David A Kass

Professor

1976 …2019
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Research Output 1976 2019

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2019

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., Apr 1 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

Research output: Contribution to journalArticle

Open Access
Cardiac Myosins
Calpain
Reperfusion Injury
Proteolysis
Phosphorylation

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

Ying, W., Zhao, D., Ouyang, P., Subramanya, V., Vaidya, D., Ndumele, C. E., Guallar, E., Sharma, K., Shah, S. J., Kass, D. A., Hoogeveen, R. C., Lima, J. A., Heckbert, S. R., deFilippi, C. R., Post, W. S. & Michos, E. D., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e013149

Research output: Contribution to journalArticle

Open Access
Natriuretic Peptides
Cyclic GMP
Atherosclerosis
Cardiovascular Diseases
Brain Natriuretic Peptide

Chronic Atrial and Ventricular Pacing in the Mouse

Ståhlberg, M., Nakagawa, R., Bedja, D., Zhu, G., Lin, B. L., Saberi, A., Lee, D. & Kass, D. A., Feb 1 2019, In : Circulation. Heart failure. 12, 2, p. e005655

Research output: Contribution to journalArticle

Heart Ventricles
Heart Atria
Reperfusion Injury
Muscle Cells
Reperfusion

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Heart Diseases
Fibrosis
Kidney
NFATC Transcription Factors
Gene Expression

Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction

Pinilla-Vera, M., Hahn, V. S. & Kass, D. A., May 24 2019, In : Circulation research. 124, 11, p. 1618-1632 15 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Treatment Failure
Cardiomyopathies
Cell Biology
Therapeutics

Nitrosative stress drives heart failure with preserved ejection fraction

Schiattarella, G. G., Altamirano, F., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., Hill, T. M., Mammen, P. P. A., Huang, J., Lee, D., Hahn, V. S., Sharma, K., Kass, D. A., Lavandero, S., Gillette, T. G. & Hill, J. A., Apr 18 2019, In : Nature. 568, 7752, p. 351-356 6 p.

Research output: Contribution to journalArticle

Heart Failure
Nitric Oxide Synthase Type II
Cardiac Myocytes
Protein Splicing
Genetic Suppression

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

Osteopontin
Left Ventricular Dysfunction
Heart Failure
Ketoglutarate Dehydrogenase Complex
Cardiac Myocytes
2018

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition

Hashimoto, T., Kim, G. E., Tunin, R. S., Adesiyun, T., Hsu, S., Nakagawa, R., Zhu, G., O'Brien, J. J., Hendrick, J. P., Davis, R. E., Yao, W., Beard, D., Hoxie, H. R., Wennogle, L. P., Lee, D. & Kass, D. A., Oct 30 2018, In : Circulation. 138, 18, p. 1974-1987 14 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Adrenergic Receptors
Heart Failure
Rabbits
Calcium

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Histone Demethylases
fibrosis
lysine
Cardiomegaly
Left Ventricular Hypertrophy

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span

Patel, N. S., Klett, J., Pilarzyk, K., Lee, D., Kass, D. A., Menniti, F. S. & Kelly, M. P., May 1 2018, In : Neurobiology of Aging. 65, p. 217-234 18 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cyclic GMP
Brain
Hippocampus
Guanosine Monophosphate

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. & Kass, D. A., Aug 9 2018, In : JCI insight. 3, 15

Research output: Contribution to journalArticle

Cyclic GMP
MicroRNAs
Heart Diseases
Pressure
Nitric Oxide

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access
Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Constriction
Cardiomegaly
Muscle Cells

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Phosphotransferases
Heart Failure
Sudden Cardiac Death

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R. L., Mathai, S., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R. J., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Diseases
Lung
Lung Compliance
Vascular Resistance

Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial

Osler Medical Housestaff, Oct 1 2018, In : JACC: Heart Failure. 6, 10, p. 859-870 12 p.

