Dominique P Frueh

Associate Professor

19972018

Research output per year

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Research Output

2018

Covariance NMR processing and analysis for protein assignment

Harden, B. J. & Frueh, D. P., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1688. p. 353-373 21 p. (Methods in Molecular Biology; vol. 1688).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Molecular Cross-Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions

Harden, B. J. & Frueh, D. P., Apr 4 2017, In : ChemBioChem. 18, 7, p. 629-632 4 p.

Research output: Contribution to journalArticle

Molecular impact of covalent modifications on nonribosomal peptide synthetase carrier protein communication

Goodrich, A. C., Meyers, D. J. & Frueh, D. P., Jun 16 2017, In : Journal of Biological Chemistry. 292, 24, p. 10002-10013 12 p.

Research output: Contribution to journalArticle

2016

15N Heteronuclear Chemical Exchange Saturation Transfer MRI

Zeng, H., Xu, J., Yadav, N. N., Mcmahon, M. T., Harden, B., Frueh, D. P. & Van Zijl, P. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11136-11139 4 p.

Research output: Contribution to journalArticle

2015

A nuclear magnetic resonance method for probing molecular influences of substrate loading in nonribosomal peptide synthetase carrier proteins

Goodrich, A. C. & Frueh, D. P., Feb 10 2015, In : Biochemistry. 54, 5, p. 1154-1156 3 p.

Research output: Contribution to journalArticle

Assignment of methyl NMR resonances of a 52 kDa protein with residue-specific 4D correlation maps

Mishra, S. H. & Frueh, D. P., May 8 2015, In : Journal of Biomolecular NMR. 62, 3, p. 281-290 10 p.

Research output: Contribution to journalArticle

Effortless assignment with 4D covariance sequential correlation maps

Harden, B. J., Mishra, S. H. & Frueh, D. P., Nov 1 2015, In : Journal of Magnetic Resonance. 260, p. 83-88 6 p., 5720.

Research output: Contribution to journalArticle

Solution Structure of a Nonribosomal Peptide Synthetase Carrier Protein Loaded with Its Substrate Reveals Transient, Well-Defined Contacts

Goodrich, A. C., Harden, B. J. & Frueh, D. P., Sep 23 2015, In : Journal of the American Chemical Society. 137, 37, p. 12100-12109 10 p.

Research output: Contribution to journalArticle

2014

A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins

Mishra, S. H., Harden, B. J. & Frueh, D. P., Dec 15 2014, In : Journal of Biomolecular NMR. 60, 4, p. 265-274 10 p.

Research output: Contribution to journalArticle

Facilitated assignment of large protein NMR signals with covariance sequential spectra using spectral derivatives

Harden, B. J., Nichols, S. R. & Frueh, D. P., Sep 24 2014, In : Journal of the American Chemical Society. 136, 38, p. 13106-13109 4 p.

Research output: Contribution to journalArticle

Resonance assignments and structure determination of large and challenging proteins

Goodrich, A. C., Nichols, S. R. & Frueh, D. P., 2014, In : eMagRes. 3, 2, p. 129-138 10 p.

Research output: Contribution to journalReview article

SARA: A software environment for the analysis of relaxation data acquired with accordion spectroscopy

Harden, B. J. & Frueh, D. P., Feb 1 2014, In : Journal of Biomolecular NMR. 58, 2, p. 83-99 17 p.

Research output: Contribution to journalArticle

2013

NMR methods for structural studies of large monomeric and multimeric proteins

Frueh, D. P., Goodrich, A. C., Mishra, S. H. & Nichols, S. R., Oct 1 2013, In : Current Opinion in Structural Biology. 23, 5, p. 734-739 6 p.

Research output: Contribution to journalReview article

2011

Global dynamic conformational changes in the suppressor domain of IP 3 receptor by stepwise binding of the two lobes of calmodulin

Kang, S., Kwon, H., Wen, H., Song, Y., Frueh, D. P., Ahn, H. C., Yoo, S. H., Wagner, G. & Park, S., Mar 2011, In : FASEB Journal. 25, 3, p. 840-850 11 p.

Research output: Contribution to journalArticle

Hidden in plain sight: Subtle effects of the 8-oxoguanine lesion on the structure, dynamics, and thermodynamics of a 15-base pair oligodeoxynucleotide duplex

Crenshaw, C. M., Wade, J. E., Arthanari, H., Frueh, D. P., Lane, B. F. & Núñez, M. E., Oct 4 2011, In : Biochemistry®. 50, 39, p. 8463-8477 15 p.

