David B Pearse

Professor

1986 …2019
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Research Output 1986 2019

2019

Does Use of Electronic Alerts for Systemic Inflammatory Response Syndrome (SIRS)to Identify Patients With Sepsis Improve Mortality?

Seetharaman, S., Wilson, C., Landrum, M., Qasba, S., Katz, M., Ladikos, N., Harris, J. E., Galiatsatos, P., Yousem, D. M., Knight, A. M., Pearse, D. B., Blanding, R., Bennett, R. G., Galai, N., Perl, T. M. & Sood, G., Jan 1 2019, In : American Journal of Medicine.

Research output: Contribution to journalArticle

Systemic Inflammatory Response Syndrome
Sepsis
Mortality
Practice Guidelines
Anti-Bacterial Agents
2018

Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a United States medical center: Results of a clinical trial

Townsend, J., Adams, V., Galiatsatos, P., Pearse, D., Pantle, H., Masterson, M., Kisuule, F., Jacob, E., Kiruthi, C., Ortiz, P., Agbanlog, A., Jurao, R., Stern, S., Nayak, S., Melgar, M., Sama, J., Irwin, J., Mazidi, C., Psoter, K. & McKenzie, R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 12

Research output: Contribution to journalArticle

Open Access
Calcitonin
Respiratory Tract Infections
Clinical Trials
Anti-Bacterial Agents
Therapeutics
2016

CD36 mediates H2O2-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A. L., Pearse, D. B. & Shimoda, L., Dec 2 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Contribution to journalArticle

TRPV Cation Channels
Endothelial Cells
Calcium
Lung
Cell Membrane

Occupational Asthma Due to Inhalation of Aerosolized Lipophilic Coating Materials

Suresh, K., Belchis, D. A., Askin, F. B., Pearse, D. B. & Terry, P. B., Jul 8 2016, (Accepted/In press) In : Lung. p. 1-3 3 p.

Research output: Contribution to journalArticle

Occupational Asthma
Inhalation
Respiratory Sounds
Asthma
2015

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

Suresh, K., Servinsky, L., Reyes, J., Baksh, S., Undem, C., Caterina, M., Pearse, D. B. & Shimoda, L., 2015, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1467-L1477

Research output: Contribution to journalArticle

TRPV Cation Channels
Hydrogen Peroxide
Endothelial Cells
Calcium
Lung

When right is redundant

Terry, P. B. & Pearse, D. B., Jun 1 2015, In : Chest. 147, 6, p. e238

Research output: Contribution to journalArticle

Lung
2014

A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome

Hikmat, F., Pearse, D. B. & Damarla, M., Nov 1 2014, In : Canadian Respiratory Journal. 21, 6, p. 337-340 4 p.

Research output: Contribution to journalArticle

Churg-Strauss Syndrome
Hemoptysis
Vasculitis
Bronchial Arteries
Tomography
Type 2 Cyclic Nucleotide Phosphodiesterases
Alveolar Macrophages
Lipopolysaccharides
Macrophages
Lung
Cyclic GMP-Dependent Protein Kinases
Oxidants
Protein-Tyrosine Kinases
Endothelial Cells
Antioxidants
2013

A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces

Kolb, T. M., King, L. S. & Pearse, D. B., Dec 2013, In : Chest. 144, 6, p. 1964-1968 5 p.

Research output: Contribution to journalArticle

Birt-Hogg-Dube Syndrome
X Ray Computed Tomography
Estrone
Pneumothorax
Dyspnea

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei

Anidi, I. U., Servinsky, L. E., Rentsendorj, O., Stephens, R., Scott, A. L. & Pearse, D. B., Aug 15 2013, In : PLoS One. 8, 8, e71010.

Research output: Contribution to journalArticle

Plasmodium berghei
malaria
Malaria
phosphotransferases (kinases)
Phosphotransferases
2012

Dieulafoy's disease of the bronchus

Kolb, T. M., Gilbert, C., Fishman, E. K., Terry, P. B., Pearse, D. B., Feller-Kopman, D. & Yarmus, L., Dec 1 2012, In : American Journal of Respiratory and Critical Care Medicine. 186, 11, p. 1191 1 p.

