1992 …2020
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Research Output 1992 2020

2020

Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Duan, X., Li, Y., Yi, K., Guo, F., Wang, H. Y., Wu, P. H., Yang, J., Mair, D. B., Morales, E. A., Kalab, P., Wirtz, D., Sun, S. X. & Li, R., Dec 1 2020, In : Nature communications. 11, 1, 277.

Research output: Contribution to journalArticle

Open Access
gametocytes
organelles
spindles
Meiosis
Organelles
2019

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Nair, P. R. & Wirtz, D., Apr 1 2019, In : The Journal of cell biology. 218, 4, p. 1092-1093 2 p.

Research output: Contribution to journalComment/debate

Open Access
Cell Movement
Physiological Phenomena
Embryonic Development
Neoplasm Metastasis

Recapitulation of molecular regulators of nuclear motion during cell migration

Sneider, A., Hah, J., Wirtz, D. & Kim, D. H., Dec 1 2019, In : Cell adhesion & migration. 13, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

Open Access
Cell Movement
Cellular Microenvironment
Stress Fibers
Cell Nucleus
Organelles

Solid Stress in Brain Tumors

Gilkes, D. & Wirtz, D., Jan 1 2019, In : Trends in Cancer.

Research output: Contribution to journalShort survey

Brain Neoplasms
Neoplasms
Quality of Life
Brain
Therapeutics

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Jan 1 2019, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Cadherins
Veins
Keratin-19

YAP and TAZ regulate cell volume

Perez-Gonzalez, N. A., Rochman, N. D., Yao, K., Tao, J., Le, M. T. T., Flanary, S., Sablich, L., Toler, B., Crentsil, E., Takaesu, F., Lambrus, B., Huang, J., Fu, V., Chengappa, P., Jones, T. M., Holland, A. J., An, S., Wirtz, D., Petrie, R. J., Guan, K. L. & 1 others, Sun, S. X., Oct 7 2019, In : The Journal of cell biology. 218, 10, p. 3472-3488 17 p.

Research output: Contribution to journalArticle

Open Access
Cell Size
Proteins
Cell Cycle
Cell Shape
Myosins
2018

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., Jun 18 2018, (Accepted/In press) In : Nature Methods. p. 1-8 8 p.

Research output: Contribution to journalArticle

Mechanical properties
Cell adhesion
Rheology
Stretching
Monolayers

Cell tension and mechanical regulation of cell volume

Gonzalez, N. P., Tao, J., Rochman, N. D., Vig, D., Chiu, E., Wirtz, D. & Sun, S. X., Oct 15 2018, In : Molecular Biology of the Cell. 29, 21, p. 2591-2600 10 p.

Research output: Contribution to journalArticle

Cell Size
Myosins
Growth
Cell Adhesion
Homeostasis

Dissecting cellular mechanics: Implications for aging, cancer, and immunity

Harris, M. J., Wirtz, D. & Wu, P. H., Jan 1 2018, (Accepted/In press) In : Seminars in Cell and Developmental Biology.

Research output: Contribution to journalArticle

Mechanics
Immunity
Neoplasms
Nuclear Lamina
Inborn Genetic Diseases

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

Jayatilaka, H., Giri, A., Karl, M., Aifuwa, I., Trenton, N. J., Phillip, J. M., Khatau, S. & Wirtz, D., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1207-1221 15 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Microtubules
Cell Movement
Cells
Dyneins

Erratum: Author Correction: Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology (Nature communications (2017) 8 1 (2123))

Kim, J. K., Louhghalam, A., Lee, G., Schafer, B. W., Wirtz, D. & Kim, D. H., Mar 13 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalComment/debate

Nanobiotechnology
Lamin Type A
harnesses
Environmental engineering
HTML

Erratum: Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software (Stem Cell Reports (2017) 9(2) (697–709) (S2213671117302692) (10.1016/j.stemcr.2017.06.006))

Perestrelo, T., Chen, W., Correia, M., Le, C., Pereira, S., Rodrigues, A. S., Sousa, M. I., Ramalho-Santos, J. & Wirtz, D., Aug 14 2018, In : Stem Cell Reports. 11, 2, 1 p.

Research output: Contribution to journalComment/debate

Embryonic Stem Cells
Stem cells
Stem Cells
Software

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Pancreas
Anatomy
Pathology
Pancreatic Neoplasms
Paraffin

Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway

Yu, Y., Suryo Rahmanto, Y., Lee, M. H., Wu, P. H., Phillip, J. M., Huang, C. H., Vitolo, M. I., Gaillard, S., Martin, S. S., Wirtz, D., Shih, I. M. & Wang, T-L., Apr 11 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Ovarian Neoplasms
Cortactin
Neoplasms
Cell Movement

Isomeric control of the mechanical properties of supramolecular filament hydrogels

Lin, Y. A., Kang, M., Chen, W. C., Ou, Y. C., Cheetham, A. G., Wu, P. H., Wirtz, D., Loverde, S. M. & Cui, H., Jan 1 2018, In : Biomaterials Science. 6, 1, p. 216-224 9 p.

