1992 …2020

Research output per year

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Article

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., Jun 18 2018, (Accepted/In press) In : Nature Methods. p. 1-8 8 p.

Research output: Contribution to journalArticle

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

Kim, D. H., Khatau, S. B., Feng, Y., Walcott, S., Sun, S. X., Longmore, G. D. & Wirtz, D., Aug 15 2012, In : Scientific reports. 2, 555.

Research output: Contribution to journalArticle

Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins

Dobrowsky, T. M., Rabi, S. A., Nedellec, R., Daniels, B. R., Mullins, J. I., Mosier, D. E., Siliciano, R. F. & Wirtz, D., Oct 31 2013, In : Scientific reports. 3, 3014.

Research output: Contribution to journalArticle

A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin

Esue, O., Carson, A. A., Tseng, Y. & Wirtz, D., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30393-30399 7 p.

Research output: Contribution to journalArticle

A distinctive role for focal adhesion proteins in three-dimensional cell motility

Fraley, S. I., Feng, Y., Krishnamurthy, R., Kim, D. H., Celedon, A., Longmore, G. D. & Wirtz, D., Jun 1 2010, In : Nature cell biology. 12, 6, p. 598-604 7 p.

Research output: Contribution to journalArticle

Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model

Wang, Y., Gong, J., Wirtz, D. & Schafer, B. W., Aug 1 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 72, p. 52-65 14 p.

Research output: Contribution to journalArticle

Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells

Stukalin, E. B., Aifuwa, I., Kim, J. S., Wirtz, D. & Sun, S. X., Aug 1 2013, In : Journal of the Royal Society Interface. 10, 85

Research output: Contribution to journalArticle

Open Access

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks

Ma, L., Yamada, S., Wirtz, D. & Coulombe, P. A., May 21 2001, In : Nature cell biology. 3, 5, p. 503-506 4 p.

Research output: Contribution to journalArticle

Altering mucus rheology to "solidify" human mucus at the nanoscale

Lai, S. K., Wang, Y. Y., Cone, R., Wirtz, D. & Hanes, J., Jan 28 2009, In : PloS one. 4, 1, e4294.

Research output: Contribution to journalArticle

A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo

Li, H. Y., Wirtz, D. & Zheng, Y., Mar 3 2003, In : Journal of Cell Biology. 160, 5, p. 635-644 10 p.

Research output: Contribution to journalArticle

A perinuclear actin cap regulates nuclear shape

Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. & Wirtz, D., Nov 10 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 45, p. 19017-19022 6 p.

Research output: Contribution to journalArticle

A physical sciences network characterization of non-tumorigenic and metastatic cells

Agus, D. B., Alexander, J. F., Arap, W., Ashili, S., Aslan, J. E., Austin, R. H., Backman, V., Bethel, K. J., Bonneau, R., Chen, W. C., Chen-Tanyolac, C., Choi, N. C., Curley, S. A., Dallas, M., Damania, D., Davies, P. C. W., Decuzzi, P., Dickinson, L., Estevez-Salmeron, L., Estrella, V. & 75 others, Ferrari, M., Fischbach, C., Foo, J., Fraley, S. I., Frantz, C., Fuhrmann, A., Gascard, P., Gatenby, R. A., Geng, Y., Gerecht, S., Gillies, R. J., Godin, B., Grady, W. M., Greenfield, A., Hemphill, C., Hempstead, B. L., Hielscher, A., Hillis, W. D., Holland, E. C., Ibrahim-Hashim, A., Jacks, T., Johnson, R. H., Joo, A., Katz, J. E., Kelbauskas, L., Kesselman, C., King, M. R., Konstantopoulos, K., Kraning-Rush, C. M., Kuhn, P., Kung, K., Kwee, B., Lakins, J. N., Lambert, G., Liao, D., Licht, J. D., Liphardt, J. T., Liu, L., Lloyd, M. C., Lyubimova, A., Mallick, P., Marko, J., McCarty, O. J. T., Meldrum, D. R., Michor, F., Mumenthaler, S. M., Nandakumar, V., O'Halloran, T. V., Oh, S., Pasqualini, R., Paszek, M. J., Philips, K. G., Poultney, C. S., Rana, K., Reinhart-King, C. A., Ros, R., Semenza, G. L., Senechal, P., Shuler, M. L., Srinivasan, S., Staunton, J. R., Stypula, Y., Subramanian, H., Tlsty, T. D., Tormoen, G. W., Tseng, Y., Van Oudenaarden, A., Verbridge, S. S., Wan, J. C., Weaver, V. M., Widom, J., Will, C., Wirtz, D., Wojtkowiak, J. & Wu, P. H., Jul 4 2013, In : Scientific reports. 3, 1449.

