David McConkey

Professor

1986 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article

Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use

Dadhania, V., Zhang, M., Zhang, L., Bondaruk, J., Majewski, T., Siefker-Radtke, A., Guo, C. C., Dinney, C., Cogdell, D. E., Zhang, S., Lee, S., Lee, J. G., Weinstein, J. N., Baggerly, K., McConkey, D. & Czerniak, B., Oct 1 2016, In : EBioMedicine. 12, p. 105-117 13 p.

Research output: Contribution to journalArticle

Micropapillary bladder cancer: Current treatment patterns and review of the literature

Willis, D. L., Flaig, T. W., Hansel, D. E., Milowsky, M. I., Grubb, R. L., Al-Ahmadie, H. A., Plimack, E. R., Koppie, T. M., McConkey, D. J., Dinney, C. P., Hoffman, V. A., Droller, M. J., Messing, E. & Kamat, A. M., Aug 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 6, p. 826-832 7 p.

Research output: Contribution to journalArticle

miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy

Adam, L., Zhong, M., Choi, W., Qi, W., Nicoloso, M., Arora, A., Calin, G., Wang, H., Siefker-Radtke, A., McConkey, D., Bar-Eli, M. & Dinney, C., Aug 15 2009, In : Clinical Cancer Research. 15, 16, p. 5060-5072 13 p.

Research output: Contribution to journalArticle

Molecular correlates of gefitinib responsiveness in human bladder cancer cells

Shrader, M., Pino, M. S., Brown, G., Black, P., Adam, L., Bar-Eli, M., Dinney, C. P. N. & McConkey, D. J., Jan 1 2007, In : Molecular cancer therapeutics. 6, 1, p. 277-285 9 p.

Research output: Contribution to journalArticle

Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy

Kim, M. P., Truty, M. J., Choi, W., Kang, YA., Chopin-Lally, X., Gallick, G. E., Wang, H., McConkey, D. J., Hwang, R., Logsdon, C., Abbruzzesse, J. & Fleming, J. B., Jul 1 2012, In : Annals of Surgical Oncology. 19, SUPPL. 3, p. S395-S403

Research output: Contribution to journalArticle

Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG

Liu, H., Zhang, T., Chen, R., McConkey, D. J., Ward, J. F. & Curley, S. A., Jul 1 2012, In : Journal of Surgical Research. 176, 1, p. 147-153 7 p.

Research output: Contribution to journalArticle

Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy

Blehm, K. N., Spiess, P. E., Bondaruk, J. E., Dujka, M. E., Villares, G. J., Zhao, Y. J., Bogler, O., Aldape, K. D., Grossman, H. B., Adam, L., McConkey, D. J., Czerniak, B. A., Dinney, C. P. & Bar-Eli, M., Aug 1 2006, In : Clinical Cancer Research. 12, 15, p. 4671-4677 7 p.

Research output: Contribution to journalArticle

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J. & McConkey, D. J., Oct 1 2008, In : Blood. 112, 7, p. 2917-2926 10 p.

Research output: Contribution to journalArticle

Neoadjuvant Dose-dense Gemcitabine and Cisplatin in Muscle-Invasive Bladder Cancer: Results of a Phase 2 Trial

Anari, F., O'Neill, J., Choi, W., Chen, D. Y. T., Haseebuddin, M., Kutikov, A., Dulaimi, E., Alpaugh, R. K., Devarajan, K., Greenberg, R. E., Bilusic, M., Wong, Y. N., Viterbo, R., Hoffman-Censits, J. H., Lallas, C. D., Trabulsi, E. J., Smaldone, M., Geynisman, D. M., Zibelman, M., Lin, J. & 4 others, Kelly, W. K., Uzzo, R., McConkey, D. & Plimack, E. R., May 2018, In : European Urology Oncology. 1, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung

Davis, D. W., Weidner, D. A., Holian, A. & McConkey, D. J., 2000, In : Journal of Experimental Medicine. 192, 6, p. 857-869 13 p.

Research output: Contribution to journalArticle

Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2

Xie, K., Wang, Y., Huang, S., Xu, L., Bielenberg, D., Salas, T., McConkey, D. J., Jiang, W. & Fidler, I. J., Jan 1 1997, In : Oncogene. 15, 7, p. 771-779 9 p.

Research output: Contribution to journalArticle

Open Access

NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target

McConkey, D. J., Chow, S. C., Orrenius, S. & Jondal, M., Jan 1 1990, In : FASEB Journal. 4, 9, p. 2661-2664 4 p.

Research output: Contribution to journalArticle

NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells

Miller, C. P., Ban, K., Dujka, M. E., McConkey, D. J., Munsell, M., Palladino, M. & Chandra, J., Jul 1 2007, In : Blood. 110, 1, p. 267-277 11 p.

