1992 …2020

Research output per year

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Research Output

2020

Dynamic organelle distribution initiates actin-based spindle migration in mouse oocytes

Duan, X., Li, Y., Yi, K., Guo, F., Wang, H. Y., Wu, P. H., Yang, J., Mair, D. B., Morales, E. A., Kalab, P., Wirtz, D., Sun, S. X. & Li, R., Dec 1 2020, In : Nature communications. 11, 1, 277.

Research output: Contribution to journalArticle

Open Access

Particle tracking microrheology of cancer cells in living subjects

Wu, P. H., Gambhir, S. S., Hale, C. M., Chen, W. C., Wirtz, D. & Smith, B. R., Jan 1 2020, (Accepted/In press) In : Materials Today.

Research output: Contribution to journalArticle

Single-cell morphology encodes metastatic potential

Wu, P. H., Gilkes, D. M., Phillip, J. M., Narkar, A., Cheng, T. W. T., Marchand, J., Lee, M. H., Li, R. & Wirtz, D., Jan 22 2020, In : Science Advances. 6, 4, eaaw6938.

Research output: Contribution to journalArticle

Open Access

Supramolecular Design of Unsymmetric Reverse Bolaamphiphiles for Cell-Sensitive Hydrogel Degradation and Drug Release

Chakroun, R. W., Sneider, A., Anderson, C. F., Wang, F., Wu, P. H., Wirtz, D. & Cui, H., Jan 1 2020, (Accepted/In press) In : Angewandte Chemie - International Edition.

Research output: Contribution to journalArticle

Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion

Hong, S. M., Jung, D. J., Kiemen, A., Gaida, M. M., Yoshizawa, T., Braxton, A. M., Noë, M., Lionheart, G., Oshima, K., Thompson, E. D., Burkhart, R., Wu, P. H., Wirtz, D., Hruban, R. H. & Wood, L. D., Apr 1 2020, In : Modern Pathology. 33, 4, p. 639-647 9 p.

Research output: Contribution to journalArticle

2019

Dissecting cellular mechanics: Implications for aging, cancer, and immunity

Harris, M. J., Wirtz, D. & Wu, P. H., Sep 2019, In : Seminars in Cell and Developmental Biology. 93, p. 16-25 10 p.

Research output: Contribution to journalReview article

Enabling migration by moderation: YAP/TAZ are essential for persistent migration

Nair, P. R. & Wirtz, D., Apr 1 2019, In : Journal of Cell Biology. 218, 4, p. 1092-1093 2 p.

Research output: Contribution to journalShort survey

Open Access

Recapitulation of molecular regulators of nuclear motion during cell migration

Sneider, A., Hah, J., Wirtz, D. & Kim, D. H., Dec 1 2019, In : Cell adhesion & migration. 13, 1, p. 50-62 13 p.

Research output: Contribution to journalArticle

Open Access

Solid Stress in Brain Tumors

Gilkes, D. M. & Wirtz, D., May 2019, In : Trends in Cancer. 5, 5, p. 266-268 3 p.

Research output: Contribution to journalShort survey

YAP and TAZ regulate cell volume

Perez-Gonzalez, N. A., Rochman, N. D., Yao, K., Tao, J., Le, M. T. T., Flanary, S., Sablich, L., Toler, B., Crentsil, E., Takaesu, F., Lambrus, B., Huang, J., Fu, V., Chengappa, P., Jones, T. M., Holland, A. J., An, S., Wirtz, D., Petrie, R. J., Guan, K. L. & 1 others, Sun, S. X., Oct 7 2019, In : Journal of Cell Biology. 218, 10, p. 3472-3488 17 p.

Research output: Contribution to journalArticle

Open Access
2018

A comparison of methods to assess cell mechanical properties

Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., Jun 18 2018, (Accepted/In press) In : Nature Methods. p. 1-8 8 p.

Research output: Contribution to journalArticle

Cell tension and mechanical regulation of cell volume

Gonzalez, N. P., Tao, J., Rochman, N. D., Vig, D., Chiu, E., Wirtz, D. & Sun, S. X., Oct 15 2018, In : Molecular Biology of the Cell. 29, 21, p. 2591-2600 10 p.