Research output: Contribution to journalArticle

Bronchial Diseases
Therapeutic Embolization
Bronchial Arteries
X Ray Computed Tomography
Hemoptysis

Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome

Eberlein, M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Shlobin, O. A., Shelhamer, J. H., Reed, R. M., Pearse, D. B., Orens, J. B. & Brower, R. G., Feb 2012, In : Chest. 141, 2, p. 451-460 10 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Total Lung Capacity
Lung Transplantation
Allografts
Lung

Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation

Eberlein, M., Reed, R. M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Iacono, A., Pearse, D. B., Fessler, H. E., Shah, A. S., Orens, J. B. & Brower, R. G., Nov 2012, In : Journal of Heart and Lung Transplantation. 31, 11

Research output: Contribution to journalArticle

Total Lung Capacity
Lung Transplantation
Tissue Donors
Survival
Proportional Hazards Models

Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase

D'Alessio, F., Tsushima, K., Aggarwal, N. R., Mock, J. R., Eto, Y., Garibaldi, B. T., Files, D. C., Avalos, C. R., Rodriguez, J. V., Waickman, A. T., Reddy, S. P., Pearse, D. B., Sidhaye, V., Hassoun, P. M., Crow, M. T. & King, L. S., Sep 1 2012, In : Journal of Immunology. 189, 5, p. 2234-2245 12 p.

Research output: Contribution to journalArticle

Lung Injury
Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Monocytes
Acute Lung Injury

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Schmidt, E. P., Yang, Y., Janssen, W. J., Gandjeva, A., Perez, M. J., Barthel, L., Zemans, R. L., Bowman, J. C., Koyanagi, D. E., Yunt, Z. X., Smith, L. P., Cheng, S. S., Overdier, K. H., Thompson, K. R., Geraci, M. W., Douglas, I. S., Pearse, D. B. & Tuder, R. M., Aug 2012, In : Nature Medicine. 18, 8, p. 1217-1223 7 p.

Research output: Contribution to journalArticle

Glycocalyx
Lung Injury
Sepsis
Neutrophils
Adhesion
2011

Idiopathic constrictive bronchiolitis with rapidly progressive bronchiectasis and Mycobacterium kansasii infection

Raparla, S., Schmidt, E. P. & Pearse, D. B., 2011, In : Respiratory Medicine CME. 4, 4, p. 172-174 3 p.

Research output: Contribution to journalArticle

Mycobacterium kansasii
Bronchiolitis Obliterans
Mycobacterium Infections
Bronchiectasis
Lung

Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury

Gurkan, O. U., He, C., Zielinski, R., Rabb, H., King, L. S., Dodd-o, J. M., D'Alessio, F., Aggarwal, N., Pearse, D. B. & Becker, P. M., Dec 2011, In : Experimental Lung Research. 37, 10, p. 575-584 10 p.

Research output: Contribution to journalArticle

Capillary Permeability
Lung Injury
Mechanical Ventilators
Interleukin-6
Lung
Type 2 Cyclic Nucleotide Phosphodiesterases
Acute Lung Injury
Inflammation
Lung
Ventilator-Induced Lung Injury

Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival

Eberlein, M., Permutt, S., Brown, R. H., Brooker, A., Chahla, M. F., Bolukbas, S., Nathan, S. D., Pearse, D. B., Orens, J. B. & Brower, R. G., Jan 1 2011, In : American Journal of Respiratory and Critical Care Medicine. 183, 1, p. 79-87 9 p.