Research output: Contribution to journalArticle

Nuclear factor-κB maintains TRAIL resistance in human pancreatic cancer cells

Khanbolooki, S., Nawrocki, S. T., Arumugam, T., Andtbacka, R., Pino, M. S., Kurzrock, R., Logsdon, C. D., Abbruzzese, J. L. & McConkey, D. J., Sep 1 2006, In : Molecular cancer therapeutics. 5, 9, p. 2251-2260 10 p.

Research output: Contribution to journalArticle

Nuclear factor-κB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8

Karashima, T., Sweeney, P., Kamat, A., Huang, S., Kim, S. J., Bar-Eli, M., McConkey, D. J. & Dinney, C. P. N., Jul 1 2003, In : Clinical Cancer Research. 9, 7, p. 2786-2797 12 p.

Research output: Contribution to journalArticle

Nuclear factor-κB p65/relA silencing induces apoptosis and increases gemcitabine effectiveness in a subset of pancreatic cancer cells

Pan, X., Arumugam, T., Yamamoto, T., Levin, P. A., Ramachandran, V., Ji, B., Lopez-Berestein, G., Vivas-Mejia, P. E., Sood, A. K., McConkey, D. J. & Logsdon, C. D., Dec 15 2008, In : Clinical Cancer Research. 14, 24, p. 8143-8151 9 p.

Research output: Contribution to journalArticle

Oncogene regulation of endonuclease activation in apoptosis

McConkey, D. J., Fernandez, A., Trent, J. & Ananthaswamy, H. N., Jul 20 1995, In : Cancer Letters. 94, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Origins of Bladder Cancer

Czerniak, B., Dinney, C. & McConkey, D., May 23 2016, In : Annual Review of Pathology: Mechanisms of Disease. 11, p. 149-174 26 p.

Research output: Contribution to journalArticle

Overexpression of CD3η during thymic development does not alter the negative selection process

Hussey, R. E., Clayton, L. K., Diener, A., McConkey, D. J., Howard, F. D., Rodewald -, H. R., D'Adamio, L., Dallenbach, F., Stein, H., Schmidt, E. V., Koyasu, S. & Reinherz, E. L., Jan 1 1993, In : Journal of Immunology. 150, 4, p. 1183-1194 12 p.

Research output: Contribution to journalArticle

Oxygen radical production and thiol depletion are required for Ca2+- mediated endogenous endonuclease activation in apoptotic thymocytes

Fernandez, A., Kiefer, J., Fosdick, L. & McConkey, D. J., Jan 1 1995, In : Journal of Immunology. 155, 11, p. 5133-5139 7 p.

Research output: Contribution to journalArticle

p53 and Fas ligand are required for psoralen and UVA-inducedapoptosis in mouse epidermal cells

Santamaria, A. B., Davis, D. W., Nghiem, D. X., McConkey, D. J., Ullrich, S. E., Kapoor, M., Lozano, G. & Ananthaswamy, H. N., Jan 1 2002, In : Cell death and differentiation. 9, 5, p. 549-560 12 p.

Research output: Contribution to journalArticle

Open Access

p63 expression correlates with sensitivity to the Eg5 inhibitor AZD4877 in bladder cancer cells

Marquis, L., Tran, M., Choi, W., Lee, I. L., Huszar, D., Siefker-Radtke, A., Dinney, C. P. & McConkey, D. J., May 1 2012, In : Cancer Biology and Therapy. 13, 7, p. 477-486 10 p.

Research output: Contribution to journalArticle

p63 expression defines a lethal subset of muscle-invasive bladder cancers

Choi, W., Shah, J. B., Tran, M., Svatek, R., Marquis, L., Lee, I. L., Yu, D., Adam, L., Wen, S., Shen, Y., Dinney, C., McConkey, D. J. & Siefker-Radtke, A., Jan 10 2012, In : PloS one. 7, 1, e30206.

Research output: Contribution to journalArticle

Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody imclone C225 in mice with metastatic human bladder transitional cell carcinoma

Inoue, K., Slaton, J. W., Perrotte, P., Davis, D. W., Bruns, C. J., Hicklin, D. J., McConkey, D. J., Sweeney, P., Radinsky, R. & Dinney, C. P. N., Dec 1 2000, In : Clinical Cancer Research. 6, 12, p. 4874-4884 11 p.

Research output: Contribution to journalArticle

Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668

Davis, D. W., Takamori, R., Raut, C. P., Xiong, H. Q., Herbst, R. S., Stadler, W. M., Heymach, J. V., Demetri, G. D., Rashid, A., Shen, Y., Wen, S., Abbruzzese, J. L. & McConkey, D. J., Jan 15 2005, In : Clinical Cancer Research. 11, 2 I, p. 678-689 12 p.