Research output: Contribution to journalArticle

EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration

Jayatilaka, H., Giri, A., Karl, M., Aifuwa, I., Trenton, N. J., Phillip, J. M., Khatau, S. & Wirtz, D., Mar 1 2018, In : FASEB Journal. 32, 3, p. 1207-1221 15 p.

Research output: Contribution to journalArticle

Erratum: Author Correction: Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology (Nature communications (2017) 8 1 (2123))

Kim, J. K., Louhghalam, A., Lee, G., Schafer, B. W., Wirtz, D. & Kim, D. H., Mar 13 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalComment/debate

Erratum: Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software (Stem Cell Reports (2017) 9(2) (697–709) (S2213671117302692) (10.1016/j.stemcr.2017.06.006))

Perestrelo, T., Chen, W., Correia, M., Le, C., Pereira, S., Rodrigues, A. S., Sousa, M. I., Ramalho-Santos, J. & Wirtz, D., Aug 14 2018, In : Stem Cell Reports. 11, 2, 1 p.

Research output: Contribution to journalComment/debate

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H., Jul 1 2018, In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway

Yu, Y., Suryo Rahmanto, Y., Lee, M. H., Wu, P. H., Phillip, J. M., Huang, C. H., Vitolo, M. I., Gaillard, S., Martin, S. S., Wirtz, D., Shih, I. M. & Wang, T-L., Apr 11 2018, (Accepted/In press) In : Oncogene. p. 1-12 12 p.

Research output: Contribution to journalArticle

Isomeric control of the mechanical properties of supramolecular filament hydrogels

Lin, Y. A., Kang, M., Chen, W. C., Ou, Y. C., Cheetham, A. G., Wu, P. H., Wirtz, D., Loverde, S. M. & Cui, H., Jan 1 2018, In : Biomaterials Science. 6, 1, p. 216-224 9 p.

Research output: Contribution to journalArticle

Mechanics of the cell nucleus

Kim, D. H., Hah, J. & Wirtz, D., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 41-55 15 p. (Advances in Experimental Medicine and Biology; vol. 1092).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metabolic and Mechanical Cues Regulating Pluripotent Stem Cell Fate

Perestrelo, T., Correia, M., Ramalho-Santos, J. & Wirtz, D., Jan 1 2018, (Accepted/In press) In : Trends in Cell Biology.

Research output: Contribution to journalArticle

Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo

Parekh, A., Das, S., Parida, S., Das, C. K., Dutta, D., Mallick, S. K., Wu, P. H., Kumar, B. N. P., Bharti, R., Dey, G., Banerjee, K., Rajput, S., Bharadwaj, D., Pal, I., Dey, K. K., Rajesh, Y., Jena, B. C., Biswas, A., Banik, P., Pradhan, A. K. & 7 others, Das, S. K., Das, A. K., Dhara, S., Fisher, P. B., Wirtz, D., Mills, G. B. & Mandal, M., May 10 2018, (Accepted/In press) In : Oncogene. p. 1-16 16 p.

Research output: Contribution to journalArticle

Role of membrane-tension gated Ca2+ flux in cell mechanosensation

He, L., Tao, J., Maity, D., Si, F., Wu, Y., Wu, T., Prasath, V., Wirtz, D. & Sun, S. X., Feb 1 2018, In : Journal of Cell Science. 131, 4, jcs208470.

Research output: Contribution to journalArticle

The Biophysics of 3D Cell Migration

Wu, P. H., Gilkes, D. & Wirtz, D., May 20 2018, In : Annual Review of Biophysics. 47, p. 549-567 19 p.

Research output: Contribution to journalReview article

Tumor cell density regulates matrix metalloproteinases for enhanced migration

Jayatilaka, H., Umanzor, F. G., Shah, V., Meirson, T., Russo, G., Starich, B., Tyle, P., Lee, J. S. H., Khatau, S., Gil-Henn, H. & Wirtz, D., Aug 24 2018, In : Oncotarget. 9, 66, p. 32556-32569 14 p.

Research output: Contribution to journalArticle

2017

Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model

Wang, Y., Gong, J., Wirtz, D. & Schafer, B. W., Aug 1 2017, In : Journal of the Mechanical Behavior of Biomedical Materials. 72, p. 52-65 14 p.