Research output: Contribution to journalArticle

Pulmonary Ventilation
Lung Transplantation
Total Lung Capacity
Lung
Transplants
2010
Cyclic GMP-Dependent Protein Kinases
Oxidants
Catalase
Reactive Oxygen Species
Cell Death
2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R. L., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 2009, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6

Research output: Contribution to journalArticle

Mechanical Ventilators
Protein C
Artificial Respiration
rho-Associated Kinases
Lung
2008

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis

Damico, R. L., Chesley, A., Johnston, L., Bind, E. P., Amaro, E., Nijmeh, J., Karakas, B., Welsh, L., Pearse, D. B., Garcia, J. G. N. & Crow, M. T., Jul 1 2008, In : American Journal of Respiratory Cell and Molecular Biology. 39, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Macrophage Migration-Inhibitory Factors
Endothelial cells
Lipopolysaccharides
Endothelial Cells
Small Interfering RNA

Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function

Rentsendorj, O., Mirzapoiazova, T., Adyshev, D., Servinsky, L. E., Renné, T., Verin, A. D. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4

Research output: Contribution to journalArticle

Pulmonary Artery
Phosphorylation
Permeability
Endothelial Cells
vasodilator-stimulated phosphoprotein

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Schmidt, E. P., Damarla, M., Rentsendorj, O., Servinsky, L. E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P. M. & Pearse, D. B., Dec 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 6

Research output: Contribution to journalArticle

Ventilator-Induced Lung Injury
Lung
Ventilation
Nitric Oxide
Soluble Guanylyl Cyclase

The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse

Dodd-o, J. M., Hristopoulos, M. L., Kibler, K., Gutkowska, J., Mukaddam-Daher, S., Gonzalez, A., Welsh-Servinsky, L. E. & Pearse, D. B., Apr 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4

Research output: Contribution to journalArticle

Reperfusion Injury
Atrial Natriuretic Factor
Reperfusion
Lung
Ischemia
2007

A 56-year-old man with choking, recurrent pneumonia, and weight loss

Eberlein, M. & Pearse, D. B., Apr 2007, In : Chest. 131, 4, p. 1248-1251 4 p.

Research output: Contribution to journalArticle

Airway Obstruction
Weight Loss
Pneumonia
2006

Reply from Drs. Brown, Pearse, Pyrgos, Liu, Togias, and Permutt [6]

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C. H., Togias, A. & Permutt, S., Dec 2006, In : Journal of Applied Physiology. 101, 6, p. 1813 1 p.

Research output: Contribution to journalArticle

Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells

Moldobaeva, A., Welsh-Servinsky, L. E., Shimoda, L., Stephens, R., Verin, A. D., Tuder, R. M. & Pearse, D. B., May 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 5

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Pulmonary Artery
Endothelial Cells
Permeability
Adenoviridae

Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice

Dodd-o, J. M., Hristopoulos, M. L., Welsh-Servinsky, L. E., Tankersley, C. G. & Pearse, D. B., May 2006, In : Journal of Applied Physiology. 100, 5, p. 1590-1595 6 p.

Research output: Contribution to journalArticle

Lung Injury
Reperfusion Injury
Lung
NADPH Oxidase
Reactive Oxygen Species

The structural basis of airways hyperresponsiveness in asthma

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C. H., Togias, A. & Permutt, S., 2006, In : Journal of Applied Physiology. 101, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Smooth Muscle
Vital Capacity
Asthma
Total Lung Capacity
Functional Residual Capacity
2005

Blood carbon monoxide will increase from a decline in pulmonary function alone [6]

Permutt, S. & Pearse, D. B., Nov 1 2005, In : American Journal of Respiratory and Critical Care Medicine. 172, 9, p. 1231 1 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Lung

Effects of tidal volume and respiratory frequency on lung lymph flow

Pearse, D. B., Searcy, R. M., Mitzner, W. A., Permutt, S. & Sylvester, J. T., Aug 2005, In : Journal of Applied Physiology. 99, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Tidal Volume
Lymph
Edema
Sheep
Lung

Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement

Kolosova, I. A., Mirzapoiazova, T., Adyshev, D., Usatyuk, P., Romer, L., Jacobson, J. R., Natarajan, V., Pearse, D. B., Garcia, J. G. N. & Verin, A. D., Jul 22 2005, In : Circulation Research. 97, 2, p. 115-124 10 p.

