David B Pearse

Professor

1986 …2020

Research output per year

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Research Output

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Article
2020

IGSF3 mutation identified in patient with severe COPD alters cell function and motility

Schweitzer, K. S., Jinawath, N., Yonescu, R., Ni, K., Rush, N., Charoensawan, V., Bronova, I., Berdyshev, E., Leach, S. M., Gillenwater, L. A., Bowler, R. P., Pearse, D. B., Griffin, C. A. & Petrache, I., Jun 23 2020, In : JCI Insight. 5, 14, e138101.

Research output: Contribution to journalArticle

Open Access
2019

Does Use of Electronic Alerts for Systemic Inflammatory Response Syndrome (SIRS)to Identify Patients With Sepsis Improve Mortality?

Seetharaman, S., Wilson, C., Landrum, M., Qasba, S., Katz, M., Ladikos, N., Harris, J. E., Galiatsatos, P., Yousem, D. M., Knight, A. M., Pearse, D. B., Blanding, R., Bennett, R., Galai, N., Perl, T. M. & Sood, G., Jan 1 2019, In : American Journal of Medicine.

Research output: Contribution to journalArticle

2018

Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a United States medical center: Results of a clinical trial

Townsend, J., Adams, V., Galiatsatos, P., Pearse, D., Pantle, H., Masterson, M., Kisuule, F., Jacob, E., Kiruthi, C., Ortiz, P., Agbanlog, A., Jurao, R., Stern, S., Nayak, S., Melgar, M., Sama, J., Irwin, J., Mazidi, C., Psoter, K. & McKenzie, R., 2018, In : Open Forum Infectious Diseases. 5, 12

Research output: Contribution to journalArticle

Open Access
2016

CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A., Pearse, D. B. & Shimoda, L. A., Dec 2 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Contribution to journalArticle

Occupational Asthma Due to Inhalation of Aerosolized Lipophilic Coating Materials

Suresh, K., Belchis, D., Askin, F., Pearse, D. B. & Terry, P. B., Oct 1 2016, In : Lung. 194, 5, p. 787-789 3 p.

Research output: Contribution to journalArticle

2015

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

Suresh, K., Servinsky, L., Reyes, J., Baksh, S., Undem, C., Caterina, M., Pearse, D. B. & Shimoda, L. A., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1467-L1477

Research output: Contribution to journalArticle

2014

A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome

Hikmat, F., Pearse, D. B. & Damarla, M., Nov 1 2014, In : Canadian Respiratory Journal. 21, 6, p. 337-340 4 p.

Research output: Contribution to journalArticle

Open Access

Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase

Scott Stephens, R., Servinsky, L. E., Rentsendorj, O., Kolb, T. M., Pfeifer, A. & Pearse, D. B., Mar 15 2014, In : American Journal of Physiology - Cell Physiology. 306, 6, p. C559-C569

Research output: Contribution to journalArticle

2013

A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces

Kolb, T. M., King, L. S. & Pearse, D. B., Dec 2013, In : CHEST. 144, 6, p. 1964-1968 5 p.

Research output: Contribution to journalArticle

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei

Anidi, I. U., Servinsky, L. E., Rentsendorj, O., Stephens, R. S., Scott, A. L. & Pearse, D. B., Aug 15 2013, In : PloS one. 8, 8, e71010.

Research output: Contribution to journalArticle

2012

Dieulafoy's disease of the bronchus

Kolb, T., Gilbert, C., Fishman, E., Terry, P., Pearse, D., Feller-Kopman, D. & Yarmus, L., Dec 1 2012, In : American journal of respiratory and critical care medicine. 186, 11, 1 p.

Research output: Contribution to journalArticle

Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome

Eberlein, M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Shlobin, O. A., Shelhamer, J. H., Reed, R. M., Pearse, D. B., Orens, J. B. & Brower, R. G., Feb 2012, In : CHEST. 141, 2, p. 451-460 10 p.

