David McConkey

Professor

1986 …2020

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Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Majewski, T., Yao, H., Bondaruk, J., Chung, W., Lee, S., Lee, J. G., Zhang, S., Cogdell, D., Yang, G., Choi, W., Dinney, C., Grossman, H. B., Logothetis, C., Scherer, S. E., Guo, C. C., Zhang, L., Wei, P., Weinstein, J. N., Issa, J. P., Baggerly, K. & 2 others, McConkey, D. J. & Czerniak, B., Feb 19 2019, In : Cell Reports. 26, 8, p. 2241-2256.e4

Research output: Contribution to journalArticle

Open Access

Vascular endothelial growth factor is an in vivo survival factor for tumor endothelium in a murine model of colorectal carcinoma liver metastases

Bruns, C. J., Liu, W., Davis, D. W., Shaheen, R. M., McConkey, D. J., Wilson, M. R., Bucana, C. D., Hicklin, D. J. & Ellis, L. M., Aug 1 2000, In : Cancer. 89, 3, p. 488-499 12 p.

Research output: Contribution to journalArticle

Validating bladder cancer xenograft bioluminescence with magnetic resonance imaging: The significance of hypoxia and necrosis

Black, P. C., Shetty, A., Brown, G. A., Esparza-Coss, E., Metwalli, A. R., Agarwal, P. K., McConkey, D. J., Hazle, J. D. & Dinney, C. P. N., Dec 1 2010, In : BJU International. 106, 11, p. 1799-1804 6 p.

Research output: Contribution to journalArticle

Urothelial-to-Neural Plasticity Drives Progression to Small Cell Bladder Cancer

Yang, G., Bondaruk, J., Cogdell, D., Wang, Z., Lee, S., Lee, J. G., Zhang, S., Choi, W., Wang, Y., Liang, Y., Wang, G., Wang, Y., Yao, H., Dadhania, V., Gao, J., Logothetis, C., Siefker-Radtke, A., Kamat, A., Dinney, C., Theodorescu, D. & 6 others, Kimmel, M., Wei, P., Guo, C. C., Weinstein, J. N., McConkey, D. J. & Czerniak, B., Jun 26 2020, In : iScience. 23, 6, 101201.

Research output: Contribution to journalArticle

Open Access

Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy

Majewski, T., Lee, S., Jeong, J., Yoon, D. S., Kram, A., Kim, M. S., Tuziak, T., Bondaruk, J., Lee, S., Park, W. S., Tang, K. S., Chung, W., Shen, L., Ahmed, S. S., Johnston, D. A., Grossman, H. B., Dinney, C. P., Zhou, J. H., Harris, R. A., Snyder, C. & 13 others, Filipek, S., Narod, S. A., Watson, P., Lynch, H. T., Gazdar, A., Bar-Eli, M., Wu, X. F., McConkey, D. J., Baggerly, K., Issa, J. P., Benedict, W. F., Scherer, S. E. & Czerniak, B., Jul 1 2008, In : Laboratory Investigation. 88, 7, p. 694-721 28 p.

Research output: Contribution to journalArticle

Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of gefitinib in bladder cancer cells

Kassouf, W., Dinney, C. P. N., Brown, G., McConkey, D. J., Diehl, A. J., Bar-Eli, M. & Adam, L., Nov 15 2005, In : Cancer Research. 65, 22, p. 10524-10535 12 p.

Research output: Contribution to journalArticle

Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms

Shaheen, R. M., Tseng, W. W., Davis, D. W., Liu, W., Reinmuth, N., Vellagas, R., Wieczorek, A. A., Ogura, Y., McConkey, D. J., Drazan, K. E., Bucana, C. D., McMahon, G. & Ellis, L. M., Feb 15 2001, In : Cancer Research. 61, 4, p. 1464-1468 5 p.

Research output: Contribution to journalArticle

Treatment with low-dose interferon-α restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder

Slaton, J. W., Karashima, T., Perrotte, P., Inoue, K., Kim, S. J., Izawa, J., Kedar, D., McConkey, D. J., Millikan, R., Sweeney, P., Yoshikawa, C., Shuin, T. & Dinney, C. P. N., Jan 1 2001, In : Clinical Cancer Research. 7, 9, p. 2840-2853 14 p.

Research output: Contribution to journalArticle

Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel

Inoue, K., Slaton, J. W., Davis, D. W., Hicklin, D. J., McConkey, D. J., Karashima, T., Radinsky, R. & Dinney, C. P. N., Jul 1 2000, In : Clinical Cancer Research. 6, 7, p. 2635-2643 9 p.

