David A Kass

Professor

1976 …2019
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Research Output 1976 2019

2019

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., Apr 1 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

Research output: Contribution to journalArticle

Open Access
Cardiac Myosins
Calpain
Reperfusion Injury
Proteolysis
Phosphorylation

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

Ying, W., Zhao, D., Ouyang, P., Subramanya, V., Vaidya, D., Ndumele, C. E., Guallar, E., Sharma, K., Shah, S. J., Kass, D. A., Hoogeveen, R. C., Lima, J. A., Heckbert, S. R., deFilippi, C. R., Post, W. S. & Michos, E. D., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e013149

Research output: Contribution to journalArticle

Open Access
Natriuretic Peptides
Cyclic GMP
Atherosclerosis
Cardiovascular Diseases
Brain Natriuretic Peptide

Chronic Atrial and Ventricular Pacing in the Mouse

Ståhlberg, M., Nakagawa, R., Bedja, D., Zhu, G., Lin, B. L., Saberi, A., Lee, D. & Kass, D. A., Feb 1 2019, In : Circulation. Heart failure. 12, 2, p. e005655

Research output: Contribution to journalArticle

Heart Ventricles
Heart Atria
Reperfusion Injury
Muscle Cells
Reperfusion

Fresh evidence overturns the identification of a factor involved in blood-vessel dilation

Kass, D. A., Feb 1 2019, In : Nature. 566, 7745, p. 462-464 3 p.

Research output: Contribution to journalComment/debate

Open Access
Singlet Oxygen
Biochemistry
Blood Vessels
Dilatation
Oxygen

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Heart Diseases
Fibrosis
Kidney
NFATC Transcription Factors
Gene Expression

Large Particle Fluorescence-Activated Cell Sorting Enables High-Quality Single-Cell RNA Sequencing and Functional Analysis of Adult Cardiomyocytes

Kannan, S., Miyamoto, M., Lin, B. L., Zhu, R., Murphy, S., Kass, D. A., Andersen, P. & Kwon, C., Aug 16 2019, In : Circulation research. 125, 5, p. 567-569 3 p.

Research output: Contribution to journalLetter

RNA Sequence Analysis
Sarcomeres
Microfluidics
Cardiac Myocytes
Flow Cytometry

Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction

Pinilla-Vera, M., Hahn, V. S. & Kass, D. A., May 24 2019, In : Circulation research. 124, 11, p. 1618-1632 15 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Treatment Failure
Cardiomyopathies
Cell Biology
Therapeutics

Nitrosative stress drives heart failure with preserved ejection fraction

Schiattarella, G. G., Altamirano, F., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., Hill, T. M., Mammen, P. P. A., Huang, J., Lee, D., Hahn, V. S., Sharma, K., Kass, D. A., Lavandero, S., Gillette, T. G. & Hill, J. A., Apr 18 2019, In : Nature. 568, 7752, p. 351-356 6 p.

Research output: Contribution to journalArticle

Heart Failure
Nitric Oxide Synthase Type II
Cardiac Myocytes
Protein Splicing
Genetic Suppression

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

Osteopontin
Left Ventricular Dysfunction
Heart Failure
Ketoglutarate Dehydrogenase Complex
Cardiac Myocytes

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Ranek, M., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J. E., Powell, J., Lee, D. & Kass, D. A., Feb 14 2019, In : Nature. 566, 7743, p. 264-269 6 p.

Research output: Contribution to journalLetter

Protein Kinases
Phosphorylation
Autophagy
Serine
Heart Diseases
Cardiac Resynchronization Therapy
Heart Failure
2018

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition

Hashimoto, T., Kim, G. E., Tunin, R. S., Adesiyun, T., Hsu, S., Nakagawa, R., Zhu, G., O'Brien, J. J., Hendrick, J. P., Davis, R. E., Yao, W., Beard, D., Hoxie, H. R., Wennogle, L. P., Lee, D. & Kass, D. A., Oct 30 2018, In : Circulation. 138, 18, p. 1974-1987 14 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Adrenergic Receptors
Heart Failure
Rabbits
Calcium

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Histone Demethylases
fibrosis
lysine
Cardiomegaly
Left Ventricular Hypertrophy

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span

Patel, N. S., Klett, J., Pilarzyk, K., Lee, D., Kass, D. A., Menniti, F. S. & Kelly, M. P., May 1 2018, In : Neurobiology of Aging. 65, p. 217-234 18 p.

