Research Output 1967 2017

2017

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

McPherson, R. L., Abraham, R., Sreekumar, E., Ong, S. E., Cheng, S. J., Baxter, V. K., Kistemaker, H. A. V., Filippov, D. V., Griffin, D. E. & Leung, A. K. L. Feb 14 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 7, p. 1666-1671 6 p.

Research output: Contribution to journalArticle

Chikungunya virus
Virus Replication
Adenosine Diphosphate
Virulence
Proteins
Nucleotide Aptamers
Sindbis Virus
Viral RNA
RNA
Viruses

Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis

Baxter, V. K., Glowinski, R., Braxton, A. M., Potter, M. C., Slusher, B. S. & Griffin, D. E. Aug 1 2017 In : Virology. 508, p. 134-149 16 p.

Research output: Contribution to journalArticle

Sindbis Virus
Alphavirus
Encephalomyelitis
Glutamine
Central Nervous System

Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Vermillion, M. S., Lei, J., Shabi, Y., Baxter, V. K., Crilly, N. P., McLane, M., Griffin, D. E., Pekosz, A., Klein, S. L. & Burd, I. Feb 21 2017 In : Nature Communications. 8, 14575

Research output: Contribution to journalArticle

Viruses
Infection
viruses
Bulimia
infectious diseases
Measles
Hospital Mortality
Coinfection
Chemokines
HIV-1

Why are neurons susceptible to Zika virus?

Griffin, D. E. Jul 7 2017 In : Science. 357, 6346, p. 33-34 2 p.

Research output: Contribution to journalShort survey

Within host RNA virus persistence: mechanisms and consequences

Randall, R. E. & Griffin, D. E. Apr 1 2017 In : Current Opinion in Virology. 23, p. 35-42 8 p.

Research output: Contribution to journalReview article

RNA Viruses
Infection
Adaptive Immunity
RNA Virus Infections
Innate Immunity

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Aliota, M. T. , Bassit, L. , Bradrick, S. S. , Cox, B. , Garcia-Blanco, M. A. , Gavegnano, C. , Friedrich, T. C. , Golos, T. G. , Griffin, D. E. , Haddow, A. D. , Kallas, E. G. , Kitron, U. , Lecuit, M. , Magnani, D. M. , Marrs, C. , Mercer, N. , McSweegan, E. , Ng, L. F. P. , O'Connor, D. H. , Osorio, J. E. & 11 others Ribeiro, G. S., Ricciardi, M., Rossi, S. L., Saade, G., Schinazi, R. F., Schott-Lerner, G. O., Shan, C., Shi, P. Y., Watkins, D. I., Vasilakis, N. & Weaver, S. C. Aug 1 2017 In : Antiviral Research. 144, p. 223-246 24 p.

Research output: Contribution to journalReview article

Viruses
Virus Diseases
Routine Diagnostic Tests
Antiviral Agents
Mosquito Control
2016

Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage

Griffin, D. E. Apr 25 2016 In : Neurotherapeutics. p. 1-6 6 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
Viruses
Infection
Neurons

Animal Models: No Model is Perfect, But Many Are Useful

Baxter, V. K. & Griffin, D. E. 2016 Viral Pathogenesis: From Basics to Systems Biology: Third Edition. Elsevier Inc., p. 125-138 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses
Infection
Ferrets
Coinfection
Primates

Dedication to Dr. Richard T. Johnson

Nath, A. & Griffin, D. E. Jun 30 2016 In : Neurotherapeutics. p. 1-2 2 p.

Research output: Contribution to journalArticle

Anniversaries and Special Events

Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis

Baxter, V. K. & Griffin, D. E. Nov 1 2016 In : Journal of General Virology. 97, 11, p. 2907-2924 18 p., 000613

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
Interferon-gamma
Antibody Formation
Central Nervous System

Measles virus neutralizing antibody response, cell-mediated immunity, and immunoglobulin G antibody avidity before and after receipt of a third dose of measles, mumps, and rubella vaccine in young adults

Fiebelkorn, A. P., Coleman, L. A., Belongia, E. A., Freeman, S. K., York, D., Bi, D., Kulkarni, A., Audet, S., Mercader, S., McGrew, M., Hickman, C. J., Bellini, W. J., Shivakoti, R., Griffin, D. E. & Beeler, J. 2016 In : Journal of Infectious Diseases. 213, 7, p. 1115-1123 9 p.

