1992 …2020

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2014

Three-dimensional cell migration does not follow a random walk

Wu, P. H., Giri, A., Sun, S. X. & Wirtz, D., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 3949-3954 6 p.

Research output: Contribution to journalArticle

Tight coupling between nucleus and cell migration through the perinuclear actin cap

Kim, D. H., Cho, S. & Wirtz, D., Jun 2014, In : Journal of cell science. 127, 11, p. 2528-2541 14 p.

Research output: Contribution to journalArticle

Water permeation drives tumor cell migration in confined microenvironments

Stroka, K. M., Jiang, H., Chen, S. H., Tong, Z., Wirtz, D., Sun, S. X. & Konstantopoulos, K., Apr 24 2014, In : Cell. 157, 3, p. 611-623 13 p.

Research output: Contribution to journalArticle

2013

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins

Dobrowsky, T. M., Rabi, S. A., Nedellec, R., Daniels, B. R., Mullins, J. I., Mosier, D. E., Siliciano, R. F. & Wirtz, D., Oct 31 2013, In : Scientific reports. 3, 3014.

Research output: Contribution to journalArticle

Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells

Stukalin, E. B., Aifuwa, I., Kim, J. S., Wirtz, D. & Sun, S. X., Aug 1 2013, In : Journal of the Royal Society Interface. 10, 85

Research output: Contribution to journalArticle

Open Access

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

Collagen prolyl hydroxylases are essential for breast cancer metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Jun 1 2013, In : Cancer Research. 73, 11, p. 3285-3296 12 p.

Research output: Contribution to journalArticle

Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro

Chau, E., Galloway, J. F., Nelson, A., Breysse, P. N., Wirtz, D., Searson, P. C. & Sidhaye, V. K., Sep 1 2013, In : Nanotoxicology. 7, 6, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Focal adhesion size uniquely predicts cell migration

Kim, D. H. & Wirtz, D., Apr 1 2013, In : FASEB Journal. 27, 4, p. 1351-1361 11 p.

Research output: Contribution to journalArticle

Form-finding model shows how cytoskeleton network stiffness is realized.

Gong, J., Zhang, D., Tseng, Y., Li, B., Wirtz, D. & Schafer, B. W., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access

Functional interplay between the cell cycle and cell phenotypes

Chen, W. C., Wu, P. H., Phillip, J. M., Khatau, S. B., Choi, J. M., Dallas, M. R., Konstantopoulos, K., Sun, S. X., Lee, J. S. H., Hodzic, D. & Wirtz, D., Mar 1 2013, In : Integrative Biology (United Kingdom). 5, 3, p. 523-534 12 p.

Research output: Contribution to journalArticle

High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity

Lu, Y., Chen, J. J., Mu, L., Xue, Q., Wu, Y., Wu, P. H., Li, J., Vortmeyer, A. O., Miller-Jensen, K., Wirtz, D. & Fan, R., Feb 19 2013, In : Analytical chemistry. 85, 4, p. 2548-2556 9 p.

Research output: Contribution to journalArticle

Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair

Guo, Q., Phillip, J. M., Majumdar, S., Wu, P. H., Chen, J., Calderón-Colón, X., Schein, O., Smith, B. J., Trexler, M. M., Wirtz, D. & Elisseeff, J. H., Dec 1 2013, In : Biomaterials. 34, 37, p. 9365-9372 8 p.

Research output: Contribution to journalArticle

Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis

Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D. & Semenza, G. L., May 1 2013, In : Molecular Cancer Research. 11, 5, p. 456-466 11 p.

Research output: Contribution to journalArticle

Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution

Chambliss, A. B., Wu, P. H., Chen, W. C., Sun, S. X. & Wirtz, D., Jul 1 2013, In : FASEB Journal. 27, 7, p. 2667-2676 10 p.

Research output: Contribution to journalArticle

The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration

Giri, A., Bajpai, S., Trenton, N., Jayatilaka, H., Longmore, G. D. & Wirtz, D., Oct 1 2013, In : FASEB Journal. 27, 10, p. 4089-4099 11 p.

Research output: Contribution to journalArticle

The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction

Chambliss, A. B., Khatau, S. B., Erdenberger, N., Robinson, D. K., Hodzic, D., Longmore, G. D. & Wirtz, D., Jan 18 2013, In : Scientific reports. 3, 1087.

