David Northrop Hager

Assistant Professor

19952019
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Research Output 1995 2019

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Article
2019

Airway Pressure Release Ventilation in Acute Hypoxemic Respiratory Failure: Curb Your Enthusiasm

Hager, D. N., Dec 1 2019, In : Critical care medicine. 47, 12, p. 1817-1818 2 p.

Research output: Contribution to journalArticle

Performance of Critical Care Outcome Prediction Models in an Intermediate Care Unit

Brusca, R. M., Simpson, C. E., Sahetya, S. K., Noorain, Z., Tanykonda, V., Stephens, R. S., Needham, D. M. & Hager, D. N., Jan 1 2019, (Accepted/In press) In : Journal of Intensive Care Medicine.

Research output: Contribution to journalArticle

Mortality
APACHE
Calibration
Multicenter Studies
Simplified Acute Physiology Score

The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: A prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

Hager, D. N., Hooper, M. H., Bernard, G. R., Busse, L. W., Ely, E. W., Fowler, A. A., Gaieski, D. F., Hall, A., Hinson, J., Jackson, J. C., Kelen, G. D., Levine, M., Lindsell, C. J., Malone, R. E., McGlothlin, A., Rothman, R., Viele, K., Wright, D. W., Sevransky, J. E. & Martin, G. S., Apr 5 2019, In : Trials. 20, 1, 197.

Research output: Contribution to journalArticle

Open Access
Thiamine
Sample Size
Ascorbic Acid
Sepsis
Randomized Controlled Trials

Understanding Vitamin C in Critical Illness: A Focus on Dose, Route, and Disease

Hooper, M. H. & Hager, D. N., Jun 1 2019, In : Critical care medicine. 47, 6, p. 867-869 3 p.

Research output: Contribution to journalArticle

Critical Illness
Ascorbic Acid

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: Statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial

Lindsell, C. J., McGlothlin, A., Nwosu, S., Rice, T. W., Hall, A., Bernard, G. R., Busse, L. W., Ely, E. W., Fowler, A. A., Gaieski, D. F., Hinson, J. S., Hooper, M. H., Jackson, J. C., Kelen, G. D., Levine, M., Martin, G. S., Rothman, R. E., Sevransky, J. E., Viele, K., Wright, D. W. & 1 others, Hager, D. N., Dec 4 2019, In : Trials. 20, 1, 670.

Research output: Contribution to journalArticle

Open Access
Thiamine
Sample Size
Ascorbic Acid
Sepsis
Randomized Controlled Trials
2018

Hospital mortality prediction for intermediate care patients: Assessing the generalizability of the Intermediate Care Unit Severity Score (IMCUSS)

Hager, D. N., Tanykonda, V., Noorain, Z., Sahetya, S., Simpson, C. E., Lucena, J. F. & Needham, D., Aug 1 2018, In : Journal of Critical Care. 46, p. 94-98 5 p.

Research output: Contribution to journalArticle

Hospital Mortality
Patient Care
Confidence Intervals
ROC Curve
Calibration

Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome

National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators, Apr 1 2018, In : Critical Care Medicine. 46, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Arterial Pressure
Oxygen
Partial Pressure
Severe Acute Respiratory Syndrome
2017

Acute Coronary Syndrome Screening and Diagnostic Practice Variation

and the ED Operations Study Group 2015, Jun 1 2017, In : Academic Emergency Medicine. 24, 6, p. 701-709 9 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Troponin
Hospital Emergency Service
Electrocardiography
Ischemia

Intermediate care to intensive care triage: A quality improvement project to reduce mortality

Hager, D. N., Chandrashekar, P., Bradsher, R. W., Abdel-Halim, A. M., Chatterjee, S., Sawyer, M., Brower, R. G. & Needham, D., Dec 1 2017, In : Journal of Critical Care. 42, p. 282-288 7 p.

Research output: Contribution to journalArticle

Triage
Critical Care
Quality Improvement
Intensive Care Units
Mortality

Outcomes of emergency medical patients admitted to an intermediate care unit with detailed admission guidelines

Simpson, C. E., Sahetya, S., Bradsher, R. W., Scholten, E. L., Bain, W., Siddique, S. M. & Hager, D. N., Jan 1 2017, In : American Journal of Critical Care. 26, 1, p. e1-e10

Research output: Contribution to journalArticle

Emergencies
Guidelines
Critical Care
Hospital Mortality
Comorbidity
2015

An Electronic Emergency Triage System to Improve Patient Distribution by Critical Outcomes

Dugas, A. S. F., Kirsch, T. D., Toerper, M., Korley, F., Yenokyan, G., France, D., Hager, D. N. & Levin, S., Mar 4 2015, (Accepted/In press) In : Journal of Emergency Medicine.

