David McConkey

Professor

1986 …2020

Research output per year

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Research Output

2020

A Consensus Molecular Classification of Muscle-invasive Bladder Cancer[Formula presented]

Kamoun, A., de Reyniès, A., Allory, Y., Sjödahl, G., Robertson, A. G., Seiler, R., Hoadley, K. A., Groeneveld, C. S., Al-Ahmadie, H., Choi, W., Castro, M. A. A., Fontugne, J., Eriksson, P., Mo, Q., Kardos, J., Zlotta, A., Hartmann, A., Dinney, C. P., Bellmunt, J., Powles, T. & 22 others, Malats, N., Chan, K. S., Kim, W. Y., McConkey, D. J., Black, P. C., Dyrskjøt, L., Höglund, M., Lerner, S. P., Real, F. X., Radvanyi, F., Aine, M., Bernard-Pierrot, I., Czerniak, B., Gibb, E. A., Kim, J., Kwiatkowski, D. J., Lebret, T., Liedberg, F., Siefker-Radtke, A., Sirab, N., Taber, A. & Weinstein, J., Apr 2020, In : European Urology. 77, 4, p. 420-433 14 p.

Research output: Contribution to journalArticle

Open Access

Adaptive immune resistance to intravesical BCG in non–muscle invasive bladder cancer: Implications for prospective BCG-unresponsive trials

Kates, M., Matoso, A., Choi, W., Baras, A. S., Daniels, M. J., Lombardo, K., Brant, A., Mikkilineni, N., McConkey, D. J., Kamat, A. M., Svatek, R. S., Porten, S. P., Meeks, J. J., Lerner, S. P., Dinney, C. P., Black, P. C., McKiernan, J. M., Anderson, C., Drake, C. G. & Bivalacqua, T. J., Feb 15 2020, In : Clinical Cancer Research. 26, 4, p. 882-891 10 p.

Research output: Contribution to journalArticle

Reply To Kenneth B. Yatai, Mark J. Dunning, Dennis Wang. Consensus Genomic Subtypes of Muscle-invasive Bladder Cancer: A Step in the Right Direction but Still a Long Way To Go. Eur Urol 2020;77:434–5

Kamoun, A., de Reyniès, A., Allory, Y., Sjödahl, G., Robertson, A. G., Seiler, R., Hoadley, K. A., Groeneveld, C. S., Al-Ahmadie, H., Choi, W., Castro, M. A. A., Fontugne, J., Eriksson, P., Mo, Q., Kardos, J., Zlotta, A., Hartmann, A., Dinney, C. P., Bellmunt, J., Powles, T. & 22 others, Malats, N., Chan, K. S., Kim, W. Y., McConkey, D. J., Black, P. C., Dyrskjøt, L., Höglund, M., Lerner, S. P., Real, F. X., Radvanyi, F., Aine, M., Bernard-Pierrot, I., Czerniak, B., Gibb, E. A., Kim, J., Kwiatkowski, D. J., Lebret, T., Liedberg, F., Siefker-Radtke, A. A., Sirab, N., Taber, A. & Weinstein, J. N., Apr 2020, In : European Urology. 77, 4, p. 436-438 3 p.

Research output: Contribution to journalEditorial

2019

Clinical implications of molecular subtyping in bladder cancer

Satyal, U., Sikder, R. K., McConkey, D., Plimack, E. R. & Abbosh, P. H., Jul 1 2019, In : Current opinion in urology. 29, 4, p. 350-356 7 p.

Research output: Contribution to journalArticle

Does it matter whether a T1 high-grade tumor is molecularly classified?

Stenzl, A., McConkey, D. & Bellmunt, J., Jan 1 2019, In : European Urology Oncology.