Research output: Contribution to journalArticle

2010

High-resolution 3D CANCA NMR experiments for complete mainchain assignments using Cα direct detection

Takeuchi, K., Frueh, D. P., Hyberts, S. G., Sun, Z. Y. J. & Wagner, G., Mar 10 2010, In : Journal of the American Chemical Society. 132, 9, p. 2945-2951 7 p.

Research output: Contribution to journalArticle

Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability

Shaw, B. F., Arthanari, H., Narovlyansky, M., Durazo, A., Frueh, D. P., Pollastri, M. P., Lee, A., Bilgicer, B., Gygi, S. P., Wagner, G. & Whitesides, G. M., Dec 15 2010, In : Journal of the American Chemical Society. 132, 49, p. 17411-17425 15 p.

Research output: Contribution to journalArticle

Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments

Takeuchi, K., Heffron, G., Sun, Z. Y. J., Frueh, D. P. & Wagner, G., Aug 2010, In : Journal of Biomolecular NMR. 47, 4, p. 271-282 12 p.

Research output: Contribution to journalArticle

2009

A double TROSY hNCAnH experiment for efficient assignment of large and challenging proteins

Frueh, D. P., Arthanari, H., Koglin, A., Walsh, C. T. & Wagner, G., Sep 16 2009, In : Journal of the American Chemical Society. 131, 36, p. 12880-12881 2 p.

Research output: Contribution to journalArticle

FM reconstruction of non-uniformly sampled protein NMR data at higher dimensions and optimization by distillation

Hyberts, S. G., Frueh, D. P., Arthanari, H. & Wagner, G., 2009, In : Journal of Biomolecular NMR. 45, 3, p. 283-294 12 p.

Research output: Contribution to journalArticle

Time-shared HSQC-NOESY for accurate distance constraints measured at high-field in 15N-13C-ILV methyl labeled proteins

Frueh, D. P., Leed, A., Arthanari, H., Koglin, A., Walsh, C. T. & Wagner, G., 2009, In : Journal of Biomolecular NMR. 45, 3, p. 311-318 8 p.

Research output: Contribution to journalArticle

2008

A nuclear receptor-like pathway regulating multidrug resistance in fungi

Thakur, J. K., Arthanari, H., Yang, F., Pan, S. J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., Struhl, K., Moye-Rowley, W. S., Cormack, B. P., Wagner, G. & Näär, A. M., Apr 3 2008, In : Nature. 452, 7187, p. 604-609 6 p.

Research output: Contribution to journalArticle

Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase

Frueh, D. P., Arthanari, H., Koglin, A., Vosburg, D. A., Bennett, A. E., Walsh, C. T. & Wagner, G., Aug 14 2008, In : Nature. 454, 7206, p. 903-906 4 p.

Research output: Contribution to journalArticle

Effects of redox potential and Ca2+ on the inositol 1,4,5-trisphosphate receptor L3-1 loop region: Implications for receptor regulation

Kang, S., Kang, J., Kwon, H., Frueh, D., Seung, H. Y., Wagner, G. & Park, S., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25567-25575 9 p.

Research output: Contribution to journalArticle

Fourier synthesis techniques for NMR spectroscopy in inhomogeneous fields

Arthanari, H., Frueh, D., Wagner, G., Pryor, B. & Khaneja, N., Jun 13 2008, In : Journal of Chemical Physics. 128, 21, 214503.

Research output: Contribution to journalArticle

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

Selenko, P., Frueh, D. P., Elsaesser, S. J., Haas, W., Gygi, S. P. & Wagner, G., Mar 2008, In : Nature structural & molecular biology. 15, 3, p. 321-329 9 p.

Research output: Contribution to journalArticle

Selective polarization transfer using a single rf field

Rey Castellanos, E. R., Frueh, D. P. & Wist, J., 2008, In : The Journal of Chemical Physics. 129, 1, 014504.

Research output: Contribution to journalArticle

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

Koglin, A., Löhr, F., Bernhard, F., Rogov, V. V., Frueh, D. P., Strieter, E. R., Mofid, M. R., Güntert, P., Wagner, G., Walsh, C. T., Marahiel, M. A. & Dötsch, V., Aug 14 2008, In : Nature. 454, 7206, p. 907-911 5 p.

Research output: Contribution to journalArticle

2007

NMR Methods for Studying Protein-Protein Interactions Involved in Translation Initiation

Marintchev, A., Frueh, D. & Wagner, G., Jan 1 2007, Translation Initiation: Reconstituted Systems and Biophysical Methods. Academic Press Inc., p. 283-331 49 p. (Methods in Enzymology; vol. 430).

Research output: Chapter in Book/Report/Conference proceedingChapter

2006

Determination of all nOes in 1H-13 C-Me-ILV-U-2H-15N proteins with two time-shared experiments

Frueh, D. P., Vosburg, D. A., Walsh, C. T. & Wagner, G., Jan 1 2006, In : Journal of Biomolecular NMR. 34, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Mapping of the Auto-inhibitory Interactions of Protein Kinase R by Nuclear Magnetic Resonance

Gelev, V., Aktas, H., Marintchev, A., Ito, T., Frueh, D. P., Hemond, M., Rovnyak, D., Debus, M., Hyberts, S., Usheva, A., Halperin, J. & Wagner, G., Dec 1 2006, In : Journal of Molecular Biology. 364, 3, p. 352-363 12 p.

Research output: Contribution to journalArticle

Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins

Frueh, D. P., Sun, Z. Y. J., Vosburg, D. A., Walsh, C. T., Hoch, J. C. & Wagner, G., May 3 2006, In : Journal of the American Chemical Society. 128, 17, p. 5757-5763 7 p.

Research output: Contribution to journalArticle

2005

Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling

Sun, Z. Y. J., Frueh, D. P., Selenko, P., Hoch, J. C. & Wagner, G., Sep 2005, In : Journal of Biomolecular NMR. 33, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Sensitivity enhancement in NMR of macromolecules by application of optimal control theory

Frueh, D. P., Ito, T., Li, J. S., Wagner, G., Glaser, S. J. & Khaneja, N., May 2005, In : Journal of Biomolecular NMR. 32, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Unambiguous assignment of NMR protein backbone signals with a time-shared triple-resonance experiment

Frueh, D. P., Arthanari, H. & Wagner, G., Nov 1 2005, In : Journal of Biomolecular NMR. 33, 3, p. 187-196 10 p.

Research output: Contribution to journalArticle

2004

Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction

Rovnyak, D., Frueh, D. P., Sastry, M., Sun, Z. Y. J., Stern, A. S., Hoch, J. C. & Wagner, G., Sep 1 2004, In : Journal of Magnetic Resonance. 170, 1, p. 15-21 7 p.

Research output: Contribution to journalArticle

Evidence of slow motions by cross-correlated chemical shift modulation in deuterated and protonated proteins

Vugmeyster, L., Perazzolo, C., Wist, J., Frueh, D. P. & Bodenhausen, G., Feb 2004, In : Journal of Biomolecular NMR. 28, 2, p. 173-177 5 p.

Research output: Contribution to journalArticle

Triple quantum decoherence under multiple refocusing: Slow correlated chemical shift modulations of C′ and N nuclei in proteins

Wist, J., Frueh, D., Tolman, J. R. & Bodenhausen, G., Mar 1 2004, In : Journal of Biomolecular NMR. 28, 3, p. 263-272 10 p.

Research output: Contribution to journalArticle

2002

Measurement of long-range cross-correlation rates using a combination of single- and multiple-quantum NMR spectroscopy in one experiment

Früh, D., Chiarparin, E., Pelupessy, P. & Bodenhausen, G., Apr 17 2002, In : Journal of the American Chemical Society. 124, 15, p. 4050-4057 8 p.

Research output: Contribution to journalArticle

Temperature dependence of internucleotide nitrogen-nitrogen scalar couplings in RNA

Bytchenkoff, D., Chiarparin, E., Früh, D., Rüdisser, S. & Bodenhausen, G., May 1 2002, In : Magnetic Resonance in Chemistry. 40, 5, p. 377-379 3 p.

Research output: Contribution to journalArticle

2001

Cross-correlated chemical shift modulation: A signature of slow internal motions in proteins

Früh, D., Tolman, J. R., Bodenhausen, G. & Zwahlen, C., Oct 6 2001, In : Journal of the American Chemical Society. 123, 20, p. 4810-4816 7 p.

Research output: Contribution to journalArticle

1999

Identification of Spin Diffusion Pathways in Isotopically Labeled Biomolecules

Eykyn, T. R., Frueh, D. P. & Bodenhausen, G., Jun 1999, In : Journal of Magnetic Resonance. 138, 2, p. 330-333 4 p.

Research output: Contribution to journalArticle

1997