Research output: Contribution to journalArticle

Protein Isoforms
Cyclic GMP
Brain
Hippocampus
Guanosine Monophosphate

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. & Kass, D. A., Aug 9 2018, In : JCI insight. 3, 15

Research output: Contribution to journalArticle

Cyclic GMP
MicroRNAs
Heart Diseases
Pressure
Nitric Oxide

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access
Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Constriction
Cardiomegaly
Muscle Cells

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Phosphotransferases
Heart Failure
Sudden Cardiac Death

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R. L., Mathai, S., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R. J., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Diseases
Lung
Lung Compliance
Vascular Resistance

Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial

Osler Medical Housestaff, Oct 1 2018, In : JACC: Heart Failure. 6, 10, p. 859-870 12 p.

Research output: Contribution to journalArticle

Dopamine
Heart Failure
Diuretics
Furosemide
Confidence Intervals

Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S., Mukherjee, M., Shah, A., Wigley, F., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., Jan 1 2018, In : Circulation. 137, 22, p. 2360-2370 11 p.

Research output: Contribution to journalArticle

Myofibrils
Systemic Scleroderma
Pulmonary Hypertension
Muscle Cells
Calcium
2017

Cardiac phosphodiesterases and their modulation for treating heart disease

Kim, G. E. & Kass, D. A., 2017, Handbook of Experimental Pharmacology. Springer New York LLC, Vol. 243. p. 249-269 21 p. (Handbook of Experimental Pharmacology; vol. 243).

Research output: Chapter in Book/Report/Conference proceedingChapter

Phosphoric Diester Hydrolases
Guanosine Monophosphate
Heart Diseases
Cyclic Nucleotides
Modulation

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization

Kirk, J. A. & Kass, D. A., Jan 1 2017, In : Heart Failure Clinics. 13, 1, p. 29-41 13 p.

Research output: Contribution to journalReview article

Cardiac Resynchronization Therapy
Heart Failure
Mechanics
Hemodynamics
Morbidity

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo

Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A. & Murphy, A. M., Sep 1 2017, In : Circulation. Heart failure. 10, 9

Research output: Contribution to journalArticle

Troponin C
Troponin I
Heart Failure
Proteolysis
Physiological Stress

Inorganic nitrates: Qi for heart failure with preserved ejection fraction?

Sharma, K. & Kass, D. A., Mar 31 2017, In : Circulation Research. 120, 7, p. 1057-1059 3 p.

Research output: Contribution to journalReview article

Qi
Nitrates
Nitric Oxide
Heart Failure
Pharmacology

Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases

Kokkonen, K. & Kass, D. A., Jan 6 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 455-479 25 p.

Research output: Contribution to journalReview article

Cyclic Nucleotides
Phosphoric Diester Hydrolases
Protein Isoforms
Health
Phosphodiesterase Inhibitors

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Cardiomyopathies
Cardiac Myocytes
Transplantation

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Rouf, R., MacFarlane, E., Takimoto, E., Chaudhary, R., Nagpal, V., Rainer, P. P., Bindman, J. G., Gerber, E. E., Bedja, D., Schiefer, C., Miller, K. L., Zhu, G., Myers, L., Amat-Alarcon, N., Lee, D., Koitabashi, N., Judge, D. P., Kass, D. A. & Dietz, H. C., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access
Marfan Syndrome
Cardiomyopathies
Angiotensin Type 1 Receptor
Pressure
Muscle Cells

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

Chung, H. S., Kim, G. E., Holewinski, R. J., Venkatraman, V., Zhu, G., Bedja, D., Kass, D. A. & Van Eyk, J. E., Dec 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. E10763-E10771

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Duchenne Muscular Dystrophy
S-Nitrosothiols
Nitric Oxide Synthase
Myocardium

Why publish in the American Journal of Physiology-heart and circulatory physiology?

