Research output per year
Research output per year
- 48 results
Search results
-
2023
Oxidative stress in the mitochondrial matrix underlies ischemia/reperfusion-induced mitochondrial instability
Solhjoo, S., Liu, T., Sidor, A., Lee, D. I., O'Rourke, B. & Steenbergen, C., Jan 2023, In: Journal of Biological Chemistry. 299, 1, 102780.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
The mitochondrial regulator PGC1α is induced by cGMP–PKG signaling and mediates the protective effects of phosphodiesterase 5 inhibition in heart failure
Zhu, G., Ueda, K., Hashimoto, M., Zhang, M., Sasaki, M., Kariya, T., Sasaki, H., Kaludercic, N., Lee, D. I., Bedja, D., Gabrielson, M., Yuan, Y., Paolocci, N., Blanton, R. M., Karas, R. H., Mendelsohn, M. E., O’Rourke, B., Kass, D. A. & Takimoto, E., Jan 2022, In: FEBS Letters. 596, 1, p. 17-28 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
NAD+ Repletion Reverses Heart Failure with Preserved Ejection Fraction
Tong, D., Schiattarella, G. G., Jiang, N., Altamirano, F., Szweda, P. A., Elnwasany, A., Lee, D. I., Yoo, H., Kass, D. A., Szweda, L. I., Lavandero, S., Verdin, E., Gillette, T. G. & Hill, J. A., May 28 2021, In: Circulation research. 128, 11, p. 1629-1641 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2
Murphy, S. A., Miyamoto, M., Kervadec, A., Kannan, S., Tampakakis, E., Kambhampati, S., Lin, B., Paek, S., Andersen, P., Lee, D. I., Zhu, R., An, S., Kass, D. A., Uosaki, H., Colas, A. R. & Kwon, C., Dec 1 2021, In: Nature communications. 12, 1, 1648.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury
Ranek, M. J., Oeing, C., Sanchez-Hodge, R., Kokkonen-Simon, K. M., Dillard, D., Aslam, M. I., Rainer, P. P., Mishra, S., Dunkerly-Eyring, B., Holewinski, R. J., Virus, C., Zhang, H., Mannion, M. M., Agrawal, V., Hahn, V., Lee, D. I., Sasaki, M., Van Eyk, J. E., Willis, M. S., Page, R. C., & 2 others, Dec 1 2020, In: Nature communications. 11, 1, 5237.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
PKG1a Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy
Oeing, C. U., Nakamura, T., Pan, S., Mishra, S., Dunkerly-Eyring, B. L., Kokkonen-Simon, K. M., Lin, B. L., Chen, A., Zhu, G., Bedja, D., Lee, D. I., Kass, D. A. & Ranek, M. J., Jul 31 2020, In: Circulation research. 127, 4, p. 522-533 12 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2019
Chronic Atrial and Ventricular Pacing in the Mouse: Application to Model Cardiac Dyssynchrony and Resynchronization in Heart Failure
Ståhlberg, M., Nakagawa, R., Bedja, D., Zhu, G., Lin, B. L., Saberi, A., Lee, D. I. & Kass, D. A., Feb 1 2019, In: Circulation: Heart Failure. 12, 2, e005655.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Nitrosative stress drives heart failure with preserved ejection fraction
Schiattarella, G. G., Altamirano, F., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., Hill, T. M., Mammen, P. P. A., Huang, J., Lee, D. I., Hahn, V. S., Sharma, K., Kass, D. A., Lavandero, S., Gillette, T. G. & Hill, J. A., Apr 18 2019, In: Nature. 568, 7752, p. 351-356 6 p.Research output: Contribution to journal › Article › peer-review
Open Access119 Scopus citations -
Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway
Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D. I., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In: Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
Ranek, M. J., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In: Nature. 566, 7743, p. 264-269 6 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2018
Acute enhancement of cardiac function by phosphodiesterase type 1 inhibition translational study in the dog and rabbit
