David B Pearse &ndash; Research Output

2019

Does Use of Electronic Alerts for Systemic Inflammatory Response Syndrome (SIRS)to Identify Patients With Sepsis Improve Mortality?

Seetharaman, S., Wilson, C., Landrum, M., Qasba, S., Katz, M., Ladikos, N., Harris, J. E., Galiatsatos, P., Yousem, D. M., Knight, A. M., Pearse, D. B., Blanding, R., Bennett, R. G., Galai, N., Perl, T. M. & Sood, G., Jan 1 2019, In : American Journal of Medicine.

Research output: Contribution to journal › Article

Systemic Inflammatory Response Syndrome

Sepsis

Mortality

Practice Guidelines

Anti-Bacterial Agents

2018

Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a United States medical center: Results of a clinical trial

Townsend, J., Adams, V., Galiatsatos, P., Pearse, D. B., Pantle, H., Masterson, M., Kisuule, F., Jacob, E., Kiruthi, C., Ortiz, P., Agbanlog, A., Jurao, R., Stern, S., Nayak, S., Melgar, M., Sama, J., Irwin, J., Mazidi, C., Psoter, K. & McKenzie, R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 12

Research output: Contribution to journal › Article

Open Access

Calcitonin

Respiratory Tract Infections

Clinical Trials

Anti-Bacterial Agents

Therapeutics

2016

CD36 mediates H₂O₂-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A. L., Pearse, D. B. & Shimoda, L., Dec 2 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Contribution to journal › Article

TRPV Cation Channels

Endothelial Cells

Calcium

Lung

Cell Membrane

Occupational Asthma Due to Inhalation of Aerosolized Lipophilic Coating Materials

Suresh, K., Belchis, D. A., Askin, F. B., Pearse, D. B. & Terry, P. B., Jul 8 2016, (Accepted/In press) In : Lung. p. 1-3 3 p.

Research output: Contribution to journal › Article

Occupational Asthma

Inhalation

Respiratory Sounds

Asthma

2015

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

Suresh, K., Servinsky, L., Reyes, J., Baksh, S., Undem, C., Caterina, M., Pearse, D. B. & Shimoda, L., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1467-L1477

Research output: Contribution to journal › Article

TRPV Cation Channels

Hydrogen Peroxide

Endothelial Cells

Calcium

Lung

When right is redundant

Terry, P. B. & Pearse, D. B., Jun 1 2015, In : Chest. 147, 6, p. e238

Research output: Contribution to journal › Article

Lung

2014

A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome

Hikmat, F., Pearse, D. B. & Damarla, M., Nov 1 2014, In : Canadian Respiratory Journal. 21, 6, p. 337-340 4 p.

Research output: Contribution to journal › Article

Churg-Strauss Syndrome

Hemoptysis

Vasculitis

Bronchial Arteries

Tomography

Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages

Rentsendorj, O., D'Alessio, F. & Pearse, D. B., Nov 1 2014, In : Journal of Leukocyte Biology. 96, 5, p. 907-915 9 p.

Research output: Contribution to journal › Article

Type 2 Cyclic Nucleotide Phosphodiesterases

Alveolar Macrophages

Lipopolysaccharides

Macrophages

Lung

Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase

Stephens, R., Servinsky, L. E., Rentsendorj, O., Kolb, T. M., Pfeifer, A. & Pearse, D. B., Mar 15 2014, In : American Journal of Physiology - Cell Physiology. 306, 6

Research output: Contribution to journal › Article

Cyclic GMP-Dependent Protein Kinases

Oxidants

Protein-Tyrosine Kinases

Endothelial Cells

Antioxidants

2013

A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces

Kolb, T. M., King, L. S. & Pearse, D. B., Dec 2013, In : Chest. 144, 6, p. 1964-1968 5 p.

Research output: Contribution to journal › Article

Birt-Hogg-Dube Syndrome

X Ray Computed Tomography

Estrone

Pneumothorax

Dyspnea

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei

Anidi, I. U., Servinsky, L. E., Rentsendorj, O., Stephens, R., Scott, A. L. & Pearse, D. B., Aug 15 2013, In : PLoS One. 8, 8, e71010.