Research output: Contribution to journalArticle

A robust nonlinear tissue-component discrimination method for computational pathology

Sarnecki, J. S., Burns, K., Wood, L. D., Waters, K. M., Hruban, R. H., Wirtz, D. & Wu, P. H., Apr 1 2016, In : Laboratory Investigation. 96, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion

Daniels, B. R., Perkins, E. M., Dobrowsky, T. M., Sun, S. X. & Wirtz, D., Feb 23 2009, In : Journal of Cell Biology. 184, 4, p. 473-479 7 p.

Research output: Contribution to journalArticle

Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow

Lee, J. S. H., Panorchan, P., Hale, C. M., Khatau, S. B., Kole, T. P., Tseng, Y. & Wirtz, D., May 1 2006, In : Journal of cell science. 119, 9, p. 1760-1768 9 p.

Research output: Contribution to journalArticle

Biophysical and biomolecular determination of cellular age in humans

Phillip, J. M., Wu, P. H., Gilkes, D., Williams, W., McGovern, S., Daya, J., Chen, J., Aifuwa, I., Lee, J. S. H., Fan, R., Walston, J. D. & Wirtz, D., Jun 30 2017, In : Nature Biomedical Engineering. 1, 7, 0093.

Research output: Contribution to journalArticle

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes

Hecht, V. C., Sullivan, L. B., Kimmerling, R. J., Kim, D. H., Hosios, A. M., Stockslager, M. A., Stevens, M. M., Kang, J. H., Wirtz, D., Vander Heiden, M. G. & Manalis, S. R., Jan 1 2016, In : Journal of Cell Biology. 212, 4, p. 439-447 9 p.

Research output: Contribution to journalArticle

Biophysics of Selectin-Ligand interactions in inflammation and cancer

Cheung, L. S. L., Raman, P. S., Balzer, E. M., Wirtz, D. & Konstantopoulos, K., Feb 2011, In : Physical biology. 8, 1, 015013.

Research output: Contribution to journalArticle

Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics

Koons, B., Sharma, P., Ye, Z., Mukherjee, A., Lee, M. H., Wirtz, D., Behkam, B. & Nain, A. S., Dec 26 2017, In : ACS Nano. 11, 12, p. 12037-12048 12 p.

Research output: Contribution to journalArticle

Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress

Lee, J. S. H., Chang, M. I., Tseng, Y. & Wirtz, D., Feb 1 2005, In : Molecular biology of the cell. 16, 2, p. 871-880 10 p.

Research output: Contribution to journalArticle

Cell migration without a lamellipodium: Translation of actin dynamics into cell movement mediated by tropomyosin

Gupton, S. L., Anderson, K. L., Kole, T. P., Fischer, R. S., Ponti, A., Hitchcock-DeGregori, S. E., Danuser, G., Fowler, V. M., Wirtz, D., Hanein, D. & Waterman-Storer, C. M., Feb 14 2005, In : Journal of Cell Biology. 168, 4, p. 619-631 13 p.

