David Kay Ryugo

Professor Emeritus

1972 …2018
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Research Output 1972 2018

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Article
2018

Hidden hearing loss and endbulbs of Held: Evidence for central pathology before detection of ABR threshold increases

Muniak, M. A., Ayeni, F. E. & Ryugo, D. K., Jan 1 2018, (Accepted/In press) In : Hearing Research.

Research output: Contribution to journalArticle

Cochlear Nerve
Brain Stem Auditory Evoked Potentials
Hearing Loss
Pathology
Sound Localization
2017

Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes

Loetsch, C., Warren, J., Laskowski, A., Vazquez-Lombardi, R., Jandl, C., Langley, D. B., Christ, D., Thorburn, D. R., Ryugo, D. K., Sprent, J., Batten, M. & King, C., Nov 7 2017, In : Cell Reports. 21, 6, p. 1624-1638 15 p.

Research output: Contribution to journalArticle

Sheep
Blood
Erythrocytes
Cells
Antigen-Presenting Cells

Descending projections from the inferior colliculus to the dorsal cochlear nucleus are excitatory

Milinkeviciute, G., Muniak, M. A. & Ryugo, D. K., Mar 1 2017, In : Journal of Comparative Neurology. 525, 4, p. 773-793 21 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Inferior Colliculi
Axons
Auditory Pathways
Post-Synaptic Density

The effect of progressive hearing loss on the morphology of endbulbs of Held and bushy cells

Connelly, C. J., Ryugo, D. K. & Muniak, M. A., Jan 1 2017, In : Hearing Research. 343, p. 14-33 20 p.

Research output: Contribution to journalArticle

Hearing Loss
Pathology
Cochlear Nucleus
Deafness
Hearing
2016
Inferior Colliculi
Deafness
Hearing Loss
Hearing
Cochlea
2015
Cochlear Nucleus
Cochlear Nerve
Hearing Loss
Acoustics
Synapses
2014

Auditory neuroplasticity, hearing loss and cochlear implants

Ryugo, D. K., Oct 10 2014, In : Cell and Tissue Research. 361, 1, p. 251-269 19 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Cochlear Implants
Hearing Loss
Pathology
Cochlear Nerve

Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats

David, V. A., Menotti-Raymond, M., Wallace, A. C., Roelke, M., Kehler, J., Leighty, R., Eizirik, E., Hannah, S. S., Nelson, G., Schäffer, A. A., Connelly, C. J., O'Brien, S. J. & Ryugo, D. K., Oct 1 2014, In : G3: Genes, Genomes, Genetics. 4, 10, p. 1881-1891 11 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Metrorrhagia
Terminal Repeat Sequences
Pedigree
Oncogenes

Tonotopic organization of vertical cells in the dorsal cochlear nucleus of the CBA/J mouse

Muniak, M. A. & Ryugo, D. K., Mar 2014, In : Journal of Comparative Neurology. 522, 4, p. 937-949 13 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Inbred CBA Mouse
Cochlear Nerve
Interneurons
Injections
2013

3D model of frequency representation in the cochlear nucleus of the CBA/J mouse

Muniak, M. A., Rivas, A., Montey, K. L., May, B. J., Francis, H. W. & Ryugo, D. K., May 1 2013, In : Journal of Comparative Neurology. 521, 7, p. 1510-1532 23 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Inbred CBA Mouse
Cochlear Nerve
Nerve Fibers
Auditory Pathways

Morphological Characterization of Bushy Cells and Their Inputs in the Laboratory Mouse (Mus musculus) Anteroventral Cochlear Nucleus

Lauer, A. M., Connelly, C. J., Graham, H. & Ryugo, D. K., Aug 26 2013, In : PLoS One. 8, 8, e73308.