Research output: Contribution to journal › Article

Plasmodium berghei

malaria

Malaria

phosphotransferases (kinases)

Phosphotransferases

2012

Dieulafoy's disease of the bronchus

Kolb, T. M., Gilbert, C., Fishman, E. K., Terry, P. B., Pearse, D. B., Feller-Kopman, D. & Yarmus, L., Dec 1 2012, In : American Journal of Respiratory and Critical Care Medicine. 186, 11, p. 1191 1 p.

Research output: Contribution to journal › Article

Bronchial Diseases

Therapeutic Embolization

Bronchial Arteries

X Ray Computed Tomography

Hemoptysis

Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome

Eberlein, M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Shlobin, O. A., Shelhamer, J. H., Reed, R. M., Pearse, D. B., Orens, J. B. & Brower, R. G., Feb 2012, In : Chest. 141, 2, p. 451-460 10 p.

Research output: Contribution to journal › Article

Bronchiolitis Obliterans

Total Lung Capacity

Lung Transplantation

Allografts

Lung

Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation

Eberlein, M., Reed, R. M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Iacono, A., Pearse, D. B., Fessler, H. E., Shah, A. S., Orens, J. B. & Brower, R. G., Nov 2012, In : Journal of Heart and Lung Transplantation. 31, 11

Research output: Contribution to journal › Article

Total Lung Capacity

Lung Transplantation

Tissue Donors

Survival

Proportional Hazards Models

Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase

D'Alessio, F., Tsushima, K., Aggarwal, N. R., Mock, J. R., Eto, Y., Garibaldi, B. T., Files, D. C., Avalos, C. R., Rodriguez, J. V., Waickman, A. T., Reddy, S. P., Pearse, D. B., Sidhaye, V., Hassoun, P. M., Crow, M. T. & King, L. S., Sep 1 2012, In : Journal of Immunology. 189, 5, p. 2234-2245 12 p.

Research output: Contribution to journal › Article

Lung Injury

Nitric Oxide Synthase Type II

Nitric Oxide Synthase

Monocytes

Acute Lung Injury

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Schmidt, E. P., Yang, Y., Janssen, W. J., Gandjeva, A., Perez, M. J., Barthel, L., Zemans, R. L., Bowman, J. C., Koyanagi, D. E., Yunt, Z. X., Smith, L. P., Cheng, S. S., Overdier, K. H., Thompson, K. R., Geraci, M. W., Douglas, I. S., Pearse, D. B. & Tuder, R. M., Aug 2012, In : Nature Medicine. 18, 8, p. 1217-1223 7 p.

Research output: Contribution to journal › Article

Glycocalyx

Lung Injury

Sepsis

Neutrophils

Adhesion

2011

Idiopathic constrictive bronchiolitis with rapidly progressive bronchiectasis and Mycobacterium kansasii infection

Raparla, S., Schmidt, E. P. & Pearse, D. B., 2011, In : Respiratory Medicine CME. 4, 4, p. 172-174 3 p.

Research output: Contribution to journal › Article

Mycobacterium kansasii

Bronchiolitis Obliterans

Mycobacterium Infections

Bronchiectasis

Lung

Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury

Gurkan, O. U., He, C., Zielinski, R., Rabb, H., King, L. S., Dodd-o, J. M., D'Alessio, F., Aggarwal, N., Pearse, D. B. & Becker, P. M., Dec 2011, In : Experimental Lung Research. 37, 10, p. 575-584 10 p.

Research output: Contribution to journal › Article

Capillary Permeability

Lung Injury

Mechanical Ventilators

Interleukin-6

Lung

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

Rentsendorj, O., Damarla, M., Aggarwal, N. R., Choi, J. Y., Johnston, L., D'Alessio, F., Crow, M. T. & Pearse, D. B., Aug 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 2

Research output: Contribution to journal › Article

Type 2 Cyclic Nucleotide Phosphodiesterases

Acute Lung Injury

Inflammation

Lung

Ventilator-Induced Lung Injury

Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival

Eberlein, M., Permutt, S., Brown, R. H., Brooker, A., Chahla, M. F., Bolukbas, S., Nathan, S. D., Pearse, D. B., Orens, J. B. & Brower, R. G., Jan 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 1, p. 79-87 9 p.