Research output: Contribution to journalArticle

Cell tension and mechanical regulation of cell volume

Gonzalez, N. P., Tao, J., Rochman, N. D., Vig, D., Chiu, E., Wirtz, D. & Sun, S. X., Oct 15 2018, In : Molecular Biology of the Cell. 29, 21, p. 2591-2600 10 p.

Research output: Contribution to journalArticle

Collagen prolyl hydroxylases are essential for breast cancer metastasis

Gilkes, D. M., Chaturvedi, P., Bajpai, S., Wong, C. C., Wei, H., Pitcairn, S., Hubbi, M. E., Wirtz, D. & Semenza, G. L., Jun 1 2013, In : Cancer Research. 73, 11, p. 3285-3296 12 p.

Research output: Contribution to journalArticle

Collective cancer cell invasion induced by coordinated contractile stresses

Valencia, A. M. J., Wu, P. H., Yogurtcu, O. N., Rao, P., DiGiacomo, J., Godet, I., He, L., Lee, M. H., Gilkes, D., Sun, S. X. & Wirtz, D., Jan 1 2015, In : Oncotarget. 6, 41, p. 43438-43451 14 p.

Research output: Contribution to journalArticle

Compliance of actin filament networks measured by particle-tracking microrheology and diffusing wave spectroscopy

Xu, J., Viasnoff, V. & Wirtz, D., Dec 1 1998, In : Rheologica Acta. 37, 4, p. 387-398 12 p.

Research output: Contribution to journalArticle

Condensation of FtsZ filaments can drive bacterial cell division

Lan, G., Daniels, B. R., Dobrowsky, T. M., Wirtz, D. & Sun, S. X., Jan 6 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 1, p. 121-126 6 p.

Research output: Contribution to journalArticle

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

Hung, W. C., Yang, J. R., Yankaskas, C. L., Wong, B. S., Wu, P. H., Pardo-Pastor, C., Serra, S. A., Chiang, M. J., Gu, Z., Wirtz, D., Valverde, M. A., Yang, J. T., Zhang, J. & Konstantopoulos, K., May 17 2016, In : Cell Reports. 15, 7, p. 1430-1441 12 p.

Research output: Contribution to journalArticle

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S. S., Mar 1 2015, In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Cross-linking FtsZ polymers into coherent Z rings

Dajkovic, A., Pichoff, S., Lutkenhaus, J. & Wirtz, D., Nov 1 2010, In : Molecular Microbiology. 78, 3, p. 651-668 18 p.

Research output: Contribution to journalArticle

Cytoskeletal tension induces the polarized architecture of the nucleus

Kim, D. H. & Wirtz, D., Apr 1 2015, In : Biomaterials. 48, p. 161-172 12 p.

Research output: Contribution to journalArticle

Dendritic branching and homogenization of actin networks mediated by Arp2/3 complex

Tseng, Y. & Wirtz, D., Dec 17 2004, In : Physical Review Letters. 93, 25, 258104.

Research output: Contribution to journalArticle

Determining the Gaussian probability distribution of the best-fit ellipsoid of revolution for a polymer chain from planar projections

Zhou, Y., Wirtz, D. & Chirikjian, G. S., Jun 1 2003, In : Inverse Problems. 19, 3, p. 725-738 14 p.

Research output: Contribution to journalArticle

Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells

Daniels, B. R., Hale, C. M., Khatau, S. B., Kusuma, S., Dobrowsky, T. M., Gerecht, S. & Wirtz, D., Dec 1 2010, In : Biophysical journal. 99, 11, p. 3563-3570 8 p.

Research output: Contribution to journalArticle

Differential vesicular sorting of AMPA and GABAA receptors

Gu, Y., Chiu, S. L., Liu, B., Wu, P. H., Delannoy, M., Lin, D. T., Wirtz, D. & Huganir, R. L., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E922-E931

Research output: Contribution to journalArticle

Diffusing wave spectroscopy microrheology of actin filament networks

Palmer, A., Mason, T. G., Xu, J., Kuo, S. C. & Wirtz, D., Jan 1 1999, In : Biophysical journal. 76, 2, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

Open Access

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners

Fraley, S. I., Feng, Y., Giri, A., Longmore, G. D. & Wirtz, D., Apr 4 2012, In : Nature communications. 3, 1711.

