David McConkey

Professor

1986 …2020

Research output per year

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1986

Glucagon activation of the thiol:Protein disulfide oxidoreductase in isolated, rat, hepatic microsomes

McConkey, D. J., Crankshaw, D. L. & Holtzman, J. L., Jun 9 1986, In : Life Sciences. 38, 23, p. 2139-2143 5 p.

Research output: Contribution to journalArticle

1987

2,5-Di(tert-butyl)-1,4-benzohydroquinone - a novel inhibitor of liver microsomal Ca2+ sequestration

Moore, G. A., McConkey, D. J., Kass, G. E. N., O'Brien, P. J. & Orrenius, S., Nov 30 1987, In : FEBS Letters. 224, 2, p. 331-336 6 p.

Research output: Contribution to journalArticle

1988

2,3,7,8-Tetrachlorodibenzo-p-dioin kills immature thymoytes by Ca2+-mediated endonudease activation

McConkey, D. J., Hartzell, P., Duddy, S. K., Håkansson, H. & Orrenius, S., Jan 1 1988, In : Science. 242, 4876, p. 256-259 4 p.

Research output: Contribution to journalArticle

Ca2+-activated mechanisms in toxicity and programmed cell death

Orrenius, S., McConkey, D. J., Jones, D. P. & Nicotera, P., Jan 1 1988, In : ISI Atlas of Science: Pharmacology. 2, 4, p. 319-324 6 p.

Research output: Contribution to journalArticle

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress

Nicotera, P., McConkey, D., Svensson, S. Å., Bellomo, G. & Orrenius, S., Nov 14 1988, In : Toxicology. 52, 1-2, p. 55-63 9 p.

Research output: Contribution to journalArticle

Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress

McConkey, D. J., Hartzell, P., Nicotera, P., Wyllie, A. H. & Orrenius, S., Aug 1988, In : Toxicology Letters. 42, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

1989

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) kills glucocorticoid-sensitive thymocytes in vivo

McConkey, D. J. & Orrenius, S., May 15 1989, In : Biochemical and Biophysical Research Communications. 160, 3, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei

Nicotera, P., McConkey, D. J., Jones, D. P. & Orrenius, S., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 2, p. 453-457 5 p.

Research output: Contribution to journalArticle

Open Access

Ca2+ activated mechanisms in cell killing

Nicotera, P., Mc Conkey, D. J., Dypbukt, J. M., Jones, D. P. & Orrenius, S., Jan 1 1989, In : Drug Metabolism Reviews. 20, 2-4, p. 193-201 9 p.

Research output: Contribution to journalArticle

Calcium-activated DNA fragmentation in rat liver nuclei

Jones, D. P., McConkey, D. J., Nicotera, P. & Orrenius, S., Jan 1 1989, In : Journal of Biological Chemistry. 264, 11, p. 6398-6403 6 p.

Research output: Contribution to journalArticle

Calcium-activated DNA fragmentation kills immature thymocytes

McConkey, D. J., Hartzell, P., Nicotera, P. & Orrenius, S., Jan 1 1989, In : FASEB Journal. 3, 7, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex

McConkey, D. J., Hartzell, P., Amador-Perez, J. F., Orrenius, S. & Jondal, M., Jan 1 1989, In : Journal of Immunology. 143, 6, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

McConkey, D. J., Nicotera, P., Hartzell, P., Bellomo, G., Wyllie, A. H. & Orrenius, S., Feb 15 1989, In : Archives of Biochemistry and Biophysics. 269, 1, p. 365-370 6 p.

Research output: Contribution to journalArticle

Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C

McConkey, D. J., Hartzell, P., Jondal, M. & Orrenius, S., Jan 1 1989, In : Journal of Biological Chemistry. 264, 23, p. 13399-13402 4 p.

Research output: Contribution to journalArticle

Quantitation of DNA fragmentation using fiberglass filters

Chow, S. C., McConkey, D. J., Orrenius, S. & Jondal, M., Nov 15 1989, In : Analytical biochemistry. 183, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

1990

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes

McConkey, D. J., Orrenius, S. & Jondal, M., Jan 1 1990, In : Journal of Immunology. 145, 4, p. 1227-1230 4 p.

Research output: Contribution to journalArticle

Calcium-dependent DNA fragmentation in human synovial cells exposed to cold shock

Perotti, M., Toddei, F., Mirabelli, F., Vairetti, M., Bellomo, G., McConkey, D. J. & Orrenius, S., Jan 1 1990, In : FEBS Letters. 259, 2, p. 331-334 4 p.

Research output: Contribution to journalArticle

Cellular signalling in programmed cell death (apoptosis)

McConkey, D. J., Orrenius, S. & Jondal, M., 1990, In : Immunology Today. 11, C, p. 120-121 2 p.