Research output: Contribution to journalArticle

Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination

Millward, M., Price, T., Townsend, A., Sweeney, C., Spencer, A., Sukumaran, S., Longenecker, A., Lee, L., Lay, A., Sharma, G., Gemmill, R. M., Drabkin, H. A., Lloyd, G. K., Neuteboom, S. T. C., McConkey, D. J., Palladino, M. A. & Spear, M. A., Dec 1 2012, In : Investigational New Drugs. 30, 6, p. 2303-2317 15 p.

Research output: Contribution to journalArticle

Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas

Heymach, J. V., Desai, J., Manola, J., Davis, D. W., McConkey, D. J., Harmon, D., Ryan, D. P., Goss, G., Quigley, T., Van Den Abbeele, A. D., Silverman, S. G., Connors, S., Folkman, J., Fletcher, C. D. M. & Demetri, G. D., Sep 1 2004, In : Clinical Cancer Research. 10, 17, p. 5732-5740 9 p.

Research output: Contribution to journalArticle

Phase II trial of imatinib mesylate in patients with metastatic melanoma

Kim, K. B., Eton, O., Davis, D. W., Frazier, M. L., McConkey, D. J., Diwan, A. H., Papadopoulos, N. E., Bedikian, A. Y., Camacho, L. H., Ross, M. I., Cormier, J. N., Gershenwald, J. E., Lee, J. E., Mansfield, P. F., Billings, L. A., Ng, C. S., Charnsangavej, C., Bar-Eli, M., Johnson, M. M., Murgo, A. J. & 1 others, Prieto, V. G., Sep 2 2008, In : British journal of cancer. 99, 5, p. 734-740 7 p.

Research output: Contribution to journalArticle

Phase I study of bortezomib in refractory of relapsed acute leukemias

Cortes, J., Thomas, D., Koller, C., Giles, F., Estey, E., Faderl, S., Garcia-Manero, G., McConkey, D., Patel, G., Guerciolini, R., Wright, J. & Kantarjian, H., May 15 2004, In : Clinical Cancer Research. 10, 10, p. 3371-3376 6 p.

Research output: Contribution to journalArticle

Phase I study of recombinant human endostatin in patients with advanced solid tumors

Herbst, R. S., Hess, K. R., Tran, H. T., Tseng, J. E., Mullani, N. A., Charnsangavej, C., Madden, T., Davis, D. W., McConkey, D. J., O'Reilly, M. S., Ellis, L. M., Pluda, J., Hong, W. K. & Abbruzzese, J. L., Sep 15 2002, In : Journal of Clinical Oncology. 20, 18, p. 3792-3803 12 p.

Research output: Contribution to journalArticle

Phosphatidylserine externalization during differentiation-triggered apoptosis of erythroleukemic cells

Diaz, C., Lee, A. T., McConkey, D. J. & Schroit, A. J., Mar 1999, In : Cell death and differentiation. 6, 3, p. 218-226 9 p.

Research output: Contribution to journalArticle

Open Access

Phosphorylation of multiple CD3ζ tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation

Koyasu, S., McConkey, D. J., Clayton, L. K., Abraham, S., Yandava, B., Katagiri, T., Moingeon, P., Yamamoto, T. & Reinherz, E. L., Jan 1 1992, In : Journal of Biological Chemistry. 267, 5, p. 3375-3381 7 p.

Research output: Contribution to journalArticle

Pilot study of bortezomib for patients with imatinib-refractory chronic myeloid leukemia in chronic or accelerated phase

Santos, F. P. S., Kantarjian, H., McConkey, D., O'Brien, S., Faderl, S., Borthakur, G., Ferrajoli, A., Wright, J. & Cortes, J., Aug 2011, In : Clinical Lymphoma, Myeloma and Leukemia. 11, 4, p. 355-360 6 p.

Research output: Contribution to journalArticle

Preclinical evaluation of intravesical cisplatin nanoparticles for non–muscle-invasive bladder cancer

Kates, M., Date, A., Yoshida, T., Afzal, U., Kanvinde, P., Babu, T., Sopko, N. A., Matsui, H., Hahn, N., McConkey, D., Baras, A., Hanes, J. S., Ensign-Hodges, L. & Bivalacqua, T., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6592-6601 10 p.

Research output: Contribution to journalArticle

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

Chonghaile, T. N., Sarosiek, K. A., Vo, T. T., Ryan, J. A., Tammareddi, A., Moore, V. D. G., Deng, J., Anderson, K. C., Richardson, P., Tai, Y. T., Mitsiades, C. S., Matulonis, U. A., Drapkin, R., Stone, R., DeAngelo, D. J., McConkey, D. J., Sallan, S. E., Silverman, L., Hirsch, M. S., Carrasco, D. R. & 1 others, Letai, A., Nov 25 2011, In : Science. 334, 6059, p. 1129-1133 5 p.

