David McConkey

Professor

1986 …2020

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2,3,7,8-Tetrachlorodibenzo-p-dioin kills immature thymoytes by Ca2+-mediated endonudease activation

McConkey, D. J., Hartzell, P., Duddy, S. K., Håkansson, H. & Orrenius, S., Jan 1 1988, In : Science. 242, 4876, p. 256-259 4 p.

Research output: Contribution to journalArticle

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo

McConkey, D. J. & Orrenius, S., May 15 1989, In : Biochemical and Biophysical Research Communications. 160, 3, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

2,5-Di(tert-butyl)-1,4-benzohydroquinone - a novel inhibitor of liver microsomal Ca2+ sequestration

Moore, G. A., McConkey, D. J., Kass, G. E. N., O'Brien, P. J. & Orrenius, S., Nov 30 1987, In : FEBS Letters. 224, 2, p. 331-336 6 p.

Research output: Contribution to journalArticle

A Consensus Molecular Classification of Muscle-invasive Bladder Cancer[Formula presented]

Kamoun, A., de Reyniès, A., Allory, Y., Sjödahl, G., Robertson, A. G., Seiler, R., Hoadley, K. A., Groeneveld, C. S., Al-Ahmadie, H., Choi, W., Castro, M. A. A., Fontugne, J., Eriksson, P., Mo, Q., Kardos, J., Zlotta, A., Hartmann, A., Dinney, C. P., Bellmunt, J., Powles, T. & 22 others, Malats, N., Chan, K. S., Kim, W. Y., McConkey, D. J., Black, P. C., Dyrskjøt, L., Höglund, M., Lerner, S. P., Real, F. X., Radvanyi, F., Aine, M., Bernard-Pierrot, I., Czerniak, B., Gibb, E. A., Kim, J., Kwiatkowski, D. J., Lebret, T., Liedberg, F., Siefker-Radtke, A., Sirab, N., Taber, A. & Weinstein, J., Apr 2020, In : European Urology. 77, 4, p. 420-433 14 p.

Research output: Contribution to journalArticle

Open Access

Adaptive immune resistance to intravesical BCG in non–muscle invasive bladder cancer: Implications for prospective BCG-unresponsive trials

Kates, M., Matoso, A., Choi, W., Baras, A. S., Daniels, M. J., Lombardo, K., Brant, A., Mikkilineni, N., McConkey, D. J., Kamat, A. M., Svatek, R. S., Porten, S. P., Meeks, J. J., Lerner, S. P., Dinney, C. P., Black, P. C., McKiernan, J. M., Anderson, C., Drake, C. G. & Bivalacqua, T. J., Feb 15 2020, In : Clinical Cancer Research. 26, 4, p. 882-891 10 p.

Research output: Contribution to journalArticle

Adenoviral Mediated Interferon-α 2b Gene Therapy Suppresses the Pro-Angiogenic Effect of Vascular Endothelial Growth Factor in Superficial Bladder Cancer

Adam, L., Black, P. C., Kassouf, W., Eve, B., McConkey, D., Munsell, M. F., Benedict, W. F. & Dinney, C. P. N., May 1 2007, In : Journal of Urology. 177, 5, p. 1900-1906 7 p.

Research output: Contribution to journalArticle

Adenoviral-mediated interferon α overcomes resistance to the interferon protein in various cancer types and has marked bystander effects

Zhang, X., Yang, Z., Dong, L., Papageorgiou, A., McConkey, D. J. & Benedict, W. F., Mar 1 2007, In : Cancer Gene Therapy. 14, 3, p. 241-250 10 p.

Research output: Contribution to journalArticle

Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells

Zhang, X., Multani, A. S., Zhou, J. H., Shay, J. W., McConkey, D., Dong, L., Kim, C. S., Rosser, C. J., Pathak, S. & Benedict, W. F., Feb 15 2003, In : Cancer Research. 63, 4, p. 760-765 6 p.

Research output: Contribution to journalArticle

Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL

Cao, X. X., Mohuiddin, I., Chada, S., Mhashilkar, A. M., Ozvaran, M. K., McConkey, D. J., Miller, S. D., Daniel, J. C. & Smythe, W. R., Dec 1 2002, In : Molecular Medicine. 8, 12, p. 869-876 8 p.

