David McConkey

Professor

1986 …2020

Research output per year

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Research Output

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2006

SU‐FF‐I‐87: High Frequency Ultrasound To Monitor Murine Orthotopic Bladder Cancer Model : An Alternative To Magnetic Resonance Imaging

Shetty, A., Stafford, R., Esparza‐coss, E., Andtbacka, R., Brown, G., Black, P., Metwalli, A., McConkey, D., Dinney, C. & Hazle, J., 2006, In : Medical Physics. 33, 6, p. 2017 1 p.

Research output: Contribution to journalArticle

Targeting endoplasmic reticulum protein transport: A novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL

Carew, J. S., Nawrocki, S. T., Krupnik, Y. V., Dunner, K., McConkey, D. J., Keating, M. J. & Huang, P., Jan 1 2006, In : Blood. 107, 1, p. 222-231 10 p.

Research output: Contribution to journalArticle

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia

Ruiz, S., Krupnik, Y., Keating, M., Chandra, J., Palladino, M. & McConkey, D., Jul 1 2006, In : Molecular cancer therapeutics. 5, 7, p. 1836-1843 8 p.

Research output: Contribution to journalArticle

Transforming growth factor α expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines

Pino, M. S., Shrader, M., Baker, C. H., Cognetti, F., Xiong, H. Q., Abbruzzese, J. L. & McConkey, D. J., Apr 1 2006, In : Cancer Research. 66, 7, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

2005

Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells

Lashinger, L. M., Zhu, K., Williams, S. A., Shrader, M., Dinney, C. P. N. & McConkey, D. J., Jun 1 2005, In : Cancer Research. 65, 11, p. 4902-4908 7 p.

Research output: Contribution to journalArticle

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Dunner, K., Boise, L. H., Chiao, P. J., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In : Cancer Research. 65, 24, p. 11510-11519 10 p.

Research output: Contribution to journalArticle

Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Dunner, K., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In : Cancer Research. 65, 24, p. 11658-11666 9 p.

Research output: Contribution to journalArticle

Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis

Nutt, L. K., Gogvadze, V., Uthaisang, W., Mirnikjoo, B., McConkey, D. J. & Orrenius, S., Apr 1 2005, In : Cancer Biology and Therapy. 4, 4, p. 459-467 9 p.

Research output: Contribution to journalArticle

Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668

Davis, D. W., Takamori, R., Raut, C. P., Xiong, H. Q., Herbst, R. S., Stadler, W. M., Heymach, J. V., Demetri, G. D., Rashid, A., Shen, Y., Wen, S., Abbruzzese, J. L. & McConkey, D. J., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 678-689 12 p.

Research output: Contribution to journalArticle

Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells

Pino, M. S., Nawrocki, S. T., Cognetti, F., Abruzzese, J. L., Xiong, H. Q. & McConkey, D. J., Nov 2005, In : Cancer Biology and Therapy. 4, 11, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

Open Access

Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of gefitinib in bladder cancer cells

Kassouf, W., Dinney, C. P. N., Brown, G., McConkey, D. J., Diehl, A. J., Bar-Eli, M. & Adam, L., Nov 15 2005, In : Cancer Research. 65, 22, p. 10524-10535 12 p.

Research output: Contribution to journalArticle

2004

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

Xiong, H. Q., Herbst, R., Faria, S. C., Scholz, C., Davis, D., Jackson, E. F., Madden, T., McConkey, D., Hicks, M., Hess, K., Charnsangavej, C. & Abbruzzese, J. L., Nov 1 2004, In : Investigational New Drugs. 22, 4, p. 459-466 8 p.

Research output: Contribution to journalArticle

Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts

Raut, C. P., Nawrocki, S., Lashinger, L. M., Davis, D. W., Khanbolooki, S., Xiong, H., Ellis, L. M. & McConkey, D. J., Dec 2004, In : Cancer Biology and Therapy. 3, 12, p. 1217-1224 8 p.

Research output: Contribution to journalArticle

Open Access

Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer

Raut, C. P., Takamori, R. K., Davis, D. W., Sweeney-Gotsch, B., O'Reilly, M. S. & McConkey, D. J., Jul 2004, In : Cancer Biology and Therapy. 3, 7, p. 679-687 9 p.

Research output: Contribution to journalArticle

Open Access

Increased mitochondrial biogenesis in primary leukemia cells: The role of endogenous nitric oxide and impact on sensitivity to fludarabine

Carew, J. S., Nawrocki, S. T., Xu, R. H., Dunner, K., McConkey, D. J., Wierda, W. G., Keating, M. J. & Huang, P., Dec 2004, In : Leukemia. 18, 12, p. 1934-1940 7 p.

Research output: Contribution to journalArticle

Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors

Zheng, B., Georgakis, G. V., Li, Y., Bharti, A., McConkey, D., Aggarwal, B. B. & Younes, A., May 1 2004, In : Clinical Cancer Research. 10, 9, p. 3207-3215 9 p.

Research output: Contribution to journalArticle

Intravesical Ad-IFNα causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-α protein

Benedict, W. F., Tao, Z., Kim, C. S., Zhang, X., Zhou, J. H., Adam, L., McConkey, D. J., Papageorgiou, A., Munsell, M., Philopena, J., Engler, H., Demers, W., Maneval, D. C., Dinney, C. P. N. & Connor, R. J., Sep 1 2004, In : Molecular Therapy. 10, 3, p. 525-532 8 p.

Research output: Contribution to journalArticle

Measurement of changes in intracellular calcium during apoptosis.

McConkey, D. J. & Nutt, L., 2004, In : Methods in molecular biology (Clifton, N.J.). 282, p. 117-130 14 p.

Research output: Contribution to journalArticle

Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas

Heymach, J. V., Desai, J., Manola, J., Davis, D. W., McConkey, D. J., Harmon, D., Ryan, D. P., Goss, G., Quigley, T., Van Den Abbeele, A. D., Silverman, S. G., Connors, S., Folkman, J., Fletcher, C. D. M. & Demetri, G. D., Sep 1 2004, In : Clinical Cancer Research. 10, 17, p. 5732-5740 9 p.

Research output: Contribution to journalArticle

Phase I study of bortezomib in refractory of relapsed acute leukemias

Cortes, J., Thomas, D., Koller, C., Giles, F., Estey, E., Faderl, S., Garcia-Manero, G., McConkey, D., Patel, G., Guerciolini, R., Wright, J. & Kantarjian, H., May 15 2004, In : Clinical Cancer Research. 10, 10, p. 3371-3376 6 p.

Research output: Contribution to journalArticle

Quantitative Analysis of Biomarkers Defines an Optimal Biological Dose for Recombinant Human Endostatin in Primary Human Tumors

Davis, D. W., Shen, Y., Mullani, N. A., Wen, S., Herbst, R. S., O'Reilly, M., Abbruzzese, J. L. & McConkey, D. J., Jan 1 2004, In : Clinical Cancer Research. 10, 1 I, p. 33-42 10 p.

Research output: Contribution to journalArticle

Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts

Davis, D. W., Inoue, K., Dinney, C. P. N., Hicklin, D. J., Abbruzzese, J. L. & McConkey, D. J., Jul 1 2004, In : Cancer Research. 64, 13, p. 4601-4610 10 p.

Research output: Contribution to journalArticle

Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells

Papageorgiou, A., Lashinger, L., Millikan, R., Grossman, H. B., Benedict, W., Dinney, C. P. N. & McConkey, D. J., Dec 15 2004, In : Cancer Research. 64, 24, p. 8973-8979 7 p.

Research output: Contribution to journalArticle

The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor zenografts

Nawrocki, S. T., Sweeney-Gotsch, B., Takamori, R. & McConkey, D. J., Jan 1 2004, In : Molecular cancer therapeutics. 3, 1, p. 59-70 12 p.

Research output: Contribution to journalArticle

The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo

Kamat, A. M., Karashima, T., Davis, D. W., Lashinger, L., Bar-Eli, M., Millikan, R., Shen, Y., Dinney, C. P. N. & McConkey, D. J., Mar 1 2004, In : Molecular cancer therapeutics. 3, 3, p. 279-290 12 p.

