David McConkey

Professor

1986 …2020

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Research Output

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2013

The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR-205

Tran, M. N., Choi, W., Wszolek, M. F., Navai, N., Lee, I. L. C., Nitti, G., Wen, S., Flores, E. R., Siefker-Radtke, A., Czerniak, B., Dinney, C., Barton, M. & McConkey, D. J., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3275-3288 14 p.

Research output: Contribution to journalArticle

2012

Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells

Dickstein, R. J., Nitti, G., Dinney, C. P., Davies, B. R., Kamat, A. M. & McConkey, D. J., Nov 1 2012, In : Cancer Biology and Therapy. 13, 13, p. 1325-1338 14 p.

Research output: Contribution to journalArticle

Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin

Braeuer, R. R., Zigler, M., Kamiya, T., Dobroff, A. S., Huang, L., Choi, W., McConkey, D. J., Shoshan, E., Mobley, A. K., Song, R., Raz, A. & Bar-Eli, M., Nov 15 2012, In : Cancer Research. 72, 22, p. 5757-5766 10 p.

Research output: Contribution to journalArticle

In-Frame cDNA Library Combined with Protein Complementation Assay Identifies ARL11-Binding Partners

Lee, S., Lee, I., Jung, Y., McConkey, D. & Czerniak, B., Dec 18 2012, In : PloS one. 7, 12, e52290.

Research output: Contribution to journalArticle

Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy

Kim, M. P., Truty, M. J., Choi, W., Kang, YA., Chopin-Lally, X., Gallick, G. E., Wang, H., McConkey, D. J., Hwang, R., Logsdon, C., Abbruzzesse, J. & Fleming, J. B., Jul 1 2012, In : Annals of Surgical Oncology. 19, SUPPL. 3, p. S395-S403

Research output: Contribution to journalArticle

Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG

Liu, H., Zhang, T., Chen, R., McConkey, D. J., Ward, J. F. & Curley, S. A., Jul 1 2012, In : Journal of Surgical Research. 176, 1, p. 147-153 7 p.

Research output: Contribution to journalArticle

p63 expression correlates with sensitivity to the Eg5 inhibitor AZD4877 in bladder cancer cells

Marquis, L., Tran, M., Choi, W., Lee, I. L., Huszar, D., Siefker-Radtke, A., Dinney, C. P. & McConkey, D. J., May 1 2012, In : Cancer Biology and Therapy. 13, 7, p. 477-486 10 p.

Research output: Contribution to journalArticle

p63 expression defines a lethal subset of muscle-invasive bladder cancers

Choi, W., Shah, J. B., Tran, M., Svatek, R., Marquis, L., Lee, I. L., Yu, D., Adam, L., Wen, S., Shen, Y., Dinney, C., McConkey, D. J. & Siefker-Radtke, A., Jan 10 2012, In : PloS one. 7, 1, e30206.

Research output: Contribution to journalArticle

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Millward, M., Price, T., Townsend, A., Sweeney, C., Spencer, A., Sukumaran, S., Longenecker, A., Lee, L., Lay, A., Sharma, G., Gemmill, R. M., Drabkin, H. A., Lloyd, G. K., Neuteboom, S. T. C., McConkey, D. J., Palladino, M. A. & Spear, M. A., Dec 1 2012, In : Investigational New Drugs. 30, 6, p. 2303-2317 15 p.

Research output: Contribution to journalArticle

2011

ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma

Kim, M. P., Fleming, J. B., Wang, H., Abbruzzese, J. L., Choi, W., Kopetz, S., McConkey, D. J., Evans, D. B. & Gallick, G. E., Jun 16 2011, In : PloS one. 6, 6, e20636.

Research output: Contribution to journalArticle

Autophagic survival in resistance to histone deacetylase inhibitors: Novel strategies to treat malignant peripheral nerve sheath tumors

Lopez, G., Torres, K., Liu, J., Hernandez, B., Young, E., Belousov, R., Bolshakov, S., Lazar, A. J., Slopis, J. M., McCutcheon, I. E., McConkey, D. & Lev, D., Jan 1 2011, In : Cancer Research. 71, 1, p. 185-196 12 p.

Research output: Contribution to journalArticle

Effects of mTOR inhibitor everolimus (RAD001) on bladder cancer cells

Chiong, E., Lee, I. L., Dadbin, A., Sabichi, A. L., Harris, L., Urbauer, D., McConkey, D. J., Dickstein, R. J., Cheng, T. & Grossman, H. B., May 1 2011, In : Clinical Cancer Research. 17, 9, p. 2863-2873 11 p.

Research output: Contribution to journalArticle

Pilot study of bortezomib for patients with imatinib-refractory chronic myeloid leukemia in chronic or accelerated phase

Santos, F. P. S., Kantarjian, H., McConkey, D., O'Brien, S., Faderl, S., Borthakur, G., Ferrajoli, A., Wright, J. & Cortes, J., Aug 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 4, p. 355-360 6 p.

Research output: Contribution to journalArticle

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

Chonghaile, T. N., Sarosiek, K. A., Vo, T. T., Ryan, J. A., Tammareddi, A., Moore, V. D. G., Deng, J., Anderson, K. C., Richardson, P., Tai, Y. T., Mitsiades, C. S., Matulonis, U. A., Drapkin, R., Stone, R., DeAngelo, D. J., McConkey, D. J., Sallan, S. E., Silverman, L., Hirsch, M. S., Carrasco, D. R. & 1 others, Letai, A., Nov 25 2011, In : Science. 334, 6059, p. 1129-1133 5 p.

Research output: Contribution to journalArticle

Receptor heterodimerization: A new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer

Black, P. C., Brown, G. A., Dinney, C. P., Kassouf, W., Inamoto, T., Arora, A., Gallagher, D., Munsell, M. F., Bar-Eli, M., McConkey, D. J. & Adam, L., Feb 1 2011, In : Journal of Urology. 185, 2, p. 693-700 8 p.

Research output: Contribution to journalArticle

2010

A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer

Svatek, R. S., Shah, J. B., Xing, J., Chang, D., Lin, J., McConkey, D. J., Wu, X. & Dinney, C. P., Oct 1 2010, In : Cancer. 116, 19, p. 4513-4519 7 p.

Research output: Contribution to journalArticle

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

Zhu, K., Dunner, K. & McConkey, D. J., Jan 1 2010, In : Oncogene. 29, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells

Metwalli, A. R., Khanbolooki, S., Jinesh, G., Sundi, D., Shah, J. B., Shrader, M., Choi, W., Lashinger, L. M., Chunduru, S., McConkey, D. J., McKinlay, M. & Kamat, A. M., Nov 1 2010, In : Cancer Biology and Therapy. 10, 9, p. 885-892 8 p.

Research output: Contribution to journalArticle

Validating bladder cancer xenograft bioluminescence with magnetic resonance imaging: The significance of hypoxia and necrosis

Black, P. C., Shetty, A., Brown, G. A., Esparza-Coss, E., Metwalli, A. R., Agarwal, P. K., McConkey, D. J., Hazle, J. D. & Dinney, C. P. N., Dec 1 2010, In : BJU International. 106, 11, p. 1799-1804 6 p.

Research output: Contribution to journalArticle

2009

Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma

Lopez, G., Liu, J., Ren, W., Wei, W., Wang, S., Lahat, G., Zhu, Q. S., Bornmann, W. G., McConkey, D. J., Pollock, R. E. & Lev, D. C., May 15 2009, In : Clinical Cancer Research. 15, 10, p. 3472-3483 12 p.

Research output: Contribution to journalArticle

Control of HIF-Iα expression by elF2α phosphrlation-mediated translational repression

Zhu, K., Chan, W. K., Heymach, J., Wilkinson, M. & McConkey, D. J., Mar 1 2009, In : Cancer Research. 69, 5, p. 1836-1843 8 p.

Research output: Contribution to journalArticle

Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation

Zhou, J., Zhang, X. Q., Ashoori, F., McConkey, D. J., Knowles, M. A., Dong, L. & Benedict, W. F., Jan 1 2009, In : Cancer Gene Therapy. 16, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

Arumugam, T., Ramachandran, V., Fournier, K. F., Wang, H., Marquis, L., Abbruzzese, J. L., Gallick, G. E., Logsdon, C. D., McConkey, D. J. & Choi, W., Jul 15 2009, In : Cancer Research. 69, 14, p. 5820-5828 9 p.

Research output: Contribution to journalArticle

miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

Adam, L., Zhong, M., Choi, W., Qi, W., Nicoloso, M., Arora, A., Calin, G., Wang, H., Siefker-Radtke, A., McConkey, D., Bar-Eli, M. & Dinney, C., Aug 15 2009, In : Clinical Cancer Research. 15, 16, p. 5060-5072 13 p.

Research output: Contribution to journalArticle

2008

Distinctive Expression Pattern of ErbB Family Receptors Signifies an Aggressive Variant of Bladder Cancer

Kassouf, W., Black, P. C., Tuziak, T., Bondaruk, J., Lee, S., Brown, G. A., Adam, L., Wei, C., Baggerly, K., Bar-Eli, M., McConkey, D., Czerniak, B. & Dinney, C. P., Jan 1 2008, In : Journal of Urology. 179, 1, p. 353-358 6 p.

Research output: Contribution to journalArticle

Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines

Pino, M. S., Balsamo, M., Modugno, F. D., Mottolese, M., Alessio, M., Melucci, E., Milella, M., McConkey, D. J., Philippar, U., Gertler, F. B., Natali, P. G. & Nisticò, P., Aug 1 2008, In : Clinical Cancer Research. 14, 15, 1 p.

Research output: Contribution to journalArticle

Is Vascular Endothelial Growth Factor Modulation a Predictor of the Therapeutic Efficacy of Gefitinib for Bladder Cancer?

Kassouf, W., Brown, G. A., Black, P. C., Fisher, M. B., Inamoto, T., Luongo, T., Gallagher, D., Bar-Eli, M., McConkey, D. J., Adam, L. & Dinney, C. P. N., Sep 1 2008, In : Journal of Urology. 180, 3, p. 1146-1153 8 p.

Research output: Contribution to journalArticle

Mechanisms of proteasome inhibitor action and resistance in cancer

McConkey, D. J. & Zhu, K., Aug 1 2008, In : Drug Resistance Updates. 11, 4-5, p. 164-179 16 p.

Research output: Contribution to journalArticle

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J. & McConkey, D. J., Oct 1 2008, In : Blood. 112, 7, p. 2917-2926 10 p.

Research output: Contribution to journalArticle

Nuclear factor-κB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells

Pan, X., Arumugam, T., Yamamoto, T., Levin, P. A., Ramachandran, V., Ji, B., Lopez-Berestein, G., Vivas-Mejia, P. E., Sood, A. K., McConkey, D. J. & Logsdon, C. D., Dec 15 2008, In : Clinical Cancer Research. 14, 24, p. 8143-8151 9 p.

Research output: Contribution to journalArticle

Phase II trial of imatinib mesylate in patients with metastatic melanoma

Kim, K. B., Eton, O., Davis, D. W., Frazier, M. L., McConkey, D. J., Diwan, A. H., Papadopoulos, N. E., Bedikian, A. Y., Camacho, L. H., Ross, M. I., Cormier, J. N., Gershenwald, J. E., Lee, J. E., Mansfield, P. F., Billings, L. A., Ng, C. S., Charnsangavej, C., Bar-Eli, M., Johnson, M. M., Murgo, A. J. & 1 others, Prieto, V. G., Sep 2 2008, In : British journal of cancer. 99, 5, p. 734-740 7 p.

Research output: Contribution to journalArticle

Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells

Black, P. C., Brown, G. A., Inamoto, T., Shrader, M., Arora, A., Siefker-Radtke, A. O., Adam, L., Theodorescu, D., Wu, X., Munsell, M. F., Bar-Eli, M., McConkey, D. J. & Dinney, C. P. N., Mar 1 2008, In : Clinical Cancer Research. 14, 5, p. 1478-1486 9 p.

Research output: Contribution to journalArticle

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

Majewski, T., Lee, S., Jeong, J., Yoon, D. S., Kram, A., Kim, M. S., Tuziak, T., Bondaruk, J., Lee, S., Park, W. S., Tang, K. S., Chung, W., Shen, L., Ahmed, S. S., Johnston, D. A., Grossman, H. B., Dinney, C. P., Zhou, J. H., Harris, R. A., Snyder, C. & 13 others, Filipek, S., Narod, S. A., Watson, P., Lynch, H. T., Gazdar, A., Bar-Eli, M., Wu, X. F., McConkey, D. J., Baggerly, K., Issa, J. P., Benedict, W. F., Scherer, S. E. & Czerniak, B., Jul 1 2008, In : Laboratory Investigation. 88, 7, p. 694-721 28 p.

Research output: Contribution to journalArticle

2007

Adenoviral Mediated Interferon-α 2b Gene Therapy Suppresses the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Superficial Bladder Cancer

Adam, L., Black, P. C., Kassouf, W., Eve, B., McConkey, D., Munsell, M. F., Benedict, W. F. & Dinney, C. P. N., May 1 2007, In : Journal of Urology. 177, 5, p. 1900-1906 7 p.

Research output: Contribution to journalArticle

Adenoviral-mediated interferon α overcomes resistance to the interferon protein in various cancer types and has marked bystander effects

Zhang, X., Yang, Z., Dong, L., Papageorgiou, A., McConkey, D. J. & Benedict, W. F., Mar 1 2007, In : Cancer Gene Therapy. 14, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

Assessment of the biological and pharmacological effects of the αvβ3 and αv β5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors

Hariharan, S., Gustafson, D., Holden, S., McConkey, D., Davis, D., Morrow, M., Basche, M., Gore, L., Zang, C., O'Bryant, C. L., Baron, A., Gallemann, D., Colevas, D. & Eckhardt, S. G., Aug 1 2007, In : Annals of Oncology. 18, 8, p. 1400-1407 8 p.

Research output: Contribution to journalArticle

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia

Lee, S., Jeong, J., Majewski, T., Scherer, S. E., Kim, M. S., Tuziak, T., Tang, K. S., Baggerly, K., Grossman, H. B., Zhou, J. H., Shen, L., Bondaruk, J., Ahmed, S. S., Samanta, S., Spiess, P., Wu, X., Filipek, S., McConkey, D., Bar-Eli, M., Issa, J. P. & 2 others, Benedict, W. F. & Czerniak, B., Aug 21 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13732-13737 6 p.

Research output: Contribution to journalArticle

Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression

Shrader, M., Pino, M. S., Lashinger, L., Bar-Eli, M., Adam, L., Dinney, C. P. N. & McConkey, D. J., Feb 15 2007, In : Cancer Research. 67, 4, p. 1430-1435 6 p.

Research output: Contribution to journalArticle

Interferon-α induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells

Papageorgiou, A., Dinney, C. P. N. & McConkey, D. J., Jun 2007, In : Cancer Biology and Therapy. 6, 6, p. 872-879 8 p.

Research output: Contribution to journalArticle

Open Access

Molecular correlates of gefitinib responsiveness in human bladder cancer cells

Shrader, M., Pino, M. S., Brown, G., Black, P., Adam, L., Bar-Eli, M., Dinney, C. P. N. & McConkey, D. J., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 277-285 9 p.

Research output: Contribution to journalArticle

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

Miller, C. P., Ban, K., Dujka, M. E., McConkey, D. J., Munsell, M., Palladino, M. & Chandra, J., Jul 1 2007, In : Blood. 110, 1, p. 267-277 11 p.

Research output: Contribution to journalArticle

Targeting EGFR in bladder cancer

Villares, G. J., Zigler, M., Blehm, K., Bogdan, C., McConkey, D., Colin, D. & Bar-Eli, M., Dec 2007, In : World journal of urology. 25, 6, p. 573-579 7 p.

Research output: Contribution to journalArticle

2006

Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H. I., Dunner, K., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., Xiong, H., Abbruzzese, J. L. & McConkey, D. J., Apr 1 2006, In : Cancer Research. 66, 7, p. 3773-3781 9 p.

Research output: Contribution to journalArticle

Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells

Canfield, S. E., Zhu, K., Williams, S. A. & McConkey, D. J., Aug 1 2006, In : Molecular cancer therapeutics. 5, 8, p. 2043-2050 8 p.

Research output: Contribution to journalArticle

Cis-uronic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5HT2A receptor

Walterscheid, J. P., Nghiem, D. X., Kazimi, N., Nutt, L. K., McConkey, D. J., Norval, M. & Ullrich, S. E., Nov 14 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 46, p. 17420-17425 6 p.

Research output: Contribution to journalArticle

Combination therapy with IFN-α plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells

Papageorgiou, A., Kamat, A., Benedict, W. F., Dinney, C. & McConkey, D. J., Dec 1 2006, In : Molecular cancer therapeutics. 5, 12, p. 3032-3041 10 p.

Research output: Contribution to journalArticle

Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy

Blehm, K. N., Spiess, P. E., Bondaruk, J. E., Dujka, M. E., Villares, G. J., Zhao, Y. J., Bogler, O., Aldape, K. D., Grossman, H. B., Adam, L., McConkey, D. J., Czerniak, B. A., Dinney, C. P. & Bar-Eli, M., Aug 1 2006, In : Clinical Cancer Research. 12, 15, p. 4671-4677 7 p.

Research output: Contribution to journalArticle

Nuclear factor-κB maintains TRAIL resistance in human pancreatic cancer cells

Khanbolooki, S., Nawrocki, S. T., Arumugam, T., Andtbacka, R., Pino, M. S., Kurzrock, R., Logsdon, C. D., Abbruzzese, J. L. & McConkey, D. J., Sep 1 2006, In : Molecular cancer therapeutics. 5, 9, p. 2251-2260 10 p.

Research output: Contribution to journalArticle