David McConkey

Professor

1986 …2020

Research output per year

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Research Output

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2001

Calcium flux measurements in apoptosis

McConkey, D. J. & Nutt, L. K., Dec 1 2001, In : Methods in cell biology. 66, p. 229-246 18 p.

Research output: Contribution to journalArticle

Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome

Bold, R. J., Virudachalam, S. & McConkey, D. J., Jan 1 2001, In : Journal of Surgical Research. 100, 1, p. 11-17 7 p.

Research output: Contribution to journalArticle

Decrease in bcl-2 expression shortly after neoadjuvant chemotherapy predicts primary breast cancer response to treatment

Buchholz, T. A., Valero, V., Gilcrease, M., Symmans, W. F., Tucker, S. L., McConkey, D. J., Pusztai, L., Davis, D., Hortobagyi, G. N. & Sahin, A., Dec 1 2001, In : Breast Cancer Research and Treatment. 69, 3, 1 p.

Research output: Contribution to journalArticle

Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells

Liu, W., Davis, D. W., Ramirez, K., McConkey, D. J. & Ellis, L. M., Apr 1 2001, In : International Journal of Cancer. 92, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

Cao, X. X., Mohuiddin, I., Ece, F., McConkey, D. J. & Smythe, W. R., Jan 1 2001, In : American journal of respiratory cell and molecular biology. 25, 5, p. 562-568 7 p.

Research output: Contribution to journalArticle

Inhibition of Angiogenesis and regression of human pancreatic cancer by blockade of egf-r signal transduction in combination with gemcitabine

Bruns, C. J., Ozawa, S., Harbison, M. T., Tsan, V., Solorzano, C. C., McConkey, D. J., Radinsky, R., Kölscher, A. H. & Fidler, I. J., Dec 1 2001, In : Langenbeck's Archives of Surgery. 386, 5, 1 p.

Research output: Contribution to journalArticle

In vivo intracellular signaling as a marker of antiangiogenic activity

Solorzano, C. C., Ellis, L. M., Jung, Y. D., Bucana, C. D., McConkey, D. J., Gallick, G. E., Ellis, L. M. & McMahon, G., Oct 1 2001, In : Cancer Research. 61, 19, p. 7048-7051 4 p.

Research output: Contribution to journalArticle

Transcription factor AP-2α is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells

Nyormoi, O., Wang, Z., Doan, D., Ruiz, M., McConkey, D. & Bar-Eli, M., Jul 28 2001, In : Molecular and cellular biology. 21, 15, p. 4856-4867 12 p.

Research output: Contribution to journalArticle

Treatment with low-dose interferon-α restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder

Slaton, J. W., Karashima, T., Perrotte, P., Inoue, K., Kim, S. J., Izawa, J., Kedar, D., McConkey, D. J., Millikan, R., Sweeney, P., Yoshikawa, C., Shuin, T. & Dinney, C. P. N., Jan 1 2001, In : Clinical Cancer Research. 7, 9, p. 2840-2853 14 p.

Research output: Contribution to journalArticle

Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms

Shaheen, R. M., Tseng, W. W., Davis, D. W., Liu, W., Reinmuth, N., Vellagas, R., Wieczorek, A. A., Ogura, Y., McConkey, D. J., Drazan, K. E., Bucana, C. D., McMahon, G. & Ellis, L. M., Feb 15 2001, In : Cancer Research. 61, 4, p. 1464-1468 5 p.

Research output: Contribution to journalArticle

2000

Apoptosis in Mycobacterium tuberculosis infection in mice exhibiting varied immunopathology

Watson, V. E., Hill, L. L., Owen-Schaub, L. B., Davis, D. W., McConkey, D. J., Jagannath, C., Hunter, R. L. & Actor, J. K., Feb 1 2000, In : Journal of Pathology. 190, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

Cardiac glycosides stimulate Ca2+increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells

McConkey, D. J., Lin, Y., Nutt, L. K., Ozel, H. Z. & Newman, R. A., Jul 15 2000, In : Cancer Research. 60, 14, p. 3807-3812 6 p.

Research output: Contribution to journalArticle

Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss

Multani, A. S., Ozen, M., Narayan, S., Kumar, V., Chandra, J., McConkey, D. J., Newman, R. A. & Pathak, S., Jan 1 2000, In : Neoplasia. 2, 4, p. 339-345 7 p.

Research output: Contribution to journalArticle

Open Access

Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms

Bruns, C. J., Harbison, M. T., Davis, D. W., Portera, C. A., Tsan, R., McConkey, D. J., Evans, D. B., Abbruzzese, J. L., Hicklin, D. J. & Radinsky, R., May 1 2000, In : Clinical Cancer Research. 6, 5, p. 1936-1948 13 p.

Research output: Contribution to journalArticle

Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis

Yano, S., Shinohara, H., Herbst, R. S., Kuniyasu, H., Bucana, C. D., Ellis, L. M., Davis, D. W., McConkey, D. J. & Fidler, I. J., Sep 1 2000, In : Cancer Research. 60, 17, p. 4959-4967 9 p.