Research output: Contribution to journalArticle

Cochlear Nucleus
Mus musculus
Electron microscopy
Optical microscopy
Volume fraction
2012

Efferent synapses return to inner hair cells in the aging cochlea

Lauer, A. M., Fuchs, P. A., Ryugo, D. K. & Francis, H. W., Dec 2012, In : Neurobiology of Aging. 33, 12, p. 2892-2902 11 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Cell Aging
Cochlea
Synapses
Outer Auditory Hair Cells

Feline Deafness

Ryugo, D. K. & Menotti-Raymond, M., Nov 2012, In : Veterinary Clinics of North America - Small Animal Practice. 42, 6, p. 1179-1207 29 p.

Research output: Contribution to journalArticle

deafness
Felidae
hearing
Deafness
Cats

Preparation of an awake mouse for recording neural responses and injecting tracers

Muniak, M. A., Mayko, Z. M., Ryugo, D. K. & Portfors, C. V., Jun 26 2012, In : Journal of Visualized Experiments. 64, p. 1 1 p., e3755.

Research output: Contribution to journalArticle

Neurons
Anesthetics
Anesthesia
Mesencephalon
Brain Stem

Synaptic plasticity in the medial superior olive of hearing, deaf, and cochlear-implanted cats

Tirko, N. N. & Ryugo, D. K., Jul 1 2012, In : Journal of Comparative Neurology. 520, 10, p. 2202-2217 16 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Cochlea
Hearing
Cats
Cochlear Implants
2011

Age-related neuronal loss in the cochlea is not delayed by synaptic modulation

Jin, D., Ohlemiller, K. K., Lei, D., Dong, E., Role, L., Ryugo, D. K. & Bao, J., Dec 2011, In : Neurobiology of Aging. 32, 12

Research output: Contribution to journalArticle

Neuregulin-1
Cochlea
Spiral Ganglion
Neurons
Inner Auditory Hair Cells

Synaptic morphology and the influence of auditory experience

O'Neil, J. N., Connelly, C. J., Limb, C. J. & Ryugo, D. K., Sep 2011, In : Hearing Research. 279, 1-2, p. 118-130 13 p.

Research output: Contribution to journalArticle

Synapses
Auditory Pathways
Auditory Cortex
Acoustics
Hearing

The spiral ganglion: Connecting the peripheral and central auditory systems

Nayagam, B. A., Muniak, M. A. & Ryugo, D. K., Aug 2011, In : Hearing Research. 278, 1-2, p. 2-20 19 p.

Research output: Contribution to journalArticle

Spiral Ganglion
Neurons
Organ of Corti
Cochlear Nerve
Acoustics
2010

Bilateral effects of unilateral cochlear implantation in congenitally deaf cats

O'Neil, J. N., Limb, C. J., Baker, C. A. & Ryugo, D. K., Jun 15 2010, In : Journal of Comparative Neurology. 518, 12, p. 2382-2404 23 p.

Research output: Contribution to journalArticle

Cochlear Implantation
Synapses
Cats
Cochlear Implants
Deafness

Erratum: Bilateral effects of unilateral cochlear implantation in congenitally deaf cats (The Journal of Comparative Neurology (2010) 518 (2382-2404))

O'Neil, J. N., Limb, C. J., Baker, C. A. & Ryugo, D. K., Oct 1 2010, In : Journal of Comparative Neurology. 518, 19, p. 4088 1 p.

Research output: Contribution to journalArticle

Cochlear Implantation
Neurology
Cats

Neural coding of interaural time differences with bilateral cochlear implants: Effects of congenital deafness

Hancock, K. E., Noel, V., Ryugo, D. K. & Delgutte, B., Oct 20 2010, In : Journal of Neuroscience. 30, 42, p. 14068-14079 12 p.

Research output: Contribution to journalArticle

Cochlear Implants
Deafness
Cats
Hearing
Neurons

Postnatal development of the endbulb of held in congenitally deaf cats

Baker, C. A., Montey, K. L., Pongstaporn, T. & Ryugo, D. K., 2010, In : Frontiers in Neuroanatomy. 4

Research output: Contribution to journalArticle

Cats
Hearing
Post-Synaptic Density
Cochlear Nerve
Synaptic Vesicles

Synaptic plasticity after chemical deafening and electrical stimulation of the auditory nerve in cats

Ryugo, D. K., Baker, C. A., Montey, K. L., Chang, L. Y., Coco, A., Fallon, J. B. & Shepherd, R. K., Apr 1 2010, In : Journal of Comparative Neurology. 518, 7, p. 1046-1063 18 p.