Research output: Contribution to journalArticle

Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer

Bouvet, M., Bold, R. J., Lee, J., Evans, D. B., Abbruzzese, J. L., Chiao, P. J., McConkey, D. J., Chandra, J., Chada, S., Fang, B. & Roth, J. A., Dec 1998, In : Annals of Surgical Oncology. 5, 8, p. 681-688 8 p.

Research output: Contribution to journalArticle

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes

McConkey, D. J., Orrenius, S. & Jondal, M., Jan 1 1990, In : Journal of Immunology. 145, 4, p. 1227-1230 4 p.

Research output: Contribution to journalArticle

Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H. I., Dunner, K., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., Xiong, H., Abbruzzese, J. L. & McConkey, D. J., Apr 1 2006, In : Cancer Research. 66, 7, p. 3773-3781 9 p.

Research output: Contribution to journalArticle

ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma

Kim, M. P., Fleming, J. B., Wang, H., Abbruzzese, J. L., Choi, W., Kopetz, S., McConkey, D. J., Evans, D. B. & Gallick, G. E., Jun 16 2011, In : PloS one. 6, 6, e20636.

Research output: Contribution to journalArticle

A multiplexed, particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer

Svatek, R. S., Shah, J. B., Xing, J., Chang, D., Lin, J., McConkey, D. J., Wu, X. & Dinney, C. P., Oct 1 2010, In : Cancer. 116, 19, p. 4513-4519 7 p.

Research output: Contribution to journalArticle

Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells

Bondar, V. M. & McConkey, D. J., Apr 1 2002, In : Prostate. 51, 1, p. 42-49 8 p.

Research output: Contribution to journalArticle

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis

Shaheen, R. M., Davis, D. W., Liu, W., Zebrowski, B. K., Wilson, M. R., Bucana, C. D., McConkey, D. J., McMahon, G. & Ellis, L. M., Nov 1 1999, In : Cancer Research. 59, 21, p. 5412-5416 5 p.

Research output: Contribution to journalArticle

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

Xiong, H. Q., Herbst, R., Faria, S. C., Scholz, C., Davis, D., Jackson, E. F., Madden, T., McConkey, D., Hicks, M., Hess, K., Charnsangavej, C. & Abbruzzese, J. L., Nov 1 2004, In : Investigational New Drugs. 22, 4, p. 459-466 8 p.

Research output: Contribution to journalArticle

Apoptosis in Mycobacterium tuberculosis infection in mice exhibiting varied immunopathology

Watson, V. E., Hill, L. L., Owen-Schaub, L. B., Davis, D. W., McConkey, D. J., Jagannath, C., Hunter, R. L. & Actor, J. K., Feb 1 2000, In : Journal of Pathology. 190, 2, p. 211-220 10 p.

Research output: Contribution to journalArticle

Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line

McConkey, D. J., Greene, G. & Pettaway, C. A., Dec 15 1996, In : Cancer Research. 56, 24, p. 5594-5599 6 p.

Research output: Contribution to journalArticle

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX

McConkey, D. J., Chandra, J., Wright, S., Plunkett, W., McDonnell, T. J., Reed, J. C. & Keating, M., Apr 1 1996, In : Journal of Immunology. 156, 7, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+

Marin, M. C., Fernandez, A., Bick, R. J., Brisbay, S., Buja, L. M., Snuggs, M., McConkey, D. J., Von Eschenbach, A. C., Keating, M. J. & McDonnell, T. J., Jul 5 1996, In : Oncogene. 12, 11, p. 2259-2266 8 p.

Research output: Contribution to journalArticle

A Prognostic Gene Expression Signature in the Molecular Classification of Chemotherapy-naïve Urothelial Cancer is Predictive of Clinical Outcomes from Neoadjuvant Chemotherapy: A Phase 2 Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin with Bevacizumab in Urothelial Cancer

McConkey, D. J., Choi, W., Shen, Y., Lee, I. L., Porten, S., Matin, S. F., Kamat, A. M., Corn, P., Millikan, R. E., Dinney, C., Czerniak, B. & Siefker-Radtke, A. O., May 1 2016, In : European Urology. 69, 5, p. 855-862 8 p.