Research output: Contribution to journalArticle

Dopamine
Heart Failure
Diuretics
Furosemide
Confidence Intervals

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

Myofibrils
Systemic Scleroderma
Pulmonary Hypertension
Muscle Cells
Calcium
2017

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo

Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A. & Murphy, A. M., Sep 1 2017, In : Circulation. Heart failure. 10, 9

Research output: Contribution to journalArticle

Troponin C
Troponin I
Heart Failure
Proteolysis
Physiological Stress

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Cardiomyopathies
Cardiac Myocytes
Transplantation

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Rouf, R., MacFarlane, E., Takimoto, E., Chaudhary, R., Nagpal, V., Rainer, P. P., Bindman, J. G., Gerber, E. E., Bedja, D., Schiefer, C., Miller, K. L., Zhu, G., Myers, L., Amat-Alarcon, N., Lee, D., Koitabashi, N., Judge, D. P., Kass, D. A. & Dietz, H. C., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
Marfan Syndrome
Cardiomyopathies
Angiotensin Type 1 Receptor
Pressure
Muscle Cells

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

Chung, H. S., Kim, G. E., Holewinski, R. J., Venkatraman, V., Zhu, G., Bedja, D., Kass, D. A. & Van Eyk, J. E., Dec 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. E10763-E10771

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Duchenne Muscular Dystrophy
S-Nitrosothiols
Nitric Oxide Synthase
Myocardium
2016

A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform

Gao, M., Rose, W. C., Fetics, B., Kass, D. A., Chen, C. H. & Mukkamala, R., Sep 14 2016, In : Scientific Reports. 6, 33230.

Research output: Contribution to journalArticle

Blood Pressure
Cardiac Catheterization
Atrial Fibrillation
Recurrence
Atrial Pressure
Left Atrial Function
Catheter Ablation

Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure with Preserved Ejection Fraction?

Hsu, S. & Kass, D. A., Feb 23 2016, In : Circulation. 133, 8, p. 692-694 3 p.

Research output: Contribution to journalArticle

Sirtuin 3
Sirtuins
AMP-Activated Protein Kinases
Nitrites
Pulmonary Hypertension

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

compliance
Compliance
heart rate
Heart Rate
lungs

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P. & 7 others, Heymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journalArticle

Myofibrils
Mast Cells
Myocardial Infarction
Calcium
Cardiac Myocytes

Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work

Inuzuka, R., Kass, D. A. & Senzaki, H., Jun 1 2016, In : Open Heart. 3, 1, e000451.

Research output: Contribution to journalArticle

Stroke
Blood Pressure
Workload
Hemodynamics
Dogs

Phenotype-specific treatment of heart failure with preserved ejection fraction

Shah, S. J., Kitzman, D. W., Borlaug, B. A., Van Heerebeek, L., Zile, M. R., Kass, D. A. & Paulus, W. J., Jul 5 2016, In : Circulation. 134, 1, p. 73-90 18 p.

Research output: Contribution to journalArticle

Treatment Failure
Heart Failure
Phenotype
Cyclic GMP
Muscle Weakness

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

Prysyazhna, O., Burgoyne, J. R., Scotcher, J., Grover, S., Kass, D. A. & Eaton, P., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17427-17436 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Doxorubicin
Heart Failure
Oxidation

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Kooij, V., Viswanathan, M. C., Lee, D., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E. & Cammarato, A. R., May 15 2016, In : Cardiovascular Research. 110, 2, p. 238-248 11 p.