Research output: Contribution to journalArticle

Triage
Emergencies
Area Under Curve
Patient Acuity
Health Care Surveys

A targeted real-time early warning score (TREWScore) for septic shock

Henry, K. E., Hager, D. N., Pronovost, P. J. & Saria, S., Aug 5 2015, In : Science Translational Medicine. 7, 299, 299ra122.

Research output: Contribution to journalArticle

Septic Shock
Sepsis
Area Under Curve
Confidence Intervals
Systemic Inflammatory Response Syndrome

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome

Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., Schoenfeld, D., Tidswell, M., Hite, R. D., Rock, P., Miller, R. R., Morris, A. H., Hudson, L., Gundel, S., Hough, C., Neff, M., Sims, K., Ungar, A., Watkins, T., Steingrub, J. & 190 others, Tidswell, M., Braden, E., DeSouza, L., Germain, J., Kardos, C., Kelley, D., Kozikowski, L., Ouellette, S., Guntupalli, K., Bandi, V., Pope, C., Ross, C., Brower, R. G., Fessler, H. E., Hager, D. N., Mendez Tellez, P. A., Needham, D., Oakjones, K., Sevransky, J., Workneh, A., Shanholtz, C., Herr, D., Howes, H., Netzer, G., Rock, P., Sampaio, A., Titus, J., Sloane, P., Beck, T., Highfield, H., King, S., Lee, B., Bolouri, N., Wiedemann, H. P., Ashton, R. W., Culver, D. A., Frederick, T., Guzman, J. A., Komara, J. J., Reddy, A. J., Hejal, R., Andrews, M., Haney, D., Connors, A. F., Lasalvia, S., Thornton, J. D., Warren, E. L., Moss, M., Burnham, E. L., Gray, L., Maloney, J., Mealer, M., Douglas, I., Overdier, K., Thompson, K., Wolken, R., Frankel, S., McKeehan, J., Warner, M. L., Bost, T., Higgins, C., Hodgin, K., MacIntyre, N., Brown, L., Cox, C., Gentile, M., Govert, J., Knudsen, N., Carson, S., Chang, L., Choudhury, S., Hall, W., Lanier, J., Wheeler, A. P., Bernard, G. R., Hays, M., Mogan, S., Rice, T., Hite, R. D., Bender, K., Harvey, A., Morris, P. E., Ragusky, M., Wright, P., Groce, S., McLean, J., Overton, A., Truwit, J., Enfield, K., Marshall, M., Morris, A., Austin, A., Barney, S., Brown, S., Ferguson, J., Gallo, H., Graydon, T., Grissom, C., Hirshberg, E., Jephson, A., Kumar, N., Miller, R., Murphy, D., Orme, J., Stowe, A., Struck, L., Thomas, F., Ward, D., Weaver, L., Bailey, P., Beninati, W., Bezdijan, L., Clemmer, T., Rimkus, S., Tanaka, R., Lawton, C., Hanselman, D., Sundar, K., Alward, W., Bishop, C., Eckley, D., Hill, T., Jensen, B., Ludwig, K., Nielsen, D., Pearce, M., Matthay, M. A., Calfee, C., Daniel, B., Eisner, M., Garcia, O., Kordesch, K., Liu, K., Shum, N., Zhou, H., Peterson, M. W., Blaauw, J., Van Gundy, K., Albertson, T., Morrissey, B., Vlastelin, E., Hubmayr, R., Brown, D., Dubin, M., Festic, E., Gajic, O., Hinds, R., Holets, S., Kor, D., Lee, A., Passe, M., Simpson, G., Wright, J., DeBoisblanc, B., Antoine, A., Charbonnet, D., Hunt, J., Lauto, P., Marr, A., Meyaski, G., Romaine, C., Tejedor, R., Brierre, S., Byrne, J., Jagneaux, T., LeBlanc, C., Moreau, K., Thomas, C., Jain, S., Taylor, D., Seoane, L., Hebert, C., Thompson, J., Simeone, F., Fearon, J., Schoenfeld, D., Guha, M., Hammond, E., Lavery, N., Lazar, P., Morse, R., Oldmixon, C., Ringwood, N., Smoot, E., Thompson, B. T., Wilson, R., Harabin, A., Bredow, S., Waclawiw, M. & Weinmann, G., Feb 1 2015, In : Critical Care Medicine. 43, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Adult Respiratory Distress Syndrome
Catheters
Therapeutics
Water-Electrolyte Balance
National Institutes of Health (U.S.)

