David McConkey

Professor

1986 …2020

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Research Output

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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

Arumugam, T., Ramachandran, V., Fournier, K. F., Wang, H., Marquis, L., Abbruzzese, J. L., Gallick, G. E., Logsdon, C. D., McConkey, D. J. & Choi, W., Jul 15 2009, In : Cancer Research. 69, 14, p. 5820-5828 9 p.

Research output: Contribution to journalArticle

ERCC2 Mutation: The Marker for Chemosensitivity in Primary and Secondary Muscle-invasive Bladder Cancers

Choi, W. & McConkey, D., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis

Yano, S., Shinohara, H., Herbst, R. S., Kuniyasu, H., Bucana, C. D., Ellis, L. M., Davis, D. W., McConkey, D. J. & Fidler, I. J., Sep 1 2000, In : Cancer Research. 60, 17, p. 4959-4967 9 p.

Research output: Contribution to journalArticle

Fibroblast growth factor receptor 3 is a rational therapeutic target in bladder cancer

Gust, K. M., McConkey, D. J., Awrey, S., Hegarty, P. K., Qing, J., Bondaruk, J., Ashkenazi, A., Czerniak, B., Dinney, C. P. & Black, P. C., Jul 2013, In : Molecular cancer therapeutics. 12, 7, p. 1245-1254 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors-1 and -3 Play Distinct Roles in the Regulation of Bladder Cancer Growth and Metastasis: Implications for Therapeutic Targeting

Cheng, T., Roth, B., Choi, W., Black, P. C., Dinney, C. & McConkey, D. J., Feb 26 2013, In : PloS one. 8, 2, e57284.

Research output: Contribution to journalArticle

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

Lee, S., Jeong, J., Majewski, T., Scherer, S. E., Kim, M. S., Tuziak, T., Tang, K. S., Baggerly, K., Grossman, H. B., Zhou, J. H., Shen, L., Bondaruk, J., Ahmed, S. S., Samanta, S., Spiess, P., Wu, X., Filipek, S., McConkey, D., Bar-Eli, M., Issa, J. P. & 2 others, Benedict, W. F. & Czerniak, B., Aug 21 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13732-13737 6 p.

Research output: Contribution to journalArticle

Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-κB

Mian, B. M., Dinney, C. P. N., Bermejo, C. E., Sweeney, P., Tellez, C., Yang, X. D., Gudas, J. M., McConkey, D. J. & Bar-Eli, M., Aug 1 2003, In : Clinical Cancer Research. 9, 8, p. 3167-3175 9 p.

Research output: Contribution to journalArticle

Functional glucocorticoid receptor expression is required for cAMP- mediated apoptosis in a human leukemic T cell line

Kiefer, J., Okret, S., Jondal, M. & McConkey, D. J., Jan 1 1995, In : Journal of Immunology. 155, 10, p. 4525-4528 4 p.

Research output: Contribution to journalArticle

Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin

Braeuer, R. R., Zigler, M., Kamiya, T., Dobroff, A. S., Huang, L., Choi, W., McConkey, D. J., Shoshan, E., Mobley, A. K., Song, R., Raz, A. & Bar-Eli, M., Nov 15 2012, In : Cancer Research. 72, 22, p. 5757-5766 10 p.

Research output: Contribution to journalArticle

Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression

Shrader, M., Pino, M. S., Lashinger, L., Bar-Eli, M., Adam, L., Dinney, C. P. N. & McConkey, D. J., Feb 15 2007, In : Cancer Research. 67, 4, p. 1430-1435 6 p.

Research output: Contribution to journalArticle

Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by bcl-2 content

Bold, R. J., Chandra, J. & McConkey, D. J., Jan 1 1999, In : Annals of Surgical Oncology. 6, 3, p. 279-285 7 p.

Research output: Contribution to journalArticle

Gene Expression Profile of the Clinically Aggressive Micropapillary Variant of Bladder Cancer

Guo, C. C., Dadhania, V., Zhang, L., Majewski, T., Bondaruk, J., Sykulski, M., Wronowska, W., Gambin, A., Wang, Y., Zhang, S., Fuentes-Mattei, E., Kamat, A. M., Dinney, C., Siefker-Radtke, A., Choi, W., Baggerly, K. A., McConkey, D., Weinstein, J. N. & Czerniak, B., Oct 1 2016, In : European Urology. 70, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

Generation of natural killer cells from both FcγRII/III+ and FcγRII/III- murine fetal liver progenitors

Moingeon, P., Rodewald, H. R., McConkey, D., Mildonian, A., Awad, K. & Reinherz, E. L., 1993, In : Blood. 82, 5, p. 1453-1462 10 p.

Research output: Contribution to journalArticle

Open Access

Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset

Choi, W., Ochoa, A., McConkey, D., Aine, M., Höglund, M., Kim, W. Y., Real, F. X., Kiltie, A. E., Milsom, I., Dyrskjøt, L. & Lerner, S. P., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Glucagon activation of the thiol:Protein disulfide oxidoreductase in isolated, rat, hepatic microsomes

McConkey, D. J., Crankshaw, D. L. & Holtzman, J. L., Jun 9 1986, In : Life Sciences. 38, 23, p. 2139-2143 5 p.

Research output: Contribution to journalArticle

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

McConkey, D. J., Nicotera, P., Hartzell, P., Bellomo, G., Wyllie, A. H. & Orrenius, S., Feb 15 1989, In : Archives of Biochemistry and Biophysics. 269, 1, p. 365-370 6 p.

Research output: Contribution to journalArticle

Hiding in plain view: Genetic profiling reveals decades old cross contamination of bladder cancer cell line ku7 with hela

Jäger, W., Horiguchi, Y., Shah, J., Hayashi, T., Awrey, S., Gust, K. M., Hadaschik, B. A., Matsui, Y., Anderson, S., Bell, R. H., Ettinger, S., So, A. I., Gleave, M. E., Lee, I. L., Dinney, C. P., Tachibana, M., McConkey, D. J. & Black, P. C., Oct 2013, In : Journal of Urology. 190, 4, p. 1404-1409 6 p.

Research output: Contribution to journalArticle

Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma

Cao, X. X., Mohuiddin, I., Ece, F., McConkey, D. J. & Smythe, W. R., Jan 1 2001, In : American journal of respiratory cell and molecular biology. 25, 5, p. 562-568 7 p.

Research output: Contribution to journalArticle

HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells

White, M. C., Schroeder, R. D., Zhu, K., Xiong, K. & McConkey, D., May 3 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines

Pino, M. S., Balsamo, M., Modugno, F. D., Mottolese, M., Alessio, M., Melucci, E., Milella, M., McConkey, D. J., Philippar, U., Gertler, F. B., Natali, P. G. & Nisticò, P., Aug 1 2008, In : Clinical Cancer Research. 14, 15, 1 p.

Research output: Contribution to journalArticle

Identification of Differential Tumor Subtypes of T1 Bladder Cancer

Robertson, A. G., Groeneveld, C. S., Jordan, B., Lin, X., McLaughlin, K. A., Das, A., Fall, L. A., Fantini, D., Taxter, T. J., Mogil, L. S., Lindskrog, S. V., Dyrskjøt, L., McConkey, D. J., Svatek, R. S., de Reyniès, A., Castro, M. A. A. & Meeks, J. J., 2020, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

Choi, W., Porten, S., Kim, S., Willis, D., Plimack, E. R., Hoffman-Censits, J., Roth, B., Cheng, T., Tran, M., Lee, I. L., Melquist, J., Bondaruk, J., Majewski, T., Zhang, S., Pretzsch, S., Baggerly, K., Siefker-Radtke, A., Czerniak, B., Dinney, C. P. N. & McConkey, D. J., Feb 10 2014, In : Cancer cell. 25, 2, p. 152-165 14 p.

Research output: Contribution to journalArticle

Impact of High-risk Features and Effect of Neoadjuvant Chemotherapy in Urothelial Cancer Patients with Invasion into the Lamina Propria on Transurethral Resection in the Absence of Deep Muscle Invasion

Metcalfe, M. J., Ferguson, J. E., Li, R., Xiao, L., Guo, C. C., Czerniak, B. A., Siefker-Radtke, A., Pretzsch, S. M., Navai, N., McConkey, D., Kamat, A. M., Campbell, M. & Dinney, C., 2017, (Accepted/In press) In : European Urology Focus.

