Dean MacKinnon

Research output

Research output per year 1989 2003 2007 2023

• 100 Article
• 4 Letter
• 4 Review article
• 2 Chapter
• 2 More
  • 1 Book
  • 1 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  Polygenic risk prediction: why and when out-of-sample prediction R² can exceed SNP-based heritability

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 6 2023, In: American journal of human genetics. 110, 7, p. 1207-1215 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Single Nucleotide Polymorphism 100%
  • Genome-Wide Association Study 62%
  • Statistics 46%
  • Data Analysis 44%
• 2022

  A Role for Psychiatry in the Personalized Medicine Curriculum

  MacKinnon, D. F. & Frosch, E., Jun 2022, In: Academic Psychiatry. 46, 3, p. 298-299 2 p.

  Research output: Contribution to journal › Letter › peer-review

• Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, MVP Suicide Exemplar Workgroup & VA Million Veteran Program, Feb 1 2022, In: Biological psychiatry. 91, 3, p. 313-327 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Suicide 100%
  • Mental Disorders 87%
  • Genome-Wide Association Study 26%
  • Risk-Taking 17%
  • Smoking 12%

• Does Nonsuicidal Self-Injury Predict Later Suicidal Attempts? A Review of Studies

  Griep, S. K. & MacKinnon, D. F., 2022, In: Archives of Suicide Research. 26, 2, p. 428-446 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • suicide attempt 100%
  • Self-Injurious Behavior 96%
  • Suicide 72%
  • common share 16%
  • Borderline Personality Disorder 16%
  2 Scopus citations

• Identifying the Common Genetic Basis of Antidepressant Response

  GSRD Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Apr 2022, In: Biological Psychiatry Global Open Science. 2, 2, p. 115-126 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antidepressive Agents 100%
  • Genome-Wide Association Study 25%
  • Genome 25%
  • Genetic Variation 23%
  • Sample Size 21%

• Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

  iPSYCH, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, Jan 1 2022, In: Biological psychiatry. 91, 1, p. 102-117 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psychotic Affective Disorders 100%
  • Schizophrenia 56%
  • Bipolar Disorder 45%
  • Genotype 41%
  • Genome 23%
• 2021

  A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

  Schizophrenia Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nov 1 2021, In: Biological psychiatry. 90, 9, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mental Disorders 100%
  • Schizophrenia 42%
  • Genetic Models 39%
  • Statistics 27%
  • Genome-Wide Association Study 18%

• Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jun 1 2021, In: Molecular psychiatry. 26, 6, p. 2457-2470 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lithium 100%
  • Bipolar Disorder 89%
  • Genome-Wide Association Study 17%
  • Genomics 8%
  • Therapeutics 6%
  7 Scopus citations

• Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Apr 1 2021, In: Molecular psychiatry. 26, 4, p. 1286-1298 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Mental Disorders 83%
  • Schizophrenia 16%
  • Mood Disorders 6%
  • Incidence 3%
  4 Scopus citations

• Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 25, 7, (1430-1446), 10.1038/s41380-019-0546-6)

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Sep 1 2021, In: Molecular psychiatry. 26, 9, p. 5465 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Psychiatry 71%
  • Genome 65%
  • Genes 38%
• 2020

  A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 1 2020, In: Nature communications. 11, 1, 2301.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Random Allocation 100%
  • White Matter 93%
  • White 85%
  • Microstructure 68%
  • Mendelian Randomization Analysis 54%
  7 Scopus citations

• Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mar 1 2020, In: Biological psychiatry. 87, 5, p. 419-430 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HLA Antigens 100%
  • Haplotypes 91%
  • Alleles 71%
  • Major Histocompatibility Complex 37%
  • Autoimmune Diseases 31%
  3 Scopus citations

• Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 1 2020, In: Molecular psychiatry. 25, 7, p. 1430-1446 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome 65%
  • Wounds and Injuries 46%
  • Genes 38%
  • Gene-Environment Interaction 11%
  • Environmental Exposure 10%
  20 Scopus citations

• The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

  Bipolar Disorder Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 15 2020, In: Biological psychiatry. 88, 2, p. 169-184 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Mood Disorders 92%
  • Bipolar Disorder 92%
  • Inborn Genetic Diseases 88%
  • Genomics 24%
  24 Scopus citations
• 2019

  Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization study

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Apr 2019, In: JAMA psychiatry. 76, 4, p. 399-408 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Random Allocation 94%
  • Exercise 56%
  • Genome-Wide Association Study 36%
  • Major Depressive Disorder 1 31%
  • Metabolic Equivalent 24%
  94 Scopus citations

• Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, Jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4, 1, p. 91-100 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • White Matter 87%
  • Anisotropy 87%
  • Genome 65%
  • Radiation 28%
  • Diffusion Tensor Imaging 21%
  9 Scopus citations

• Identification of common genetic risk variants for autism spectrum disorder

  Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & 23andMe Research Team, Mar 1 2019, In: Nature genetics. 51, 3, p. 431-444 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Autism Spectrum Disorder 100%
  • Genome-Wide Association Study 50%
  • Phenotype 19%
  • Sample Size 14%
  • Schizophrenia 13%
  373 Scopus citations

• Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 1 2019, In: Nature communications. 10, 1, 2548.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • methylation 100%
  • Cord 77%
  • DNA Methylation 62%
  • Fetal Blood 62%
  • blood 60%
  28 Scopus citations

• The familial aggregation of psychotic symptoms in bipolar disorder pedigrees

  Potash, J. B., Willour, V. L., Chiu, Y. F., Simpson, S. G., MacKinnon, D. F., Pearlson, G., Raymond DePaulo, J. & McLnnis, M. G., Jan 1 2019, Bipolar Disorder: The Science of Mental Health. Taylor and Francis, p. 48-54 7 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Pedigree 100%
  • aggregation 97%
  • Bipolar Disorder 88%
  • schizophrenia 37%
  • Cluster Analysis 34%
• 2018

  Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

  Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Dec 1 2018, In: Communications biology. 1, 1, 163.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mental depression 100%
  • bipolar disorder 97%
  • behavior disorders 81%
  • Bipolar Disorder 57%
  • Disorder 50%
  7 Scopus citations

• Change in Medical Student Attitudes Toward Patients with Substance Use Disorders After Course Exposure

  Koyi, M., Nelliot, A., MacKinnon, D., Rastegar, D. A., Fingerhood, M., Alvanzo, A., Feldman, L. & Neufeld, K. J., Apr 1 2018, In: Academic Psychiatry. 42, 2, p. 283-287 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Medical Students 100%
  • medical student 90%
  • Substance-Related Disorders 88%
  • optimism 50%
  • Optimism 40%
  10 Scopus citations

• Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

  Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jul 15 2018, In: Biological psychiatry. 84, 2, p. 138-147 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genomics 97%
  • Meta-Analysis 71%
  • Psychiatry 71%
  • Wounds and Injuries 46%
  • Odds Ratio 30%
  39 Scopus citations

• Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

  Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S. A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., & 196 othersCastelao, E., Christensen, J. H., Clarke, T. K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., DIrek, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Escott-Price, V., Kiadeh, F. H. F., Finucane, H. K., Forstner, A. J., Frank, J., Gaspar, H. A., Gill, M., Giusti-Rodríguez, P., Goes, F. S., Gordon, S. D., Grove, J., Hall, L. S., Hannon, E., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Hoffmann, P., Homuth, G., Horn, C., Hottenga, J. J., Hougaard, D. M., Hu, M., Hyde, C. L., Ising, M., Jansen, R., Jin, F., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Lane, J. M., Li, Y., Li, Y., Lind, P. A., Liu, X., Lu, L., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., McGrath, P., McGuffin, P., Medland, S. E., Mehta, DI., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Mill, J., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Purcell, S. M., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Saeed Mirza, S., Saxena, R., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. B. C., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Stockmeier, C. A., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Tian, C., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van Der Auwera, S., Van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Cichon, S., Dannlowski, U., De Geus, E. C. J., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Hinds, D. A., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. F. A., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Müller-Myhsok, B., Nordentoft, M., Nöthen, M. M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Potash, J. B., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Völzke, H., Weissman, M. M., Werge, T., Winslow, A. R., Lewis, C. M., Levinson, D. F., Breen, G., Børglum, A. D. & Sullivan, P. F., May 1 2018, In: Nature genetics. 50, 5, p. 668-681 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Schizophrenia 31%
  • Suicide 17%
  • Antidepressive Agents 17%
  • Genes 15%
  777 Scopus citations

• Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

  Generation Scotland & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dec 2018, In: PloS one. 13, 12, e0209160.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroticism 100%
  • Proxy 88%
  • Genome 57%
  • Single Nucleotide Polymorphism 42%
  • Scotland 39%
  2 Scopus citations
• 2017

  Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulations

  CHARGE InflammationWorking Group and the Major Depressive DisorderWorking Group of the Psychiatric Genomics Consortium, Dec 2017, In: JAMA psychiatry. 74, 12, p. 1214-1225 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Appetite 100%
  • Obesity 66%
  • Weights and Measures 60%
  • Body Mass Index 34%
  • Leptin 23%
  77 Scopus citations
• 2016

  The "hard" and "soft" phenotypic boundaries of bipolar disorder

  Mackinnon, D. F., Aug 1 2016, In: Psychiatric Times. 33, 8

  Research output: Contribution to journal › Article › peer-review
• 2015

  Distinguishing bipolar from unipolar depression: The importance of clinical symptoms and illness features

  Leonpacher, A. K., Liebers, D., Pirooznia, M., Jancic, D., Mackinnon, D. F., Mondimore, F. M., Schweizer, B., Potash, J. B., Zandi, P. P. & Goes, F. S., May 4 2015, In: Psychological medicine. 45, 11, p. 2437-2446 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Depressive Disorder 99%
  • Bipolar Disorder 92%
  • illness 76%
  • diagnostic 40%
  • recipient 40%
  27 Scopus citations

• Test-retest reliability of a new questionnaire for the retrospective assessment of long-term lithium use in bipolar disorder

  Tighe, S. K., Ritchey, M., Schweizer, B., Goes, F. S., Mackinnon, D., Mondimore, F., Raymond Depaulo, J., McMahon, F. J., Schulze, T. G., Zandi, P. P. & Potash, J. B., Feb 1 2015, In: Journal of Affective Disorders. 174, p. 589-593 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Lithium 100%
  • Bipolar Disorder 89%
  • Reproducibility of Results 82%
  • questionnaire 46%
  • clinical outcomes 20%
  4 Scopus citations
• 2014

  Delirium presenting as mania in a patient with end-stage COPD

  Wilkinson, S. T., Chang, S. B., Foley, T., Lipsey, J. R. & MacKinnon, D. F., 2014, In: American Journal of Psychiatry. 171, 8, p. 821-824 4 p.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• Type I interferon signaling genes in recurrent major depression: Increased expression detected by whole-blood RNA sequencing

  Mostafavi, S., Battle, A., Zhu, X., Potash, J. B., Weissman, M. M., Shi, J., Beckman, K., Haudenschild, C., Mccormick, C., Mei, R., Gameroff, M. J., Gindes, H., Adams, P., Goes, F. S., Mondimore, F. M., Mackinnon, D. F., Notes, L., Schweizer, B., Furman, D., Montgomery, S. B., & 3 othersUrban, A. E., Koller, D. & Levinson, D. F., Dec 11 2014, In: Molecular psychiatry. 19, 12, p. 1267-1274 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interferon Type I 100%
  • RNA Sequence Analysis 94%
  • Genes 33%
  • Gene Expression 33%
  • Genome 28%
  84 Scopus citations
• 2013

  Posttraumatic stress disorder increases risk for suicide attempt in adults with recurrent major depression

  Stevens, D., Wilcox, H. C., Mackinnon, D. F., Mondimore, F. M., Schweizer, B., Jancic, D., Coryell, W. H., Weissman, M. M., Levinson, D. F. & Potash, J. B., Oct 2013, In: Depression and anxiety. 30, 10, p. 940-946 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • suicide attempt 100%
  • posttraumatic stress disorder 90%
  • Post-Traumatic Stress Disorders 77%
  • Suicide 72%
  • Attempted Suicide 29%
  28 Scopus citations
• 2012

  A collaborative approach to teaching medical students how to screen, intervene, and treat substance use disorders