Research output: Contribution to journalArticle

A Smac mimetic augments the response of urothelial cancer cells to gemcitabine and cisplatin

Lee, E. K., Goodwin Jinesh, G., Laing, N. M., Choi, W., McConkey, D. J. & Kamat, A. M., Sep 2013, In : Cancer Biology and Therapy. 14, 9, p. 812-822 11 p.

Research output: Contribution to journalArticle

Assessment of Luminal and Basal Phenotypes in Bladder Cancer

Guo, C. C., Bondaruk, J., Yao, H., Wang, Z., Zhang, L., Lee, S., Lee, J. G., Cogdell, D., Zhang, M., Yang, G., Dadhania, V., Choi, W., Wei, P., Gao, J., Theodorescu, D., Logothetis, C., Dinney, C., Kimmel, M., Weinstein, J. N., McConkey, D. J. & 1 others, Czerniak, B., Dec 1 2020, In : Scientific reports. 10, 1, 9743.

Research output: Contribution to journalArticle

Open Access

Assessment of the biological and pharmacological effects of the αvβ3 and αv β5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors

Hariharan, S., Gustafson, D., Holden, S., McConkey, D., Davis, D., Morrow, M., Basche, M., Gore, L., Zang, C., O'Bryant, C. L., Baron, A., Gallemann, D., Colevas, D. & Eckhardt, S. G., Aug 1 2007, In : Annals of Oncology. 18, 8, p. 1400-1407 8 p.

Research output: Contribution to journalArticle

At least two ways to apoptose

McConkey, D. J., Mar 1996, In : Human & Experimental Toxicology. 15, 3, p. 274-276 3 p.

Research output: Contribution to journalArticle

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei

Nicotera, P., McConkey, D. J., Jones, D. P. & Orrenius, S., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 2, p. 453-457 5 p.

Research output: Contribution to journalArticle

Open Access

Aurora kinase A is a biomarker for bladder cancer detection and contributes to its aggressive behavior

Mobley, A., Zhang, S., Bondaruk, J., Wang, Y., Majewski, T., Caraway, N. P., Huang, L., Shoshan, E., Velazquez-Torres, G., Nitti, G., Lee, S., Lee, J. G., Fuentes-Mattei, E., Willis, D., Zhang, L., Guo, C. C., Yao, H., Baggerly, K., Lotan, Y., Lerner, S. P. & 4 others, Dinney, C., McConkey, D., Bar-Eli, M. & Czerniak, B., Jan 19 2017, In : Scientific Reports. 7, 40714.

Research output: Contribution to journalArticle

Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: Early assessment predicts clinical response

Davis, D. W., Buchholz, T. A., Hess, K. R., Sahin, A. A., Valero, V. & McConkey, D. J., Mar 1 2003, In : Clinical Cancer Research. 9, 3, p. 955-960 6 p.

Research output: Contribution to journalArticle

Autophagic survival in resistance to histone deacetylase inhibitors: Novel strategies to treat malignant peripheral nerve sheath tumors

Lopez, G., Torres, K., Liu, J., Hernandez, B., Young, E., Belousov, R., Bolshakov, S., Lazar, A. J., Slopis, J. M., McCutcheon, I. E., McConkey, D. & Lev, D., Jan 1 2011, In : Cancer Research. 71, 1, p. 185-196 12 p.

Research output: Contribution to journalArticle

Autophagy is required for crizotinib-induced apoptosis in MET-amplified gastric cancer cells

Schroeder, R. D., Choi, W., Hong, D. S. & McConkey, D. J., Feb 7 2017, In : Oncotarget. 8, 31, p. 51675-51687 13 p.

Research output: Contribution to journalArticle

Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells

Dickstein, R. J., Nitti, G., Dinney, C. P., Davies, B. R., Kamat, A. M. & McConkey, D. J., Nov 1 2012, In : Cancer Biology and Therapy. 13, 13, p. 1325-1338 14 p.

Research output: Contribution to journalArticle

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

Nutt, L. K., Pataer, A., Pahler, J., Fang, B., Roth, J., McConkey, D. J. & Swisher, S. G., Mar 15 2002, In : Journal of Biological Chemistry. 277, 11, p. 9219-9225 7 p.