Research output: Contribution to journalArticle

Open Access

Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer

Guo, C. C., Majewski, T., Zhang, L., Yao, H., Bondaruk, J., Wang, Y., Zhang, S., Wang, Z., Lee, J. G., Lee, S., Cogdell, D., Zhang, M., Wei, P., Grossman, H. B., Kamat, A., Duplisea, J. J., Ferguson, J. E., Huang, H., Dadhania, V., Gao, J. & 5 others, Dinney, C., Weinstein, J. N., Baggerly, K., McConkey, D. & Czerniak, B., May 7 2019, In : Cell Reports. 27, 6, p. 1781-1793.e4

Research output: Contribution to journalArticle

Open Access

Impact of spheroid culture on molecular and functional characteristics of bladder cancer cell lines

Yoshida, T., Sopko, N. A., Kates, M., Liu, X., Joice, G., McConkey, D. J. & Bivalacqua, T. J., Jan 1 2019, In : Oncology Letters. 18, 5, p. 4923-4929 7 p.

Research output: Contribution to journalArticle

Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation

Plote, D., Choi, W., Mokkapati, S., Sundi, D., Ferguson, J. E., Duplisea, J., Parker, N. R., Yla-Herttuala, S., Committee, SUO. CTC. B., McConkey, D., Schluns, K. S. & Dinney, C. P., May 4 2019, In : OncoImmunology. 8, 5, e1577125.

Research output: Contribution to journalArticle

Open Access

Limited Upstaging in Luminal Subtype Tumors: Ready for Clinical Practice?

Meeks, J. J. & McConkey, D., Jan 1 2019, In : European Urology.

Research output: Contribution to journalEditorial

Predictive biomarkers for drug response in bladder cancer

Yoshida, T., Kates, M., Fujita, K., Bivalacqua, T. & McConkey, D., Jan 1 2019, In : International Journal of Urology.

Research output: Contribution to journalReview article

Open Access

The Cancer Genome Atlas Expression Subtypes Stratify Response to Checkpoint Inhibition in Advanced Urothelial Cancer and Identify a Subset of Patients with High Survival Probability

Kim, J., Kwiatkowski, D., McConkey, D., Meeks, J. J., Freeman, S. S., Bellmunt, J., Getz, G. & Lerner, S. P., Jan 1 2019, In : European Urology.

Research output: Contribution to journalArticle

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis

Majewski, T., Yao, H., Bondaruk, J., Chung, W., Lee, S., Lee, J. G., Zhang, S., Cogdell, D., Yang, G., Choi, W., Dinney, C., Grossman, H. B., Logothetis, C., Scherer, S. E., Guo, C. C., Zhang, L., Wei, P., Weinstein, J. N., Issa, J. P., Baggerly, K. & 2 others, McConkey, D. J. & Czerniak, B., Feb 19 2019, In : Cell Reports. 26, 8, p. 2241-2256.e4

Research output: Contribution to journalArticle

Open Access
2018

Apoptosis: Signaling pathways in pancreatic cancer pathogenesis

McConkey, D. J. & Choi, W., Apr 11 2018, Pancreatic Cancer. Springer New York, p. 369-382 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Comparison of Pathological Stage in Patients Treated with and without Neoadjuvant Chemotherapy for High Risk Upper Tract Urothelial Carcinoma

Liao, R. S., Gupta, M., Schwen, Z. R., Patel, H. D., Kates, M., Johnson, M., Hahn, N., McConkey, D., Bivalacqua, T. & Pierorazio, P. M., Jul 1 2018, In : Journal of Urology. 200, 1, p. 68-73 6 p.

Research output: Contribution to journalArticle

ERCC2 Mutation: The Marker for Chemosensitivity in Primary and Secondary Muscle-invasive Bladder Cancers

Choi, W. & McConkey, D., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells

White, M. C., Schroeder, R. D., Zhu, K., Xiong, K. & McConkey, D., May 3 2018, (Accepted/In press) In : Oncogene. p. 1-15 15 p.

Research output: Contribution to journalArticle

Molecular Subtypes of Bladder Cancer

McConkey, D. J. & Choi, W., Oct 1 2018, In : Current oncology reports. 20, 10, 77.