Research output: Contribution to journalArticle

Measles-Mumps-Rubella Vaccine
Measles virus
Antibody Affinity
Measles
Neutralizing Antibodies

Neurotropic alphaviruses

Griffin, D. E. Jan 1 2016 Neurotropic Viral Infections: Volume 1: Neurotropic RNA Viruses. Springer International Publishing, p. 175-204 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Alphavirus
Encephalomyelitis
Viral RNA
Vertebrates
Eastern Equine Encephalomyelitis

Neurotropic virus infections as the cause of immediate and delayed neuropathology

Ludlow, M., Kortekaas, J., Herden, C., Hoffmann, B., Tappe, D., Trebst, C., Griffin, D. E., Brindle, H. E., Solomon, T., Brown, A. S., van Riel, D., Wolthers, K. C., Pajkrt, D., Wohlsein, P., Martina, B. E. E., Baumgärtner, W., Verjans, G. M. & Osterhaus, A. D. M. E. Feb 1 2016 In : Acta Neuropathologica. 131, 2, p. 159-184 26 p.

Research output: Contribution to journalArticle

Viruses
Infection
Neurologic Manifestations
Central Nervous System

Protective effects of glutamine antagonist 6-diazo-5-oxo-L-norleucine in mice with alphavirus encephalomyelitis

Manivannan, S., Baxter, V. K., Schultz, K. L. W., Slusher, B. S. & Griffin, D. E. 2016 In : Journal of Virology. 90, 20, p. 9251-9262 12 p.

Research output: Contribution to journalArticle

Diazooxonorleucine
Alphavirus
Encephalomyelitis
Glutamine
Central Nervous System

T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis

Kulcsar, K. A. & Griffin, D. E. Jun 15 2016 In : Journal of Neuroimmunology. 295-296, p. 60-67 8 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
Interleukin-10
T-Lymphocytes
Th17 Cells
Public Health
History
Viruses
Infection
Bovine Viral Diarrhea Viruses

The immune response in measles: Virus control, clearance and protective immunity

Griffin, D. E. Oct 12 2016 In : Viruses. 8, 10, 282

Research output: Contribution to journalReview article

Measles virus
Immunity
Exanthema
Infection
Viral RNA
2015

Differentiation of neurons restricts arbovirus replication and increases expression of the alpha isoform of IRF-7

Schultz, K. L. W., Vernon, P. S. & Griffin, D. E. 2015 In : Journal of Virology. 89, 1, p. 48-60 13 p.

Research output: Contribution to journalArticle

Arboviruses
Protein Isoforms
Neurons
neurons
Virus Replication

Distinct immune responses in resistant and susceptible strains of mice during neurovirulent alphavirus encephalomyelitis

Kulcsar, K. A., Baxter, V. K., Abraham, R., Nelson, A. & Griffin, D. E. 2015 In : Journal of Virology. 89, 16, p. 8280-8291 12 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
mice
encephalitis
Sindbis Virus

Limited in vivo production of type i or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus

Shivakoti, R., Hauer, D., Adams, R. J., Lin, W. H. W., Duprex, W. P., De Swart, R. L. & Griffin, D. E. Apr 1 2015 In : Journal of Interferon and Cytokine Research. 35, 4, p. 292-301 10 p.

Research output: Contribution to journalArticle

Measles virus
Macaca
Interferons
Vaccines
Infection

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

Potter, M. C., Baxter, V. K., Mathey, R. W., Alt, J., Rojas, C., Griffin, D. E. & Slusher, B. S. Apr 1 2015 In : Journal of NeuroVirology. 21, 2, p. 159-173 15 p.

Research output: Contribution to journalArticle

Alphavirus Infections
Diazooxonorleucine
Glutamine
Infection
Viruses
2014

Current progress in pulmonary delivery of measles vaccine

Griffin, D. E. 2014 In : Expert Review of Vaccines. 13, 6, p. 751-759 9 p.