Zucker, I. H., Lindsey, M. L., Delmar, M., De Windt, L. J., Des Rosiers, C., Diz, D. I., Hester, R. L., Jones, S. P., Kanagy, N. L., Kitakaze, M., Liao, R., Lopaschuk, G. D., Patel, K. P., Recchia, F. A., Sadoshima, J., Shah, A. M., Ungvari, Z., Benjamin, I. J., Blaustein, M. P., Charkoudian, N. & 7 others, Efimov, I. R., Gutterman, D., Kass, D. A., Liao, Y., O’Leary, D. S., Ripplinger, C. M. & Wolin, M. S., 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H221-H223

Research output: Contribution to journalEditorial

2016

A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform

Gao, M., Rose, W. C., Fetics, B., Kass, D. A., Chen, C. H. & Mukkamala, R., Sep 14 2016, In : Scientific Reports. 6, 33230.

Research output: Contribution to journalArticle

Blood Pressure
Cardiac Catheterization
Atrial Fibrillation
Recurrence
Atrial Pressure
Left Atrial Function
Catheter Ablation

Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure with Preserved Ejection Fraction?

Hsu, S. & Kass, D. A., Feb 23 2016, In : Circulation. 133, 8, p. 692-694 3 p.

Research output: Contribution to journalArticle

Sirtuin 3
Sirtuins
AMP-Activated Protein Kinases
Nitrites
Pulmonary Hypertension

From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond

Paolocci, N., Keceli, G., Wink, D. A. & Kass, D. A., Sep 1 2016, The Chemistry and Biology of Nitroxyl (HNO). Elsevier Inc., p. 353-387 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiovascular system
nitroxyl
Nitric Oxide
Reactive Nitrogen Species
Electrons

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

compliance
Compliance
heart rate
Heart Rate
lungs

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P. & 7 others, Heymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., 2016, In : Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journalArticle

Myofibrils
Mast Cells
Myocardial Infarction
Calcium
Cardiac Myocytes

Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work

Inuzuka, R., Kass, D. A. & Senzaki, H., Jun 1 2016, In : Open Heart. 3, 1, e000451.

Research output: Contribution to journalArticle

Stroke
Blood Pressure
Workload
Hemodynamics
Dogs

Old dog, new tricks: Novel cardiac targets and stress regulation by protein kinase G

Rainer, P. P. & Kass, D. A., 2016, In : Cardiovascular Research. 111, 2, p. 154-162 9 p.

Research output: Contribution to journalReview article

Cyclic GMP-Dependent Protein Kinases
Cyclic GMP
Heat-Shock Proteins
Dogs
Heart Failure

Phenotype-specific treatment of heart failure with preserved ejection fraction

Shah, S. J., Kitzman, D. W., Borlaug, B. A., Van Heerebeek, L., Zile, M. R., Kass, D. A. & Paulus, W. J., Jul 5 2016, In : Circulation. 134, 1, p. 73-90 18 p.

Research output: Contribution to journalArticle

Treatment Failure
Heart Failure
Phenotype
Cyclic GMP
Muscle Weakness

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

Prysyazhna, O., Burgoyne, J. R., Scotcher, J., Grover, S., Kass, D. A. & Eaton, P., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17427-17436 10 p.

Research output: Contribution to journalArticle

Type 5 Cyclic Nucleotide Phosphodiesterases
Cyclic GMP-Dependent Protein Kinases
Doxorubicin
Heart Failure
Oxidation

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Kooij, V., Viswanathan, M. C., Lee, D., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E. & Cammarato, A. R., May 15 2016, In : Cardiovascular Research. 110, 2, p. 238-248 11 p.