Research output: Contribution to journalReview article

Neoadjuvant Dose-dense Gemcitabine and Cisplatin in Muscle-Invasive Bladder Cancer: Results of a Phase 2 Trial

Anari, F., O'Neill, J., Choi, W., Chen, D. Y. T., Haseebuddin, M., Kutikov, A., Dulaimi, E., Alpaugh, R. K., Devarajan, K., Greenberg, R. E., Bilusic, M., Wong, Y. N., Viterbo, R., Hoffman-Censits, J. H., Lallas, C. D., Trabulsi, E. J., Smaldone, M., Geynisman, D. M., Zibelman, M., Lin, J. & 4 others, Kelly, W. K., Uzzo, R., McConkey, D. & Plimack, E. R., May 2018, In : European Urology Oncology. 1, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Organoid culture of bladder cancer cells

Yoshida, T., Singh, A. K., Bishai, W. R., McConkey, D. J. & Bivalacqua, T. J., May 2018, In : Investigative and Clinical Urology. 59, 3, p. 149-151 3 p.

Research output: Contribution to journalEditorial

SIU–ICUD consultation on bladder cancer: basic science

McConkey, D. & Lerner, S. P., Jan 1 2018, (Accepted/In press) In : World Journal of Urology.

Research output: Contribution to journalArticle

Subtyping Bladder Cancers: Biology vs Bioinformatics

McConkey, D. & Choi, W., May 1 2018, In : Journal of the National Cancer Institute. 110, 5, p. 439-440 2 p.

Research output: Contribution to journalComment/debate

Open Access

The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside

Duplisea, J. J., Mokkapati, S., Plote, D., Schluns, K. S., McConkey, D., Yla-Herttuala, S., Parker, N. R. & Dinney, C. P., Jan 1 2018, (Accepted/In press) In : World Journal of Urology.

Research output: Contribution to journalArticle

Three-dimensional organoid culture reveals involvement of Wnt/β-catenin pathway in proliferation of bladder cancer cells

Yoshida, T., Sopko, N. A., Kates, M., Liu, X., Joice, G., McConkey, D. & Bivalacqua, T., Jan 1 2018, In : Oncotarget. 9, 13, p. 11060-11070 11 p.

Research output: Contribution to journalArticle

2017

Aurora kinase A is a biomarker for bladder cancer detection and contributes to its aggressive behavior

Mobley, A., Zhang, S., Bondaruk, J., Wang, Y., Majewski, T., Caraway, N. P., Huang, L., Shoshan, E., Velazquez-Torres, G., Nitti, G., Lee, S., Lee, J. G., Fuentes-Mattei, E., Willis, D., Zhang, L., Guo, C. C., Yao, H., Baggerly, K., Lotan, Y., Lerner, S. P. & 4 others, Dinney, C., McConkey, D., Bar-Eli, M. & Czerniak, B., Jan 19 2017, In : Scientific Reports. 7, 40714.

Research output: Contribution to journalArticle

Autophagy is required for crizotinib-induced apoptosis in MET-amplified gastric cancer cells

Schroeder, R. D., Choi, W., Hong, D. S. & McConkey, D. J., Feb 7 2017, In : Oncotarget. 8, 31, p. 51675-51687 13 p.

Research output: Contribution to journalArticle

Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer

Fernández, M. I., Williams, S. B., Willis, D. L., Slack, R. S., Dickstein, R. J., Parikh, S., Chiong, E., Siefker-Radtke, A. O., Guo, C. C., Czerniak, B. A., McConkey, D., Shah, J. B., Pisters, L. L., Grossman, H. B., Dinney, C. P. N. & Kamat, A. M., May 1 2017, In : BJU International. 119, 5, p. 684-691 8 p.

