1992 …2020

Research output per year

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Research Output

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Article

Shear-induced assembly of λ-phage DNA

Haber, C. & Wirtz, D., Jan 1 2000, In : Biophysical journal. 79, 3, p. 1530-1536 7 p.

Research output: Contribution to journalArticle

Open Access

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution

Chambliss, A. B., Wu, P. H., Chen, W. C., Sun, S. X. & Wirtz, D., Jul 1 2013, In : FASEB Journal. 27, 7, p. 2667-2676 10 p.

Research output: Contribution to journalArticle

Single-cell morphology encodes metastatic potential

Wu, P. H., Gilkes, D. M., Phillip, J. M., Narkar, A., Cheng, T. W. T., Marchand, J., Lee, M. H., Li, R. & Wirtz, D., Jan 22 2020, In : Science Advances. 6, 4, eaaw6938.

Research output: Contribution to journalArticle

Open Access

Single-molecule analysis of cadherin-mediated cell-cell adhesion

Panorchan, P., Thompson, M. S., Davis, K. J., Tseng, Y., Konstantopoulos, K. & Wirtz, D., Jan 1 2006, In : Journal of cell science. 119, 1, p. 66-74 9 p.

Research output: Contribution to journalArticle

Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells

Chang, M. I., Panorchan, P., Dobrowsky, T. M., Tseng, Y. & Wirtz, D., Dec 1 2005, In : Journal of virology. 79, 23, p. 14748-14755 8 p.

Research output: Contribution to journalArticle

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer

Raman, P. S., Alves, C. S., Wirtz, D. & Konstantopoulos, K., Jun 1 2011, In : Journal of cell science. 124, 11, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

Single molecule characterization of P-selectin/ligand binding

Hanley, W., McCarty, O., Jadhav, S., Tseng, Y., Wirtz, D. & Konstantopoulos, K., Mar 21 2003, In : Journal of Biological Chemistry. 278, 12, p. 10556-10561 6 p.

Research output: Contribution to journalArticle

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization

Hale, C. M., Chen, W. C., Khatau, S. B., Daniels, B. R., Lee, J. S. H. & Wirtz, D., Dec 1 2011, In : Journal of cell science. 124, 24, p. 4267-4285 19 p.

Research output: Contribution to journalArticle

Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model

Wu, P. H., Giri, A. & Wirtz, D., Mar 2 2015, In : Nature protocols. 10, 3, p. 517-527 11 p.

Research output: Contribution to journalArticle

Strain hardening of actin filament networks: Regulation by the dynamic cross-linking protein α-actinin

Xu, J., Tseng, Y. & Wirtz, D., Nov 17 2000, In : Journal of Biological Chemistry. 275, 46, p. 35886-35892 7 p.

Research output: Contribution to journalArticle

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

Stewart-Hutchinson, P. J., Hale, C. M., Wirtz, D. & Hodzic, D., May 1 2008, In : Experimental cell research. 314, 8, p. 1892-1905 14 p.

Research output: Contribution to journalArticle

Structure and dynamics of actin filament solutions in the presence of latrunculin A

Palmer, A., Cha, B. & Wirtz, D., Dec 1998, In : Journal of Polymer Science, Part B: Polymer Physics. 36, 17, p. 3007-3015 9 p.

Research output: Contribution to journalArticle

Structure and optical anisotropies of critical polymer solutions in electric fields

Wirtz, D., Werner, D. E. & Fuller, G. G., Jan 1 1994, In : The Journal of Chemical Physics. 101, 2, p. 1679-1686 8 p.

Research output: Contribution to journalArticle

Structure of the actin crosslinking core of fimbrin

Klein, M. G., Shi, W., Ramagopal, U., Tseng, Y., Wirtz, D., Kovar, D. R., Staiger, C. J. & Almo, S. C., Jun 1 2004, In : Structure. 12, 6, p. 999-1013 15 p.

Research output: Contribution to journalArticle

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

Chakroun, R. W., Sneider, A., Anderson, C. F., Wang, F., Wu, P. H., Wirtz, D. & Cui, H., Jan 1 2020, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P. H., Gilkes, D., Fan, R. & Wirtz, D., May 26 2017, In : Nature Communications. 8, 15584.

Research output: Contribution to journalArticle

The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration

Giri, A., Bajpai, S., Trenton, N., Jayatilaka, H., Longmore, G. D. & Wirtz, D., Oct 1 2013, In : FASEB Journal. 27, 10, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

The assembly of MreB, a prokaryotic homolog of actin

Esue, O., Cordero, M., Wirtz, D. & Tseng, Y., Jan 28 2005, In : Journal of Biological Chemistry. 280, 4, p. 2628-2635 8 p.

Research output: Contribution to journalArticle

The Bimodal Role of Filamin in Controlling the Architecture and Mechanics of F-actin Networks

Tseng, Y., An, K. M., Esue, O. & Wirtz, D., Jan 16 2004, In : Journal of Biological Chemistry. 279, 3, p. 1819-1826 8 p.

Research output: Contribution to journalArticle

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells

Khatau, S. B., Kusuma, S., Hanjaya-Putra, D., Mali, P., Cheng, L., Lee, J. S. H., Gerecht, S. & Wirtz, D., May 4 2012, In : PloS one. 7, 5, e36689.

Research output: Contribution to journalArticle

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

Khatau, S. B., Bloom, R. J., Bajpai, S., Razafsky, D., Zang, S., Giri, A., Wu, P. H., Marchand, J., Celedon, A., Hale, C. M., Sun, S. X., Hodzic, D. & Wirtz, D., Jul 18 2012, In : Scientific reports. 2, 488.

Research output: Contribution to journalArticle

The Filamentous Actin Cross-Linking/Bundling Activity of Mammalian Formins

Esue, O., Harris, E. S., Higgs, H. N. & Wirtz, D., Dec 12 2008, In : Journal of molecular biology. 384, 2, p. 324-334 11 p.

Research output: Contribution to journalArticle

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

Chambliss, A. B., Khatau, S. B., Erdenberger, N., Robinson, D. K., Hodzic, D., Longmore, G. D. & Wirtz, D., Jan 18 2013, In : Scientific reports. 3, 1087.

Research output: Contribution to journalArticle

The mechanical properties of simple epithelial keratins 8 and 18: Discriminating between interfacial and bulk elasticities

Yamada, S., Wirtz, D. & Coulombe, P. A., Jul 1 2003, In : Journal of Structural Biology. 143, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro

Bousquet, O., Linglei, M., Yamada, S., Gu, C., Idei, T., Takahashi, K., Wirtz, D. & Coulombe, P. A., Nov 26 2001, In : Journal of Cell Biology. 155, 5, p. 747-753 7 p.

Research output: Contribution to journalArticle

The perinuclear actin cap in health and disease

Khatau, S. B., Kim, D. H., Hale, C. M., Bloom, R. J. & Wirtz, D., Jan 1 2010, In : Nucleus. 1, 4, p. 337-342 6 p.

Research output: Contribution to journalArticle

Open Access

The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ

Esue, O., Tseng, Y. & Wirtz, D., Jul 29 2005, In : Biochemical and Biophysical Research Communications. 333, 2, p. 508-516 9 p.

Research output: Contribution to journalArticle

Three-dimensional cell migration does not follow a random walk

Wu, P. H., Giri, A., Sun, S. X. & Wirtz, D., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 3949-3954 6 p.

Research output: Contribution to journalArticle

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions

Fraley, S. I., Wu, P. H., He, L., Feng, Y., Krisnamurthy, R., Longmore, G. D. & Wirtz, D., Oct 1 2015, In : Scientific reports. 5, 14580.

Research output: Contribution to journalArticle

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Apr 1 2020, In : Modern Pathology. 33, 4, p. 639-647 9 p.

Research output: Contribution to journalArticle

Tight coupling between nucleus and cell migration through the perinuclear actin cap

Kim, D. H., Cho, S. & Wirtz, D., Jun 2014, In : Journal of cell science. 127, 11, p. 2528-2541 14 p.

Research output: Contribution to journalArticle

Torsional mechanics of DNA are regulated by small-molecule intercalation

Celedon, A., Wirtz, D. & Sun, S., Dec 23 2010, In : Journal of Physical Chemistry B. 114, 50, p. 16929-16935 7 p.

Research output: Contribution to journalArticle

Towards a regional approach to cell mechanics

Heidemann, S. R. & Wirtz, D., Apr 2004, In : Trends in Cell Biology. 14, 4, p. 160-166 7 p.

Research output: Contribution to journalArticle

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P. H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D. & Bergles, D. E., Feb 8 2017, In : Neuron. 93, 3, p. 587-605.e7

Research output: Contribution to journalArticle

Transport of polymeric nanoparticle gene carriers in gastric mucus

Dawson, M., Krauland, E., Wirtz, D. & Hanes, J., May 1 2004, In : Biotechnology Progress. 20, 3, p. 851-857 7 p.

Research output: Contribution to journalArticle

Triggering cell detachment from patterned electrode arrays by programmed subcellular release

Wildt, B., Wirtz, D. & Searson, P. C., Jul 2010, In : Nature protocols. 5, 7, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

Tumor cell density regulates matrix metalloproteinases for enhanced migration

Jayatilaka, H., Umanzor, F. G., Shah, V., Meirson, T., Russo, G., Starich, B., Tyle, P., Lee, J. S. H., Khatau, S., Gil-Henn, H. & Wirtz, D., Aug 24 2018, In : Oncotarget. 9, 66, p. 32556-32569 14 p.

Research output: Contribution to journalArticle

Volume regulation and shape bifurcation in the cell nucleus

Kim, D. H., Li, B., Si, F., Phillip, J. M., Wirtz, D. & Sun, S. X., Jan 1 2015, In : Journal of cell science. 128, 18, p. 3375-3385 11 p.

Research output: Contribution to journalArticle

Water permeation drives tumor cell migration in confined microenvironments

Stroka, K. M., Jiang, H., Chen, S. H., Tong, Z., Wirtz, D., Sun, S. X. & Konstantopoulos, K., Apr 24 2014, In : Cell. 157, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

YAP and TAZ regulate cell volume

Perez-Gonzalez, N. A., Rochman, N. D., Yao, K., Tao, J., Le, M. T. T., Flanary, S., Sablich, L., Toler, B., Crentsil, E., Takaesu, F., Lambrus, B., Huang, J., Fu, V., Chengappa, P., Jones, T. M., Holland, A. J., An, S., Wirtz, D., Petrie, R. J., Guan, K. L. & 1 others, Sun, S. X., Oct 7 2019, In : Journal of Cell Biology. 218, 10, p. 3472-3488 17 p.

Research output: Contribution to journalArticle

Open Access

α-actinin and filamin cooperatively enhance the stiffness of actin filament networks

Esue, O., Tseng, Y. & Wirtz, D., Feb 9 2009, In : PloS one. 4, 2, e4411.

Research output: Contribution to journalArticle

α-Catenin mediates initial E-cadherin-dependent cell- cell recognition and subsequent bond strengthening

Bajpai, S., Correia, J., Feng, Y., Figueiredo, J., Sun, S. X., Longmore, G. D., Suriano, G. & Wirtz, D., Nov 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 47, p. 18331-18336 6 p.

Research output: Contribution to journalArticle

β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths

Bajpai, S., Feng, Y., Wirtz, D. & Longmore, G. D., Nov 19 2013, In : Biophysical journal. 105, 10, p. 2289-2300 12 p.

Research output: Contribution to journalArticle