Research output: Contribution to journalArticle

β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths

Bajpai, S., Feng, Y., Wirtz, D. & Longmore, G. D., Nov 19 2013, In : Biophysical journal. 105, 10, p. 2289-2300 12 p.

Research output: Contribution to journalArticle

2012

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

Kim, D. H., Khatau, S. B., Feng, Y., Walcott, S., Sun, S. X., Longmore, G. D. & Wirtz, D., Aug 15 2012, In : Scientific reports. 2, 555.

Research output: Contribution to journalArticle

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners

Fraley, S. I., Feng, Y., Giri, A., Longmore, G. D. & Wirtz, D., Apr 4 2012, In : Nature communications. 3, 1711.

Research output: Contribution to journalArticle

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

Raman, P. S., Alves, C. S., Wirtz, D. & Konstantopoulos, K., Aug 8 2012, In : Biophysical journal. 103, 3, p. 415-423 9 p.

Research output: Contribution to journalArticle

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis

Dallas, M. R., Liu, G., Chen, W. C., Thomas, S. N., Wirtz, D., Huso, D. L. & Konstantopoulos, K., Jun 1 2012, In : FASEB Journal. 26, 6, p. 2648-2656 9 p.

Research output: Contribution to journalArticle

High-throughput ballistic injection nanorheology to measure cell mechanics

Wu, P. H., Hale, C. M., Chen, W. C., Lee, J. S. H., Tseng, Y. & Wirtz, D., Jan 1 2012, In : Nature protocols. 7, 1, p. 155-170 16 p.

Research output: Contribution to journalArticle

Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer

Lee, M. H., Wu, P. H., Staunton, J. R., Ros, R., Longmore, G. D. & Wirtz, D., Jun 20 2012, In : Biophysical journal. 102, 12, p. 2731-2741 11 p.

Research output: Contribution to journalArticle

MO‐C‐BRCD‐02: Physics of Cancer Cell Migration

Wirtz, D., 2012, In : Medical Physics. 39, 6, p. 3864 1 p.

Research output: Contribution to journalArticle

NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells

Yap, K. L., Fraley, S. I., Thiaville, M. M., Jinawath, N., Nakayama, K., Wang, J., Wang, T. L., Wirtz, D. & Shih, I. M., Aug 15 2012, In : Cancer Research. 72, 16, p. 4085-4096 12 p.

Research output: Contribution to journalArticle

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells

Khatau, S. B., Kusuma, S., Hanjaya-Putra, D., Mali, P., Cheng, L., Lee, J. S. H., Gerecht, S. & Wirtz, D., May 4 2012, In : PloS one. 7, 5, e36689.

Research output: Contribution to journalArticle

The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration

Khatau, S. B., Bloom, R. J., Bajpai, S., Razafsky, D., Zang, S., Giri, A., Wu, P. H., Marchand, J., Celedon, A., Hale, C. M., Sun, S. X., Hodzic, D. & Wirtz, D., Jul 18 2012, In : Scientific reports. 2, 488.

Research output: Contribution to journalArticle

2011

Biophysics of Selectin-Ligand interactions in inflammation and cancer

Cheung, L. S. L., Raman, P. S., Balzer, E. M., Wirtz, D. & Konstantopoulos, K., Feb 2011, In : Physical biology. 8, 1, 015013.

Research output: Contribution to journalArticle

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C. L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C. M., Khoo, U. S., Ng, I. O. L., Wirtz, D. & Semenza, G. L., Sep 27 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 39, p. 16369-16374 6 p.

Research output: Contribution to journalArticle

Magnetic manipulation of nanorods in the nucleus of living cells

Celedon, A., Hale, C. M. & Wirtz, D., Oct 19 2011, In : Biophysical journal. 101, 8, p. 1880-1886 7 p.

Research output: Contribution to journalArticle

Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer

Raman, P. S., Alves, C. S., Wirtz, D. & Konstantopoulos, K., Jun 1 2011, In : Journal of cell science. 124, 11, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization

Hale, C. M., Chen, W. C., Khatau, S. B., Daniels, B. R., Lee, J. S. H. & Wirtz, D., Dec 1 2011, In : Journal of cell science. 124, 24, p. 4267-4285 19 p.