Research output: Contribution to journalArticle

Endothelial Cells
Adenosine Triphosphate
Myosin-Light-Chain Phosphatase
Cyclic AMP-Dependent Protein Kinases
GTP-Binding Proteins
2004

Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury

Dodd-o, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Bethea, B. T., Cattaneo, S. M., Baumgartner, W. A. & Pearse, D. B., Feb 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2

Research output: Contribution to journalArticle

Bronchial Arteries
Lung Injury
Cardiopulmonary Bypass
Swine
Lung

Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury

Dodd-o, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Ziegelstein, R., Zweier, J. L., Baumgartner, W. A. & Pearse, D. B., Aug 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 2 56-2

Research output: Contribution to journalArticle

NADPH Oxidase
Lung Injury
Cardiopulmonary Bypass
Reactive Oxygen Species
Lung

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D. B., Tuder, R. M. & Garcia, J. G. N., Jun 1 2004, In : American Journal of Respiratory and Critical Care Medicine. 169, 11, p. 1245-1251 7 p.

Research output: Contribution to journalArticle

Lung Injury
Endotoxins
Blood Vessels
Lung
Evans Blue
2003

Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide

Pearse, D. B., Shimoda, L., Verin, A. D., Bogatcheva, N., Moon, C., Ronnett, G. V., Welsh, L. E. & Becker, P. M., 2003, In : Endothelium: Journal of Endothelial Cell Research. 10, 6, p. 309-317 9 p.

Research output: Contribution to journalArticle

Guanosine Monophosphate
Hydrogen Peroxide
Lung
Electric Impedance
Endothelial Cells
Reperfusion
Blood Vessels
Ischemia
Lung
Evans Blue

Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice

Becker, P. M., Kazi, A. A., Wadgaonkar, R., Pearse, D. B., Kwiatkowski, D. & Garcia, J. G. N., Apr 1 2003, In : American Journal of Respiratory Cell and Molecular Biology. 28, 4, p. 478-484 7 p.

Research output: Contribution to journalArticle

Gelsolin
Capillary Permeability
Lung
Wounds and Injuries
Bronchoalveolar Lavage
2002
Inwardly Rectifying Potassium Channel
Endothelial Cells
Cyclic GMP-Dependent Protein Kinases
Lung
Guanosine

Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy

Sung, Y. K., Moon, C., Yoo, J. Y., Moon, C., Pearse, D. B., Pevsner, J. A. & Ronnett, G. V., Apr 12 2002, In : Journal of Biological Chemistry. 277, 15, p. 12762-12769 8 p.

Research output: Contribution to journalArticle

Respiratory Mucosa
Nasal Mucosa
Rats
Thymus
Salivary Glands

Treatment of right heart thromboemboli

Rose, P. S., Punjabi, N. M. & Pearse, D. B., 2002, In : Chest. 121, 3 SUPPL., p. 806-814 9 p.

Research output: Contribution to journalArticle

Mortality
Embolectomy
Therapeutics
Thrombolytic Therapy
Thromboembolism
2001
Blood Vessels
Lung
Ferrets
Proteins
Hematocrit
2000
Liquid Ventilation
Hemodynamics
Pressure
Ventilation
Gases
NADPH Oxidase
Lung Injury
Reperfusion Injury
Leukocytes
Albumins
Cyclic Nucleotides
Blood Vessels
Permeability
Pressure
Lung

Measurements of free radicals in isolated, ischemic lungs and lung mitochondria

Sanders, S. P., Bassett, D. J. P., Harrison, S. J., Pearse, D. B., Zweier, J. L. & Becker, P. M., 2000, In : Lung. 178, 2, p. 105-118 14 p.

Research output: Contribution to journalArticle

Free Radicals
Mitochondria
Oxides
Electron Spin Resonance Spectroscopy
Lung
1999

Effect of ventilation on vascular permeability and cyclic nucleotide concentrations in ischemic sheep lungs

Pearse, D. B., Wagner, E. M. & Permutt, S., Jan 1999, In : Journal of Applied Physiology. 86, 1, p. 123-132 10 p.

Research output: Contribution to journalArticle

Cyclic Nucleotides
Capillary Permeability
Ventilation
Sheep
Lung
Acetophenones
NADPH Oxidase
Lung Injury
Enzyme Inhibitors
Reperfusion Injury