Dominique P Frueh

Associate Professor

19972018
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Research Output 1997 2018

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Article
2017
Nuclear magnetic resonance
Proteins
Inspection
Molecules

Molecular Cross-Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions

Harden, B. J. & Frueh, D. P., Apr 4 2017, In : ChemBioChem. 18, 7, p. 629-632 4 p.

Research output: Contribution to journalArticle

Peptide Synthases
Carrier Proteins
Substrates
Post Translational Protein Processing
Biological Products

Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication

Goodrich, A. C., Meyers, D. J. & Frueh, D. P., Jun 16 2017, In : Journal of Biological Chemistry. 292, 24, p. 10002-10013 12 p.

Research output: Contribution to journalArticle

Peptide Synthases
Carrier Proteins
Communication
Chemical modification
Proteins
2016

15N Heteronuclear Chemical Exchange Saturation Transfer MRI

Zeng, H., Xu, J., Yadav, N. N., McMahon, M. T., Harden, B., Frueh, D. & Van Zijl, P. C. M., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11136-11139 4 p.

Research output: Contribution to journalArticle

Magnetic resonance imaging
Protons
Water
Molecules
Proton transfer
2015

A nuclear magnetic resonance method for probing molecular influences of substrate loading in nonribosomal peptide synthetase carrier proteins

Goodrich, A. C. & Frueh, D. P., Feb 10 2015, In : Biochemistry®. 54, 5, p. 1154-1156 3 p.

Research output: Contribution to journalArticle

Peptide Synthases
Carrier Proteins
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Substrates

Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps

Mishra, S. H. & Frueh, D. P., May 8 2015, In : Journal of Biomolecular NMR. 62, 3, p. 281-290 10 p.

Research output: Contribution to journalArticle

Amides
Nuclear magnetic resonance
Proteins
Peptide Synthases
Isoleucine

Effortless assignment with 4D covariance sequential correlation maps

Harden, B. J., Mishra, S. H. & Frueh, D. P., Nov 1 2015, In : Journal of Magnetic Resonance. 260, p. 83-88 6 p., 5720.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Peptide Synthases
Cyclization
proteins

Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts

Goodrich, A. C., Harden, B. J. & Frueh, D. P., Sep 23 2015, In : Journal of the American Chemical Society. 137, 37, p. 12100-12109 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Peptides
Carrier Proteins
Substrates
Prosthetics
2014

A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins

Mishra, S. H., Harden, B. J. & Frueh, D. P., Dec 15 2014, In : Journal of Biomolecular NMR. 60, 4, p. 265-274 10 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Experiments
Spectral resolution
Structural Models

Facilitated assignment of large protein NMR signals with covariance sequential spectra using spectral derivatives

Harden, B. J., Nichols, S. R. & Frueh, D. P., Sep 24 2014, In : Journal of the American Chemical Society. 136, 38, p. 13106-13109 4 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Derivatives
Proteins
Peptide Synthases
Nuclear magnetic resonance
proteins
Proteins
nuclear magnetic resonance
ambiguity

SARA: A software environment for the analysis of relaxation data acquired with accordion spectroscopy

Harden, B. J. & Frueh, D. P., Feb 2014, In : Journal of Biomolecular NMR. 58, 2, p. 83-99 17 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Software
Spectroscopy
Nuclear magnetic resonance
Network protocols
2013

NMR methods for structural studies of large monomeric and multimeric proteins

Frueh, D. P., Goodrich, A. C., Mishra, S. H. & Nichols, S. R., Oct 2013, In : Current Opinion in Structural Biology. 23, 5, p. 734-739 6 p.

Research output: Contribution to journalArticle

Proteins
Speech Disorders
2011

Global dynamic conformational changes in the suppressor domain of IP 3 receptor by stepwise binding of the two lobes of calmodulin

Kang, S., Kwon, H., Wen, H., Song, Y., Frueh, D., Ahn, H. C., Yoo, S. H., Wagner, G. & Park, S., Mar 2011, In : FASEB Journal. 25, 3, p. 840-850 11 p.

Research output: Contribution to journalArticle

Calmodulin
Calcium
Nuclear magnetic resonance
Inositol 1,4,5-Trisphosphate Receptors
Experiments

Hidden in plain sight: Subtle effects of the 8-oxoguanine lesion on the structure, dynamics, and thermodynamics of a 15-base pair oligodeoxynucleotide duplex

Crenshaw, C. M., Wade, J. E., Arthanari, H., Frueh, D., Lane, B. F. & Núñez, M. E., Oct 4 2011, In : Biochemistry®. 50, 39, p. 8463-8477 15 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Cytosine
Thermodynamics
Base Pairing
Guanine
2010
Dihedral angle
Glycerol
Labeling
Amino Acids
Experiments

High-resolution 3D CANCA NMR experiments for complete mainchain assignments using Cα direct detection

Takeuchi, K., Frueh, D. P., Hyberts, S. G., Sun, Z. Y. J. & Wagner, G., Mar 10 2010, In : Journal of the American Chemical Society. 132, 9, p. 2945-2951 7 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Carbon
Proteins
Nitrogen
Experiments

Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability

Shaw, B. F., Arthanari, H., Narovlyansky, M., Durazo, A., Frueh, D. P., Pollastri, M. P., Lee, A., Bilgicer, B., Gygi, S. P., Wagner, G. & Whitesides, G. M., Dec 15 2010, In : Journal of the American Chemical Society. 132, 49, p. 17411-17425 15 p.