Research output: Contribution to journalArticle

Profilins
Cardiac Myocytes
Hypertrophy
Muscle Cells
Drosophila

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor

Bullen, J. W., Tchernyshyov, I., Holewinski, R. J., Devine, L., Wu, F., Venkatraman, V., Kass, D. A., Cole, R. N., Van Eyk, J. & Semenza, G. L., May 31 2016, In : Science Signaling. 9, 430, RA56.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Adenosine

Response to Letter Regarding Article, "circulating MicroRNA-30d Is Associated with Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study"

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., Chakir, K., Lewis, G. D., Lavender, Z., Truong, Q. A., Kleber, A., Das, R., Rosenzweig, A., Wang, Y., Kass, D. A., Singh, J. P. & Das, S., Feb 9 2016, In : Circulation. 133, 6, p. e389-e390

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Translational Medical Research
MicroRNAs
Cardiac Myocytes
Heart Failure

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Ergometry
Right Ventricular Function
Systemic Scleroderma
Recycling

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

Duan, D., Rafael-Fortney, J. A., Blain, A., Kass, D. A., McNally, E. M., Metzger, J. M., Spurney, C. F. & Kinnett, K., Feb 1 2016, In : Journal of Cardiovascular Translational Research. 9, 1, p. 85-86 2 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
National Heart, Lung, and Blood Institute (U.S.)
Group Processes
Muscular Dystrophies
Cardiomyopathies
2015
Cardiac Resynchronization Therapy
Cholinergic Agents
Heart Failure
Muscarinic Receptors
Adrenergic Agents

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization

Kirk, J. A. & Kass, D. A., 2015, In : Cardiac Electrophysiology Clinics. 7, 4, p. 585-597 13 p.

Research output: Contribution to journalArticle

Heart Conduction System
Cardiovascular Models
Myocardial Contraction
Excitation Contraction Coupling
Cardiac Resynchronization Therapy

Circulating MicroRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis a translational pilot study

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., Chakir, K., Lewis, G. D., Lavender, Z., Truong, Q. A., Kleber, A., Das, R., Rosenzweig, A., Wang, Y., Kass, D. A., Singh, J. P. & Das, S., 2015, In : Circulation. 131, 25, p. 2202-2216 15 p.

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
MicroRNAs
Cardiac Myocytes
Heart Failure
Apoptosis

Citrullination of myofilament proteins in heart failure

Fert-Bober, J., Giles, J. T., Holewinski, R. J., Kirk, J. A., Uhrigshardt, H., Crowgey, E. L., Andrade, F. A., Bingham, C., Park, J. K., Halushka, M. K., Kass, D. A., Bathon, J. M. & Van Eyk, J. E., Jan 7 2015, In : Cardiovascular Research. 108, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Myofibrils
pioglitazone
Heart Failure
Adenosine Triphosphatases
Proteins

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Burks, T. N., Marx-Rattner, R., Powell, L., Rucker, J., Bedja, D., Heacock, E., Smith, B. J., Foster, D. B., Kass, D. A., O'Rourke, B., Walston, J. D. & Abadir, P., 2015, In : Oncotarget. 6, 14, p. 11979-11993 15 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Cardiomyopathies
Inflammation
Myocardium
Premature Aging

Dual Labeling Biotin Switch Assay to Reduce Bias Derived from Different Cysteine Subpopulations: A Method to Maximize S-Nitrosylation Detection

Chung, H. S., Murray, C. I., Venkatraman, V., Crowgey, E. L., Rainer, P. P., Cole, R. N., Bomgarden, R. D., Rogers, J. C., Balkan, W., Hare, J. M., Kass, D. A. & Van Eyk, J. E., Oct 23 2015, In : Circulation Research. 117, 10, p. 846-857 12 p.

Research output: Contribution to journalArticle

Biotin
Cysteine
glutathione-independent formaldehyde dehydrogenase
Mouse Adh5 protein
S-Nitrosoglutathione

Erratum: Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation (Proc Natl Acad Sci USA (2015) 112 (1880-1885) DOI: 10.1073/pnas.1504270112)

Feng, N., Huke, S., Zhu, G., Tocchetti, C. G., Shi, S., Aiba, T., Kaludercic, N., Hoover, D. B., Beck, S., Mankowski, J. L., Tomaselli, G. F., Bers, D. M., Kass, D. A. & Paolocci, N., Mar 31 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 13, p. E1691

Research output: Contribution to journalArticle

Glycoproteins identified from heart failure and treatment models

Yang, S., Chen, L., Sun, S., Shah, P., Yang, W., Zhang, B., Zhang, Z., Chan, D. W-Y., Kass, D. A., van Eyk, J. E. & Zhang, H., Jan 1 2015, In : Proteomics. 15, 2-3, p. 567-579 13 p.