Recent Advances in the Management of the Acute Respiratory Distress Syndrome

Hager, D. N., Sep 1 2015, In : Clinics in Chest Medicine. 36, 3, p. 481-496 16 p.

Research output: Contribution to journalArticle

Cell Hypoxia
Positive-Pressure Respiration
Adult Respiratory Distress Syndrome
Artificial Respiration
Epidemiology
2013

Reducing deep sedation and delirium in acute lung injury patients: A quality improvement project

Hager, D. N., Dinglas, V., Subhas, S., Rowden, A. M., Neufeld, K. J., Bienvenu, O. J., Touradji, P., Colantuoni, E. A., Reddy, D. R. S., Brower, R. G. & Needham, D., Jun 2013, In : Critical Care Medicine. 41, 6, p. 1435-1442 8 p.

Research output: Contribution to journalArticle

Deep Sedation
Delirium
Acute Lung Injury
Quality Improvement
Hypnotics and Sedatives
Deep Sedation
Delirium
Acute Lung Injury
Quality Improvement
Hypnotics and Sedatives
2012
High-Frequency Ventilation
Adult Respiratory Distress Syndrome
Tidal Volume
Ventilation
Mechanical Ventilators
2011

In vitro performance comparison of the Sensormedics 3100A and B high-frequency oscillatory ventilators

Custer, J. W., Ahmed, A., Kaczka, D. W., Mulreany, D. G., Hager, D. N., Simon, B. A. & Easley, R. B., Jul 2011, In : Pediatric Critical Care Medicine. 12, 4

Research output: Contribution to journalArticle

Tidal Volume
Mechanical Ventilators
High-Frequency Ventilation
Lung
Pressure
Delirium
Rehabilitation Nursing
Medicine
Physical and Rehabilitation Medicine
Anesthesiology
2010

A 41-year-old woman with AIDS and recurrent pneumonia

Cho, E., Garibaldi, B. T. & Hager, D. N., Jan 1 2010, In : Chest. 137, 1, p. 224-227 4 p.

Research output: Contribution to journalArticle

Pneumonia
Acquired Immunodeficiency Syndrome

The 6-minute walk is associated with frailty and predicts mortality in older adults with heart failure

Boxer, R., Kleppinger, A., Ahmad, A., Annis, K., Hager, D. N. & Kenny, A., Sep 2010, In : Congestive heart failure (Greenwich, Conn.). 16, 5, p. 208-213 6 p.

Research output: Contribution to journalArticle

Heart Failure
Mortality
Interleukin-6
Confidence Intervals
Dilatation and Curettage
2009
Cryptococcosis
Peritonitis
Meningitis
Cryptococcus neoformans
Fibrosis

Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lung

Easley, R. B., Lancaster, C. T., Fuld, M. K., Custer, J. W., Hager, D. N., Kaczka, D. W. & Simon, B. A., Jan 1 2009, In : Respiratory Physiology and Neurobiology. 165, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

High-Frequency Ventilation
Lung
Continuous Positive Airway Pressure
Tidal Volume
Canidae
2008
High-Frequency Ventilation
Adult Respiratory Distress Syndrome
Gases
Tidal Volume
Respiratory Acidosis

The utility of the 6-minute walk test as a measure of frailty in older adults with heart failure

Boxer, R. S., Wang, Z., Walsh, S. J., Hager, D. N. & Kenny, A. M., Jan 2008, In : The American journal of geriatric cardiology. 17, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

Heart Failure
Confidence Intervals
Phenotype
Hand Strength
Body Mass Index
2007

A protocol for high-frequency oscillatory ventilation in adults: Results from a roundtable discussion

Fessler, H. E., Derdak, S., Ferguson, N. D., Hager, D. N., Kacmarek, R. M., Thompson, B. T. & Brower, R. G., Jul 2007, In : Critical Care Medicine. 35, 7, p. 1649-1654 6 p.