Research output: Contribution to journalArticle

Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer

Robertson, A. G., Kim, J., Al-Ahmadie, H., Bellmunt, J., Guo, G., Cherniack, A. D., Hinoue, T., Laird, P. W., Hoadley, K. A., Akbani, R., Castro, M. A. A., Gibb, E. A., Kanchi, R. S., Gordenin, D. A., Shukla, S. A., Sanchez-Vega, F., Hansel, D. E., Czerniak, B. A., Reuter, V. E., Su, X. & 154 others, de Sa Carvalho, B., Chagas, V. S., Mungall, K. L., Sadeghi, S., Pedamallu, C. S., Lu, Y., Klimczak, L. J., Zhang, J., Choo, C., Ojesina, A. I., Bullman, S., Leraas, K. M., Lichtenberg, T. M., Wu, C. J., Schultz, N., Getz, G., Meyerson, M., Mills, G. B., McConkey, D. J., Albert, M., Alexopoulou, I., Ally, A., Antic, T., Aron, M., Balasundaram, M., Bartlett, J., Baylin, S. B., Beaver, A., Birol, I., Boice, L., Bootwalla, M. S., Bowen, J., Bowlby, R., Brooks, D., Broom, B. M., Bshara, W., Burks, E., Cárcano, F. M., Carlsen, R., Carvalho, B. S., Carvalho, A. L., Castle, E. P., Castro, P., Catto, J. W., Chesla, D. W., Chuah, E., Chudamani, S., Cortessis, V. K., Cottingham, S. L., Crain, D., Curley, E., Daneshmand, S., Demchok, J. A., Dhalla, N., Djaladat, H., Eckman, J., Egea, S. C., Engel, J., Felau, I., Ferguson, M. L., Gardner, J., Gastier-Foster, J. M., Gerken, M., Gomez-Fernandez, C. R., Harr, J., Hartmann, A., Herbert, L. M., Ho, T. H., Holt, R. A., Hutter, C. M., Jones, S. J. M., Jorda, M., Kahnoski, R. J., Kasaian, K., Kwiatkowski, D. J., Lai, P. H., Lane, B. R., Lerner, S. P., Liu, J., Lolla, L., Lotan, Y., Lucchesi, F. R., Ma, Y., Machado, R. D., Maglinte, D. T., Mallery, D., Marra, M. A., Martin, S. E., Mayo, M., Meraney, A., Moinzadeh, A., Moore, R. A., Mora Pinero, E. M., Morris, S., Morrison, C., Mungall, A. J., Myers, J. B., Naresh, R., O'Donnell, P. H., Parekh, D. J., Parfitt, J., Paulauskis, J. D., Sekhar Pedamallu, C., Penny, R. J., Pihl, T., Porten, S., Quintero-Aguilo, M. E., Ramirez, N. C., Rathmell, W. K., Rieger-Christ, K., Saller, C., Salner, A., Sandusky, G., Scapulatempo-Neto, C., Schein, J. E., Schuckman, A. K., Shelton, C., Shelton, T., Simko, J., Singh, P., Sipahimalani, P., Smith, N. D., Sofia, H. J., Sorcini, A., Stanton, M. L., Steinberg, G. D., Stoehr, R., Su, X., Sullivan, T., Sun, Q., Tam, A., Tarnuzzer, R., Tarvin, K., Taubert, H., Thiessen, N., Thorne, L., Tse, K., Tucker, K., Van Den Berg, D. J., van Kessel, K. E., Wach, S., Wan, Y., Wang, Z., Weinstein, J. N., Weisenberger, D. J., Wise, L., Wong, T., Wu, Y., Yang, L., Zach, L. A., Zenklusen, J. C., Zhang, J. J., Zmuda, E. & Zwarthoff, E. C., Oct 19 2017, In : Cell. 171, 3, p. 540-556.e25