  Neufeld, K. J., Alvanzo, A., King, V., Feldman, L., Hsu, J. H., Rastegar, D. A., Colbert, J. M. & MacKinnon, D. F., Jul 1 2012, In: Substance Abuse. 33, 3, p. 286-291 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Medical Students 100%
  • Substance-Related Disorders 88%
  • Teaching 88%
  • Referral and Consultation 74%
  • Medical Schools 52%
  14 Scopus citations

• A genome-wide association study of attempted suicide

  Willour, V. L., Seifuddin, F., Mahon, P. B., Jancic, D., Pirooznia, M., Steele, J., Schweizer, B., Goes, F. S., Mondimore, F. M., MacKinnon, D. F., Perlis, R. H., Lee, P. H., Huang, J., Kelsoe, J. R., Shilling, P. D., Rietschel, M., Nöthen, M., Cichon, S., Gurling, H., Purcell, S., & 7 othersSmoller, J. W., Craddock, N., DePaulo, J. R., Schulze, T. G., McMahon, F. J., Zandi, P. P. & Potash, J. B., Apr 2012, In: Molecular psychiatry. 17, 4, p. 433-444 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Attempted Suicide 100%
  • Genome-Wide Association Study 82%
  • Single Nucleotide Polymorphism 66%
  • Acid Phosphatase 54%
  • Completed Suicide 45%
  96 Scopus citations

• Association study of serotonin pathway genes in attempted suicide

  Judy, J. T., Seifuddin, F., Mahon, P. B., Huo, Y., Goes, F. S., Jancic, D., Schweizer, B., Mondimore, F. M., Mackinnon, D. F., Depaulo, J. R., Gershon, E. S., Mcmahon, F. J., Cutler, D. J., Zandi, P. P., Potash, J. B. & Willour, V. L., Jan 2012, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 159 B, 1, p. 112-119 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Attempted Suicide 100%
  • Serotonin 67%
  • Single Nucleotide Polymorphism 33%
  • Genes 31%
  • Haplotypes 24%
  16 Scopus citations

• Co-morbid anxiety disorders in bipolar disorder and major depression: Familial aggregation and clinical characteristics of co-morbid panic disorder, social phobia, specific phobia and obsessive-compulsive disorder

  Goes, F. S., McCusker, M. G., Bienvenu, O. J., MacKinnon, D. F., Mondimore, F. M., Schweizer, B., Depaulo, J. R. & Potash, J. B., Jul 2012, In: Psychological medicine. 42, 7, p. 1449-1459 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Specific Phobia 100%
  • phobia 86%
  • Social Phobia 84%
  • Panic Disorder 79%
  • Obsessive-Compulsive Disorder 76%
  86 Scopus citations
• 2011

  Genetic association of bipolar disorder with the β₃ nicotinic receptor subunit gene

  NIMH Genetics Initiative Bipolar Disorder Consortium, Apr 2011, In: Psychiatric genetics. 21, 2, p. 77-84 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nicotinic Receptors 100%
  • Tobacco Use Disorder 90%
  • Bipolar Disorder 87%
  • Genes 36%
  • Single Nucleotide Polymorphism 34%
  6 Scopus citations

• Trouble in mind: An unorthodox introduction to psychiatry

  MacKinnon, D. F., Jan 1 2011, Johns Hopkins University Press. 323 p.

  Research output: Book/Report › Book

  • psychiatry 100%
  • mental illness 92%
  • mood 64%
  • clinician 57%
  • self-destruction 50%
  1 Scopus citations
• 2010

  An investigation of candidate regions for association with bipolar disorder

  NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium, NIMH Genetics Initiative Bipolar Disorder Consortium & NIMH Genetics Initiative Bipolar Disorder Consortium, Oct 1 2010, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153, 7, p. 1292-1297 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Single Nucleotide Polymorphism 43%
  • Chromosomes, Human, Pair 6 34%
  • Adenosine Triphosphatases 25%
  • Case-Control Studies 20%
  4 Scopus citations

• Sex-specific association of the reelin gene with bipolar disorder

  Goes, F. S., Willour, V. L., Zandi, P. P., Belmonte, P. L., MacKinnon, D. F., Mondimore, F. M., Schweizer, B., DePaulo, J. R., Gershon, E. S., McMahon, F. J. & Potash, J. B., Mar 2010, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153, 2, p. 549-553 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Genes 41%
  • Genetic Variation 40%
  • Neuronal Plasticity 39%
  • reelin protein 36%
  46 Scopus citations
• 2009