Research output: Contribution to journal › Article

Pulmonary Ventilation

Lung Transplantation

Total Lung Capacity

Lung

Transplants

2010

cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism

Stephens, R., Rentsendorj, O., Servinsky, L. E., Moldobaeva, A., Damico, R. L. & Pearse, D. B., Sep 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 299, 3

Research output: Contribution to journal › Article

Cyclic GMP-Dependent Protein Kinases

Oxidants

Catalase

Reactive Oxygen Species

Cell Death

2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R. L., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6

Research output: Contribution to journal › Article

Mechanical Ventilators

Protein C

Artificial Respiration

rho-Associated Kinases

Lung

2008

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis

Damico, R. L., Chesley, A., Johnston, L., Bind, E. P., Amaro, E., Nijmeh, J., Karakas, B., Welsh, L., Pearse, D. B., Garcia, J. G. N. & Crow, M. T., Jul 1 2008, In : American Journal of Respiratory Cell and Molecular Biology. 39, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article

Macrophage Migration-Inhibitory Factors

Endothelial cells

Lipopolysaccharides

Endothelial Cells

Small Interfering RNA

Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function

Rentsendorj, O., Mirzapoiazova, T., Adyshev, D., Servinsky, L. E., Renné, T., Verin, A. D. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4

Research output: Contribution to journal › Article

Pulmonary Artery

Phosphorylation

Permeability

Endothelial Cells

vasodilator-stimulated phosphoprotein

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Schmidt, E. P., Damarla, M., Rentsendorj, O., Servinsky, L. E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P. M. & Pearse, D. B., Dec 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 6

Research output: Contribution to journal › Article

Ventilator-Induced Lung Injury

Lung

Ventilation

Nitric Oxide

Soluble Guanylyl Cyclase

The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse

Dodd-o, J. M., Hristopoulos, M. L., Kibler, K., Gutkowska, J., Mukaddam-Daher, S., Gonzalez, A., Welsh-Servinsky, L. E. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4

Research output: Contribution to journal › Article

Reperfusion Injury

Atrial Natriuretic Factor

Reperfusion

Lung

Ischemia

2007

A 56-year-old man with choking, recurrent pneumonia, and weight loss

Eberlein, M. & Pearse, D. B., Apr 2007, In : Chest. 131, 4, p. 1248-1251 4 p.

Research output: Contribution to journal › Article

Airway Obstruction

Weight Loss

Pneumonia

2006

Reply from Drs. Brown, Pearse, Pyrgos, Liu, Togias, and Permutt [6]

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C. H., Togias, A. & Permutt, S., Dec 2006, In : Journal of Applied Physiology. 101, 6, p. 1813 1 p.

Research output: Contribution to journal › Article

Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells

Moldobaeva, A., Welsh-Servinsky, L. E., Shimoda, L., Stephens, R., Verin, A. D., Tuder, R. M. & Pearse, D. B., May 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 5

Research output: Contribution to journal › Article

Cyclic GMP-Dependent Protein Kinases

Pulmonary Artery

Endothelial Cells

Permeability

Adenoviridae

Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice

Dodd-o, J. M., Hristopoulos, M. L., Welsh-Servinsky, L. E., Tankersley, C. G. & Pearse, D. B., May 2006, In : Journal of Applied Physiology. 100, 5, p. 1590-1595 6 p.

Research output: Contribution to journal › Article

Lung Injury

Reperfusion Injury

Lung

NADPH Oxidase

Reactive Oxygen Species

The structural basis of airways hyperresponsiveness in asthma

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C. H., Togias, A. & Permutt, S., 2006, In : Journal of Applied Physiology. 101, 1, p. 30-39 10 p.

Research output: Contribution to journal › Article

Smooth Muscle

Vital Capacity

Asthma

Total Lung Capacity

Functional Residual Capacity

2005

Blood carbon monoxide will increase from a decline in pulmonary function alone [6]

Permutt, S. & Pearse, D. B., Nov 1 2005, In : American Journal of Respiratory and Critical Care Medicine. 172, 9, p. 1231 1 p.