Research output: Contribution to journalArticle

Hydrogels
Hydrocarbons
Peptides
Mechanical properties
Tuning

Mechanics of the cell nucleus

Kim, D. H., Hah, J. & Wirtz, D., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 41-55 15 p. (Advances in Experimental Medicine and Biology; vol. 1092).

Research output: Chapter in Book/Report/Conference proceedingChapter

Control towers
Mechanics
Cell Nucleus
Cells
Cellular Microenvironment

Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate

Perestrelo, T., Correia, M., Ramalho-Santos, J. & Wirtz, D., Jan 1 2018, (Accepted/In press) In : Trends in Cell Biology.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Embryonic Development
Cues
Aptitude
1-Phosphatidylinositol 4-Kinase

Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

Parekh, A., Das, S., Parida, S., Das, C. K., Dutta, D., Mallick, S. K., Wu, P. H., Kumar, B. N. P., Bharti, R., Dey, G., Banerjee, K., Rajput, S., Bharadwaj, D., Pal, I., Dey, K. K., Rajesh, Y., Jena, B. C., Biswas, A., Banik, P., Pradhan, A. K. & 7 others, Das, S. K., Das, A. K., Dhara, S., Fisher, P. B., Wirtz, D., Mills, G. B. & Mandal, M., May 10 2018, (Accepted/In press) In : Oncogene. p. 1-16 16 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Breast Neoplasms
Vascular Endothelial Growth Factor A
Neoplasms
Apoptosis Regulatory Proteins

Role of membrane-tension gated Ca2+ flux in cell mechanosensation

He, L., Tao, J., Maity, D., Si, F., Wu, Y., Wu, T., Prasath, V., Wirtz, D. & Sun, S. X., Feb 1 2018, In : Journal of Cell Science. 131, 4, jcs208470.

Research output: Contribution to journalArticle

Myosins
Membranes
Lab-On-A-Chip Devices
Cytoskeleton
Cytoplasm

The Biophysics of 3D Cell Migration

Wu, P. H., Gilkes, D. & Wirtz, D., May 20 2018, In : Annual Review of Biophysics. 47, p. 549-567 19 p.

Research output: Contribution to journalReview article

Biophysics
Cell culture
Cell Movement
Cell Culture Techniques
Developmental Biology

Tumor cell density regulates matrix metalloproteinases for enhanced migration

Jayatilaka, H., Umanzor, F. G., Shah, V., Meirson, T., Russo, G., Starich, B., Tyle, P., Lee, J. S. H., Khatau, S., Gil-Henn, H. & Wirtz, D., Aug 24 2018, In : Oncotarget. 9, 66, p. 32556-32569 14 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Cell Count
Neoplasms
Interleukin-8
Interleukin-6
2017

Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model

Wang, Y., Gong, J., Wirtz, D. & Schafer, B. W., Aug 1 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 72, p. 52-65 14 p.

Research output: Contribution to journalArticle

Actins
Finite element method
Fluidics
Bending moments
Strain energy

Biophysical and biomolecular determination of cellular age in humans

Phillip, J. M., Wu, P. H., Gilkes, D., Williams, W., McGovern, S., Daya, J., Chen, J., Aifuwa, I., Lee, J. S. H., Fan, R., Walston, J. D. & Wirtz, D., Jun 30 2017, In : Nature Biomedical Engineering. 1, 7, 0093.

Research output: Contribution to journalArticle

Aging of materials
Fibroblasts
Progeria
Metabolism
Gene expression

Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics

Koons, B., Sharma, P., Ye, Z., Mukherjee, A., Lee, M. H., Wirtz, D., Behkam, B. & Nain, A. S., Dec 26 2017, In : ACS Nano. 11, 12, p. 12037-12048 12 p.

Research output: Contribution to journalArticle

Nanofibers
cancer
curvature
fibers
Fibers

Going with the Flow: Water Flux and Cell Shape during Cytokinesis

Li, Y., He, L., Gonzalez, N. A. P., Graham, J., Wolgemuth, C., Wirtz, D. & Sun, S. X., Dec 5 2017, In : Biophysical Journal. 113, 11, p. 2487-2495 9 p.