Research output: Contribution to journalArticle

Measles Vaccine
Vaccines
Lung
Measles virus
Macaca

Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis

Kulcsar, K. A., Baxter, V. K., Greene, I. P. & Griffin, D. E. Nov 11 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 45, p. 16053-16058 6 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
Th17 Cells
Interleukin-10
Granulocyte-Macrophage Colony-Stimulating Factor

Measles and rubella

Griffin, D. E. Apr 21 2014 Infections of the Central Nervous System: Fourth Edition. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Rubella
Measles

Measles virus and the nervous system

Griffin, D. E. 2014 In : Handbook of Clinical Neurology. 123, p. 577-590 14 p.

Research output: Contribution to journalArticle

Measles virus
Measles
Nervous System
Subacute Sclerosing Panencephalitis
Pathology

Paramyxoviruses: Measles

Moss, W. J. & Griffin, D. E. Jun 1 2014 Viral Infections of Humans: Epidemiology and Control. Springer US, p. 537-552 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Measles
Measles virus
Vaccination
Measles Vaccine
Exanthema

Replication of many human viruses is refractory to inhibition by endogenous cellular MicroRNAs

Bogerd, H. P., Skalsky, R. L., Kennedy, E. M., Furuse, Y., Whisnant, A. W., Flores, O., Schultz, K. L. W., Putnam, N., Barrows, N. J., Sherry, B., Scholle, F., Garcia-Blanco, M. A., Griffin, D. E. & Cullen, B. R. 2014 In : Journal of Virology. 88, 14, p. 8065-8076 12 p.

Research output: Contribution to journalArticle

microRNA
MicroRNAs
Viruses
viruses
Small Interfering RNA

Sprouty-2 regulates HIV-specific T cell polyfunctionality

Chiu, Y. L., Shan, L., Huang, H., Haupt, C., Bessell, C., Canaday, D. H., Zhang, H., Ho, Y. C., Powell, J. D., Oelke, M., Margolick, J. B., Blankson, J. N., Griffin, D. E. & Schneck, J. P. Jan 2 2014 In : Journal of Clinical Investigation. 124, 1, p. 198-208 11 p.

Research output: Contribution to journalArticle

HIV-2
T-Lymphocytes
HIV
Antigens
MAP Kinase Signaling System

Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA

Lin, W. H. W., Pan, C. H., Adams, R. J., Laube, B. L. & Griffin, D. E. Apr 15 2014 In : mBio. 5, 2, e01047-14

Research output: Contribution to journalArticle

Measles virus
Viral RNA
Vaccines
T-Lymphocytes
Infection
2013

Alphaviruses

Griffin, D. E. May 21 2013 Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1

Research output: Chapter in Book/Report/Conference proceedingChapter

Alphavirus

Arthropodborne viruses

Griffin, D. E. Jul 8 2013 Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 348-355 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses

Functional characterization of the alphavirus TF protein

Snyder, J. E., Kulcsar, K. A., Schultz, K. L. W., Riley, C. P., Neary, J. T., Marr, S., Jose, J., Griffin, D. E. & Kuhn, R. R. 2013 In : Journal of Virology. 87, 15, p. 8511-8523 13 p.

Research output: Contribution to journalArticle

proteins
Alphavirus
Proteins
Sindbis virus
virion

Induction of dendritic cell production of type i and type iii interferons by wild-type and vaccine strains of measles virus: Role of defective interfering RNAs

Shivakoti, R., Siwek, M., Hauer, D., Schultz, K. L. W. & Griffin, D. E. Jul 2013 In : Journal of Virology. 87, 14, p. 7816-7827 12 p.

Research output: Contribution to journalArticle

Measles virus
Dendritic Cells
Interferons
Vaccines
RNA

Measles virus

Griffin, D. E. May 21 2013 Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1

Research output: Chapter in Book/Report/Conference proceedingChapter

Measles virus

Mice Deficient in Interferon-Gamma or Interferon-Gamma Receptor 1 Have Distinct Inflammatory Responses to Acute Viral Encephalomyelitis

Lee, E. Y., Schultz, K. L. W. & Griffin, D. E. Oct 24 2013 In : PLoS One. 8, 10, e76412

Research output: Contribution to journalArticle

Interferon Receptors
Encephalomyelitis
Interferon-gamma
mice
interferon-gamma

Poor immune responses of newborn rhesus macaques to measles virus DNA vaccines expressing the hemagglutinin and fusion glycoproteins

Polack, F. P., Lydy, S. L., Lee, S. H., Rota, P. A., Bellini, W. J., Adams, R. J., Robinson, H. L. & Griffin, D. E. Feb 2013 In : Clinical and Vaccine Immunology. 20, 2, p. 205-210 6 p.

Research output: Contribution to journalArticle

Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta
Glycoproteins

Preface

Knipe, D. M., Howley, P. M., Cohen, J. I., Griffin, D. E., Lamb, R. A., Martin, M. A., Racaniello, V. R. & Roizman, B. May 21 2013 Fields Virology: Sixth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1

Research output: Chapter in Book/Report/Conference proceedingForeword/postscript

Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis

Metcalf, T. U., Baxter, V. K., Nilaratanakul, V. & Griffin, D. E. Mar 2013 In : Journal of Virology. 87, 5, p. 2420-2429 10 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
B-Lymphocytes
Central Nervous System
B-lymphocytes

Vaxfectin adjuvant improves antibody responses of juvenile rhesus macaques to a DNA vaccine encoding the measles virus hemagglutinin and fusion proteins

Lin, W. H. W., Vilalta, A., Adams, R. J., Rolland, A., Sullivan, S. M. & Griffin, D. E. Jun 2013 In : Journal of Virology. 87, 12, p. 6560-6568 9 p.

Research output: Contribution to journalArticle

Viral Fusion Proteins
Measles virus
DNA Vaccines
Hemagglutinins
Macaca mulatta
2012

Arthropodborne viruses

Griffin, D. E. May 15 2012 Schaechter's Mechanisms of Microbial Disease: Fifth Edition. Wolters Kluwer Health Adis (ESP), p. 348-355 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Viruses

How respiratory viruses overcome mucosal defenses and exploit the unique environment of the respiratory tract

Von Messling, V. A. & Griffin, D. E. Jun 2012 In : Current Opinion in Virology. 2, 3, p. 221-224 4 p.

Research output: Contribution to journalArticle

Respiratory System
Viruses
Measles virus
Organ Culture Techniques
Thymocytes
Bulimia
Infection

Measles

Moss, W. J. & Griffin, D. E. Jan 14 2012 In : The Lancet. 379, 9811, p. 153-164 12 p.

Research output: Contribution to journalArticle

Measles
Measles Vaccine
Measles virus
Vaccination
Africa South of the Sahara

Measles virus, immune control, and persistence

Griffin, D. E., Lin, W. H. & Pan, C. H. May 2012 In : FEMS Microbiology Reviews. 36, 3, p. 649-662 14 p.

Research output: Contribution to journalArticle

Measles virus
Infection
Viruses
Measles
RNA

Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics

Lin, W. H. W., Kouyos, R. D., Adams, R. J., Grenfell, B. T. & Griffin, D. E. Sep 11 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14989-14994 6 p.

Research output: Contribution to journalArticle

Measles virus
RNA
Infection
Viral RNA
Immunity
2011

Alphavirus-induced encephalomyelitis: Antibody-secreting cells and viral clearance from the nervous system

Metcalf, T. U. & Griffin, D. E. Nov 2011 In : Journal of Virology. 85, 21, p. 11490-11501 12 p.

Research output: Contribution to journalArticle

Alphavirus
Encephalomyelitis
Antibody-Producing Cells
Nervous System
antibodies

Clearance of virus infection from the CNS

Griffin, D. E. & Metcalf, T. 2011 In : Current Opinion in Virology. 1, 3, p. 216-221 6 p.

Research output: Contribution to journalArticle

Viruses
Infection
Viral RNA
Nervous System
Antibodies

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques

Lin, W. H., Griffin, D. E., Rota, P. A., Papania, M., Cape, S. P., Bennett, D., Quinn, B., Sievers, R. E., Shermer, C., Powell, K., Adams, R. J., Godin, S. & Winston, S. Feb 15 2011 In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2987-2992 6 p.

Research output: Contribution to journalArticle

Measles Vaccine
Attenuated Vaccines
Measles virus
Measles
Macaca mulatta