Research output: Contribution to journalArticle

Effects of thiazolidinedione in patients with active bladder cancer

Li, R., Metcalfe, M. J., Ferguson, J. E., Mokkapati, S., Nogueras González, G. M., Dinney, C. P., Navai, N., McConkey, D., Sahai, S. K. & Kamat, A. M., 2017, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

Employing an orthotopic model to study the role of epithelialmesenchymal transition in bladder cancer metastasis

Roth, B., Jayaratna, I., Sundi, D., Cheng, T., Melquist, J., Choi, W., Porten, S., Nitti, G., Navai, N., Wszolek, M., Guo, C., Czerniak, B., McConkey, D. & Dinney, C., Jan 1 2017, In : Oncotarget. 8, 21, p. 34205-34222 18 p.

Research output: Contribution to journalArticle

Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset

Choi, W., Ochoa, A., McConkey, D., Aine, M., Höglund, M., Kim, W. Y., Real, F. X., Kiltie, A. E., Milsom, I., Dyrskjøt, L. & Lerner, S. P., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Impact of High-risk Features and Effect of Neoadjuvant Chemotherapy in Urothelial Cancer Patients with Invasion into the Lamina Propria on Transurethral Resection in the Absence of Deep Muscle Invasion

Metcalfe, M. J., Ferguson, J. E., Li, R., Xiao, L., Guo, C. C., Czerniak, B. A., Siefker-Radtke, A., Pretzsch, S. M., Navai, N., McConkey, D., Kamat, A. M., Campbell, M. & Dinney, C., 2017, (Accepted/In press) In : European Urology Focus.

Research output: Contribution to journalArticle

Impact of Molecular Subtypes in Muscle-invasive Bladder Cancer on Predicting Response and Survival after Neoadjuvant Chemotherapy

Seiler, R., Ashab, H. A. D., Erho, N., van Rhijn, B. W. G., Winters, B., Douglas, J., Van Kessel, K. E., Fransen van de Putte, E. E., Sommerlad, M., Wang, N. Q., Choeurng, V., Gibb, E. A., Palmer-Aronsten, B., Lam, L. L., Buerki, C., Davicioni, E., Sjödahl, G., Kardos, J., Hoadley, K. A., Lerner, S. P. & 14 others, McConkey, D., Choi, W., Kim, W. Y., Kiss, B., Thalmann, G. N., Todenhöfer, T., Crabb, S. J., North, S., Zwarthoff, E. C., Boormans, J. L., Wright, J., Dall'Era, M., van der Heijden, M. S. & Black, P. C., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Intravesical BCG Induces CD4+ T-cell expansion in an immune competent model of bladder cancer

Kates, M., Nirschl, T., Sopko, N. A., Matsui, H., Kochel, C. M., Reis, L. O., Netto, G. J., Hoque, M., Hahn, N., McConkey, D., Baras, A., Drake, C. G. & Bivalacqua, T., Jul 1 2017, In : Cancer immunology research. 5, 7, p. 594-603 10 p.

Research output: Contribution to journalArticle

Preclinical evaluation of intravesical cisplatin nanoparticles for non–muscle-invasive bladder cancer

Kates, M., Date, A., Yoshida, T., Afzal, U., Kanvinde, P., Babu, T., Sopko, N. A., Matsui, H., Hahn, N., McConkey, D., Baras, A., Hanes, J. S., Ensign-Hodges, L. & Bivalacqua, T., Nov 1 2017, In : Clinical Cancer Research. 23, 21, p. 6592-6601 10 p.

Research output: Contribution to journalArticle

Predicting Response to Intravesical Bacillus Calmette-Guérin Immunotherapy: Are We There Yet? A Systematic Review

Kamat, A. M., Li, R., O'Donnell, M. A., Black, P. C., Roupret, M., Catto, J. W., Comperat, E., Ingersoll, M. A., Witjes, W. P., McConkey, D. & Witjes, J. A., 2017, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Prognostic Significance of Neutrophilic Infiltration in Benign Lymph Nodes in Patients with Muscle-invasive Bladder Cancer

Pal, S. K., Pham, A., Vuong, W., Liu, X., Lin, Y., Ruel, N., Yuh, B. E., Chan, K., Wilson, T., Lerner, S. P., McConkey, D., Jove, R. & Liang, W., Feb 1 2017, In : European Urology Focus. 3, 1, p. 130-135 6 p.