Research output: Contribution to journalArticle

Biophysical and biomolecular determination of cellular age in humans

Phillip, J. M., Wu, P. H., Gilkes, D., Williams, W., McGovern, S., Daya, J., Chen, J., Aifuwa, I., Lee, J. S. H., Fan, R., Walston, J. D. & Wirtz, D., Jun 30 2017, In : Nature Biomedical Engineering. 1, 7, 0093.

Research output: Contribution to journalArticle

Cancer Protrusions on a Tightrope: Nanofiber Curvature Contrast Quantitates Single Protrusion Dynamics

Koons, B., Sharma, P., Ye, Z., Mukherjee, A., Lee, M. H., Wirtz, D., Behkam, B. & Nain, A. S., Dec 26 2017, In : ACS Nano. 11, 12, p. 12037-12048 12 p.

Research output: Contribution to journalArticle

Going with the Flow: Water Flux and Cell Shape during Cytokinesis

Li, Y., He, L., Gonzalez, N. A. P., Graham, J., Wolgemuth, C., Wirtz, D. & Sun, S. X., Dec 5 2017, In : Biophysical Journal. 113, 11, p. 2487-2495 9 p.

Research output: Contribution to journalArticle

Hypoxia Selectively Enhances Integrin α5β1 receptor expression in breast cancer to promote metastasis

Ju, J. A., Godet, I., Ye, I. C., Byun, J., Jayatilaka, H., Lee, S. J., Xiang, L., Samanta, D., Lee, M. H., Wu, P. H., Wirtz, D., Semenza, G. L. & Gilkes, D., Jun 1 2017, In : Molecular Cancer Research. 15, 6, p. 723-734 12 p.

Research output: Contribution to journalArticle

Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness

Stroka, K. M., Wong, B. S., Shriver, M., Phillip, J. M., Wirtz, D., Kontrogianni-Konstantopoulos, A. & Konstantopoulos, K., Jan 1 2017, In : Oncotarget. 8, 33, p. 54004-54020 17 p.

Research output: Contribution to journalArticle

Mammalian cell division in 3D matrices via quantitative confocal reflection microscopy

He, L., Sneider, A., Chen, W., Karl, M., Prasath, V., Wu, P. H., Mattson, G. & Wirtz, D., Nov 29 2017, In : Journal of Visualized Experiments. 2017, 129, e56364.

Research output: Contribution to journalArticle

Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion

Ahmadzadeh, H., Webster, M. R., Behera, R., Valencia, A. M. J., Wirtz, D., Weeraratna, A. T. & Shenoy, V. B., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. E1617-E1626

Research output: Contribution to journalArticle

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

Kim, J. K., Louhghalam, A., Lee, G., Schafer, B. W., Wirtz, D. & Kim, D. H., Dec 1 2017, In : Nature Communications. 8, 1, 2123.

Research output: Contribution to journalArticle

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software

Perestrelo, T., Chen, W., Correia, M., Le, C., Pereira, S., Rodrigues, A. S., Sousa, M. I., Ramalho-Santos, J. & Wirtz, D., Aug 8 2017, In : Stem Cell Reports. 9, 2, p. 697-709 13 p.

Research output: Contribution to journalArticle

Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration

Jayatilaka, H., Tyle, P., Chen, J. J., Kwak, M., Ju, J., Kim, H. J., Lee, J. S. H., Wu, P. H., Gilkes, D., Fan, R. & Wirtz, D., May 26 2017, In : Nature Communications. 8, 15584.

Research output: Contribution to journalArticle

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P. H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D. & Bergles, D. E., Feb 8 2017, In : Neuron. 93, 3, p. 587-605.e7

Research output: Contribution to journalArticle

Tumour mechanopathology: Cutting the stress out

Gilkes, D. & Wirtz, D., Jan 10 2017, In : Nature Biomedical Engineering. 1, 1, 0012.

Research output: Contribution to journalShort survey

2016

A robust nonlinear tissue-component discrimination method for computational pathology

Sarnecki, J. S., Burns, K., Wood, L. D., Waters, K. M., Hruban, R. H., Wirtz, D. & Wu, P. H., Apr 1 2016, In : Laboratory Investigation. 96, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes

Hecht, V. C., Sullivan, L. B., Kimmerling, R. J., Kim, D. H., Hosios, A. M., Stockslager, M. A., Stevens, M. M., Kang, J. H., Wirtz, D., Vander Heiden, M. G. & Manalis, S. R., Jan 1 2016, In : Journal of Cell Biology. 212, 4, p. 439-447 9 p.