Research output: Contribution to journalArticle

Transforming growth factor α expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines

Pino, M. S., Shrader, M., Baker, C. H., Cognetti, F., Xiong, H. Q., Abbruzzese, J. L. & McConkey, D. J., Apr 1 2006, In : Cancer Research. 66, 7, p. 3802-3812 11 p.

Research output: Contribution to journalArticle

Transcription factor AP-2α is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells

Nyormoi, O., Wang, Z., Doan, D., Ruiz, M., McConkey, D. & Bar-Eli, M., Jul 28 2001, In : Molecular and cellular biology. 21, 15, p. 4856-4867 12 p.

Research output: Contribution to journalArticle

Three-dimensional organoid culture reveals involvement of Wnt/β-catenin pathway in proliferation of bladder cancer cells

Yoshida, T., Sopko, N. A., Kates, M., Liu, X., Joice, G., McConkey, D. J. & Bivalacqua, T. J., 2018, In : Oncotarget. 9, 13, p. 11060-11070 11 p.

Research output: Contribution to journalArticle

The role of calcium in the regulation of apoptosis

McConkey, D. J., Dec 1 1996, In : Scanning microscopy. 10, 3, p. 777-794 18 p.

Research output: Contribution to journalArticle

The regulation of apoptosis in thymocytes

McConkey, D. J., Jondal, M. & Orrenius, S., Jan 1 1994, In : Biochemical Society transactions. 22, 3, p. 606-610 5 p.

Research output: Contribution to journalArticle

Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages

Bruns, C. J., Shinohara, H., Harbison, M. T., Davis, D. W., Nelkin, G., Killion, J. J., McConkey, D. J., Dong, Z. & Fidler, I. J., Jan 1 2000, In : Cancer Research. 60, 1, p. 2-7 6 p.

Research output: Contribution to journalArticle

The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia

Ruiz, S., Krupnik, Y., Keating, M., Chandra, J., Palladino, M. & McConkey, D., Jul 1 2006, In : Molecular cancer therapeutics. 5, 7, p. 1836-1843 8 p.

Research output: Contribution to journalArticle

The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo

Kamat, A. M., Karashima, T., Davis, D. W., Lashinger, L., Bar-Eli, M., Millikan, R., Shen, Y., Dinney, C. P. N. & McConkey, D. J., Mar 1 2004, In : Molecular cancer therapeutics. 3, 3, p. 279-290 12 p.

Research output: Contribution to journalArticle

The Proteasome Inhibitor Bortezomib Stabilizes a Novel Active Form of p53 in Human LNCaP-Pro5 Prostate Cancer Cells

Williams, S. A. & McConkey, D. J., Nov 1 2003, In : Cancer Research. 63, 21, p. 7338-7344 7 p.

Research output: Contribution to journalArticle

The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor zenografts

Nawrocki, S. T., Sweeney-Gotsch, B., Takamori, R. & McConkey, D. J., Jan 1 2004, In : Molecular cancer therapeutics. 3, 1, p. 59-70 12 p.

Research output: Contribution to journalArticle

The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR-205

Tran, M. N., Choi, W., Wszolek, M. F., Navai, N., Lee, I. L. C., Nitti, G., Wen, S., Flores, E. R., Siefker-Radtke, A., Czerniak, B., Dinney, C., Barton, M. & McConkey, D. J., Feb 1 2013, In : Journal of Biological Chemistry. 288, 5, p. 3275-3288 14 p.

Research output: Contribution to journalArticle

The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells

McConkey, D. J., Goodrich, D., Bucana, C. & Klostergaard, J., Nov 20 1996, In : Oncogene. 13, 8, p. 1693-1700 8 p.

Research output: Contribution to journalArticle

The CD3ζ cytoplasmic domain mediates CD2-induced T cell activation

Howard, F. D., Moingeon, P., Moebius, U., McConkey, D. J., Yandava, B., Gennert, T. E. & Reinherz, E. L., Jul 1 1992, In : Journal of Experimental Medicine. 176, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

Open Access

The Cancer Genome Atlas Expression Subtypes Stratify Response to Checkpoint Inhibition in Advanced Urothelial Cancer and Identify a Subset of Patients with High Survival Probability

Kim, J., Kwiatkowski, D., McConkey, D., Meeks, J. J., Freeman, S. S., Bellmunt, J., Getz, G. & Lerner, S. P., Jan 1 2019, In : European Urology.