Research output: Contribution to journalArticle

2010

A distinctive role for focal adhesion proteins in three-dimensional cell motility

Fraley, S. I., Feng, Y., Krishnamurthy, R., Kim, D. H., Celedon, A., Longmore, G. D. & Wirtz, D., Jun 1 2010, In : Nature cell biology. 12, 6, p. 598-604 7 p.

Research output: Contribution to journalArticle

Cross-linking FtsZ polymers into coherent Z rings

Dajkovic, A., Pichoff, S., Lutkenhaus, J. & Wirtz, D., Nov 1 2010, In : Molecular Microbiology. 78, 3, p. 651-668 18 p.

Research output: Contribution to journalArticle

Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells

Daniels, B. R., Hale, C. M., Khatau, S. B., Kusuma, S., Dobrowsky, T. M., Gerecht, S. & Wirtz, D., Dec 1 2010, In : Biophysical journal. 99, 11, p. 3563-3570 8 p.

Research output: Contribution to journalArticle

Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo

Esue, O., Rupprecht, L., Sun, S. X. & Wirtz, D., Jan 25 2010, In : PloS one. 5, 1, e8855.

Research output: Contribution to journalArticle

Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis

Mali, P., Wirtz, D. & Searson, P. C., Dec 1 2010, In : Biophysical journal. 99, 11, p. 3526-3534 9 p.

Research output: Contribution to journalArticle

MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion

Daniels, B. R., Dobrowsky, T. M., Perkins, E. M., Sun, S. X. & Wirtz, D., Aug 1 2010, In : Development. 137, 15, p. 2579-2585 7 p.

Research output: Contribution to journalArticle

Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion

Dobrowsky, T. M., Daniels, B. R., Siliciano, R. F., Sun, S. X. & Wirtz, D., Jul 1 2010, In : PLoS computational biology. 6, 7, 1 p., e1000855.

Research output: Contribution to journalArticle

PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links

Stahl, P. J., Romano, N. H., Wirtz, D. & Yu, S. M., Sep 13 2010, In : Biomacromolecules. 11, 9, p. 2336-2344 9 p.

Research output: Contribution to journalArticle

Protein filaments: Bundles from boundaries

Wirtz, D. & Khatau, S. B., Oct 2010, In : Nature Materials. 9, 10, p. 788-790 3 p.

Research output: Contribution to journalArticle

The perinuclear actin cap in health and disease

Khatau, S. B., Kim, D. H., Hale, C. M., Bloom, R. J. & Wirtz, D., Jan 1 2010, In : Nucleus. 1, 4, p. 337-342 6 p.

Research output: Contribution to journalArticle

Open Access

Torsional mechanics of DNA are regulated by small-molecule intercalation

Celedon, A., Wirtz, D. & Sun, S., Dec 23 2010, In : Journal of Physical Chemistry B. 114, 50, p. 16929-16935 7 p.

Research output: Contribution to journalArticle

Triggering cell detachment from patterned electrode arrays by programmed subcellular release

Wildt, B., Wirtz, D. & Searson, P. C., Jul 2010, In : Nature protocols. 5, 7, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

2009

Altering mucus rheology to "solidify" human mucus at the nanoscale

Lai, S. K., Wang, Y. Y., Cone, R., Wirtz, D. & Hanes, J., Jan 28 2009, In : PloS one. 4, 1, e4294.

Research output: Contribution to journalArticle

A perinuclear actin cap regulates nuclear shape

Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. & Wirtz, D., Nov 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 45, p. 19017-19022 6 p.

Research output: Contribution to journalArticle

Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion

Daniels, B. R., Perkins, E. M., Dobrowsky, T. M., Sun, S. X. & Wirtz, D., Feb 23 2009, In : Journal of Cell Biology. 184, 4, p. 473-479 7 p.

Research output: Contribution to journalArticle

Condensation of FtsZ filaments can drive bacterial cell division

Lan, G., Daniels, B. R., Dobrowsky, T. M., Wirtz, D. & Sun, S. X., Jan 6 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 1, p. 121-126 6 p.

Research output: Contribution to journalArticle