Research output: Contribution to journalArticle

Profilins
Cardiac Myocytes
Hypertrophy
Muscle Cells
Drosophila

Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor

Bullen, J. W., Tchernyshyov, I., Holewinski, R. J., Devine, L., Wu, F., Venkatraman, V., Kass, D. A., Cole, R. N., Van Eyk, J. & Semenza, G. L., May 31 2016, In : Science Signaling. 9, 430, RA56.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Phosphorylation
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Adenosine

Response to Letter Regarding Article, "circulating MicroRNA-30d Is Associated with Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study"

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., Chakir, K., Lewis, G. D., Lavender, Z., Truong, Q. A., Kleber, A., Das, R., Rosenzweig, A., Wang, Y., Kass, D. A., Singh, J. P. & Das, S., Feb 9 2016, In : Circulation. 133, 6, p. e389-e390

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Translational Medical Research
MicroRNAs
Cardiac Myocytes
Heart Failure

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension

Hsu, S., Houston, B. A., Tampakakis, E., Bacher, A. C., Rhodes, P. S., Mathai, S., Damico, R. L., Kolb, T. M., Hummers, L., Shah, A., McMahan, Z., Corona Villalobos, C., Zimmerman, S., Wigley, F., Hassoun, P. M., Kass, D. A. & Tedford, R. J., May 12 2016, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Ergometry
Right Ventricular Function
Systemic Scleroderma
Recycling

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

Duan, D., Rafael-Fortney, J. A., Blain, A., Kass, D. A., McNally, E. M., Metzger, J. M., Spurney, C. F. & Kinnett, K., Feb 1 2016, In : Journal of Cardiovascular Translational Research. 9, 1, p. 85-86 2 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
National Heart, Lung, and Blood Institute (U.S.)
Group Processes
Muscular Dystrophies
Cardiomyopathies

Ventricular Systolic Function

Kass, D. A., Nov 15 2016, Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc., p. 3-19 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ventricular Function
Heart Diseases
Ventricular Dysfunction
Pressure
Muscle Cells
2015
Cardiac Resynchronization Therapy
Cholinergic Agents
Heart Failure
Muscarinic Receptors
Adrenergic Agents

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization

Kirk, J. A. & Kass, D. A., 2015, In : Cardiac Electrophysiology Clinics. 7, 4, p. 585-597 13 p.

Research output: Contribution to journalArticle

Heart Conduction System
Cardiovascular Models
Myocardial Contraction
Excitation Contraction Coupling
Cardiac Resynchronization Therapy

Circulating MicroRNA-30d is associated with response to cardiac resynchronization therapy in heart failure and regulates cardiomyocyte apoptosis a translational pilot study

Melman, Y. F., Shah, R., Danielson, K., Xiao, J., Simonson, B., Barth, A., Chakir, K., Lewis, G. D., Lavender, Z., Truong, Q. A., Kleber, A., Das, R., Rosenzweig, A., Wang, Y., Kass, D. A., Singh, J. P. & Das, S., 2015, In : Circulation. 131, 25, p. 2202-2216 15 p.

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
MicroRNAs
Cardiac Myocytes
Heart Failure
Apoptosis

Citrullination of myofilament proteins in heart failure

Fert-Bober, J., Giles, J. T., Holewinski, R. J., Kirk, J. A., Uhrigshardt, H., Crowgey, E. L., Andrade, F. A., Bingham, C., Park, J. K., Halushka, M. K., Kass, D. A., Bathon, J. M. & Van Eyk, J. E., Jan 7 2015, In : Cardiovascular Research. 108, 2, p. 232-242 11 p.

Research output: Contribution to journalArticle

Myofibrils
pioglitazone
Heart Failure
Adenosine Triphosphatases
Proteins

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Burks, T. N., Marx-Rattner, R., Powell, L., Rucker, J., Bedja, D., Heacock, E., Smith, B. J., Foster, D. B., Kass, D. A., O'Rourke, B., Walston, J. D. & Abadir, P., 2015, In : Oncotarget. 6, 14, p. 11979-11993 15 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Cardiomyopathies
Inflammation
Myocardium
Premature Aging