Research output: Contribution to journalArticle

Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin

Ouhtit, A., Muller, H. K., Davis, D. W., Ullrich, S. E., McConkey, D. & Ananthaswamy, H. N., Jan 1 2000, In : American Journal of Pathology. 156, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

TCF21 promotes luminal-like differentiation and suppresses metastasis in bladder cancer

Mokkapati, S., Porten, S. P., Narayan, V. M., Lim, A. H., Jayaratna, I. S., Roth, B., Roth, B., Cheng, T., Navai, N., Wszolek, M., Melquist, J., Manyam, G., Choi, W., Broom, B., Pretzsch, S., Czerniak, B., McConkey, D. J. & Dinney, C. P. N., Jun 1 2020, In : Molecular Cancer Research. 18, 6, p. 811-821 11 p.

Research output: Contribution to journalArticle

Targeting endoplasmic reticulum protein transport: A novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL

Carew, J. S., Nawrocki, S. T., Krupnik, Y. V., Dunner, K., McConkey, D. J., Keating, M. J. & Huang, P., Jan 1 2006, In : Blood. 107, 1, p. 222-231 10 p.

Research output: Contribution to journalArticle

Targeting EGFR in bladder cancer

Villares, G. J., Zigler, M., Blehm, K., Bogdan, C., McConkey, D., Colin, D. & Bar-Eli, M., Dec 2007, In : World journal of urology. 25, 6, p. 573-579 7 p.

Research output: Contribution to journalArticle

Summary and recommendations from the national cancer institute's clinical trials planning meeting on novel therapeutics for non-muscle invasive bladder cancer

Lerner, S. P., Bajorin, D. F., Dinney, C. P., Efstathiou, J. A., Groshen, S., Hahn, N. M., Hansel, D., Kwiatkowski, D., O'Donnell, M., Rosenberg, J., Svatek, R., Abrams, J. S., Al-Ahmadie, H., Apolo, A. B., Bellmunt, J., Callahan, M., Cha, E. K., Drake, C., Jarow, J., Kamat, A. & 16 others, Kim, W., Knowles, M., Mann, B., Marchionni, L., McConkey, D., McShane, L., Ramirez, N., Sharabi, A., Sharpe, A. H., Solit, D., Tangen, C. M., Amiri, A. T., Van Allen, E., West, P. J., Witjes, J. A. & Quale, D. Z., 2016, In : Bladder Cancer. 2, 2, p. 165-201 37 p.

Research output: Contribution to journalArticle

SU‐FF‐I‐87: High Frequency Ultrasound To Monitor Murine Orthotopic Bladder Cancer Model : An Alternative To Magnetic Resonance Imaging

Shetty, A., Stafford, R., Esparza‐coss, E., Andtbacka, R., Brown, G., Black, P., Metwalli, A., McConkey, D., Dinney, C. & Hazle, J., 2006, In : Medical Physics. 33, 6, p. 2017 1 p.

Research output: Contribution to journalArticle

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

McConkey, D. J., Hartzell, P., Nicotera, P., Wyllie, A. H. & Orrenius, S., Aug 1988, In : Toxicology Letters. 42, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

Src activation regulates anoikis in human colon tumor cell lines

Windham, T. C., Parikh, N. U., Siwak, D. R., Summy, J. M., McConkey, D. J., Kraker, A. J. & Gallick, G. E., Nov 7 2002, In : Oncogene. 21, 51, p. 7797-7807 11 p.

Research output: Contribution to journalArticle

Src activation of Stat3 is an independent requirement from NF-κB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells

Trevino, J. G., Gray, M. J., Nawrocki, S. T., Summy, J. M., Lesslie, D. P., Evans, D. B., Sawyer, T. K., Shakespeare, W. C., Watowich, S. S., Chiao, P. J., McConkey, D. J. & Gallick, G. E., Jun 1 2006, In : Angiogenesis. 9, 2, p. 101-110 10 p.

Research output: Contribution to journalArticle

Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion.

Pathak, S., Multani, A. S., McConkey, D. J., Imam, A. S. & Amoss, M. S., Dec 2000, In : International journal of oncology. 17, 6, p. 1219-1224 6 p.

Research output: Contribution to journalArticle

Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer

Ochoa, A. E., Choi, W., Su, X., Siefker-Radtke, A., Czerniak, B., Dinney, C. & McConkey, D. J., Jan 1 2016, In : Oncotarget. 7, 49, p. 80164-80174 11 p.

Research output: Contribution to journalArticle

Smac mimetic reverses resistance to TRAIL and chemotherapy in human urothelial cancer cells

Metwalli, A. R., Khanbolooki, S., Jinesh, G., Sundi, D., Shah, J. B., Shrader, M., Choi, W., Lashinger, L. M., Chunduru, S., McConkey, D. J., McKinlay, M. & Kamat, A. M., Nov 1 2010, In : Cancer Biology and Therapy. 10, 9, p. 885-892 8 p.