Hashimoto, T., Kim, G. E., Tunin, R. S., Adesiyun, T., Hsu, S., Nakagawa, R., Zhu, G., O'Brien, J. J., Hendrick, J. P., Davis, R. E., Yao, W., Beard, D., Hoxie, H. R., Wennogle, L. P., Lee, D. I. & Kass, D. A., 2018, In: Circulation. 138, 18, p. 1974-1987 14 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Pyun, J. H., Kim, H. J., Jeong, M. H., Ahn, B. Y., Vuong, T. A., Lee, D. I., Choi, S., Koo, S. H., Cho, H. & Kang, J. S., Dec 1 2018, In: Nature communications. 9, 1, 5107.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span
Patel, N. S., Klett, J., Pilarzyk, K., Lee, D. I., Kass, D., Menniti, F. S. & Kelly, M. P., May 2018, In: Neurobiology of aging. 65, p. 217-234 18 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease
Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M. J., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. I. & Kass, D. A., Aug 9 2018, In: JCI Insight. 3, 15, e121739.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function
Keceli, G., Majumdar, A., Thorpe, C. N., Jun, S., Tocchetti, C. G., Lee, D. I., Mahaney, J. E., Paolocci, N. & Toscano, J. P., Jun 4 2018, In: Journal of General Physiology. 151, 6, p. 758-770 13 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2017
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling
Jeong, M. H., Kim, H. J., Pyun, J. H., Choi, K. S., Lee, D. I., Solhjoo, S., O'Rourke, B., Tomaselli, G. F., Jeong, D. S., Cho, H. & Kang, J. S., Feb 21 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. E1345-E1354Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Divergent effects of miR-181 family members on myocardial function through protective cytosolic and detrimental mitochondrial microRNA targets
Das, S., Kohr, M., Dunkerly-Eyring, B., Lee, D. I., Bedja, D., Kent, O. A., Leung, A. K. L., Henao-Mejia, J., Flavell, R. A. & Steenbergen, C., 2017, In: Journal of the American Heart Association. 6, 3, e004694.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
Cho, G. S., Lee, D. I., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In: Cell Reports. 18, 2, p. 571-582 12 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice
Rouf, R., MacFarlane, E. G., Takimoto, E., Chaudhary, R., Nagpal, V., Rainer, P. P., Bindman, J. G., Gerber, E. E., Bedja, D., Schiefer, C., Miller, K. L., Zhu, G., Myers, L., Amat-Alarcon, N., Lee, D. I., Koitabashi, N., Judge, D. P., Kass, D. A. & Dietz, H. C., Aug 3 2017, In: JCI Insight. 2, 15, e91588.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2016
Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy
Kooij, V., Viswanathan, M. C., Lee, D. I., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E. & Cammarato, A., May 15 2016, In: Cardiovascular research. 110, 2, p. 238-248 11 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Saxagliptin and tadalafil differentially alter cyclic guanosine monophosphate (cGMP) signaling and left ventricular function in aortic-banded mini-swine
Hiemstra, J. A., Lee, D. I., Chakir, K., Gutiérrez-Aguilar, M., Marshall, K. D., Zgoda, P. J., Rivera, N. C., Dozier, D. G., Ferguson, B. S., Heublein, D. M., Burnett, J. C., Scherf, C., Ivey, J. R., Minervini, G., McDonald, K. S., Baines, C. P., Krenz, M., Domeier, T. L. & Emter, C. A., Apr 1 2016, In: Journal of the American Heart Association. 5, 4, e003277.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2015
Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate
Thoonen, R., Giovanni, S., Govindan, S., Lee, D. I., Wang, G. R., Calamaras, T. D., Takimoto, E., Kass, D. A., Sadayappan, S. & Blanton, R. M., Nov 1 2015, In: Circulation: Heart Failure. 8, 6, p. 1115-1122 8 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
Lee, D. I., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M. J., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In: Nature. 519, 7544, p. 472-476 5 p.Research output: Contribution to journal › Article › peer-review
Open Access165 Scopus citations -
Prevention of PKG1a oxidation augments cardioprotection in the stressed heart
Nakamura, T., Ranek, M. J., Lee, D. I., Hahn, V. S., Kim, C., Eaton, P. & Kass, D. A., Jun 1 2015, In: Journal of Clinical Investigation. 125, 6, p. 2468-2472 5 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Transcriptional Landscape of Cardiomyocyte Maturation