Research output: Contribution to journalArticle

Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

Nutt, L. K., Chandra, J., Pataer, A., Fang, B., Roth, J. A., Swisher, S. G., O'Neil, R. G. & McConkey, D. J., Jun 7 2002, In : Journal of Biological Chemistry. 277, 23, p. 20301-20308 8 p.

Research output: Contribution to journalArticle

Bcl-2 expression causes redistribution of glutathione to the nucleus

Voehringer, D. W., Mcconkey, D. J., Mcdonnell, T. J., Brisbay, S. & Meyn, R. E., Mar 17 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 6, p. 2956-2960 5 p.

Research output: Contribution to journalArticle

BCL2 expression correlates with metastatic potential in pancreatic cancer cell lines

Bold, R. J., Virudachalam, S. & McConkey, D. J., Sep 1 2001, In : Cancer. 92, 5, p. 1122-1129 8 p.

Research output: Contribution to journalArticle

Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

Xie, K., Huang, S., Wang, Y., Beltran, P. J., Juang, S. H., Dong, Z., Reed, J. C., McDonnell, T. J., McConkey, D. J. & Fidler, I. J., Nov 27 1996, In : Cancer Immunology Immunotherapy. 43, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

Biochemical determinants of apoptosis and necrosis

McConkey, D. J., Nov 12 1998, In : Toxicology Letters. 99, 3, p. 157-168 12 p.

Research output: Contribution to journalArticle

Bladder cancer molecular taxonomy: Summary from a consensus meeting

Lerner, S. P., McConkey, D. J., Hoadley, K. A., Chan, K. S., Kim, W. Y., Radvanyi, F., Höglund, M. & Real, F. X., Jan 1 2016, In : Bladder Cancer. 2, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells

Lashinger, L. M., Zhu, K., Williams, S. A., Shrader, M., Dinney, C. P. N. & McConkey, D. J., Jun 1 2005, In : Cancer Research. 65, 11, p. 4902-4908 7 p.

Research output: Contribution to journalArticle

Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells

Canfield, S. E., Zhu, K., Williams, S. A. & McConkey, D. J., Aug 1 2006, In : Molecular cancer therapeutics. 5, 8, p. 2043-2050 8 p.

Research output: Contribution to journalArticle

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Dunner, K., Boise, L. H., Chiao, P. J., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In : Cancer Research. 65, 24, p. 11510-11519 10 p.

Research output: Contribution to journalArticle

Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Dunner, K., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In : Cancer Research. 65, 24, p. 11658-11666 9 p.

Research output: Contribution to journalArticle

Ca2+ activated mechanisms in cell killing

Nicotera, P., Mc Conkey, D. J., Dypbukt, J. M., Jones, D. P. & Orrenius, S., Jan 1 1989, In : Drug Metabolism Reviews. 20, 2-4, p. 193-201 9 p.

Research output: Contribution to journalArticle

Ca2+-activated mechanisms in toxicity and programmed cell death

Orrenius, S., McConkey, D. J., Jones, D. P. & Nicotera, P., Jan 1 1988, In : ISI Atlas of Science: Pharmacology. 2, 4, p. 319-324 6 p.

Research output: Contribution to journalArticle

Calcium-activated DNA fragmentation in rat liver nuclei

Jones, D. P., McConkey, D. J., Nicotera, P. & Orrenius, S., Jan 1 1989, In : Journal of Biological Chemistry. 264, 11, p. 6398-6403 6 p.

Research output: Contribution to journalArticle

Calcium-activated DNA fragmentation kills immature thymocytes

McConkey, D. J., Hartzell, P., Nicotera, P. & Orrenius, S., Jan 1 1989, In : FASEB Journal. 3, 7, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

Open Access

Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock

Perotti, M., Toddei, F., Mirabelli, F., Vairetti, M., Bellomo, G., McConkey, D. J. & Orrenius, S., Jan 1 1990, In : FEBS Letters. 259, 2, p. 331-334 4 p.

Research output: Contribution to journalArticle

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex

McConkey, D. J., Hartzell, P., Amador-Perez, J. F., Orrenius, S. & Jondal, M., Jan 1 1989, In : Journal of Immunology. 143, 6, p. 1801-1806 6 p.

Research output: Contribution to journalArticle