  Carbon dioxide induces erratic respiratory responses in bipolar disorder

  MacKinnon, D. F., Craighead, B. & Lorenz, L., Jan 2009, In: Journal of Affective Disorders. 112, 1-3, p. 193-200 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbon Dioxide 100%
  • Bipolar Disorder 91%
  • Panic 79%
  • Air 76%
  • air 74%
  2 Scopus citations

• Family-based association of FKBP5 in bipolar disorder

  Willour, V. L., Chen, H., Toolan, J., Belmonte, P., Cutler, D. J., Goes, F. S., Zandi, P. P., Lee, R. S., MacKinnon, D. F., Mondimore, F. M., Schweizer, B., DePaulo, J. R., Gershon, E., McMahon, F. J., Potash, J. B., Miller, E., Pearl, J., Kassem, L., Lopez, V., Nurnberger, J., & 46 othersMiller, M. J., Bowman, E. S., Reich, T., Goate, A., Rice, J., Stine, C., Kazuba, D., Maxwell, E., Rau, N. L., Moe, P. R., Samavedy, N., El-Mallakh, R., Manji, H., Glitz, D. A., Meyer, E. T., Smiley, C., Foroud, T., Flury, L., Dick, D. M., Edenberg, H., Bierut, L., McInnis, M., Avramopoulos, D., Payne, J., Berrettini, W., Byerley, W., Vawter, M., Coryell, W., Crowe, R., Badner, J., Liu, C., Sanders, A., Caserta, M., Dinwiddie, S., Nguyen, T., Harakal, D., Kelsoe, J., McKinney, R., Scheftner, W., Kravitz, H. M., Marta, D., Vaughn-Brown, A., Bederow, L., Detera-Wadleigh, S., Austin, L. & Murphy, D. L., Jan 1 2009, In: Molecular psychiatry. 14, 3, p. 261-268 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Hydrocortisone 61%
  • Single Nucleotide Polymorphism 57%
  • Attempted Suicide 43%
  • Genes 41%
  128 Scopus citations

• Family-based association of YWHAH in psychotic bipolar disorder

  Grover, D., Verma, R., Goes, F. S., Belmonte Mahon, P. L., Gershon, E. S., McMahon, F. J., Potash, J. B., Steele, J., Kassem, L., Pearl, J., Schulze, T., MacKinnon, D. F., Miller, E., Toolan, J., Zandi, P. P., Simpson, S., Nurnberger, J., Miller, M. J., Bowman, E. S., Reich, T., & 45 othersGoate, A., Rice, J., DePaulo, J. R., Stine, C., Kazuba, D., Maxwell, E., Rau, N. L., Moe, P. R., Samavedy, N., El-Mallakh, R., Manji, H., Glitz, D. A., Meyer, E. T., Smiley, C., Foroud, T., Flury, L., Dick, D. M., Edenberg, H., Bierut, L., McInnis, M., Mondimore, F. M., Avramopoulos, D., Payne, J., Berrettini, W., Byerley, W., Vawter, M., Coryell, W., Crowe, R., Badner, J., Liu, C., Sanders, A., Caserta, M., Dinwiddie, S., Nguyen, T., Harakal, D., Kelsoe, J., McKinney, R., Scheftner, W., Kravitz, H. M., Marta, D., Vaughn-Brown, A., Bederow, L., Detera-Wadleigh, S., Austin, L. & Murphy, D. L., Oct 5 2009, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 7, p. 977-983 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Psychotic Disorders 96%
  • Schizophrenia 31%
  • Single Nucleotide Polymorphism 21%
  • Chromosome Disorders 18%
  38 Scopus citations

• Family-based association study of neuregulin 1 with psychotic bipolar disorder

  Goes, F. S., Willour, V. L., Zandi, P. P., Belmonte, P. L., MacKinnon, D. F., Mondimore, F. M., Schweizer, B., Gershon, E. S., McMahon, F. J. & Potash, J. B., Jul 5 2009, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 150, 5, p. 693-702 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuregulin-1 100%
  • Bipolar Disorder 68%
  • Psychotic Disorders 66%
  • Haplotypes 33%
  • Single Nucleotide Polymorphism 22%
  29 Scopus citations

