Research Output 1967 2017

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2017

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

McPherson, R. L., Abraham, R., Sreekumar, E., Ong, S. E., Cheng, S. J., Baxter, V. K., Kistemaker, H. A. V., Filippov, D. V., Griffin, D. E. & Leung, A. K. L. Feb 14 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1666-1671 6 p.

Research output: Research - peer-reviewArticle

ADP-ribosylarginine hydrolase
Chikungunya virus
Virus Replication
Virulence
Proteins
Nucleotide Aptamers
Sindbis Virus
Viral RNA
RNA
Viruses

Evolution of T Cell Responses during Measles Virus Infection and RNA Clearance

Nelson, A. N., Putnam, N., Hauer, D., Baxter, V. K., Adams, R. J. & Griffin, D. E. Dec 1 2017 In : Scientific Reports. 7, 1, 11474

Research output: Research - peer-reviewArticle

Measles virus
Virus Diseases
RNA
T-Lymphocytes
Interleukin-17

Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis

Baxter, V. K., Glowinski, R., Braxton, A. M., Potter, M. C., Slusher, B. S. & Griffin, D. E. Aug 1 2017 In : Virology. 508, p. 134-149 16 p.

Research output: Research - peer-reviewArticle

Sindbis Virus
Alphavirus
Encephalomyelitis
Glutamine
Central Nervous System

Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D. E., Pekosz, A., Klein, S. L. & Burd, I. Feb 21 2017 In : Nature Communications. 8, 14575

Research output: Research - peer-reviewArticle

Zika Virus Infection
Zika Virus
viruses
infectious diseases
mice
Measles
Hospital Mortality
Coinfection
Chemokines
HIV-1
2016

Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage

Griffin, D. E. Apr 25 2016 (Accepted/In press) In : Neurotherapeutics. p. 1-6 6 p.

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
Viruses
Neurons
Infection

Dedication to Dr. Richard T. Johnson

Nath, A. & Griffin, D. E. Jun 30 2016 (Accepted/In press) In : Neurotherapeutics. p. 1-2 2 p.

Research output: Research - peer-reviewArticle

Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis

Baxter, V. K. & Griffin, D. E. Nov 1 2016 In : Journal of General Virology. 97, 11, p. 2907-2924 18 p., 000613

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
Interferon-gamma
Antibody Formation
Central Nervous System

Measles virus neutralizing antibody response, cell-mediated immunity, and immunoglobulin G antibody avidity before and after receipt of a third dose of measles, mumps, and rubella vaccine in young adults

Fiebelkorn, A. P., Coleman, L. A., Belongia, E. A., Freeman, S. K., York, D., Bi, D., Kulkarni, A., Audet, S., Mercader, S., McGrew, M., Hickman, C. J., Bellini, W. J., Shivakoti, R., Griffin, D. E. & Beeler, J. 2016 In : Journal of Infectious Diseases. 213, 7, p. 1115-1123 9 p.

Research output: Research - peer-reviewArticle

Measles-Mumps-Rubella Vaccine
Measles virus
Antibody Affinity
Measles
Neutralizing Antibodies

Neurotropic virus infections as the cause of immediate and delayed neuropathology

Ludlow, M., Kortekaas, J., Herden, C., Hoffmann, B., Tappe, D., Trebst, C., Griffin, D. E., Brindle, H. E., Solomon, T., Brown, A. S., van Riel, D., Wolthers, K. C., Pajkrt, D., Wohlsein, P., Martina, B. E. E., Baumgärtner, W., Verjans, G. M. & Osterhaus, A. D. M. E. Feb 1 2016 In : Acta Neuropathologica. 131, 2, p. 159-184 26 p.

Research output: Research - peer-reviewArticle

Virus Diseases
Neuropathology
Viruses
Neurologic Manifestations
Central Nervous System

Protective effects of glutamine antagonist 6-diazo-5-oxo-L-norleucine in mice with alphavirus encephalomyelitis

Manivannan, S., Baxter, V. K., Schultz, K. L. W., Slusher, B. S. & Griffin, D. E. 2016 In : Journal of Virology. 90, 20, p. 9251-9262 12 p.