Research output: Contribution to journalArticle

Chemical Stimulation
Cochlear Nerve
Neuronal Plasticity
Deafness
Electric Stimulation
Spiral Ganglion
Cochlear Implants
Electric Stimulation
Cats
Cochlea
2009
Transgenic Rats
Neural Stem Cells
Spinal Cord
Suid Herpesvirus 1
Transplants

Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum

Nasonkin, I., Machairaki, V., Xu, L., Hatfield, G., Cummings, B. J., Eberhart, C. G., Ryugo, D. K., Maric, D., Bar, E. & Koliatsos, V. E., Oct 2009, In : Stem Cells. 27, 10, p. 2414-2426 13 p.

Research output: Contribution to journalArticle

Neostriatum
Neurons
Prosencephalon
Transplants
Transplantation
2008
Cochlear Nucleus
Cochlear Nerve
Neurosciences
Nerve Fibers
Cats
Cochlear Nucleus
Cochlear Nerve
Nerve Fibers
Cats
Neuropil

Revealing the molecular layer of the primate dorsal cochlear nucleus

Rubio, M. E., Gudsnuk, K. A., Smith, Y. & Ryugo, D. K., Jun 12 2008, In : Neuroscience. 154, 1, p. 99-113 15 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Primates
Mammals
Macaca mulatta
Synapses
2007

Four independent mutations in the feline Fibroblast Growth Factor 5 gene determine the long-haired phenotype in domestic cats

Kehler, J. S., David, V. A., Schäffer, A. A., Bajema, K., Eizirik, E., Ryugo, D. K., Hannah, S. S., O'Brien, S. J. & Menotti-Raymond, M., Sep 2007, In : The Journal of heredity. 98, 6, p. 555-566 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 5
fibroblast growth factors
Felidae
Cats
cats

Hearing molecules: Contributions from genetic deafness

Eisen, M. D. & Ryugo, D. K., Mar 2007, In : Cellular and Molecular Life Sciences. 64, 5, p. 566-580 15 p.

Research output: Contribution to journalArticle

Audition
Deafness
Hearing
Molecules
Cochlea

Projections of the lateral reticular nucleus to the cochlear nucleus in rats

Zhan, X. & Ryugo, D. K., Oct 10 2007, In : Journal of Comparative Neurology. 504, 5, p. 583-598 16 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Synapses
Electron Microscopy
Hoof and Claw
Pons
2006

A modified Golgi staining protocol for use in the human brain stem and cerebellum

Friedland, D. R., Los, J. G. & Ryugo, D. K., Jan 15 2006, In : Journal of Neuroscience Methods. 150, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

Cerebellum
Brain Stem
Staining and Labeling
Cochlear Nucleus
Tissue Banks

Efficient quantification of afferent cochlear ultrastructure using design-based stereology

Francis, H. W., Rivas, A., Lehar, M., Saito, Y., Mouton, P. R. & Ryugo, D. K., Jan 30 2006, In : Journal of Neuroscience Methods. 150, 2, p. 150-158 9 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Cochlea
Synapses
Hearing
Cochlear Nerve

Erratum: Restoration of auditory nerve synapses in cats by cochlear implants (Science (December 2, 2005) (1490))

Ryugo, D. K., Feb 17 2006, In : Science. 311, 5763, p. 954 1 p.

Research output: Contribution to journalArticle

Postnatal development of a large auditory nerve terminal: The endbulb of Held in cats

Ryugo, D. K., Montey, K. L., Wright, A. L., Bennett, M. L. & Pongstaporn, T., Jun 2006, In : Hearing Research. 216-217, p. 100-115 16 p.