Research output: Contribution to journalArticle

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes

McConkey, D. J., Hartzell, P., Chow, S. C., Orrenius, S. & Jondal, M., Mar 23 1990, In : Journal of Biological Chemistry. 265, 6, p. 3009-3011 3 p.

Research output: Contribution to journalArticle

NK cell-induced cytotoxicity is dependent on a Ca2+ increase in the target

McConkey, D. J., Chow, S. C., Orrenius, S. & Jondal, M., Jan 1 1990, In : FASEB Journal. 4, 9, p. 2661-2664 4 p.

Research output: Contribution to journalArticle

Rapid turnover of endogenous endonuclease activity in thymocytes: Effects of inhibitors of macromolecular synthesis

McConkey, D. J., Hartzell, P. & Orrenius, S., Apr 1990, In : Archives of Biochemistry and Biophysics. 278, 1, p. 284-287 4 p.

Research output: Contribution to journalArticle

1991

Differential signal transduction via T-cell receptor CD3ζ2, CD3ζ-η, and CD3η2 isoforms

Bauer, A., McConkey, D. J., Howard, F. D., Clayton, L. K., Novick, D., Koyasu, S. & Reinherz, E. L., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 9, p. 3842-3846 5 p.

Research output: Contribution to journalArticle

Open Access

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells

McConkey, D. J., Aguilar-Santelises, M., Hartzell, P., Eriksson, I., Mellstedt, H., Orrenius, S. & Jondal, M., Jan 1 1991, In : Journal of Immunology. 146, 3, p. 1072-1076 5 p.

Research output: Contribution to journalArticle

Role of calcium in toxic and programmed cell death

Orrenius, S., McConkey, D. J. & Nicotera, P., Jan 1 1991, In : Advances in experimental medicine and biology. 283, p. 419-425 7 p.

Research output: Contribution to journalArticle

1992

CD3ζ dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells

Moingeon, P., Lucich, J. L., McConkey, D. J., Letourneur, F., Malissen, B., Kochan, J., Chang, H. C., Rodewald, H. R. & Reinherz, E. L., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 4, p. 1492-1496 5 p.

Research output: Contribution to journalArticle

Open Access

Cellular signaling in thymocyte apoptosis

McConkey, D. J., Jondal, M. & Orrenius, S., Dec 1 1992, In : Seminars in immunology. 4, 6, p. 371-377 7 p.

Research output: Contribution to journalArticle

Phosphorylation of multiple CD3ζ tyrosine residues leads to formation of pp21 in vitro and in vivo. Structural changes upon T cell receptor stimulation

Koyasu, S., McConkey, D. J., Clayton, L. K., Abraham, S., Yandava, B., Katagiri, T., Moingeon, P., Yamamoto, T. & Reinherz, E. L., Jan 1 1992, In : Journal of Biological Chemistry. 267, 5, p. 3375-3381 7 p.

Research output: Contribution to journalArticle

The CD3ζ cytoplasmic domain mediates CD2-induced T cell activation

Howard, F. D., Moingeon, P., Moebius, U., McConkey, D. J., Yandava, B., Gennert, T. E. & Reinherz, E. L., Jul 1 1992, In : Journal of Experimental Medicine. 176, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

Open Access
1993

Cyclic AMP potentiates glucocorticoid-induced endogenous endonuclease activation in thymocytes

McConkey, D. J., Orrenius, S., Okret, S. & Jondal, M., Jan 1 1993, In : FASEB Journal. 7, 6, p. 580-585 6 p.

Research output: Contribution to journalArticle

Generation of natural killer cells from both FcγRII/III+ and FcγRII/III- murine fetal liver progenitors

Moingeon, P., Rodewald, H. R., McConkey, D., Mildonian, A., Awad, K. & Reinherz, E. L., Jan 1 1993, In : Blood. 82, 5, p. 1453-1462 10 p.

Research output: Contribution to journalArticle

Overexpression of CD3η during thymic development does not alter the negative selection process

Hussey, R. E., Clayton, L. K., Diener, A., McConkey, D. J., Howard, F. D., Rodewald -, H. R., D'Adamio, L., Dallenbach, F., Stein, H., Schmidt, E. V., Koyasu, S. & Reinherz, E. L., Jan 1 1993, In : Journal of Immunology. 150, 4, p. 1183-1194 12 p.

Research output: Contribution to journalArticle

1994

Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes: Implications for negative selection

McConkey, D. J., Fosdick, L., D'Adamio, L., Jondal, M. & Orrenius, S., Sep 15 1994, In : Journal of Immunology. 153, 6, p. 2436-2443 8 p.