Research output: Contribution to journalArticle

Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy

Seiler, R., Ashab, H. A. D., Erho, N., van Rhijn, B. W. G., Winters, B., Douglas, J., Van Kessel, K. E., Fransen van de Putte, E. E., Sommerlad, M., Wang, N. Q., Choeurng, V., Gibb, E. A., Palmer-Aronsten, B., Lam, L. L., Buerki, C., Davicioni, E., Sjödahl, G., Kardos, J., Hoadley, K. A., Lerner, S. P. & 14 others, McConkey, D., Choi, W., Kim, W. Y., Kiss, B., Thalmann, G. N., Todenhöfer, T., Crabb, S. J., North, S., Zwarthoff, E. C., Boormans, J. L., Wright, J., Dall'Era, M., van der Heijden, M. S. & Black, P. C., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Impact of spheroid culture on molecular and functional characteristics of bladder cancer cell lines

Yoshida, T., Sopko, N. A., Kates, M., Liu, X., Joice, G., McConkey, D. J. & Bivalacqua, T. J., Jan 1 2019, In : Oncology Letters. 18, 5, p. 4923-4929 7 p.

Research output: Contribution to journalArticle

Increased apoptosis in metastatic human colonic adenocarcinomas

Termuhlen, P. M., Sweeney-Gotsch, B. M., Berman, R. S., Ellis, L. M., Bucana, C., Shen, Y., Cleary, K. R. & McConkey, D. J., Jan 1 2002, In : Cancer Biology and Therapy. 1, 1, p. 58-63 6 p.

Research output: Contribution to journalArticle

Increased mitochondrial biogenesis in primary leukemia cells: The role of endogenous nitric oxide and impact on sensitivity to fludarabine

Carew, J. S., Nawrocki, S. T., Xu, R. H., Dunner, K., McConkey, D. J., Wierda, W. G., Keating, M. J. & Huang, P., Dec 2004, In : Leukemia. 18, 12, p. 1934-1940 7 p.

Research output: Contribution to journalArticle

Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis

Nutt, L. K., Gogvadze, V., Uthaisang, W., Mirnikjoo, B., McConkey, D. J. & Orrenius, S., Apr 1 2005, In : Cancer Biology and Therapy. 4, 4, p. 459-467 9 p.

Research output: Contribution to journalArticle

Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors

Zheng, B., Georgakis, G. V., Li, Y., Bharti, A., McConkey, D., Aggarwal, B. B. & Younes, A., May 1 2004, In : Clinical Cancer Research. 10, 9, p. 3207-3215 9 p.

Research output: Contribution to journalArticle

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells

McConkey, D. J., Aguilar-Santelises, M., Hartzell, P., Eriksson, I., Mellstedt, H., Orrenius, S. & Jondal, M., Jan 1 1991, In : Journal of Immunology. 146, 3, p. 1072-1076 5 p.

Research output: Contribution to journalArticle

In-Frame cDNA Library Combined with Protein Complementation Assay Identifies ARL11-Binding Partners

Lee, S., Lee, I., Jung, Y., McConkey, D. & Czerniak, B., Dec 18 2012, In : PloS one. 7, 12, e52290.

Research output: Contribution to journalArticle

Inhibition of Angiogenesis and regression of human pancreatic cancer by blockade of egf-r signal transduction in combination with gemcitabine

Bruns, C. J., Ozawa, S., Harbison, M. T., Tsan, V., Solorzano, C. C., McConkey, D. J., Radinsky, R., Kölscher, A. H. & Fidler, I. J., Dec 1 2001, In : Langenbeck's Archives of Surgery. 386, 5, 1 p.

Research output: Contribution to journalArticle

Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C

McConkey, D. J., Hartzell, P., Jondal, M. & Orrenius, S., Jan 1 1989, In : Journal of Biological Chemistry. 264, 23, p. 13399-13402 4 p.

Research output: Contribution to journalArticle

Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Xue, Y., Murdjeva, M., Okret, S., McConkey, D., Kiuossis, D. & Jondal, M., Feb 1996, In : European Journal of Immunology. 26, 2, p. 428-434 7 p.

Research output: Contribution to journalArticle

Inhibition of Inducible Heat Shock Protein-70 (Hsp72) Enhances Bortezomib-Induced Cell Death in Human Bladder Cancer Cells

Qi, W., White, M. C., Choi, W., Guo, C., Dinney, C., McConkey, D. J. & Siefker-Radtke, A., Jul 18 2013, In : PloS one. 8, 7, e69509.