Research output: Contribution to journal › Article

Carbon Monoxide

Lung

Effects of tidal volume and respiratory frequency on lung lymph flow

Pearse, D. B., Searcy, R. M., Mitzner, W. A., Permutt, S. & Sylvester, J. T., Aug 2005, In : Journal of Applied Physiology. 99, 2, p. 556-563 8 p.

Research output: Contribution to journal › Article

Tidal Volume

Lymph

Edema

Sheep

Lung

Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement

Kolosova, I. A., Mirzapoiazova, T., Adyshev, D., Usatyuk, P., Romer, L., Jacobson, J. R., Natarajan, V., Pearse, D. B., Garcia, J. G. N. & Verin, A. D., Jul 22 2005, In : Circulation Research. 97, 2, p. 115-124 10 p.

Research output: Contribution to journal › Article

Endothelial Cells

Adenosine Triphosphate

Myosin-Light-Chain Phosphatase

Cyclic AMP-Dependent Protein Kinases

GTP-Binding Proteins

2004

Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury

Dodd-o, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Bethea, B. T., Cattaneo, S. M., Baumgartner, W. A. & Pearse, D. B., Feb 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2

Research output: Contribution to journal › Article

Bronchial Arteries

Lung Injury

Cardiopulmonary Bypass

Swine

Lung

Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury

Dodd-o, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Ziegelstein, R., Zweier, J. L., Baumgartner, W. A. & Pearse, D. B., Aug 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 2 56-2

Research output: Contribution to journal › Article

NADPH Oxidase

Lung Injury

Cardiopulmonary Bypass

Reactive Oxygen Species

Lung

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D. B., Tuder, R. M. & Garcia, J. G. N., Jun 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 11, p. 1245-1251 7 p.

Research output: Contribution to journal › Article

Lung Injury

Endotoxins

Blood Vessels

Lung

Evans Blue

2003

Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide

Pearse, D. B., Shimoda, L., Verin, A. D., Bogatcheva, N., Moon, C., Ronnett, G. V., Welsh, L. E. & Becker, P. M., 2003, In : Endothelium: Journal of Endothelial Cell Research. 10, 6, p. 309-317 9 p.

Research output: Contribution to journal › Article

Guanosine Monophosphate

Hydrogen Peroxide

Lung

Electric Impedance

Endothelial Cells

Effect of ischemia and reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lung

Dodd-o, J. M., Hristopoulos, M. L., Faraday, N. & Pearse, D. B., Nov 2003, In : Journal of Applied Physiology. 95, 5, p. 1971-1978 8 p.

Research output: Contribution to journal › Article

Reperfusion

Blood Vessels

Ischemia

Lung

Evans Blue

Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice

Becker, P. M., Kazi, A. A., Wadgaonkar, R., Pearse, D. B., Kwiatkowski, D. & Garcia, J. G. N., Apr 1 2003, In : American Journal of Respiratory Cell and Molecular Biology. 28, 4, p. 478-484 7 p.

Research output: Contribution to journal › Article

Gelsolin

Capillary Permeability

Lung

Wounds and Injuries

Bronchoalveolar Lavage

2002

Inhibition of inwardly rectifying K+ channels by cGMP in pulmonary vascular endothelial cells

Shimoda, L., Welsh, L. E. & Pearse, D. B., 2002, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 2 27-2

Research output: Contribution to journal › Article

Inwardly Rectifying Potassium Channel

Endothelial Cells

Cyclic GMP-Dependent Protein Kinases

Lung

Guanosine

Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy

Sung, Y. K., Moon, C., Yoo, J. Y., Moon, C., Pearse, D. B., Pevsner, J. A. & Ronnett, G. V., Apr 12 2002, In : Journal of Biological Chemistry. 277, 15, p. 12762-12769 8 p.

Research output: Contribution to journal › Article

Respiratory Mucosa

Nasal Mucosa

Rats

Thymus

Salivary Glands