Research output: Contribution to journalArticle

Amides
Deuterium
Hydrogen
Membrane Proteins
Acetylation

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments

Takeuchi, K., Heffron, G., Sun, Z. Y. J., Frueh, D. P. & Wagner, G., Aug 2010, In : Journal of Biomolecular NMR. 47, 4, p. 271-282 12 p.

Research output: Contribution to journalArticle

Amides
Nitrogen
Nuclear magnetic resonance
Proteins
Experiments
2009

A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins

Frueh, D. P., Arthanari, H., Koglin, A., Walsh, C. T. & Wagner, G., Sep 16 2009, In : Journal of the American Chemical Society. 131, 36, p. 12880-12881 2 p.

Research output: Contribution to journalArticle

Peptide Synthases
Proteins
Amides
Protons
Nitrogen

FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation

Hyberts, S. G., Frueh, D. P., Arthanari, H. & Wagner, G., 2009, In : Journal of Biomolecular NMR. 45, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

Distillation
Optical resolving power
Entropy
Nuclear magnetic resonance
Proteins

Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in 15N-13C-ILV methyl labeled proteins

Frueh, D. P., Leed, A., Arthanari, H., Koglin, A., Walsh, C. T. & Wagner, G., 2009, In : Journal of Biomolecular NMR. 45, 3, p. 311-318 8 p.

Research output: Contribution to journalArticle

Proteins
Experiments
Protons
2008

A nuclear receptor-like pathway regulating multidrug resistance in fungi

Thakur, J. K., Arthanari, H., Yang, F., Pan, S. J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., Struhl, K., Moye-Rowley, W. S., Cormack, B. P., Wagner, G. & Näär, A. M., Apr 3 2008, In : Nature. 452, 7187, p. 604-609 6 p.

Research output: Contribution to journalArticle

Multiple Drug Resistance
Cytoplasmic and Nuclear Receptors
Fungi
Mycoses
Xenobiotics

Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase

Frueh, D. P., Arthanari, H., Koglin, A., Vosburg, D. A., Bennett, A. E., Walsh, C. T. & Wagner, G., Aug 14 2008, In : Nature. 454, 7206, p. 903-906 4 p.

Research output: Contribution to journalArticle

Peptide Synthases
Polyketide Synthases
Fatty Acid Synthases
Enterobactin
Holoenzymes

Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: Implications for receptor regulation

Kang, S., Kang, J., Kwon, H., Frueh, D., Seung, H. Y., Wagner, G. & Park, S., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25567-25575 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Oxidation-Reduction
Oxidation
Conformations
Glutathione Disulfide

Fourier synthesis techniques for NMR spectroscopy in inhomogeneous fields

Arthanari, H., Frueh, D. P., Wagner, G., Pryor, B. & Khaneja, N., 2008, In : The Journal of Chemical Physics. 128, 21, 214503.

Research output: Contribution to journalArticle

Nuclear magnetic resonance spectroscopy
Magnetic fields
nuclear magnetic resonance
synthesis
Spatial distribution

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

Selenko, P., Frueh, D. P., Elsaesser, S. J., Haas, W., Gygi, S. P. & Wagner, G., Mar 2008, In : Nature structural & molecular biology. 15, 3, p. 321-329 9 p.

Research output: Contribution to journalArticle

Casein Kinase II
Magnetic Resonance Spectroscopy
Phosphorylation
Observation
Phosphotransferases

Selective polarization transfer using a single rf field

Rey Castellanos, E. R., Frueh, D. P. & Wist, J., 2008, In : The Journal of Chemical Physics. 129, 1, 014504.

Research output: Contribution to journalArticle

Polarization
polarization
Experiments
cross polarization
population inversion

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

Koglin, A., Löhr, F., Bernhard, F., Rogov, V. V., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V., Aug 14 2008, In : Nature. 454, 7206, p. 907-911 5 p.

Research output: Contribution to journalArticle

Peptide Synthases
Polyketide Synthases
Enzymes
Palmitoyl-CoA Hydrolase
Bacteria
2007

NMR Methods for Studying Protein-Protein Interactions Involved in Translation Initiation

Marintchev, A., Frueh, D. P. & Wagner, G., 2007, In : Methods in Enzymology. 430, p. 283-331 49 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Molecules
RNA
Technology
2006

Determination of all nOes in 1H-13 C-Me-ILV-U-2H-15N proteins with two time-shared experiments

Frueh, D. P., Vosburg, D. A., Walsh, C. T. & Wagner, G., Jan 2006, In : Journal of Biomolecular NMR. 34, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Protons
Amides
Proteins
Experiments
Chemical shift

Mapping of the Auto-inhibitory Interactions of Protein Kinase R by Nuclear Magnetic Resonance

Gelev, V., Aktas, H., Marintchev, A., Ito, T., Frueh, D., Hemond, M., Rovnyak, D., Debus, M., Hyberts, S., Usheva, A., Halperin, J. & Wagner, G., Dec 1 2006, In : Journal of Molecular Biology. 364, 3, p. 352-363 12 p.