Research output: Contribution to journalArticle

Cardiac resynchronization therapy
Cardiac Resynchronization Therapy
Glycoproteins
Heart Failure
Glycopeptides
Enzyme Activators
Cardiotonic Agents
Left Ventricular Dysfunction
Myosins
Left Ventricular Function
Molecular imaging
Molecular Imaging
Macrophages
Apolipoproteins E
Atherosclerosis

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate

Thoonen, R., Giovanni, S., Govindan, S., Lee, D., Wang, G. R., Calamaras, T. D., Takimoto, E., Kass, D. A., Sadayappan, S. & Blanton, R. M., Nov 1 2015, In : Circulation: Heart Failure. 8, 6, p. 1115-1122 8 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Cyclic GMP-Dependent Protein Kinases
Leucine Zippers
Phosphorylation
Cardiac Myocytes

Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration

Ong, S., Ligons, D. L., Barin, J. G., Wu, L., Talor, M. V., Diny, N., Fontes, J. A., Gebremariam, E., Kass, D. A., Rose, N. R. & Cihakova, D., Mar 1 2015, In : American Journal of Pathology. 185, 3, p. 847-861 15 p.

Research output: Contribution to journalArticle

Myocarditis
Eosinophils
Natural Killer Cells
Fibrosis
Inflammation

Outcomes and Worsening Renal Function in Patients Hospitalized with Heart Failure with Preserved Ejection Fraction

Sharma, K., Hill, T., Grams, M., Daya, N. R., Hays, A., Fine, D. M., Thiemann, D. R., Weiss, R. G., Tedford, R. J., Kass, D. A., Schulman, S. P. & Russell, S. D., Nov 15 2015, In : The American Journal of Cardiology. 116, 10, p. 1534-1540 7 p.

Research output: Contribution to journalArticle

Heart Failure
Kidney
Morbidity
Urban Population
Hypertension

Pacemaker-induced transient asynchrony suppresses heart failure progression

Kirk, J. A., Chakir, K., Lee, K. H., Karst, E., Holewinski, R. J., Pironti, G., Tunin, R. S., Pozios, I., Abraham, T. P., De Tombe, P., Rockman, H. A., Van Eyk, J. E., Craig, R., Farazi, T. G. & Kass, D. A., Dec 23 2015, In : Science Translational Medicine. 7, 319

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Heart Failure
Muscle Cells
Dogs
Sarcomeres

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D., Zhu, G., Sasaki, T., Cho, G. S., Hamdani, N., Holewinski, R., Jo, S. H., Danner, T., Zhang, M., Rainer, P. P., Bedja, D., Kirk, J. A., Ranek, M., Dostmann, W. R., Kwon, C., Margulies, K. B., Van Eyk, J. E., Paulus, W. J., Takimoto, E. & Kass, D. A., Mar 26 2015, In : Nature. 519, 7544, p. 472-476 5 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Type 5 Cyclic Nucleotide Phosphodiesterases
Heart Diseases
Nitric Oxide

Prevention of PKG1a oxidation augments cardioprotection in the stressed heart

Nakamura, T., Ranek, M., Lee, D., Hahn, V. S., Kim, C., Eaton, P. & Kass, D. A., Jun 1 2015, In : Journal of Clinical Investigation. 125, 6, p. 2468-2472 5 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Heart Diseases
Rodent Diseases
Transient Receptor Potential Channels
Cyclic GMP-Dependent Protein Kinases

Response to letter from Villa-Abrille et al

Kass, D. A., Seo, K. & Rainer, P., Jan 2 2015, In : Circulation Research. 116, 1, p. e12

Research output: Contribution to journalArticle

TRPC Cation Channels
Cyclic GMP-Dependent Protein Kinases
Duchenne Muscular Dystrophy