Research output: Contribution to journalArticle

Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment

Jean, D., Tellez, C., Huang, S., Davis, D. W., Bruns, C. J., McConkey, D. J., Hinrichs, S. H. & Bar-Eli, M., May 18 2000, In : Oncogene. 19, 22, p. 2721-2730 10 p.

Research output: Contribution to journalArticle

Open Access

Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung

Davis, D. W., Weidner, D. A., Holian, A. & McConkey, D. J., Oct 13 2000, In : Journal of Experimental Medicine. 192, 6, p. 857-869 13 p.

Research output: Contribution to journalArticle

Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody imclone C225 in mice with metastatic human bladder transitional cell carcinoma

Inoue, K., Slaton, J. W., Perrotte, P., Davis, D. W., Bruns, C. J., Hicklin, D. J., McConkey, D. J., Sweeney, P., Radinsky, R. & Dinney, C. P. N., Dec 1 2000, In : Clinical Cancer Research. 6, 12, p. 4874-4884 11 p.

Research output: Contribution to journalArticle

Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion.

Pathak, S., Multani, A. S., McConkey, D. J., Imam, A. S. & Amoss, M. S., Dec 2000, In : International journal of oncology. 17, 6, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin

Ouhtit, A., Muller, H. K., Davis, D. W., Ullrich, S. E., McConkey, D. & Ananthaswamy, H. N., Jan 1 2000, In : American Journal of Pathology. 156, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages

Bruns, C. J., Shinohara, H., Harbison, M. T., Davis, D. W., Nelkin, G., Killion, J. J., McConkey, D. J., Dong, Z. & Fidler, I. J., Jan 1 2000, In : Cancer Research. 60, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel

Inoue, K., Slaton, J. W., Davis, D. W., Hicklin, D. J., McConkey, D. J., Karashima, T., Radinsky, R. & Dinney, C. P. N., Jul 1 2000, In : Clinical Cancer Research. 6, 7, p. 2635-2643 9 p.

Research output: Contribution to journalArticle

Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases

Bruns, C. J., Liu, W., Davis, D. W., Shaheen, R. M., McConkey, D. J., Wilson, M. R., Bucana, C. D., Hicklin, D. J. & Ellis, L. M., Aug 1 2000, In : Cancer. 89, 3, p. 488-499 12 p.

Research output: Contribution to journalArticle

1999

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis

Shaheen, R. M., Davis, D. W., Liu, W., Zebrowski, B. K., Wilson, M. R., Bucana, C. D., McConkey, D. J., McMahon, G. & Ellis, L. M., Nov 1 1999, In : Cancer Research. 59, 21, p. 5412-5416 5 p.

Research output: Contribution to journalArticle

Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats

Multani, A. S., Chandra, J., McConkey, D. J., Sen, S., Cabral, F. & Pathak, S., Dec 1 1999, In : Oncology Research. 11, 10, p. 455-460 6 p.

Research output: Contribution to journalArticle

Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by bcl-2 content

Bold, R. J., Chandra, J. & McConkey, D. J., Jan 1 1999, In : Annals of Surgical Oncology. 6, 3, p. 279-285 7 p.

Research output: Contribution to journalArticle

Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells

Diaz, C., Lee, A. T., McConkey, D. J. & Schroit, A. J., Mar 1999, In : Cell death and differentiation. 6, 3, p. 218-226 9 p.

Research output: Contribution to journalArticle

Open Access

Prognostic Factors in Resectable Pancreatic Cancer: p53 and Bcl-2

Bold, R. J., Hess, K. R., Pearson, A. S., Grau, A. M., Sinicrope, F. A., Jennings, M., McConkey, D. J., Bucana, C. D., Cleary, K. R., Hallin, P. A., Chiao, P. J., Abbruzzese, J. L. & Evans, D. B., Jan 1 1999, In : Journal of Gastrointestinal Surgery. 3, 3, p. 263-277 15 p.

Research output: Contribution to journalArticle

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

Davies, M. A., Koul, D., Dhesi, H., Berman, R., McDonnell, T. J., McConkey, D., Yung, W. K. A. & Steck, P. A., Jun 1 1999, In : Cancer Research. 59, 11, p. 2551-2556 6 p.

Research output: Contribution to journalArticle

1998

Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer

Bouvet, M., Bold, R. J., Lee, J., Evans, D. B., Abbruzzese, J. L., Chiao, P. J., McConkey, D. J., Chandra, J., Chada, S., Fang, B. & Roth, J. A., Dec 1998, In : Annals of Surgical Oncology. 5, 8, p. 681-688 8 p.

Research output: Contribution to journalArticle

Bcl-2 expression causes redistribution of glutathione to the nucleus

Voehringer, D. W., Mcconkey, D. J., Mcdonnell, T. J., Brisbay, S. & Meyn, R. E., Mar 17 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 6, p. 2956-2960 5 p.