Research output: Contribution to journalArticle

Cytokinesis
Cell Shape
Actomyosin
Water
Ion Channels

Hypoxia Selectively Enhances Integrin α5β1 receptor expression in breast cancer to promote metastasis

Ju, J. A., Godet, I., Ye, I. C., Byun, J., Jayatilaka, H., Lee, S. J., Xiang, L., Samanta, D., Lee, M. H., Wu, P. H., Wirtz, D., Semenza, G. L. & Gilkes, D., Jun 1 2017, In : Molecular Cancer Research. 15, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

Integrins
Breast Neoplasms
Neoplasm Metastasis
Hypoxia-Inducible Factor 1
Mortality

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Stroka, K. M., Wong, B. S., Shriver, M., Phillip, J. M., Wirtz, D., Kontrogianni-Konstantopoulos, A. & Konstantopoulos, K., 2017, In : Oncotarget. 8, 33, p. 54004-54020 17 p.

Research output: Contribution to journalArticle

Breast
Epithelial Cells
Cell Movement
rho-Associated Kinases
Down-Regulation

Mammalian cell division in 3D matrices via quantitative confocal reflection microscopy

He, L., Sneider, A., Chen, W., Karl, M., Prasath, V., Wu, P. H., Mattson, G. & Wirtz, D., Nov 29 2017, In : Journal of Visualized Experiments. 2017, 129, e56364.

Research output: Contribution to journalArticle

Confocal Microscopy
Cell Division
Microscopic examination
Cells
Collagen

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion

Ahmadzadeh, H., Webster, M. R., Behera, R., Valencia, A. M. J., Wirtz, D., Weeraratna, A. T. & Shenoy, V. B., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. E1617-E1626

Research output: Contribution to journalArticle

Neoplasms
Extracellular Matrix
Actomyosin
Mechanics
Cell Adhesion

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

Kim, J. K., Louhghalam, A., Lee, G., Schafer, B. W., Wirtz, D. & Kim, D. H., Dec 1 2017, In : Nature Communications. 8, 1, 2123.

Research output: Contribution to journalArticle

Lamin Type A
harnesses
caps
cables
Actins

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software

Perestrelo, T., Chen, W., Correia, M., Le, C., Pereira, S., Rodrigues, A. S., Sousa, M. I., Ramalho-Santos, J. & Wirtz, D., Aug 8 2017, In : Stem Cell Reports. 9, 2, p. 697-709 13 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Stem cells
Software
Image analysis
Staining and Labeling

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P. H., Gilkes, D., Fan, R. & Wirtz, D., May 26 2017, In : Nature Communications. 8, 15584.

Research output: Contribution to journalArticle

Paracrine Communication
Interleukin-8
Cell Movement
Tumors
Interleukin-6

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P. H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D. & Bergles, D. E., Feb 8 2017, In : Neuron. 93, 3, p. 587-605.e7

Research output: Contribution to journalArticle

Astrocytes
Calcium
Mitochondria
Oxidative Phosphorylation
Amyotrophic Lateral Sclerosis

Tumour mechanopathology: Cutting the stress out

Gilkes, D. & Wirtz, D., Jan 10 2017, In : Nature Biomedical Engineering. 1, 1, 0012.

Research output: Contribution to journalShort survey

2016

A robust nonlinear tissue-component discrimination method for computational pathology

Sarnecki, J. S., Burns, K., Wood, L. D., Waters, K. M., Hruban, R. H., Wirtz, D. & Wu, P. H., Apr 1 2016, In : Laboratory Investigation. 96, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

Pathology
Color
Tissue Fixation
Biomedical Research
Immunohistochemistry

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes

Hecht, V. C., Sullivan, L. B., Kimmerling, R. J., Kim, D. H., Hosios, A. M., Stockslager, M. A., Stevens, M. M., Kang, J. H., Wirtz, D., Vander Heiden, M. G. & Manalis, S. R., 2016, In : Journal of Cell Biology. 212, 4, p. 439-447 9 p.

Research output: Contribution to journalArticle

Intercellular Signaling Peptides and Proteins
Lymphocytes
Autophagy
Food
Interleukin-3

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

Hung, W. C., Yang, J. R., Yankaskas, C. L., Wong, B. S., Wu, P. H., Pardo-Pastor, C., Serra, S. A., Chiang, M. J., Gu, Z., Wirtz, D., Valverde, M. A., Yang, J. T., Zhang, J. & Konstantopoulos, K., May 17 2016, In : Cell Reports. 15, 7, p. 1430-1441 12 p.

Research output: Contribution to journalArticle

Myosin Type II
Cyclic AMP-Dependent Protein Kinases
Cell signaling
Confined Spaces
Phosphoric Diester Hydrolases

Correction to "Volume regulation and shape bifurcation in the cell nucleus" [J. Cell Sci. 128, (2015) 3375-3385.]

Kim, D. H., Li, B., Si, F., Phillip, J. M., Wirtz, D. & Sun, S. X., 2016, In : Journal of Cell Science. 129, 2, p. 457 1 p.

Research output: Contribution to journalArticle

Cell Nucleus

Differential vesicular sorting of AMPA and GABAA receptors

Gu, Y., Chiu, S-L., Liu, B., Wu, P. H., Delannoy, M., Lin, D. T., Wirtz, D. & Huganir, R. L., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E922-E931

Research output: Contribution to journalArticle

AMPA Receptors
GABA-A Receptors
Vesicle-Associated Membrane Protein 2
SNARE Proteins
Synapses

Engineered Models of Confined Cell Migration

Paul, C. D., Hung, W. C., Wirtz, D. & Konstantopoulos, K., Jul 11 2016, In : Annual Review of Biomedical Engineering. 18, p. 159-180 22 p.

Research output: Contribution to journalReview article

Cell Movement
Assays
Lab-On-A-Chip Devices
Cell Migration Assays
Equipment and Supplies

Local 3D matrix confinement determines division axis through cell shape

He, L., Chen, W., Wu, P. H., Jimenez, A., Wong, B. S., San, A., Konstantopoulos, K. & Wirtz, D., 2016, In : Oncotarget. 7, 6, p. 6994-7011 18 p.

Research output: Contribution to journalArticle

Cell Shape
Integrins
Cell Division
Collagen
Fibrosarcoma

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

Shah, M. Y., Martinez-Garcia, E., Phillip, J. M., Chambliss, A. B., Popovic, R., Ezponda, T., Small, E. C., Will, C., Phillip, M. P., Neri, P., Bahlis, N. J., Wirtz, D. & Licht, J. D., Nov 10 2016, In : Oncogene. 35, 45, p. 5905-5915 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
DNA Repair
DNA Damage
Histones
Lysine
2015

Collective cancer cell invasion induced by coordinated contractile stresses

Valencia, A. M. J., Wu, P. H., Yogurtcu, O. N., Rao, P., DiGiacomo, J., Godet, I., He, L., Lee, M. H., Gilkes, D., Sun, S. X. & Wirtz, D., 2015, In : Oncotarget. 6, 41, p. 43438-43451 14 p.

Research output: Contribution to journalArticle

Fibrosarcoma
Neoplasms
Collagen
Cell-Matrix Junctions
Myosin Type II

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S., Mar 1 2015, In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Dinoprostone
Traction
Mechanical Phenomena
Biological Phenomena

Cytoskeletal tension induces the polarized architecture of the nucleus

Kim, D. H. & Wirtz, D., Apr 1 2015, In : Biomaterials. 48, p. 161-172 12 p.

Research output: Contribution to journalArticle

Nuclear Lamina
Actins
Lamins
Lamin Type A
Chromatin

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear f low

Shea, D. J., Wirtz, D., Stebe, K. J. & Konstantopoulos, K., 2015, In : Oncotarget. 6, 28, p. 24842-24855 14 p.

Research output: Contribution to journalArticle

CA-125 Antigen
L-Selectin
Selectins
E-Selectin
Cell Adhesion

Evolution of cellular morpho-phenotypes in cancer metastasis

Wu, P. H., Phillip, J. M., Khatau, S. B., Chen, W. C., Stirman, J., Rosseel, S., Tschudi, K., Van Patten, J., Wong, M., Gupta, S., Baras, A., Leek, J. T., Maitra, A. & Wirtz, D., Dec 17 2015, In : Scientific Reports. 5, 18437.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Phenotype
Neoplasms
Pancreatic Neoplasms
Cell Cycle

Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules

Yu, Y., Gaillard, S., Phillip, J., Huang, T. C., Pinto, S., Tessarollo, N., Zhang, Z., Pandey, A., Wirtz, D., Ayhan, A., Davidson, B., Wang, T-L. & Shih, I. M., Jul 13 2015, In : Cancer Cell. 28, 1, p. 82-96 15 p.

Research output: Contribution to journalArticle

Paclitaxel
Microtubules
Ovarian Neoplasms
Gene Knockdown Techniques
Syk Kinase

Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility

Palmieri, B., Bresler, Y., Wirtz, D. & Grant, M., Jul 2 2015, In : Scientific Reports. 5, 11745.

Research output: Contribution to journalArticle

Cell Movement
Elasticity
Neoplasms

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions

Lee, M. H., Wu, P. H., Gilkes, D., Aifuwa, I. & Wirtz, D., 2015, In : Oncotarget. 6, 32, p. 32634-32645 12 p.

Research output: Contribution to journalArticle

Basement Membrane
Microtubules
Breast
Epithelial Cells
Carcinoma