Research output: Contribution to journalArticle

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

Hung, W. C., Yang, J. R., Yankaskas, C. L., Wong, B. S., Wu, P. H., Pardo-Pastor, C., Serra, S. A., Chiang, M. J., Gu, Z., Wirtz, D., Valverde, M. A., Yang, J. T., Zhang, J. & Konstantopoulos, K., May 17 2016, In : Cell Reports. 15, 7, p. 1430-1441 12 p.

Research output: Contribution to journalArticle

Correction to "Volume regulation and shape bifurcation in the cell nucleus" [J. Cell Sci. 128, (2015) 3375-3385.]

Kim, D. H., Li, B., Si, F., Phillip, J. M., Wirtz, D. & Sun, S. X., Jan 1 2016, In : Journal of cell science. 129, 2, 1 p.

Research output: Contribution to journalComment/debate

Differential vesicular sorting of AMPA and GABAA receptors

Gu, Y., Chiu, S. L., Liu, B., Wu, P. H., Delannoy, M., Lin, D. T., Wirtz, D. & Huganir, R. L., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E922-E931

Research output: Contribution to journalArticle

Engineered Models of Confined Cell Migration

Paul, C. D., Hung, W. C., Wirtz, D. & Konstantopoulos, K., Jul 11 2016, In : Annual Review of Biomedical Engineering. 18, p. 159-180 22 p.

Research output: Contribution to journalReview article

Local 3D matrix confinement determines division axis through cell shape

He, L., Chen, W., Wu, P. H., Jimenez, A., Wong, B. S., San, A., Konstantopoulos, K. & Wirtz, D., Jan 1 2016, In : Oncotarget. 7, 6, p. 6994-7011 18 p.

Research output: Contribution to journalArticle

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

Shah, M. Y., Martinez-Garcia, E., Phillip, J. M., Chambliss, A. B., Popovic, R., Ezponda, T., Small, E. C., Will, C., Phillip, M. P., Neri, P., Bahlis, N. J., Wirtz, D. & Licht, J. D., Nov 10 2016, In : Oncogene. 35, 45, p. 5905-5915 11 p.

Research output: Contribution to journalArticle

2015

Collective cancer cell invasion induced by coordinated contractile stresses

Valencia, A. M. J., Wu, P. H., Yogurtcu, O. N., Rao, P., DiGiacomo, J., Godet, I., He, L., Lee, M. H., Gilkes, D., Sun, S. X. & Wirtz, D., Jan 1 2015, In : Oncotarget. 6, 41, p. 43438-43451 14 p.

Research output: Contribution to journalArticle

COX-2 dependent regulation of mechanotransduction in human breast cancer cells

Yoon, A. R., Stasinopoulos, I., Kim, J. H., Yong, H. M., Kilic, O., Wirtz, D., Bhujwalla, Z. M. & An, S. S., Mar 1 2015, In : Cancer Biology and Therapy. 16, 3, p. 430-437 8 p.

Research output: Contribution to journalArticle

Cytoskeletal tension induces the polarized architecture of the nucleus

Kim, D. H. & Wirtz, D., Apr 1 2015, In : Biomaterials. 48, p. 161-172 12 p.

Research output: Contribution to journalArticle

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear f low

Shea, D. J., Wirtz, D., Stebe, K. J. & Konstantopoulos, K., Jan 1 2015, In : Oncotarget. 6, 28, p. 24842-24855 14 p.

Research output: Contribution to journalArticle

Evolution of cellular morpho-phenotypes in cancer metastasis

Wu, P. H., Phillip, J. M., Khatau, S. B., Chen, W. C., Stirman, J., Rosseel, S., Tschudi, K., Van Patten, J., Wong, M., Gupta, S., Baras, A. S., Leek, J. T., Maitra, A. & Wirtz, D., Dec 17 2015, In : Scientific reports. 5, 18437.

Research output: Contribution to journalArticle