Research output: Contribution to journalArticle

Biochemical determinants of apoptosis and necrosis

McConkey, D. J., Nov 12 1998, In : Toxicology Letters. 99, 3, p. 157-168 12 p.

Research output: Contribution to journalArticle

CREB and its associated proteins act as survival factors for human melanoma cells

Jean, D., Harbison, M., McConkey, D. J., Ronai, Z. & Bar-Eli, M., Sep 18 1998, In : Journal of Biological Chemistry. 273, 38, p. 24884-24890 7 p.

Research output: Contribution to journalArticle

Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes

Chandra, J., Niemer, I., Gilbreath, J., Kliche, K. O., Andreeff, M., Freireich, E. J., Keating, M. & McConkey, D. J., Dec 1 1998, In : Blood. 92, 11, p. 4220-4229 10 p.

Research output: Contribution to journalArticle

1997

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2

Xie, K., Wang, Y., Huang, S., Xu, L., Bielenberg, D., Salas, T., McConkey, D. J., Jiang, W. & Fidler, I. J., Jan 1 1997, In : Oncogene. 15, 7, p. 771-779 9 p.

Research output: Contribution to journalArticle

Open Access

Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes

Chandra, J., Gilbreath, J., Freireich, E. J., Kliche, K. O., Andreeff, M., Keating, M. & McConkey, D. J., Nov 15 1997, In : Blood. 90, 9, p. 3673-3681 9 p.

Research output: Contribution to journalArticle

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

Mirkovic, N., Voehringer, D. W., Story, M. D., McConkey, D. J., McDonnell, T. J. & Meyn, R. E., Jan 1 1997, In : Oncogene. 15, 12, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

Open Access
1996

Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line

McConkey, D. J., Greene, G. & Pettaway, C. A., Dec 15 1996, In : Cancer Research. 56, 24, p. 5594-5599 6 p.

Research output: Contribution to journalArticle

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX

McConkey, D. J., Chandra, J., Wright, S., Plunkett, W., McDonnell, T. J., Reed, J. C. & Keating, M., Apr 1 1996, In : Journal of Immunology. 156, 7, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+

Marin, M. C., Fernandez, A., Bick, R. J., Brisbay, S., Buja, L. M., Snuggs, M., McConkey, D. J., Von Eschenbach, A. C., Keating, M. J. & McDonnell, T. J., Jul 5 1996, In : Oncogene. 12, 11, p. 2259-2266 8 p.

Research output: Contribution to journalArticle

At least two ways to apoptose

McConkey, D. J., Mar 1996, In : Human & Experimental Toxicology. 15, 3, p. 274-276 3 p.

Research output: Contribution to journalArticle

Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

Xie, K., Huang, S., Wang, Y., Beltran, P. J., Juang, S. H., Dong, Z., Reed, J. C., McDonnell, T. J., McConkey, D. J. & Fidler, I. J., Nov 27 1996, In : Cancer Immunology Immunotherapy. 43, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

Open Access

CD98: A type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells

Warren, A. P., Patel, K., McConkev, D. J. & Palacios, R., May 1 1996, In : Blood. 87, 9, p. 3676-3687 12 p.

Research output: Contribution to journalArticle

Cycloheximide-induced apoptosis in melanoma cells derived from regressing cutaneous tumours of Sinclair swine

Gossett, R., Kier, A. B., Schroeder, F., McConkey, D., Fadok, V. & Amoss, M. S., Jan 1 1996, In : Journal of comparative pathology. 115, 4, p. 353-372 20 p.

Research output: Contribution to journalArticle

Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential

Huang, S., Luca, M., Gutman, M., McConkey, D. J., Langley, K. E., Lyman, S. D. & Bar-Eli, M., Dec 1 1996, In : Oncogene. 13, 11, p. 2339-2347 9 p.

Research output: Contribution to journalArticle

Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Xue, Y., Murdjeva, M., Okret, S., McConkey, D., Kiuossis, D. & Jondal, M., Feb 1996, In : European Journal of Immunology. 26, 2, p. 428-434 7 p.

Research output: Contribution to journalArticle

Proteolytic cleavage of vimentin during glucocorticoid-induced apoptosis

Kiefer, J. & McConkey, D. J., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1072

Research output: Contribution to journalArticle

Ras signaling in tumor necrosis factor-induced apoptosis

Trent, J. C., McConkey, D. J., Loughlin, S. M., Harbison, M. T., Fernandez, A. & Ananthaswamy, H. N., Sep 2 1996, In : EMBO Journal. 15, 17, p. 4497-4505 9 p.

Research output: Contribution to journalArticle

The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells

McConkey, D. J., Goodrich, D., Bucana, C. & Klostergaard, J., Nov 20 1996, In : Oncogene. 13, 8, p. 1693-1700 8 p.

Research output: Contribution to journalArticle