Research output: Contribution to journalArticle

Mitochondrial Size
Post-Synaptic Density
Cochlear Nerve
Cats
Cell Membrane
Cochlear Nucleus
Auditory Cortex
granules
cortex
dendrites

Projections of the second cervical dorsal root ganglion to the cochlear nucleus in rats

Zhan, X., Pongstaporn, T. & Ryugo, D. K., May 20 2006, In : Journal of Comparative Neurology. 496, 3, p. 335-348 14 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Spinal Ganglia
Synaptic Vesicles
Dendrites
Spinal Nerves
Cochlear Nucleus
neurons
Neurons
cells
Axons

Synaptic alterations at inner hair cells precede spiral ganglion cell loss in aging C57BL/6J mice

Stamataki, S., Francis, H. W., Lehar, M., May, B. J. & Ryugo, D. K., Nov 2006, In : Hearing Research. 221, 1-2, p. 104-118 15 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Spiral Ganglion
Inbred C57BL Mouse
Cochlea
Synapses
2005

Neuroscience: Restoration of auditory nerve synapses in cats by cochlear implants

Ryugo, D. K., Kretzmer, E. A. & Niparko, J. K., Dec 2 2005, In : Science. 310, 5753, p. 1490-1492 3 p.

Research output: Contribution to journalArticle

Cochlear Nerve
Cochlear Implants
Neurosciences
Synapses
Cats

Projections from the spinal trigeminal nucleus to the cochlear nucleus in the rat

Haenggeli, C. A., Pongstaporn, T., Doucet, J. R. & Ryugo, D. K., Apr 4 2005, In : Journal of Comparative Neurology. 484, 2, p. 191-205 15 p.

Research output: Contribution to journalArticle

Spinal Trigeminal Nucleus
Cochlear Nucleus
Auditory Pathways
Neurons
Injections
2004

An Animal Model for Cochlear Implants

Kretzmer, E. A., Meltzer, N. E., Haenggeli, C. A. & Ryugo, D. K., May 2004, In : Archives of Otolaryngology--Head and Neck Surgery. 130, 5, p. 499-508 10 p.

Research output: Contribution to journalArticle

Cochlear Implants
Deafness
Animal Models
Auditory Pathways
Equipment and Supplies

PHR1, a PH domain-containing protein expressed in primary sensory neurons

Xu, S., Wang, Y., Zhao, H., Zhang, L., Xiong, W., Yau, K-W., Hiel, H., Glowatzki, E. B., Ryugo, D. K. & Valle, D., Oct 2004, In : Molecular and Cellular Biology. 24, 20, p. 9137-9151 15 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Auditory Hair Cells
Vestibular Hair Cells
Galactosidases
Olfactory Receptor Neurons

Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice

Francis, H. W., Rivas, A., Lehar, M. & Ryugo, D. K., Aug 6 2004, In : Brain Research. 1016, 2, p. 182-194 13 p.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Presbycusis
Inbred C57BL Mouse
Synapses
Cochlear Diseases
2003
Cochlear Nucleus
Injections
Axons
Brain Stem
biotinylated dextran amine
Cochlear Nucleus
Cochlear Nerve
Nerve Fibers
Electric Stimulation
Neurons
Cochlear Nucleus
Deafness
Synapses
Post-Synaptic Density
Hearing

Multimodal inputs to the granule cell domain of the cochlear nucleus

Ryugo, D. K., Haenggeli, C. A. & Doucet, J. R., Dec 2003, In : Experimental Brain Research. 153, 4, p. 477-485 9 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Hearing
Learning
Brain

Primary innervation of the avian and mammalian cochlear nucleus

Ryugo, D. K. & Parks, T. N., Jun 15 2003, In : Brain Research Bulletin. 60, 5-6, p. 435-456 22 p.

Research output: Contribution to journalArticle

Cochlear Nucleus
Cochlear Nerve
Mammals
Heredity
Diptera