Research output: Contribution to journalArticle

Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase

Yang, P., Collin, P., Madden, T., Chan, D., Sweeney-Gotsch, B., McConkey, D. & Newman, R. A., Jun 1 2003, In : Prostate. 55, 4, p. 281-291 11 p.

Research output: Contribution to journalArticle

Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

Bondar, V. M., Sweeney-Gotsch, B., Andreeff, M., Mills, G. B. & McConkey, D. J., Oct 1 2002, In : Molecular cancer therapeutics. 1, 12, p. 989-997 9 p.

Research output: Contribution to journalArticle

Inhibition of tumor growth and metastasis of human melanoma by intracellular anti-ATF-1 single chain Fv fragment

Jean, D., Tellez, C., Huang, S., Davis, D. W., Bruns, C. J., McConkey, D. J., Hinrichs, S. H. & Bar-Eli, M., May 18 2000, In : Oncogene. 19, 22, p. 2721-2730 10 p.

Research output: Contribution to journalArticle

Open Access

Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

Plote, D., Choi, W., Mokkapati, S., Sundi, D., Ferguson, J. E., Duplisea, J., Parker, N. R., Yla-Herttuala, S., Committee, SUO. CTC. B., McConkey, D., Schluns, K. S. & Dinney, C. P., May 4 2019, In : OncoImmunology. 8, 5, e1577125.

Research output: Contribution to journalArticle

Open Access

Interferon-α induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells

Papageorgiou, A., Dinney, C. P. N. & McConkey, D. J., Jun 2007, In : Cancer Biology and Therapy. 6, 6, p. 872-879 8 p.

Research output: Contribution to journalArticle

Open Access

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes

McConkey, D. J., Hartzell, P., Chow, S. C., Orrenius, S. & Jondal, M., Mar 23 1990, In : Journal of Biological Chemistry. 265, 6, p. 3009-3011 3 p.

Research output: Contribution to journalArticle

Intravesical Ad-IFNα causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-α protein

Benedict, W. F., Tao, Z., Kim, C. S., Zhang, X., Zhou, J. H., Adam, L., McConkey, D. J., Papageorgiou, A., Munsell, M., Philopena, J., Engler, H., Demers, W., Maneval, D. C., Dinney, C. P. N. & Connor, R. J., Sep 1 2004, In : Molecular Therapy. 10, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

Intravesical BCG Induces CD4+ T-cell expansion in an immune competent model of bladder cancer

Kates, M., Nirschl, T., Sopko, N. A., Matsui, H., Kochel, C. M., Reis, L. O., Netto, G. J., Hoque, M., Hahn, N. M., McConkey, D. J., Baras, A. S., Drake, C. G. & Bivalacqua, T. J., Jul 1 2017, In : Cancer immunology research. 5, 7, p. 594-603 10 p.

Research output: Contribution to journalArticle

In vivo intracellular signaling as a marker of antiangiogenic activity

Solorzano, C. C., Ellis, L. M., Jung, Y. D., Bucana, C. D., McConkey, D. J., Gallick, G. E., Ellis, L. M. & McMahon, G., Oct 1 2001, In : Cancer Research. 61, 19, p. 7048-7051 4 p.

Research output: Contribution to journalArticle

Is Vascular Endothelial Growth Factor Modulation a Predictor of the Therapeutic Efficacy of Gefitinib for Bladder Cancer?

Kassouf, W., Brown, G. A., Black, P. C., Fisher, M. B., Inamoto, T., Luongo, T., Gallagher, D., Bar-Eli, M., McConkey, D. J., Adam, L. & Dinney, C. P. N., Sep 1 2008, In : Journal of Urology. 180, 3, p. 1146-1153 8 p.

Research output: Contribution to journalArticle

Measurement of changes in intracellular calcium during apoptosis.

McConkey, D. J. & Nutt, L., 2004, In : Methods in molecular biology (Clifton, N.J.). 282, p. 117-130 14 p.

Research output: Contribution to journalArticle

Mechanisms of proteasome inhibitor action and resistance in cancer

McConkey, D. J. & Zhu, K., Aug 1 2008, In : Drug Resistance Updates. 11, 4-5, p. 164-179 16 p.

Research output: Contribution to journalArticle