• Genome-wide linkage and follow-up association study of postpartum mood symptoms

  NIMH Bipolar Disorder Genetics Initiative, the "Molecular Genetics of Schizophrenia II" (MGS-2) collaboration, Bipolar Genetics Studies (BiGS) Collaboration & NIMH Genetics of Recurrent Early-Onset Depression (GenRED) project, Nov 1 2009, In: American Journal of Psychiatry. 166, 11, p. 1229-1237 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Postpartum Period 100%
  • Genome 71%
  • Chromosomes 27%
  • Mood Disorders 22%
  • Single Nucleotide Polymorphism 19%
  65 Scopus citations

• Premenstrual mood symptoms: Study of familiality and personality correlates in mood disorder pedigrees

  NIMH Genetics Initiative Bipolar Disorder Consortium, Feb 1 2009, In: Archives of Women's Mental Health. 12, 1, p. 27-34 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pedigree 100%
  • Mood Disorders 88%
  • Personality 82%
  • Bipolar Disorder 70%
  • Siblings 33%
  9 Scopus citations
• 2008

  Association study of Wnt signaling pathway genes in bipolar disorder

  Zandi, P. P., Belmonte, P. L., Willour, V. L., Goes, F. S., Badner, J. A., Simpson, S. G., Gershon, E. S., McMahon, F. J., DePaulo, J. R., Potash, J. B., Steele, J., Pearl, J., Kassem, L., Lopez, V., MacKinnon, D., Miller, E., Toolan, J., Schulze, T., Byerley, W., Coryell, W., & 3 othersKelsoe, J., Rice, J. & Nurnberger, J., Jul 2008, In: Archives of general psychiatry. 65, 7, p. 785-793 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Polymorphism 78%
  • Pathway 50%
  • Gene 49%
  • Single Nucleotide Polymorphism 46%
  57 Scopus citations

• Bipolar disorder as maladaptive arousal

  MacKinnon, D. F., May 2008, In: Annals of the New York Academy of Sciences. 1129, p. 185-189 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Bipolar Disorder 100%
  • Arousal 66%
  • Disorder 47%
  • Endophenotypes 18%
  • Respiration 16%
  5 Scopus citations

• Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder

  Liu, L., Foroud, T., Xuei, X., Berrettini, W., Byerley, W., Coryell, W., El-Mallakh, R., Gershon, E. S., Kelsoe, J. R., Lawson, W. B., MacKinnon, D. F., McInnis, M., McMahon, F. J., Murphy, D. L., Rice, J., Scheftner, W., Zandi, P. R., Lohoff, F. W., Niculescu, A. B., Meyer, E. T., & 2 othersEdenberg, H. J. & Nurnberger, J. I., Dec 2008, In: Psychiatric genetics. 18, 6, p. 267-274 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain-Derived Neurotrophic Factor 100%
  • Bipolar Disorder 91%
  • Single Nucleotide Polymorphism 66%
  • Genes 38%
  • Mood Disorders 15%
  46 Scopus citations

• Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees

  Payne, J. L., Mackinnon, D. F., Mondimore, F. M., Mcinnis, M. G., Schweizer, B., Zamoiski, R. B., Mcmahon, F. J., Nurnberger, J. I., Rice, J. P., Scheftner, W., Coryell, W., Berrettini, W. H., Kelsoe, J. R., Byerley, W., Gershon, E. S., Depaulo, J. R. & Potash, J. B., Feb 2008, In: Bipolar Disorders. 10, 1, p. 38-44 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pedigree 100%
  • Bipolar Disorder 88%
  • Postpartum Period 86%
  • National Institute of Mental Health (U.S.) 14%
  • Interviews 13%
  35 Scopus citations

• Rapid switching of mood in families with familial bipolar disorder

  Nwulia, E. A., Zandi, P. P., McInnis, M. G., DePaulo, J. R. & MacKinnon, D. F., Aug 2008, In: Bipolar Disorders. 10, 5, p. 597-606 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bipolar Disorder 100%
  • Comorbidity 48%
  • Anxiety 44%
  • Odds Ratio 39%
  • Age of Onset 39%
  11 Scopus citations