Research output: Contribution to journalArticle

Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation

Eberlein, M., Reed, R. M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Iacono, A., Pearse, D. B., Fessler, H. E., Shah, A. S., Orens, J. B. & Brower, R. G., Nov 2012, In : Journal of Heart and Lung Transplantation. 31, 11, p. 1207-1213.e7

Research output: Contribution to journalArticle

Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase

D'Alessio, F. R., Tsushima, K., Aggarwal, N. R., Mock, J. R., Eto, Y., Garibaldi, B. T., Files, D. C., Avalos, C. R., Rodriguez, J. V., Waickman, A. T., Reddy, S. P., Pearse, D. B., Sidhaye, V. K., Hassoun, P. M., Crow, M. T. & King, L. S., Sep 1 2012, In : Journal of Immunology. 189, 5, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Schmidt, E. P., Yang, Y., Janssen, W. J., Gandjeva, A., Perez, M. J., Barthel, L., Zemans, R. L., Bowman, J. C., Koyanagi, D. E., Yunt, Z. X., Smith, L. P., Cheng, S. S., Overdier, K. H., Thompson, K. R., Geraci, M. W., Douglas, I. S., Pearse, D. B. & Tuder, R. M., Aug 1 2012, In : Nature medicine. 18, 8, p. 1217-1223 7 p.

Research output: Contribution to journalArticle

2011

Idiopathic constrictive bronchiolitis with rapidly progressive bronchiectasis and Mycobacterium kansasii infection

Raparla, S., Schmidt, E. P. & Pearse, D. B., Jun 21 2011, In : Respiratory Medicine CME. 4, 4, p. 172-174 3 p.

Research output: Contribution to journalArticle

Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury

Gurkan, O. U., He, C., Zielinski, R., Rabb, H., King, L. S., Dodd-O, J. M., D'Alessio, F. R., Aggarwal, N., Pearse, D. & Becker, P. M., Dec 1 2011, In : Experimental Lung Research. 37, 10, p. 575-584 10 p.

Research output: Contribution to journalArticle

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

Rentsendorj, O., Damarla, M., Aggarwal, N. R., Choi, J. Y., Johnston, L., D'Alessio, F. R., Crow, M. T. & Pearse, D. B., Aug 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 2, p. L161-L170

Research output: Contribution to journalArticle

Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival

Eberlein, M., Permutt, S., Brown, R. H., Brooker, A., Chahla, M. F., Bolukbas, S., Nathan, S. D., Pearse, D. B., Orens, J. B. & Brower, R. G., Jan 1 2011, In : American journal of respiratory and critical care medicine. 183, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

2010
2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L1002-L1011

Research output: Contribution to journalArticle

2008

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis

Damico, R. L., Chesley, A., Johnston, L., Bind, E. P., Amaro, E., Nijmeh, J., Karakas, B., Welsh, L., Pearse, D. B., Garcia, J. G. N. & Crow, M. T., Jul 1 2008, In : American journal of respiratory cell and molecular biology. 39, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function

Rentsendorj, O., Mirzapoiazova, T., Adyshev, D., Servinsky, L. E., Renné, T., Verin, A. D. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4, p. L686-L697

Research output: Contribution to journalArticle

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Schmidt, E. P., Damarla, M., Rentsendorj, O., Servinsky, L. E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P. M. & Pearse, D. B., Dec 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 6, p. L1056-L1065

Research output: Contribution to journalArticle

The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse

Dodd-o, J. M., Hristopoulos, M. L., Kibler, K., Gutkowska, J., Mukaddam-Daher, S., Gonzalez, A., Welsh-Servinsky, L. E. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4, p. L714-L723

Research output: Contribution to journalArticle

2007

A 56-year-old man with choking, recurrent pneumonia, and weight loss

Eberlein, M. & Pearse, D. B., Apr 2007, In : CHEST. 131, 4, p. 1248-1251 4 p.

Research output: Contribution to journalArticle

2006

Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells

Moldobaeva, A., Welsh-Servinsky, L. E., Shimoda, L. A., Stephens, R. S., Verin, A. D., Tuder, R. M. & Pearse, D. B., May 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 5, p. L919-L930

Research output: Contribution to journalArticle

Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice

Dodd-o, J. M., Hristopoulos, M. L., Welsh-Servinsky, L. E., Tankersley, C. G. & Pearse, D. B., May 1 2006, In : Journal of applied physiology. 100, 5, p. 1590-1595 6 p.