Research output: Research - peer-reviewArticle

Alphavirus
encephalitis
glutamine
central nervous system
protective effect

T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis

Kulcsar, K. A. & Griffin, D. E. Jun 15 2016 In : Journal of Neuroimmunology. 295-296, p. 60-67 8 p.

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
Interleukin-10
T-Lymphocytes
Th17 Cells
Public Health
History
Mothers
Research
Zika Virus
2015

Differentiation of neurons restricts arbovirus replication and increases expression of the alpha isoform of IRF-7

Schultz, K. L. W., Vernon, P. S. & Griffin, D. E. 2015 In : Journal of Virology. 89, 1, p. 48-60 13 p.

Research output: Research - peer-reviewArticle

Arboviruses
Protein Isoforms
Neurons
arboviruses
neurons

Distinct immune responses in resistant and susceptible strains of mice during neurovirulent alphavirus encephalomyelitis

Kulcsar, K. A., Baxter, V. K., Abraham, R., Nelson, A. & Griffin, D. E. 2015 In : Journal of Virology. 89, 16, p. 8280-8291 12 p.

Research output: Research - peer-reviewArticle

Alphavirus
encephalitis
immune response
mice
Encephalomyelitis

Limited in vivo production of type i or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus

Shivakoti, R., Hauer, D., Adams, R. J., Lin, W. H. W., Duprex, W. P., De Swart, R. L. & Griffin, D. E. Apr 1 2015 In : Journal of Interferon and Cytokine Research. 35, 4, p. 292-301 10 p.

Research output: Research - peer-reviewArticle

Measles virus
Macaca
Interferons
Vaccines
Infection

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

Potter, M. C., Baxter, V. K., Mathey, R. W., Alt, J., Rojas, C., Griffin, D. E. & Slusher, B. S. Apr 1 2015 In : Journal of NeuroVirology. 21, 2, p. 159-173 15 p.

Research output: Research - peer-reviewArticle

Alphavirus Infections
Diazooxonorleucine
Glutamine
Infection
Alphavirus
2014

Current progress in pulmonary delivery of measles vaccine

Griffin, D. E. 2014 In : Expert Review of Vaccines. 13, 6, p. 751-759 9 p.

Research output: Research - peer-reviewArticle

Measles Vaccine
Vaccines
Lung
Measles virus
Macaca

Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis

Kulcsar, K. A., Baxter, V. K., Greene, I. P. & Griffin, D. E. Nov 11 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 16053-16058 6 p.

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
Th17 Cells
Interleukin-10
Granulocyte-Macrophage Colony-Stimulating Factor

Measles virus and the nervous system

Griffin, D. E. 2014 In : Handbook of Clinical Neurology. 123, p. 577-590 14 p.

Research output: Research - peer-reviewArticle

Measles virus
Measles
Nervous System
Subacute Sclerosing Panencephalitis
Virus Diseases

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R. 2014 In : Journal of Virology. 88, 14, p. 8065-8076 12 p.

Research output: Research - peer-reviewArticle

vertebrate viruses
microRNA
MicroRNAs
Viruses
viruses

Sprouty-2 regulates HIV-specific T cell polyfunctionality

Chiu, Y. L., Shan, L., Huang, H., Haupt, C., Bessell, C., Canaday, D. H., Zhang, H., Ho, Y. C., Powell, J. D., Oelke, M., Margolick, J. B., Blankson, J. N., Griffin, D. E. & Schneck, J. P. Jan 2 2014 In : Journal of Clinical Investigation. 124, 1, p. 198-208 11 p.

Research output: Research - peer-reviewArticle

HIV-2
T-Lymphocytes
HIV
Antigens
MAP Kinase Signaling System

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA

Lin, W. H. W., Pan, C. H., Adams, R. J., Laube, B. L. & Griffin, D. E. Apr 15 2014 In : mBio. 5, 2, e01047-14

Research output: Research - peer-reviewArticle

Measles virus
Viral RNA
Vaccines
T-Lymphocytes
Infection
2013

Functional characterization of the alphavirus TF protein

Snyder, J. E., Kulcsar, K. A., Schultz, K. L. W., Riley, C. P., Neary, J. T., Marr, S., Jose, J., Griffin, D. E. & Kuhn, R. R. 2013 In : Journal of Virology. 87, 15, p. 8511-8523 13 p.