Research output: Contribution to journalArticle

High-Frequency Ventilation
Pressure
Lung
Tidal Volume
Adult Respiratory Distress Syndrome

Lessons from pediatric high-frequency oscillatory ventilation may extend the application in critically ill adults [19]

Fessler, H. E., Derdak, S., Ferguson, N. D., Hager, D. N., Kacmarek, R. M., Thompson, B. T. & Brower, R. G., Oct 2007, In : Critical Care Medicine. 35, 10, p. 2473 1 p.

Research output: Contribution to journalArticle

High-Frequency Ventilation
Critical Illness
Pediatrics

Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome

Hager, D. N., Fessler, H. E., Kaczka, D. W., Shanholtz, C. B., Fuld, M. K., Simon, B. A. & Brower, R. G., Jun 2007, In : Critical Care Medicine. 35, 6, p. 1522-1529 8 p.

Research output: Contribution to journalArticle

High-Frequency Ventilation
Tidal Volume
Adult Respiratory Distress Syndrome
Pressure
Mechanical Ventilators
2006

Customizing lung-protective mechanical ventilation strategies

Hager, D. N. & Brower, R. G., May 2006, In : Critical Care Medicine. 34, 5, p. 1554-1555 2 p.

Research output: Contribution to journalArticle

Respiratory Mechanics
Positive-Pressure Respiration
Acute Lung Injury
Adult Respiratory Distress Syndrome
Manometry

Four methods of measuring tidal volume during high-frequency oscillatory ventilation

Hager, D. N., Fuld, M., Kaczka, D. W., Fessler, H. E., Brower, R. G. & Simon, B. A., Mar 2006, In : Critical Care Medicine. 34, 3, p. 751-757 7 p.

Research output: Contribution to journalArticle

High-Frequency Ventilation
Tidal Volume
Pressure
Equipment and Supplies
Humidity
Acute Lung Injury
Adult Respiratory Distress Syndrome
Pressure
2005

Quantifying mechanical heterogeneity in canine acute lung injury: Impact of mean airway pressure

Kaczka, D. W., Hager, D. N., Hawley, M. L. & Simon, B. A., Aug 2005, In : Anesthesiology. 103, 2, p. 306-317 12 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Canidae
Pressure
Lung
Respiratory Mechanics

Tidal volume reduction in patients with acute lung injury when plateau pressures are not high

Hager, D. N., Krishnan, J. A., Hayden, D. L. & Brower, R. G., Nov 15 2005, In : American Journal of Respiratory and Critical Care Medicine. 172, 10, p. 1241-1245 5 p.

Research output: Contribution to journalArticle

Acute Lung Injury
Tidal Volume
Adult Respiratory Distress Syndrome
Pressure
Artificial Respiration
2004

Effect of spironolactone on endothelial function in patients with congestive heart failure on conventional medical therapy

Abiose, A. K., Mansoor, G. A., Barry, M., Soucier, R., Nair, C. K. & Hager, D. N., Jun 15 2004, In : The American Journal of Cardiology. 93, 12, p. 1564-1566 3 p.

Research output: Contribution to journalArticle

Spironolactone
Brachial Artery
Heart Failure
Mineralocorticoid Receptor Antagonists
Aldosterone
2003

Correlation of B-type natriuretic peptide level to 6-min walk test performance in patients with left ventricular systolic dysfunction

Wieczorek, S. J., Hager, D. N., Barry, M. B., Kearney, L., Ferrier, A. & Wu, A. H. B., Feb 2003, In : Clinica Chimica Acta. 328, 1-2, p. 87-90 4 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Left Ventricular Dysfunction
Blood
Heart Failure
Neurotransmitter Agents
2002

A rapid B-type natriuretic peptide assay accurately diagnoses left ventricular dysfunction and heart failure: A multicenter evaluation

Wieczorek, S. J., Wu, A. H. B., Christenson, R., Krishnaswamy, P., Gottlieb, S., Rosano, T., Hager, D. N., Gardetto, N., Chiu, A., Bailly, K. R. & Maisel, A., Nov 1 2002, In : American Heart Journal. 144, 5, p. 834-839 6 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Left Ventricular Dysfunction
Heart Failure
Point-of-Care Systems
Multicenter Studies
2000

Intraoperative cerebral arterial embolization during total hip arthroplasty

Edmonds, C. R., Barbut, D., Hager, D. N. & Sharrock, N. E., 2000, In : Anesthesiology. 93, 2, p. 315-318 4 p.