Uosaki, H., Cahan, P., Lee, D. I., Wang, S., Miyamoto, M., Fernandez, L., Kass, D. A. & Kwon, C., Nov 24 2015, In: Cell Reports. 13, 8, p. 1705-1716 12 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
2014
Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction
Rainer, P. P., Hao, S., Vanhoutte, D., Lee, D. I., Koitabashi, N., Molkentin, J. D. & Kass, D. A., 2014, In: Circulation research. 114, 8, p. 1246-1257 12 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy
Seo, K., Rainer, P. P., Hahn, V. S., Lee, D. I., Jo, S. H., Andersen, A., Liu, T., Xu, X., Willette, R. N., Lepore, J. J., Marino, J. P., Birnbaumer, L., Schnackenberg, C. G. & Kass, D. A., Jan 28 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 4, p. 1551-1556 6 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Erratum: Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 4, (1551-1556) doi:10.1073/pnas.1308963111)
Seo, K., Rainer, P. P., Hahn, V. S., Lee, D. I., Jo, S. H., Andersen, A., Liu, T., Xu, X., Willette, R. N., Lepore, J. J., Marino, J. P., Birnbaumer, L., Schnackenberg, C. G. & Kass, D. A., Apr 22 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 16, p. 6115 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cgmp-protein kinase g modulation
Seo, K., Rainer, P. P., Lee, D. I., Hao, S., Bedja, D., Birnbaumer, L., Cingolani, O. H. & Kass, D. A., Feb 28 2014, In: Circulation research. 114, 5, p. 823-832 10 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
PDE5 inhibitor efficacy is estrogen dependent in female heart disease
Sasaki, H., Nagayama, T., Blanton, R. M., Seo, K., Zhang, M., Zhu, G., Lee, D. I., Bedja, D., Hsu, S., Tsukamoto, O., Takashima, S., Kitakaze, M., Mendelsohn, M. E., Karas, R. H., Kass, D. A. & Takimoto, E., Jun 2 2014, In: Journal of Clinical Investigation. 124, 6, p. 2464-2471 8 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Precardiac deletion of numb and numblike reveals renewal of cardiac progenitors
Shenje, L. T., Andersen, P., Uosaki, H., Fernandez, L., Rainer, P. P., Cho, G. S., Lee, D. I., Zhong, W., Harvey, R. P., Kass, D. A. & Kwon, C., Apr 24 2014, In: eLife. 2014, 3, e02164.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2013
HNO Enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization
Sivakumaran, V., Stanley, B. A., Tocchetti, C. G., Ballin, J. D., Caceres, V., Zhou, L., Keceli, G., Rainer, P. P., Lee, D. I., Huke, S., Ziolo, M. T., Kranias, E. G., Toscano, J. P., Wilson, G. M., O'Rourke, B., Kass, D. A., Mahaney, J. E. & Paolocci, N., Oct 10 2013, In: Antioxidants and Redox Signaling. 19, 11, p. 1185-1197 13 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
2012
Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling
Zhang, M., Takimoto, E., Lee, D. I., Santos, C. X. C., Nakamura, T., Hsu, S., Jiang, A., Nagayama, T., Bedja, D., Yuan, Y., Eaton, P., Shah, A. M. & Kass, D. A., Aug 21 2012, In: Circulation. 126, 8, p. 942-951 10 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Phosphodiesterases and cyclic GMP regulation in heart muscle
Lee, D. I. & Kass, D. A., Aug 1 2012, In: Physiology. 27, 4, p. 248-258 11 p.Research output: Contribution to journal › Review article › peer-review
34 Scopus citations -
2011
Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle short communication
Cingolani, O. H., Kirk, J. A., Seo, K., Koitabashi, N., Lee, D. I., Ramirez-Correa, G., Bedja, D., Barth, A. S., Moens, A. L. & Kass, D. A., Dec 9 2011, In: Circulation research. 109, 12, p. 1410-1414 5 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
2010
Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5
Zhang, M., Takimoto, E., Hsu, S., Lee, D. I., Nagayama, T., Danner, T., Koitabashi, N., Barth, A. S., Bedja, D., Gabrielson, K. L., Wang, Y. & Kass, D. A., Dec 7 2010, In: Journal of the American College of Cardiology. 56, 24, p. 2021-2030 10 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