Research output: Contribution to journalArticle

Prognostic Factors in Resectable Pancreatic Cancer: p53 and Bcl-2

Bold, R. J., Hess, K. R., Pearson, A. S., Grau, A. M., Sinicrope, F. A., Jennings, M., McConkey, D. J., Bucana, C. D., Cleary, K. R., Hallin, P. A., Chiao, P. J., Abbruzzese, J. L. & Evans, D. B., Jan 1 1999, In : Journal of Gastrointestinal Surgery. 3, 3, p. 263-277 15 p.

Research output: Contribution to journalArticle

Prognostic Significance of Neutrophilic Infiltration in Benign Lymph Nodes in Patients with Muscle-invasive Bladder Cancer

Pal, S. K., Pham, A., Vuong, W., Liu, X., Lin, Y., Ruel, N., Yuh, B. E., Chan, K., Wilson, T., Lerner, S. P., McConkey, D., Jove, R. & Liang, W., Feb 1 2017, In : European Urology Focus. 3, 1, p. 130-135 6 p.

Research output: Contribution to journalArticle

Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells

Pino, M. S., Nawrocki, S. T., Cognetti, F., Abruzzese, J. L., Xiong, H. Q. & McConkey, D. J., Nov 2005, In : Cancer Biology and Therapy. 4, 11, p. 1263-1269 7 p.

Research output: Contribution to journalArticle

Open Access

Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes

Chandra, J., Gilbreath, J., Freireich, E. J., Kliche, K. O., Andreeff, M., Keating, M. & McConkey, D. J., Nov 15 1997, In : Blood. 90, 9, p. 3673-3681 9 p.

Research output: Contribution to journalArticle

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

Zhu, K., Dunner, K. & McConkey, D. J., Jan 1 2010, In : Oncogene. 29, 3, p. 451-462 12 p.

Research output: Contribution to journalArticle

Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes

Chandra, J., Niemer, I., Gilbreath, J., Kliche, K. O., Andreeff, M., Freireich, E. J., Keating, M. & McConkey, D. J., Dec 1 1998, In : Blood. 92, 11, p. 4220-4229 10 p.

Research output: Contribution to journalArticle

Proteolytic cleavage of vimentin during glucocorticoid-induced apoptosis

Kiefer, J. & McConkey, D. J., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1072

Research output: Contribution to journalArticle

Quantitation of DNA fragmentation using fiberglass filters

Chow, S. C., McConkey, D. J., Orrenius, S. & Jondal, M., Nov 15 1989, In : Analytical biochemistry. 183, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

Quantitative Analysis of Biomarkers Defines an Optimal Biological Dose for Recombinant Human Endostatin in Primary Human Tumors

Davis, D. W., Shen, Y., Mullani, N. A., Wen, S., Herbst, R. S., O'Reilly, M., Abbruzzese, J. L. & McConkey, D. J., Jan 1 2004, In : Clinical Cancer Research. 10, 1 I, p. 33-42 10 p.

Research output: Contribution to journalArticle

Rapid turnover of endogenous endonuclease activity in thymocytes: Effects of inhibitors of macromolecular synthesis

McConkey, D. J., Hartzell, P. & Orrenius, S., Apr 1990, In : Archives of Biochemistry and Biophysics. 278, 1, p. 284-287 4 p.

Research output: Contribution to journalArticle

Ras signaling in tumor necrosis factor-induced apoptosis

Trent, J. C., McConkey, D. J., Loughlin, S. M., Harbison, M. T., Fernandez, A. & Ananthaswamy, H. N., Sep 2 1996, In : EMBO Journal. 15, 17, p. 4497-4505 9 p.

Research output: Contribution to journalArticle

Receptor heterodimerization: A new mechanism for platelet-derived growth factor induced resistance to anti-epidermal growth factor receptor therapy for bladder cancer

Black, P. C., Brown, G. A., Dinney, C. P., Kassouf, W., Inamoto, T., Arora, A., Gallagher, D., Munsell, M. F., Bar-Eli, M., McConkey, D. J. & Adam, L., Feb 1 2011, In : Journal of Urology. 185, 2, p. 693-700 8 p.

Research output: Contribution to journalArticle

Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts

Davis, D. W., Inoue, K., Dinney, C. P. N., Hicklin, D. J., Abbruzzese, J. L. & McConkey, D. J., Jul 1 2004, In : Cancer Research. 64, 13, p. 4601-4610 10 p.

Research output: Contribution to journalArticle

Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN

Davies, M. A., Koul, D., Dhesi, H., Berman, R., McDonnell, T. J., McConkey, D., Yung, W. K. A. & Steck, P. A., Jun 1 1999, In : Cancer Research. 59, 11, p. 2551-2556 6 p.

Research output: Contribution to journalArticle