Research output: Contribution to journalArticle

Direct measurement of the transport properties of a single DNA molecule

Wirtz, D., Jan 1 1995, In : Physical Review Letters. 75, 12, p. 2436-2439 4 p.

Research output: Contribution to journalArticle

Dissecting cellular mechanics: Implications for aging, cancer, and immunity

Harris, M. J., Wirtz, D. & Wu, P. H., Jan 1 2018, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear f low

Shea, D. J., Wirtz, D., Stebe, K. J. & Konstantopoulos, K., Jan 1 2015, In : Oncotarget. 6, 28, p. 24842-24855 14 p.

Research output: Contribution to journalArticle

Distinct kinetic and mechanical properties govern selectin-leukocyte interactions

Hanley, W. D., Wirtz, D. & Konstantopoulos, K., May 15 2004, In : Journal of cell science. 117, 12, p. 2503-2511 9 p.

Research output: Contribution to journalArticle

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

Raman, P. S., Alves, C. S., Wirtz, D. & Konstantopoulos, K., Aug 8 2012, In : Biophysical journal. 103, 3, p. 415-423 9 p.

Research output: Contribution to journalArticle

Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis

Dallas, M. R., Liu, G., Chen, W. C., Thomas, S. N., Wirtz, D., Huso, D. L. & Konstantopoulos, K., Jun 1 2012, In : FASEB Journal. 26, 6, p. 2648-2656 9 p.

Research output: Contribution to journalArticle

Dominant diffusing mode in the self-similar phase separation of a magnetic suspension in a magnetic field

Silva, A. S. & Wirtz, D., Feb 3 1998, In : Langmuir. 14, 3, p. 578-581 4 p.

Research output: Contribution to journalArticle

Dynamic cross-linking by α-actinin determines the mechanical properties of actin filament networks

Xu, J., Wirtz, D. & Pollard, T. D., Apr 17 1998, In : Journal of Biological Chemistry. 273, 16, p. 9570-9576 7 p.

Research output: Contribution to journalArticle

Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Duan, X., Li, Y., Yi, K., Guo, F., Wang, H. Y., Wu, P. H., Yang, J., Mair, D. B., Morales, E. A., Kalab, P., Wirtz, D., Sun, S. X. & Li, R., Dec 1 2020, In : Nature communications. 11, 1, 277.

Research output: Contribution to journalArticle

Open Access

Dynamics of individual flexible polymers in a shear flow

LeDuc, P., Haber, C., Bao, G. & Wirtz, D., Jun 10 1999, In : Nature. 399, 6736, p. 564-566 3 p.

Research output: Contribution to journalArticle

Dynamics of the bacterial intermediate filament crescentin in vitroand in vivo

Esue, O., Rupprecht, L., Sun, S. X. & Wirtz, D., Jan 25 2010, In : PloS one. 5, 1, e8855.

Research output: Contribution to journalArticle

Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models

Hale, C. M., Shrestha, A. L., Khatau, S. B., Stewart-Hutchinson, P. J., Hernandez, L., Stewart, C. L., Hodzic, D. & Wirtz, D., Dec 1 2008, In : Biophysical journal. 95, 11, p. 5462-5475 14 p.

Research output: Contribution to journalArticle

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

Jayatilaka, H., Giri, A., Karl, M., Aifuwa, I., Trenton, N. J., Phillip, J. M., Khatau, S. & Wirtz, D., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1207-1221 15 p.

Research output: Contribution to journalArticle

Effect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutions

Goodman, A., Tseng, Y. & Wirtz, D., Jan 1 2002, In : Journal of molecular biology. 323, 2, p. 199-215 17 p.

Research output: Contribution to journalArticle