Research output: Contribution to journalArticle

Signalling and Chromatin Fragmentation in Thymocyte Apoptosis

McConkey, D. J., Nicotera, P. & Orrenius, S., Dec 1994, In : Immunological reviews. 142, 1, p. 343-363 21 p.

Research output: Contribution to journalArticle

The regulation of apoptosis in thymocytes

McConkey, D. J., Jondal, M. & Orrenius, S., Jan 1 1994, In : Biochemical Society transactions. 22, 3, p. 606-610 5 p.

Research output: Contribution to journalArticle

1995

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei

Neamati, N., Fernandez, A., Wright, S., Kiefer, J. & McConkey, D. J., Apr 21 1995, In : Journal of Immunology. 154, 8, p. 3788-3795 8 p.

Research output: Contribution to journalArticle

Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2

Fernandez, A., Fosdick, L. J., Marin, M. C., Diaz, C., McDonnell, T. J., Ananthaswamy, H. N. & McConkey, D. J., Jan 1 1995, In : Oncogene. 10, 4, p. 769-774 6 p.

Research output: Contribution to journalArticle

Functional glucocorticoid receptor expression is required for cAMP- mediated apoptosis in a human leukemic T cell line

Kiefer, J., Okret, S., Jondal, M. & McConkey, D. J., Jan 1 1995, In : Journal of Immunology. 155, 10, p. 4525-4528 4 p.

Research output: Contribution to journalArticle

Oncogene regulation of endonuclease activation in apoptosis

McConkey, D. J., Fernandez, A., Trent, J. & Ananthaswamy, H. N., Jul 20 1995, In : Cancer Letters. 94, 1, p. 9-16 8 p.

Research output: Contribution to journalArticle

Oxygen radical production and thiol depletion are required for Ca2+- mediated endogenous endonuclease activation in apoptotic thymocytes

Fernandez, A., Kiefer, J., Fosdick, L. & McConkey, D. J., Jan 1 1995, In : Journal of Immunology. 155, 11, p. 5133-5139 7 p.

Research output: Contribution to journalArticle

1996

Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line

McConkey, D. J., Greene, G. & Pettaway, C. A., Dec 15 1996, In : Cancer Research. 56, 24, p. 5594-5599 6 p.

Research output: Contribution to journalArticle

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX

McConkey, D. J., Chandra, J., Wright, S., Plunkett, W., McDonnell, T. J., Reed, J. C. & Keating, M., Apr 1 1996, In : Journal of Immunology. 156, 7, p. 2624-2630 7 p.

Research output: Contribution to journalArticle

Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+

Marin, M. C., Fernandez, A., Bick, R. J., Brisbay, S., Buja, L. M., Snuggs, M., McConkey, D. J., Von Eschenbach, A. C., Keating, M. J. & McDonnell, T. J., Jul 5 1996, In : Oncogene. 12, 11, p. 2259-2266 8 p.

Research output: Contribution to journalArticle

At least two ways to apoptose

McConkey, D. J., Mar 1996, In : Human & Experimental Toxicology. 15, 3, p. 274-276 3 p.

Research output: Contribution to journalArticle

Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis

Xie, K., Huang, S., Wang, Y., Beltran, P. J., Juang, S. H., Dong, Z., Reed, J. C., McDonnell, T. J., McConkey, D. J. & Fidler, I. J., Nov 27 1996, In : Cancer Immunology Immunotherapy. 43, 2, p. 109-115 7 p.

Research output: Contribution to journalArticle

Open Access

CD98: A type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells

Warren, A. P., Patel, K., McConkev, D. J. & Palacios, R., May 1 1996, In : Blood. 87, 9, p. 3676-3687 12 p.

Research output: Contribution to journalArticle

Cycloheximide-induced apoptosis in melanoma cells derived from regressing cutaneous tumours of Sinclair swine

Gossett, R., Kier, A. B., Schroeder, F., McConkey, D., Fadok, V. & Amoss, M. S., Jan 1 1996, In : Journal of comparative pathology. 115, 4, p. 353-372 20 p.

Research output: Contribution to journalArticle

Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential

Huang, S., Luca, M., Gutman, M., McConkey, D. J., Langley, K. E., Lyman, S. D. & Bar-Eli, M., Dec 1 1996, In : Oncogene. 13, 11, p. 2339-2347 9 p.

Research output: Contribution to journalArticle

Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice

Xue, Y., Murdjeva, M., Okret, S., McConkey, D., Kiuossis, D. & Jondal, M., Feb 1996, In : European Journal of Immunology. 26, 2, p. 428-434 7 p.

Research output: Contribution to journalArticle