PDE5A suppression of acute β-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin i phosphorylation
Lee, D. I., Vahebi, S., Tocchetti, C. G., Barouch, L. A., Solaro, R. J., Takimoto, E. & Kass, D. A., May 2010, In: Basic Research in Cardiology. 105, 3, p. 337-347 11 p.Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
2009
Activation of (Na + + K +)-ATPase modulates cardiac L-type Ca 2+ channel function
Lee, D. I., Klein, M. G., Zhu, W., Xiao, R. P., Gerzanich, V. & Xu, K. Y., Apr 2009, In: Molecular Pharmacology. 75, 4, p. 774-781 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
The relationship of neuroendocrine carcinomas to anti-tumor therapies in TRAMP mice
Tang, Y., Wang, L., Goloubeva, O., Khan, M. A., Lee, D. I. & Hussain, A., Dec 1 2009, In: Prostate. 69, 16, p. 1763-1773 11 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
2008
Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl
Froehlich, J. P., Mahaney, J. E., Keceli, G., Pavlos, C. M., Goldstein, R., Redwood, A. J., Sumbilla, C., Lee, D. I., Tocchetti, C. G., Kass, D. A., Paolocci, N. & Toscano, J. P., Dec 16 2008, In: Biochemistry. 47, 50, p. 13150-13152 3 p.Research output: Contribution to journal › Article › peer-review
76 Scopus citations -
2007
Mechanisms of resistance and adaptation to thapsigargin in androgen-independent prostate cancer PC3 and DU145 cells
Lee, D. I., Sumbilla, C., Lee, M., Natesavelalar, C., Klein, M. G., Ross, D. D., Inesi, G. & Hussain, A., Aug 1 2007, In: Archives of Biochemistry and Biophysics. 464, 1, p. 19-27 9 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca 2+ signaling in neonatal rat cardiac myocytes
Prasad, A. M., Ma, H., Sumbilla, C., Lee, D. I., Klein, M. G. & Inesi, G., Jun 2007, In: American Journal of Physiology - Cell Physiology. 292, 6, p. C2269-C2275Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
2006
Docetaxel followed by castration improves outcomes in LNCaP prostate cancer - Bearing severe combined immunodeficient mice
Tang, Y., Khan, M. A., Goloubeva, O., Lee, D. I., Jelovac, D., Brodie, A. M. & Hussain, A., Jan 1 2006, In: Clinical Cancer Research. 12, 1, p. 169-174 6 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Thapsigargin resistance in human prostate cancer cells
O'Neill, J. P., Velalar, C. N., Lee, D. I., Zhang, B., Nakanishi, T., Tang, Y., Selaru, F., Ross, D., Meltzer, S. J. & Hussain, A., Aug 1 2006, In: Cancer. 107, 3, p. 649-659 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
2002
Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway
He, Q., Lee, D. I., Rong, R., Yu, M., Luo, X., Klein, M., El-Deiry, W. S., Huang, Y., Hussain, A. & Sheikh, M. S., Apr 18 2002, In: Oncogene. 21, 17, p. 2623-2633 11 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
2001
Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa
Lillehoj, E. P., Hyun, S. W., Kim, B. T., Zhang, X. G., Lee, D. I., Rowland, S. & Kim, K. C., Jan 2001, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 280, 1 24-1, p. L181-L187Research output: Contribution to journal › Article › peer-review
98 Scopus citations -
1998
Identification and characterization of high molecular-mass mucin-like glycoproteins in the plasma membrane of airway epithelial cells
Paul, E., Lee, D. I., Hyun, S. W., Gendler, S. & Kim, K. C., 1998, In: American journal of respiratory cell and molecular biology. 19, 4, p. 681-690 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
1996
Cloning and characterization of cDNAs coding for heavy and light chains of a monoclonal antibody (MabB23) specific for human plasma apolipoprotein B-100
Kwak, J. W., Choi, B. K., Lee, D., Kang, Y. K., Seo, Y. G., Cho, W. K. & Han, M. H., Mar 9 1996, In: Gene. 169, 2, p. 237239 1 p.Research output: Contribution to journal › Article › peer-review