Research output: Research - peer-reviewArticle

Alphavirus
proteins
Proteins
Sindbis virus
virion
Measles virus
Dendritic Cells
Interferons
Vaccines
RNA

Mice Deficient in Interferon-Gamma or Interferon-Gamma Receptor 1 Have Distinct Inflammatory Responses to Acute Viral Encephalomyelitis

Lee, E. Y., Schultz, K. L. W. & Griffin, D. E. Oct 24 2013 In : PLoS One. 8, 10, e76412

Research output: Research - peer-reviewArticle

Encephalomyelitis
Interferon-gamma
interferon gamma receptor
viral encephalitis
interferon-gamma

Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins

Polack, F. P., Lydy, S. L., Lee, S. H., Rota, P. A., Bellini, W. J., Adams, R. J., Robinson, H. L. & Griffin, D. E. Feb 2013 In : Clinical and Vaccine Immunology. 20, 2, p. 205-210 6 p.

Research output: Research - peer-reviewArticle

Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta
Haplorhini

Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis

Metcalf, T. U., Baxter, V. K., Nilaratanakul, V. & Griffin, D. E. Mar 2013 In : Journal of Virology. 87, 5, p. 2420-2429 10 p.

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
B-Lymphocytes
Central Nervous System
encephalitis

Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins

Lin, W. H. W., Vilalta, A., Adams, R. J., Rolland, A., Sullivan, S. M. & Griffin, D. E. Jun 2013 In : Journal of Virology. 87, 12, p. 6560-6568 9 p.

Research output: Research - peer-reviewArticle

Viral Fusion Proteins
Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta
2012

How respiratory viruses overcome mucosal defenses and exploit the unique environment of the respiratory tract

Von Messling, V. A. & Griffin, D. E. Jun 2012 In : Current Opinion in Virology. 2, 3, p. 221-224 4 p.

Research output: Research - peer-reviewArticle

Measles virus
organ culture
thymocytes
immatures
Organ Culture Techniques

Measles

Moss, W. J. & Griffin, D. E. Jan 14 2012 In : The Lancet. 379, 9811, p. 153-164 12 p.

Research output: Research - peer-reviewArticle

Measles
Measles Vaccine
Measles virus
Vaccination
Africa South of the Sahara

Measles virus, immune control, and persistence

Griffin, D. E., Lin, W. H. & Pan, C. H. May 2012 In : FEMS Microbiology Reviews. 36, 3, p. 649-662 14 p.

Research output: Research - peer-reviewArticle

Measles virus
Viruses
Infection
Measles
RNA

Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics

Lin, W. H. W., Kouyos, R. D., Adams, R. J., Grenfell, B. T. & Griffin, D. E. Sep 11 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14989-14994 6 p.

Research output: Research - peer-reviewArticle

Measles virus
RNA
Infection
Viral RNA
Immunity
2011

Alphavirus-induced encephalomyelitis: Antibody-secreting cells and viral clearance from the nervous system

Metcalf, T. U. & Griffin, D. E. Nov 2011 In : Journal of Virology. 85, 21, p. 11490-11501 12 p.

Research output: Research - peer-reviewArticle

Alphavirus
Encephalomyelitis
Antibody-Producing Cells
Nervous System
Central Nervous System

Clearance of virus infection from the CNS

Griffin, D. E. & Metcalf, T. 2011 In : Current Opinion in Virology. 1, 3, p. 216-221 6 p.

Research output: Research - peer-reviewArticle

Virus Diseases
Viruses
Viral RNA
Nervous System
Antibodies

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques

Lin, W. H., Griffin, D. E., Rota, P. A., Papania, M., Cape, S. P., Bennett, D., Quinn, B., Sievers, R. E., Shermer, C., Powell, K., Adams, R. J., Godin, S. & Winston, S. Feb 15 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2987-2992 6 p.

Research output: Research - peer-reviewArticle

Measles Vaccine
Attenuated Vaccines
Measles virus
Measles
Macaca mulatta

Viral encephalomyelitis

Griffin, D. E. Mar 2011 In : PLoS Pathogens. 7, 3, e1002004

Research output: Research - peer-reviewArticle

2010

A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles

Pan, C. H., Greer, C. E., Hauer, D., Legg, H. S., Lee, E. Y., Bergen, M. J., Lau, B., Adams, R. J., Polo, J. M. & Griffin, D. E. Apr 2010 In : Journal of Virology. 84, 8, p. 3798-3807 10 p.

Research output: Research - peer-reviewArticle

Venezuelan Equine Encephalitis Viruses
Sindbis Virus
Alphavirus
Replicon
Measles

Comparison of the immune responses induced by Chimeric Alphavirus-Vectored and formalin-inactivated alum-precipitated measles vaccines in mice

Bergen, M. J., Pan, C. H., Greer, C. E., Legg, H. S., Polo, J. M. & Griffin, D. E. 2010 In : PLoS One. 5, 4, e10297

Research output: Research - peer-reviewArticle

Alphavirus
Measles Vaccine
Formaldehyde
aluminum sulfate
alum

Dynamic regulation of functionally distinct virus-specific T cells

Ndhlovu, Z. M., Oelke, M., Schneck, J. P. & Griffin, D. E. Feb 23 2010 In : Proceedings of the National Academy of Sciences of the United States of America. 107, 8, p. 3669-3674 6 p.

Research output: Research - peer-reviewArticle

Viruses
T-Lymphocytes
Dendritic Cells
Monocytes
Phenotype

Emergence and re-emergence of viral diseases of the central nervous system

Griffin, D. E. Jun 2010 In : Progress in Neurobiology. 91, 2, p. 95-101 7 p.

Research output: Research - peer-reviewArticle

Central Nervous System Viral Diseases
Viruses
Rabies
Nervous System Diseases
Chikungunya virus

Measles virus-induced suppression of immune responses

Griffin, D. E. Jul 2010 In : Immunological Reviews. 236, 1, p. 176-189 14 p.

Research output: Research - peer-reviewArticle

Measles virus
Infection
Lymphocytes
T-Lymphocytes
Viral RNA

Recovery from viral encephalomyelitis: Immune-mediated noncytolytic virus clearance from neurons

Griffin, D. E. Jul 2010 In : Immunologic Research. 47, 1-3, p. 123-133 11 p.

Research output: Research - peer-reviewArticle

Encephalomyelitis
Viruses
Neurons
Nervous System
Spinal Cord
2009

Current topics in microbiology and immunology: Introduction

Griffin, D. E. & Oldstone, M. B. A. 2009 In : Current Topics in Microbiology and Immunology. 330, p. 1 1 p.

Research output: Research - peer-reviewArticle

Measles virus
Antigen-Presenting Cells
Viruses
T-Lymphocytes
T-cells

HIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection

Nair, N., Moss, W. J., Scott, S., Mugala, N., Ndhlovu, Z. M., Lilo, K., Ryon, J. J., Monze, M., Quinn, T. C., Cousens, S., Cutts, F. & Griffin, D. E. Oct 1 2009 In : Journal of Infectious Diseases. 200, 7, p. 1031-1038 8 p.

Research output: Research - peer-reviewArticle

Measles virus
Measles
Virus Diseases
Child Development
HIV-1

Infectious diseases of the nervous system and their impact in developing countries

Bruzzone, R., Dubois-Dalcq, M., Grau, G. E., Griffin, D. E. & Kristensson, K. Feb 2009 In : PLoS Pathogens. 5, 2, e1000199

Research output: Research - peer-reviewArticle

Sindbis Virus
Viral Structural Proteins
Proteins
Poly (ADP-Ribose) Polymerase-1
Virus Diseases