Research output: Contribution to journalArticle

Arthroplasty
Hip
Pulmonary Circulation
Embolism
Fat Embolism
1999

Carrier-mediated uptake of lucifer yellow in skate and rat hepatocytes: A fluid-phase marker revisited

Ballatori, N., Hager, D. N., Nundy, S., Miller, D. S. & Boyer, J. L., Oct 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 4 40-4

Research output: Contribution to journalArticle

Hepatocytes
Bile
Anions
lucifer yellow
Liver
1997

Aortic atheroma is related to outcome but not numbers of emboli during coronary bypass

Barbut, D., Lo, Y. W., Hartman, G. S., Yao, F. S. F., Trifiletti, R. R., Hager, D. N., Hinton, R. B., Gold, J. P. & Isom, O. W., Aug 1997, In : Annals of Thoracic Surgery. 64, 2, p. 454-459 6 p.

Research output: Contribution to journalArticle

Atherosclerotic Plaques
Embolism
Stroke
Thoracic Aorta
Coronary Artery Bypass

Determination of size of aortic emboli and embolic load during coronary artery bypass grafting

Barbut, D., Yao, F. S. F., Lo, Y. W., Silverman, R., Hager, D. N., Trifiletti, R. R. & Gold, J. P., May 1997, In : Annals of Thoracic Surgery. 63, 5, p. 1262-1267 6 p.

Research output: Contribution to journalArticle

Embolism
Coronary Artery Bypass
Cerebrovascular Circulation
Doppler Transcranial Ultrasonography
Constitution and Bylaws

Impact of embolization during coronary artery bypass grafting on outcome and length of stay

Barbut, D., Lo, Y. W., Gold, J. P., Trifiletti, R. R., Yao, F. S. F., Hager, D. N., Hinton, R. B. & Wayne Isom, O., Apr 1997, In : Annals of Thoracic Surgery. 63, 4, p. 998-1002 5 p.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Embolism
Length of Stay
Stroke
Doppler Transcranial Ultrasonography
1996

Active microtubule-dependent secretion of a fluorescent bile salt derivative in skate hepatocyte clusters

Miller, D. S., Fricker, G., Schramm, U., Henson, J. H., Hager, D. N., Nundy, S., Ballatori, N. & Boyer, J. L., Jun 1996, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 270, 6 33-6

Research output: Contribution to journalArticle

Bile Acids and Salts
Microtubules
Hepatocytes
Nocodazole
Skates (Fish)

Comparison of transcranial Doppler ultrasonography and transesophageal echocardiography to monitor emboli during coronary artery bypass surgery

Barbut, D., Yao, F. S., Hager, D. N., Kavanaugh, P., Trifiletti, R. R. & Gold, J. P., Jan 1996, In : Stroke. 27, 1, p. 87-90 4 p.

Research output: Contribution to journalArticle

Doppler Echocardiography
Transesophageal Echocardiography
Doppler Transcranial Ultrasonography
Embolism
Coronary Artery Bypass

Detection of aortic emboli by transesophageal echocardiography during coronary artery bypass surgery

Yao, F. S. F., Barbut, D., Hager, D. N., Trifiletti, R. R. & Gold, J. P., 1996, In : Journal of Cardiothoracic and Vascular Anesthesia. 10, 3, p. 314-317 4 p.

Research output: Contribution to journalArticle

Transesophageal Echocardiography
Embolism
Coronary Artery Bypass
Subclavian Artery
Thoracic Aorta

Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/radioresistance gene that shares sequence homology with human and mouse ERCC1

Hang, H., Hager, D. N., Goriparthi, L., Hopkins, K. M., Shih, H. & Lieberman, H. B., Apr 17 1996, In : Gene. 170, 1, p. 113-117 5 p.

Research output: Contribution to journalArticle

Schizosaccharomyces
Sequence Homology
Genetic Complementation Test
Genes
Terminator Codon
1995

Cytoskeletal organization in clusters of isolated polarized skate hepatocytes: Structural and functional evidence for microtubule-dependent transcytosis

Henson, J. H., Capuano, S., Nesbitt, D., Hager, D. N., Nundy, S., Miller, D. S., Ballatori, N. & Boyer, J. L., Mar 1 1995, In : Journal of Experimental Zoology. 271, 4, p. 273-284 12 p.

Research output: Contribution to journalArticle

dynein ATPase
Skates (Fish)
physiological transport
Transcytosis
Dyneins