Research output: Contribution to journalArticle

The structural basis of airways hyperresponsiveness in asthma

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C., Togias, A. & Permutt, S., 2006, In : Journal of applied physiology. 101, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

2005

Effects of tidal volume and respiratory frequency on lung lymph flow

Pearse, D. B., Searcy, R. M., Mitzner, W., Permutt, S. & Sylvester, J. T., Aug 1 2005, In : Journal of applied physiology. 99, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement

Kolosova, I. A., Mirzapoiazova, T., Adyshev, D., Usatyuk, P., Romer, L. H., Jacobson, J. R., Natarajan, V., Pearse, D. B., Garcia, J. G. N. & Verin, A. D., Jul 22 2005, In : Circulation research. 97, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

2004

Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury

Dodd-O, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Bethea, B. T., Cattaneo, S. M., Baumgartner, W. A. & Pearse, D. B., Feb 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2, p. H693-H700

Research output: Contribution to journalArticle

Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury

Dodd-O, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Ziegelstein, R. C., Zweier, J. L., Baumgartner, W. A. & Pearse, D. B., Aug 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 2 56-2, p. H927-H936

Research output: Contribution to journalArticle

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D., Tuder, R. M. & Garcia, J. G. N., Jun 1 2004, In : American journal of respiratory and critical care medicine. 169, 11, p. 1245-1251 7 p.

Research output: Contribution to journalArticle

2003

Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide

Pearse, D. B., Shimoda, L. A., Verin, A. D., Bogatcheva, N., Moon, C., Ronnett, G. V., Welsh, L. E. & Becker, P. M., Jan 1 2003, In : Endothelium: Journal of Endothelial Cell Research. 10, 6, p. 309-317 9 p.

Research output: Contribution to journalArticle

Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice

Becker, P. M., Kazi, A. A., Wadgaonkar, R., Pearse, D. B., Kwiatkowski, D. & Garcia, J. G. N., Apr 1 2003, In : American journal of respiratory cell and molecular biology. 28, 4, p. 478-484 7 p.

Research output: Contribution to journalArticle

2002

Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy

Sung, Y. K., Moon, C., Yoo, J. Y., Moon, C., Pearse, D., Pevsner, J. & Ronnett, G. V., Apr 12 2002, In : Journal of Biological Chemistry. 277, 15, p. 12762-12769 8 p.

Research output: Contribution to journalArticle

Treatment of right heart thromboemboli

Rose, P. S., Punjabi, N. M. & Pearse, D. B., Jan 1 2002, In : CHEST. 121, 3, p. 806-814 9 p.

Research output: Contribution to journalArticle

2001

Effect of changing vascular volume on measurement of protein reflection coefficient in ischemic lungs

Pearse, D. B., Becker, P. M. & Permutt, S., Feb 2001, In : American Journal of Physiology - Heart and Circulatory Physiology. 280, 2 49-2, p. H918-H924

Research output: Contribution to journalArticle

2000

Measurements of free radicals in isolated, ischemic lungs and lung mitochondria

Sanders, S. P., Bassett, D. J. P., Harrison, S. J., Pearse, D., Zweier, J. L. & Becker, P. M., 2000, In : Lung. 178, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

1999

Effect of ventilation on vascular permeability and cyclic nucleotide concentrations in ischemic sheep lungs

Pearse, D. B., Wagner, E. M. & Permutt, S., Jan 1999, In : Journal of applied physiology. 86, 1, p. 123-132 10 p.

Research output: Contribution to journalArticle

Ischemia-reperfusion lung injury is prevented by apocynin, a novel inhibitor of leukocyte NADPH oxidase

Pearse, D. B. & Dodd-O, J. M., Jan 1 1999, In : CHEST. 116, SUPPL., p. 55S-56S

Research output: Contribution to journalArticle

1998
1996