Research output: Contribution to journalArticle

2003

Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells

Zhang, X., Multani, A. S., Zhou, J. H., Shay, J. W., McConkey, D., Dong, L., Kim, C. S., Rosser, C. J., Pathak, S. & Benedict, W. F., Feb 15 2003, In : Cancer Research. 63, 4, p. 760-765 6 p.

Research output: Contribution to journalArticle

Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: Early assessment predicts clinical response

Davis, D. W., Buchholz, T. A., Hess, K. R., Sahin, A. A., Valero, V. & McConkey, D. J., Mar 1 2003, In : Clinical Cancer Research. 9, 3, p. 955-960 6 p.

Research output: Contribution to journalArticle

Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy

Buchholz, T. A., Davis, D. W., McConkey, D. J., Symmans, W. F., Valero, V., Jhingran, A., Tucker, S. L., Pusztai, L., Cristofanilli, M., Esteva, F. J., Hortobagyi, G. N. & Sahin, A. A., Jan 1 2003, In : Cancer Journal. 9, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts

Williams, S., Pettaway, C., Song, R., Papandreou, C., Logothetis, C. & McConkey, D. J., Sep 1 2003, In : Molecular cancer therapeutics. 2, 9, p. 835-843 9 p.

Research output: Contribution to journalArticle

Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia

Pahler, J. C., Ruiz, S., Niemer, I., Calvert, L. R., Andreeff, M., Keating, M., Faderl, S. & McConkey, D. J., Oct 1 2003, In : Clinical Cancer Research. 9, 12, p. 4570-4577 8 p.

Research output: Contribution to journalArticle

Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-κB

Mian, B. M., Dinney, C. P. N., Bermejo, C. E., Sweeney, P., Tellez, C., Yang, X. D., Gudas, J. M., McConkey, D. J. & Bar-Eli, M., Aug 1 2003, In : Clinical Cancer Research. 9, 8, p. 3167-3175 9 p.

Research output: Contribution to journalArticle

Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase

Yang, P., Collin, P., Madden, T., Chan, D., Sweeney-Gotsch, B., McConkey, D. & Newman, R. A., Jun 1 2003, In : Prostate. 55, 4, p. 281-291 11 p.

Research output: Contribution to journalArticle

Nuclear factor-κB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8

Karashima, T., Sweeney, P., Kamat, A., Huang, S., Kim, S. J., Bar-Eli, M., McConkey, D. J. & Dinney, C. P. N., Jul 1 2003, In : Clinical Cancer Research. 9, 7, p. 2786-2797 12 p.

Research output: Contribution to journalArticle

The Proteasome Inhibitor Bortezomib Stabilizes a Novel Active Form of p53 in Human LNCaP-Pro5 Prostate Cancer Cells

Williams, S. A. & McConkey, D. J., Nov 1 2003, In : Cancer Research. 63, 21, p. 7338-7344 7 p.

Research output: Contribution to journalArticle

2002

Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL

Cao, X. X., Mohuiddin, I., Chada, S., Mhashilkar, A. M., Ozvaran, M. K., McConkey, D. J., Miller, S. D., Daniel, J. C. & Smythe, W. R., Dec 1 2002, In : Molecular Medicine. 8, 12, p. 869-876 8 p.

Research output: Contribution to journalArticle

Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells

Bondar, V. M. & McConkey, D. J., Apr 1 2002, In : Prostate. 51, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

Nutt, L. K., Pataer, A., Pahler, J., Fang, B., Roth, J., McConkey, D. J. & Swisher, S. G., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9219-9225 7 p.

Research output: Contribution to journalArticle

Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

Nutt, L. K., Chandra, J., Pataer, A., Fang, B., Roth, J. A., Swisher, S. G., O'Neil, R. G. & McConkey, D. J., Jun 7 2002, In : Journal of Biological Chemistry. 277, 23, p. 20301-20308 8 p.

Research output: Contribution to journalArticle

Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas

Agui, T., McConkey, D. J. & Tanigawa, N., Aug 14 2002, In : Anticancer Research. 22, 3, p. 1769-1776 8 p.

Research output: Contribution to journalArticle

Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin

Herbst, R. S., Mullani, N. A., Davis, D. W., Hess, K. R., McConkey, D. J., Charnsangavej, C., O'Reilly, M. S., Kim, H. W., Baker, C., Roach, J., Ellis, L. M., Rashid, A., Pluda, J., Bucana, C., Madden, T. L., Tran, H. T. & Abbruzzese, J. L., Sep 15 2002, In : Journal of Clinical Oncology. 20, 18, p. 3804-3814 11 p.

Research output: Contribution to journalArticle

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction

Guo, Z., Clydesdale, G., Cheng, J., Kim, K., Gan, L., McConkey, D. J., Ullrich, S. E., Zhuang, Y. & Su, B., Aug 7 2002, In : Molecular and cellular biology. 22, 16, p. 5761-5768 8 p.

Research output: Contribution to journalArticle

Effects of the proteasome inhibitor ps-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts

Nawrocki, S. T., Bruns, C. J., Harbison, M. T., Bold, R. J., Gotsch, B. S., Abbruzzese, J. L., Elliott, P., Adams, J. & McConkey, D. J., Dec 1 2002, In : Molecular cancer therapeutics. 1, 14, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

Increased apoptosis in metastatic human colonic adenocarcinomas

Termuhlen, P. M., Sweeney-Gotsch, B. M., Berman, R. S., Ellis, L. M., Bucana, C., Shen, Y., Cleary, K. R. & McConkey, D. J., Jan 1 2002, In : Cancer Biology and Therapy. 1, 1, p. 58-63 6 p.

Research output: Contribution to journalArticle

Inhibition of the phosphatidylinositol 3′-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo

Bondar, V. M., Sweeney-Gotsch, B., Andreeff, M., Mills, G. B. & McConkey, D. J., Oct 1 2002, In : Molecular cancer therapeutics. 1, 12, p. 989-997 9 p.

Research output: Contribution to journalArticle

p53 and Fas ligand are required for psoralen and UVA-inducedapoptosis in mouse epidermal cells

Santamaria, A. B., Davis, D. W., Nghiem, D. X., McConkey, D. J., Ullrich, S. E., Kapoor, M., Lozano, G. & Ananthaswamy, H. N., Jan 1 2002, In : Cell death and differentiation. 9, 5, p. 549-560 12 p.

Research output: Contribution to journalArticle

Open Access

Phase I study of recombinant human endostatin in patients with advanced solid tumors

Herbst, R. S., Hess, K. R., Tran, H. T., Tseng, J. E., Mullani, N. A., Charnsangavej, C., Madden, T., Davis, D. W., McConkey, D. J., O'Reilly, M. S., Ellis, L. M., Pluda, J., Hong, W. K. & Abbruzzese, J. L., Sep 15 2002, In : Journal of Clinical Oncology. 20, 18, p. 3792-3803 12 p.

Research output: Contribution to journalArticle

Role of P38 MAPK, AP-1, and NF-κb in interleukin-1β-induced IL-8 expression in human vascular smooth muscle cells

Jung, Y. D., Fan, F., McConkey, D. J., Jean, M. E., Liu, W., Reinmuth, N., Stoeltzing, O., Ahmad, S. A., Parikh, A. A., Mukaida, N. & Ellis, L. M., May 2002, In : Cytokine. 18, 4, p. 206-213 8 p.

Research output: Contribution to journalArticle

Src activation regulates anoikis in human colon tumor cell lines

Windham, T. C., Parikh, N. U., Siwak, D. R., Summy, J. M., McConkey, D. J., Kraker, A. J. & Gallick, G. E., Nov 7 2002, In : Oncogene. 21, 51, p. 7797-7807 11 p.

Research output: Contribution to journalArticle

2001

BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines

Bold, R. J., Virudachalam, S. & McConkey, D. J., Sep 1 2001, In : Cancer. 92, 5, p. 1122-1129 8 p.

Research output: Contribution to journalArticle

Calcium flux measurements in apoptosis

McConkey, D. J. & Nutt, L. K., Dec 1 2001, In : Methods in cell biology. 66, p. 229-246 18 p.

Research output: Contribution to journalArticle