Research output: Contribution to journalArticle

Protein Kinases
Phosphotransferases
Magnetic Resonance Spectroscopy
eIF-2 Kinase
Interferons

Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins

Frueh, D. P., Sun, Z. Y. J., Vosburg, D. A., Walsh, C. T., Hoch, J. C. & Wagner, G., May 3 2006, In : Journal of the American Chemical Society. 128, 17, p. 5757-5763 7 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Anisotropy
Signal-To-Noise Ratio
Entropy
2005

Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling

Sun, Z. Y. J., Frueh, D. P., Selenko, P., Hoch, J. C. & Wagner, G., Sep 2005, In : Journal of Biomolecular NMR. 33, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Amides
Sampling
Proteins
Experiments
Nuclear magnetic resonance

Sensitivity enhancement in NMR of macromolecules by application of optimal control theory

Frueh, D. P., Ito, T., Li, J. S., Wagner, G., Glaser, S. J. & Khaneja, N., May 2005, In : Journal of Biomolecular NMR. 32, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Macromolecules
Control theory
Nuclear magnetic resonance
Biological systems
Experiments

Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment

Frueh, D. P., Arthanari, H. & Wagner, G., Nov 2005, In : Journal of Biomolecular NMR. 33, 3, p. 187-196 10 p.

Research output: Contribution to journalArticle

Nuclear magnetic resonance
Proteins
Experiments
Amides
Stairs
2004

Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction

Rovnyak, D., Frueh, D. P., Sastry, M., Sun, Z. Y. J., Stern, A. S., Hoch, J. C. & Wagner, G., Sep 2004, In : Journal of Magnetic Resonance. 170, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

Entropy
Carbon Monoxide
acquisition
sampling
entropy

Evidence of slow motions by cross-correlated chemical shift modulation in deuterated and protonated proteins

Vugmeyster, L., Perazzolo, C., Wist, J., Frueh, D. & Bodenhausen, G., Feb 2004, In : Journal of Biomolecular NMR. 28, 2, p. 173-177 5 p.

Research output: Contribution to journalArticle

Chemical shift
Ubiquitin
Ubiquitin C
Modulation
Biomolecules

Triple quantum decoherence under multiple refocusing: Slow correlated chemical shift modulations of C′ and N nuclei in proteins

Wist, J., Frueh, D., Tolman, J. R. & Bodenhausen, G., Mar 2004, In : Journal of Biomolecular NMR. 28, 3, p. 263-272 10 p.

Research output: Contribution to journalArticle

Pulse repetition rate
Chemical shift
Amides
Nitrogen
Heart Rate
2002

Internal motions in proteins and interference effects in nuclear magnetic resonance

Frueh, D., Dec 2 2002, In : Progress in Nuclear Magnetic Resonance Spectroscopy. 41, 3-4, p. 305-324 20 p.

Research output: Contribution to journalArticle

Measurement of long-range cross-correlation rates using a combination of single- and multiple-quantum NMR spectroscopy in one experiment

Frueh, D. P., Chiarparin, E., Pelupessy, P. & Bodenhausen, G., Apr 17 2002, In : Journal of the American Chemical Society. 124, 15, p. 4050-4057 8 p.

Research output: Contribution to journalArticle

Amides
Nuclear magnetic resonance spectroscopy
Protons
Magnetic Resonance Spectroscopy
Hydrogen

Temperature dependence of internucleotide nitrogen-nitrogen scalar couplings in RNA

Bytchenkoff, D., Chiarparin, E., Frueh, D. P., Rüdisser, S. & Bodenhausen, G., May 1 2002, In : Magnetic Resonance in Chemistry. 40, 5, p. 377-379 3 p.

Research output: Contribution to journalArticle

Uracil
Adenine
RNA
Nitrogen
Cytosine
2001

Cross-correlated chemical shift modulation: A signature of slow internal motions in proteins

Frueh, D. P., Tolman, J. R., Bodenhausen, G. & Zwahlen, C., 2001, In : Journal of the American Chemical Society. 123, 20, p. 4810-4816 7 p.

Research output: Contribution to journalArticle

Chemical shift
Modulation
Proteins
Dihedral angle
Ubiquitin
1999

Identification of Spin Diffusion Pathways in Isotopically Labeled Biomolecules

Eykyn, T. R., Früh, D. & Bodenhausen, G., Jun 1999, In : Journal of Magnetic Resonance. 138, 2, p. 330-333 4 p.

Research output: Contribution to journalArticle

Biomolecules
Ubiquitin
Macromolecules
Experiments
macromolecules
1997
Lanthanoid Series Elements
Isomerization
Kinetic parameters
Bearings (structural)
Nuclear magnetic resonance