Research output: Contribution to journalArticle

The integrated stress response and proteotoxicity in cancer therapy

McConkey, D., Jan 15 2017, In : Biochemical and Biophysical Research Communications. 482, 3, p. 450-453 4 p.

Research output: Contribution to journalReview article

2016

A Prognostic Gene Expression Signature in the Molecular Classification of Chemotherapy-naïve Urothelial Cancer is Predictive of Clinical Outcomes from Neoadjuvant Chemotherapy: A Phase 2 Trial of Dose-dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin with Bevacizumab in Urothelial Cancer

McConkey, D. J., Choi, W., Shen, Y., Lee, I. L., Porten, S., Matin, S. F., Kamat, A. M., Corn, P., Millikan, R. E., Dinney, C., Czerniak, B. & Siefker-Radtke, A. O., May 1 2016, In : European Urology. 69, 5, p. 855-862 8 p.

Research output: Contribution to journalArticle

Biology and therapy of urological cancer metastasis

Posadas, E. M., McConkey, D. & Chung, L. W. K., Oct 1 2016, In : Asian Journal of Urology. 3, 4, p. 167-169 3 p.

Research output: Contribution to journalEditorial

Bladder cancer molecular taxonomy: Summary from a consensus meeting

Lerner, S. P., McConkey, D. J., Hoadley, K. A., Chan, K. S., Kim, W. Y., Radvanyi, F., Höglund, M. & Real, F. X., Jan 1 2016, In : Bladder Cancer. 2, 1, p. 37-47 11 p.

Research output: Contribution to journalArticle

Gene Expression Profile of the Clinically Aggressive Micropapillary Variant of Bladder Cancer

Guo, C. C., Dadhania, V., Zhang, L., Majewski, T., Bondaruk, J., Sykulski, M., Wronowska, W., Gambin, A., Wang, Y., Zhang, S., Fuentes-Mattei, E., Kamat, A. M., Dinney, C., Siefker-Radtke, A., Choi, W., Baggerly, K. A., McConkey, D., Weinstein, J. N. & Czerniak, B., Oct 1 2016, In : European Urology. 70, 4, p. 611-620 10 p.

Research output: Contribution to journalArticle

Intrinsic subtypes and bladder cancer metastasis

McConkey, D., Choi, W., Ochoa, A. & Dinney, C. P. N., Oct 1 2016, In : Asian Journal of Urology. 3, 4, p. 260-267 8 p.

Research output: Contribution to journalReview article

Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use

Dadhania, V., Zhang, M., Zhang, L., Bondaruk, J., Majewski, T., Siefker-Radtke, A., Guo, C. C., Dinney, C., Cogdell, D. E., Zhang, S., Lee, S., Lee, J. G., Weinstein, J. N., Baggerly, K., McConkey, D. & Czerniak, B., Oct 1 2016, In : EBioMedicine. 12, p. 105-117 13 p.

Research output: Contribution to journalArticle

Origins of Bladder Cancer

Czerniak, B., Dinney, C. & McConkey, D., May 23 2016, In : Annual Review of Pathology: Mechanisms of Disease. 11, p. 149-174 26 p.

Research output: Contribution to journalArticle

Specific micro-RNA expression patterns distinguish the basal and luminal subtypes of muscle-invasive bladder cancer

Ochoa, A. E., Choi, W., Su, X., Siefker-Radtke, A., Czerniak, B., Dinney, C. & McConkey, D. J., Jan 1 2016, In : Oncotarget. 7, 49, p. 80164-80174 11 p.

Research output: Contribution to journalArticle