Research output: Contribution to journalArticle

SIU–ICUD consultation on bladder cancer: basic science

McConkey, D. & Lerner, S. P., Jan 1 2018, (Accepted/In press) In : World Journal of Urology.

Research output: Contribution to journalArticle

Signalling and Chromatin Fragmentation in Thymocyte Apoptosis

McConkey, D. J., Nicotera, P. & Orrenius, S., Dec 1994, In : Immunological reviews. 142, 1, p. 343-363 21 p.

Research output: Contribution to journalArticle

Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells

Black, P. C., Brown, G. A., Inamoto, T., Shrader, M., Arora, A., Siefker-Radtke, A. O., Adam, L., Theodorescu, D., Wu, X., Munsell, M. F., Bar-Eli, M., McConkey, D. J. & Dinney, C. P. N., Mar 1 2008, In : Clinical Cancer Research. 14, 5, p. 1478-1486 9 p.

Research output: Contribution to journalArticle

Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells

Papageorgiou, A., Lashinger, L., Millikan, R., Grossman, H. B., Benedict, W., Dinney, C. P. N. & McConkey, D. J., Dec 15 2004, In : Cancer Research. 64, 24, p. 8973-8979 7 p.

Research output: Contribution to journalArticle

Role of P38 MAPK, AP-1, and NF-κb in interleukin-1β-induced IL-8 expression in human vascular smooth muscle cells

Jung, Y. D., Fan, F., McConkey, D. J., Jean, M. E., Liu, W., Reinmuth, N., Stoeltzing, O., Ahmad, S. A., Parikh, A. A., Mukaida, N. & Ellis, L. M., May 2002, In : Cytokine. 18, 4, p. 206-213 8 p.

Research output: Contribution to journalArticle

Role of calcium in toxic and programmed cell death

Orrenius, S., McConkey, D. J. & Nicotera, P., 1991, In : Advances in experimental medicine and biology. 283, p. 419-425 7 p.

Research output: Contribution to journalArticle

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

Mirkovic, N., Voehringer, D. W., Story, M. D., McConkey, D. J., McDonnell, T. J. & Meyn, R. E., Jan 1 1997, In : Oncogene. 15, 12, p. 1461-1470 10 p.

Research output: Contribution to journalArticle

Open Access

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

Davies, M. A., Koul, D., Dhesi, H., Berman, R., McDonnell, T. J., McConkey, D., Yung, W. K. A. & Steck, P. A., Jun 1 1999, In : Cancer Research. 59, 11, p. 2551-2556 6 p.

Research output: Contribution to journalArticle

Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts

Davis, D. W., Inoue, K., Dinney, C. P. N., Hicklin, D. J., Abbruzzese, J. L. & McConkey, D. J., Jul 1 2004, In : Cancer Research. 64, 13, p. 4601-4610 10 p.

Research output: Contribution to journalArticle

Receptor heterodimerization: A new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer

Black, P. C., Brown, G. A., Dinney, C. P., Kassouf, W., Inamoto, T., Arora, A., Gallagher, D., Munsell, M. F., Bar-Eli, M., McConkey, D. J. & Adam, L., Feb 1 2011, In : Journal of Urology. 185, 2, p. 693-700 8 p.

Research output: Contribution to journalArticle

Ras signaling in tumor necrosis factor-induced apoptosis

Trent, J. C., McConkey, D. J., Loughlin, S. M., Harbison, M. T., Fernandez, A. & Ananthaswamy, H. N., Sep 2 1996, In : EMBO Journal. 15, 17, p. 4497-4505 9 p.

Research output: Contribution to journalArticle

Rapid turnover of endogenous endonuclease activity in thymocytes: Effects of inhibitors of macromolecular synthesis

McConkey, D. J., Hartzell, P. & Orrenius, S., Apr 1990, In : Archives of Biochemistry and Biophysics. 278, 1, p. 284-287 4 p.

Research output: Contribution to journalArticle

Quantitative Analysis of Biomarkers Defines an Optimal Biological Dose for Recombinant Human Endostatin in Primary Human Tumors

Davis, D. W., Shen, Y., Mullani, N. A., Wen, S., Herbst, R. S., O'Reilly, M., Abbruzzese, J. L. & McConkey, D. J., Jan 1 2004, In : Clinical Cancer Research. 10, 1 I, p. 33-42 10 p.

Research output: Contribution to journalArticle

Quantitation of DNA fragmentation using fiberglass filters

Chow, S. C., McConkey, D. J., Orrenius, S. & Jondal, M., Nov 15 1989, In : Analytical biochemistry. 183, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle