cyclophosphamide
Transplantation
Bone Marrow

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

Kreitman, R. J., Dearden, C., Zinzani, P. L., Delgado, J., Karlin, L., Robak, T., Gladstone, D., le Coutre, P., Dietrich, S., Gotic, M., Larratt, L., Offner, F., Schiller, G., Swords, R., Bacon, L., Bocchia, M., Bouabdallah, K., Breems, D. A., Cortelezzi, A., Dinner, S. & 23 others, Doubek, M., Gjertsen, B. T., Gobbi, M., Hellmann, A., Lepretre, S., Maloisel, F., Ravandi, F., Rousselot, P., Rummel, M., Siddiqi, T., Tadmor, T., Troussard, X., Yi, C. A., Saglio, G., Roboz, G. J., Balic, K., Standifer, N., He, P., Marshall, S., Wilson, W., Pastan, I., Yao, N. S. & Giles, F., Aug 1 2018, In : Leukemia. 32, 8, p. 1768-1777 10 p.

Research output: Contribution to journalArticle

Hairy Cell Leukemia
Residual Neoplasm
Capillary Leak Syndrome
Disease Eradication
Purine Nucleosides
Tacrolimus
Graft vs Host Disease
Bone Marrow Transplantation
Transplantation
Arm

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M., Levis, M. J., Dezern, A., Gladstone, D., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek-Renaut, M., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

temozolomide
Acute Myeloid Leukemia
Methylation
Phosphorylation
Polymers

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K., Rudek-Renaut, M., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M., Gladstone, D., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Topotecan
Carboplatin
Leukemia
Neoplasms

Change in IgHV Mutational Status of CLL Suggests Origin From Multiple Clones

Osman, A., Gocke, C. & Gladstone, D., Feb 1 2017, In : Clinical Lymphoma, Myeloma and Leukemia. 17, 2, p. 97-99 3 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Clone Cells
Immunoglobulin Heavy Chains
Immunoglobulin Genes
Cohort Studies
Graft vs Host Disease
Cyclophosphamide
Transplantation
Recurrence
Bone Marrow
Hematopoietic Stem Cell Transplantation
Antibodies
Hematopoietic Stem Cells
Immunoassay
HLA Antigens
Homologous Transplantation
Bone Marrow Transplantation
Systemic Lupus Erythematosus
Cyclophosphamide
Transplantation

Low immunosuppressive burden after HLA-matched related or unrelated BMT using posttransplantation cyclophosphamide

Kanakry, C. G., Bolanos Meade, F. J., Kasamon, Y. L., Zahurak, M., Durakovic, N., Furlong, T., Mielcarek, M., Medeot, M., Gojo, I., Smith, B. D., Kanakry, J. A., Borrello, I. M., Brodsky, R. A., Gladstone, D., Huff, C. A., Matsui, W. H., Swinnen, L., Cooke, K. R., Ambinder, R. F., Fuchs, E. J. & 6 others, De Lima, M. J., Andersson, B. S., Varadhan, R., O'Donnell, P. V., Jones, R. J. & Luznik, L., Mar 9 2017, In : Blood. 129, 10, p. 1389-1393 5 p.

Research output: Contribution to journalArticle

Busulfan
Immunosuppressive Agents
Cyclophosphamide
Immunosuppression
Grafts
Histocompatibility
Homologous Transplantation
Bone Marrow Transplantation
Tissue Donors
Allografts

Pharmacokinetically-targeted dosed everolimus maintenance therapy in lymphoma patients

Schoch, L. K., Asiama, A., Zahurak, M., Shanbhag, S. P., Hurtt, J., Sawyer, K., Swinnen, L., Wagner-Johnston, N., Jones, R. J., Ambinder, R. F. & Gladstone, D., Dec 13 2017, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Lymphoma
Cyclophosphamide
Toxicity
Therapeutics
Serum
Open Access
Cyclophosphamide
Graft vs Host Disease
Unrelated Donors
Transplantation
Bone Marrow

Timed sequential therapy for acute myelogenous leukemia: Results of a retrospective study of 301 patients and review of the literature

Norsworthy, K. J., Dezern, A., Tsai, H. L., Hand, W. A., Varadhan, R., Gore, S. D., Gojo, I., Pratz, K., Carraway, H. E., Showel, M., McDevitt, M. A., Gladstone, D., Ghiaur, G., Prince, G., Seung, A. H., Benani, D., Levis, M. J., Karp, J. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 25-32 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Retrospective Studies
Cytarabine
Survival
Therapeutics
2016

Therapeutic drug monitoring for either oral or intravenous busulfan when combined with pre-and post-transplantation cyclophosphamide

Lombardi, L. R., Kanakry, C. G., Zahurak, M., Durakovic, N., Bolanos Meade, F. J., Kasamon, Y. L., Gladstone, D., Matsui, W., Borrello, I. M., Huff, C. A., Swinnen, L., Brodsky, R. A., Ambinder, R. F., Fuchs, E. J., Rosner, G., Jones, R. J. & Luznik, L., Mar 3 2016, In : Leukemia and Lymphoma. 57, 3, p. 666-675 10 p.

Research output: Contribution to journalArticle

Busulfan
Drug Monitoring
Cyclophosphamide
Transplantation
Pharmacokinetics
2015

A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor

Kern, J. B., Hii, A., Kruse, M. J., Szabo, Z., Argani, P., Hibbard, M. K., Gladstone, D., Meyer, C., Zheng, R., Borowitz, M. J. & Duffield, A. S., Feb 13 2015, In : International Journal of Surgical Pathology. 23, 1, p. 75-77 3 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Bone Marrow
Neoplasms
Rhabdomyosarcoma
Fluorodeoxyglucose F18

Donor HLA-specific Abs: To BMT or not to BMT?

Leffell, M. S., Jones, R. J. & Gladstone, D., Jun 4 2015, In : Bone Marrow Transplantation. 50, 6, p. 751-758 8 p.

Research output: Contribution to journalArticle

Tissue Donors
Plasmapheresis
Immunoassay
Transplantation
Transplants
Cyclophosphamide
Transplantation
Bone Marrow
Graft vs Host Disease
Disease-Free Survival

Pre-radiation lymphocyte harvesting and post-radiation reinfusion in patients with newly diagnosed high grade gliomas

Campian, J. L., Ye, X., Gladstone, D., Ambady, P., Nirschl, T. R., Borrello, I. M., Golightly, M., King, K. E., Holdhoff, M., Karp, J., Drake, C. G. & Grossman, S. A., Jun 13 2015, In : Journal of Neuro-Oncology. 124, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Lymphocyte Count
Glioma
Lymphopenia
Lymphocytes
Radiation

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

McCurdy, S. R., Kanakry, J. A., Showel, M., Tsai, H. L., Bolanos Meade, F. J., Rosner, G., Kanakry, C. G., Perica, K., Symons, H., Brodsky, R. A., Gladstone, D., Huff, C. A., Pratz, K., Prince, G. T., Dezern, A., Gojo, I., Matsui, W. H., Borrello, I. M., McDevitt, M. A., Swinnen, L. & 7 others, Smith, B. D., Levis, M. J., Ambinder, R. F., Luznik, L., Jones, R. J., Fuchs, E. J. & Kasamon, Y. L., May 7 2015, In : Blood. 125, 19, p. 3024-3031 8 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Blood
Transplantation
Bone Marrow
Disease-Free Survival
2014
Granulocyte-Macrophage Colony-Stimulating Factor
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferons
Cytogenetics
Protein-Tyrosine Kinases

Infusion of cryopreserved autologous lymphocytes using a standard peripheral i.v. catheter

Gladstone, D., Davis Sproul, J., Campian, J., Lemas, M. V., Malatyali, S., Borrello, I. M., King, K. E. & Grossman, S. A., 2014, In : Bone Marrow Transplantation. 49, 8, p. 1119-1120 2 p.

Research output: Contribution to journalArticle

Lymphocyte Transfusion
Central Venous Catheters
Cryopreservation
Autografts
Glioma

Poly(ADP-ribose) polymerase inhibitor CEP-8983 synergizes with bendamustine in chronic lymphocytic leukemia cells in vitro

Dilley, R. L., Poh, W., Gladstone, D., Herman, J. G., Showel, M., Karp, J., McDevitt, M. A. & Pratz, K., Mar 2014, In : Leukemia Research. 38, 3, p. 411-417 7 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
DNA Repair
Methylation
Cytogenetics
Chromosomal Instability
Graft vs Host Disease
Grafts
Cyclophosphamide
Transplantation
Bone Marrow

Sustained remission and reversal of end-organ dysfunction in a patient with anaplastic myeloma

Agrawal, M., Kanakry, J., Arnold, C. A., Suzman, D. L., Mathieu, L., Kasamon, Y. L., Gladstone, D., Ambinder, R. F. & Ghosh, N., 2014, In : Annals of Hematology. 93, 7, p. 1245-1246 2 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Remission Induction
Acute Liver Failure
Multiple Myeloma
Renal Insufficiency
Boronic Acids
Pyrazines
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Salvage Therapy
Adult T Cell Leukemia Lymphoma

Brief intensive therapy for older adults with newly diagnosed Burkitt or atypical Burkitt lymphoma/leukemia

Kasamon, Y. L., Brodsky, R. A., Borowitz, M. J., Ambinder, R. F., Crilley, P. A., Cho, S. Y., Tsai, H. L., Smith, B. D., Gladstone, D., Carraway, H. E., Huff, C. A., Matsui, W. H., Bolanos Meade, F. J., Jones, R. J. & Swinnen, L., Mar 2013, In : Leukemia and Lymphoma. 54, 3, p. 483-490 8 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Cyclophosphamide
Therapeutics
Anthracyclines
Cytarabine
Intravenous Immunoglobulins
Hemostasis
Maintenance
Lymphocytosis
Lymphoproliferative Disorders
Peripheral T-Cell Lymphoma
Transplantation
Bone Marrow
Tissue Donors
Confidence Intervals
HLA Antigens
Transplantation
Antibodies
Tissue Donors
Unrelated Donors
2012

Hematopoietic stem cell transplantation for chronic lymphocytic leukemia

Gladstone, D. & Fuchs, E. J., Mar 2012, In : Current Opinion in Oncology. 24, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
B-Cell Chronic Lymphocytic Leukemia
Homologous Transplantation
Transplants
Therapeutics

Phase 1 dose-escalation trial of clofarabine followed by escalating dose of fractionated cyclophosphamide in adults with relapsed or refractory acute leukaemias

Zeidan, A. M., Ricklis, R. M., Carraway, H. E., Yun, H. D., Greer, J. M., Smith, B. D., Levis, M. J., McDevitt, M. A., Pratz, K., Showel, M., Gladstone, D., Gore, S. D. & Karp, J., Jul 2012, In : British Journal of Haematology. 158, 2, p. 198-207 10 p.

Research output: Contribution to journalArticle

Cyclophosphamide
Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute Myeloid Leukemia
Neutrophils

Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma

Kasamon, Y. L., Jacene, H. A., Gocke, C., Swinnen, L., Gladstone, D., Perkins, B., Link, B. K., Popplewell, L. L., Habermann, T. M., Herman, J. M., Matsui, W. H., Jones, R. J. & Ambinder, R. F., May 3 2012, In : Blood. 119, 18, p. 4129-4132 4 p.

Research output: Contribution to journalArticle

Hodgkin Disease
B-Lymphocytes
Bleomycin
Cells
Human Herpesvirus 4

Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias

Karp, J., Thomas, B. M., Greer, J. M., Sorge, C., Gore, S. D., Pratz, K., Smith, B. D., Flatten, K. S., Peterson, K., Schneider, P., Mackey, K., Freshwater, T., Levis, M. J., McDevitt, M. A., Carraway, H. E., Gladstone, D., Showel, M., Loechner, S., Parry, D. A., Horowitz, J. A. & 2 others, Isaacs, R. & Kaufmann, S. H., Dec 15 2012, In : Clinical Cancer Research. 18, 24, p. 6723-6731 9 p.

Research output: Contribution to journalArticle

Cytarabine
Leukemia
S Phase
MK-8776
DNA Damage

Randomized phase II study of two schedules of flavopiridol given as timed sequential therapy with cytosine arabinoside and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia

Karp, J., Garrett-Mayer, E., Estey, E. H., Rudek-Renaut, M., Smith, B. D., Greer, J. M., Michelle Drye, D., Mackey, K., Dorcy, K. S., Gore, S. D., Levis, M. J., McDevitt, M. A., Carraway, H. E., Pratz, K., Gladstone, D., Showel, M., Othus, M., Austin Doyle, L., Wright, J. J. & Pagel, J. M., Nov 1 2012, In : Haematologica. 97, 11, p. 1736-1742 7 p.

Research output: Contribution to journalArticle

alvocidib
Mitoxantrone
Cytarabine
Acute Myeloid Leukemia
Appointments and Schedules

The importance of IGHV mutational status in del(11q) and del(17p) chronic lymphocytic leukemia

Gladstone, D., Blackford, A., Cho, E., Swinnen, L., Kasamon, Y., Gocke, C., Griffin, C. A., Bolanos Meade, F. J. & Jones, R. J., Apr 2012, In : Clinical Lymphoma, Myeloma and Leukemia. 12, 2, p. 132-137 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Cytogenetics
Survival

Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance

Harrison, D. M., Gladstone, D., Hammond, E., Cheng, J., Jones, R. J., Brodsky, R. A., Kerr, D., McArthur, J. C. & Kaplin, A. I., 2012, In : Multiple Sclerosis. 18, 2, p. 202-209 8 p.

Research output: Contribution to journalArticle

Relapsing-Remitting Multiple Sclerosis
Cyclophosphamide
Maintenance
Multiple Sclerosis
Recurrence
2011

High-dose chemotherapy and multiple sclerosis

Harrison, D. & Gladstone, D., Mar 2011, In : Current Opinion in Oncology. 23, 2, p. 221-226 6 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Stem Cells
Drug Therapy
Poisons
Immune System Diseases