Research Output 1972 2017

Filter
Article
2017

Drug Burden and its Association with Falls Among Older Adults in New Zealand: A National Population Cross-Sectional Study

Jamieson, H. A., Nishtala, P. S., Scrase, R., Deely, J. M., Abey-Nesbit, R., Connolly, M. J., Hilmer, S. N., Abernethy, D. R. & Schluter, P. J. Dec 8 2017 (Accepted/In press) In : Drugs and Aging. p. 1-9 9 p.

Research output: Research - peer-reviewArticle

New Zealand
Cross-Sectional Studies
Pharmaceutical Preparations
Population
Independent Living

Improving Therapeutics to Better Care for Older Adults and the Young: Report From the American College of Clinical Pharmacology Workshop

Lau, S. W. J., Schlender, J. F., Abernethy, D. R., Burckart, G. J., Golden, A., Slattum, P. W., Stegemann, S. & Eissing, T. 2017 (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Research - peer-reviewArticle

Clinical Pharmacology
Young Adult
Education
Therapeutics

Improving the tools of clinical pharmacology: Goals for 2017 and beyond

Zineh, I., Abernethy, D., Hop, C. E. C. A., Bello, A., McClellan, M. B., Daniel, G. W. & Romine, M. H. Jan 1 2017 In : Clinical Pharmacology and Therapeutics. 101, 1, p. 22-24 3 p.

Research output: Research - peer-reviewArticle

Drug Evaluation
Clinical Pharmacology
Delivery of Health Care
Pharmaceutical Preparations

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Yoshida, K., Zhao, P., Zhang, L., Abernethy, D. R., Rekić, D., Reynolds, K. S., Galetin, A. & Huang, S. M. 2017 (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Research - peer-reviewArticle

Drug Interactions
Pharmaceutical Preparations
In Vitro Techniques
Investigational Drugs
Drug Evaluation

Tyrosine kinase-targeting drugs-associated heart failure

Gronich, N., Lavi, I., Barnett-Griness, O., Saliba, W., Abernethy, D. R. & Rennert, G. Apr 11 2017 (Accepted/In press) In : British Journal of Cancer.

Research output: Research - peer-reviewArticle

Drug Delivery Systems
Protein-Tyrosine Kinases
Heart Failure
Odds Ratio
Neoplasms

Use of biomedical ontologies for integration of biological knowledge for learning and prediction of adverse drug reactions

Zaman, S., Sarntivijai, S. & Abernethy, D. R. Mar 15 2017 In : Gene Regulation and Systems Biology. 11, 1177625017696075

Research output: Research - peer-reviewArticle

Biological Ontologies
Drug-Related Side Effects and Adverse Reactions
Learning
drug
learning
2016

In Memoriam: David A Flockhart, 1952-2015

Greenblatt, D. J. & Abernethy, D. R. 2016 (Accepted/In press) In : Clinical Pharmacology in Drug Development.

Research output: Research - peer-reviewArticle

In Memoriam: David A. Flockhart, 1952-2015

Greenblatt, D. J. & Abernethy, D. R. Apr 1 2016 In : Journal of clinical pharmacology. 56, 4, p. 509-510 2 p.

Research output: Research - peer-reviewArticle

Medical Laboratory Personnel
Pharmacogenetics
Research Personnel

Linking MedDRA®-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors

Sarntivijai, S., Zhang, S., Jagannathan, D. G., Zaman, S., Burkhart, K. K., Omenn, G. S., He, Y., Athey, B. D. & Abernethy, D. R. Mar 22 2016 (Accepted/In press) In : Drug Safety. p. 1-11 11 p.

Research output: Research - peer-reviewArticle

Biological Ontologies
Protein-Tyrosine Kinases
Phenotype
Ontology
Monoclonal Antibodies

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5

Yoshida, K., Sun, B., Zhang, L., Zhao, P., Abernethy, D., Nolin, T., Rostami-Hodjegan, A., Zineh, I. & Huang, S. M. 2016 (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Research - peer-reviewArticle

Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Chronic Renal Insufficiency
Pharmaceutical Preparations
Pharmacokinetics
2015

Adverse Event Detection and Labeling in Pediatric Drug Development: Antiretroviral Drugs

Momper, J. D., Chang, Y., Jackson, M., Schuette, P., Seo, S., Younis, I., Abernethy, D. R., Yao, L., Capparelli, E. V. & Burckart, G. J. Mar 15 2015 In : Therapeutic Innovation and Regulatory Science. 49, 2, p. 302-309 8 p.

Research output: Research - peer-reviewArticle

Pediatrics
Pharmaceutical Preparations
Confidence Intervals
Safety
Population

Bidirectional interactions between indomethacin and the murine intestinal microbiota

Liang, X., Bittinger, K., Xuanwen, L., Abernethy, D. R., Bushman, F. D. & Fitzgerald, G. A. Dec 23 2015 In : eLife. 4, DECEMBER2015, e08973

Research output: Research - peer-reviewArticle

Indomethacin
Gastrointestinal Microbiome
Pharmaceutical Preparations
Cyclooxygenase 1
Microbiota

Consensus Recommendations for Systematic Evaluation of Drug–Drug Interaction Evidence for Clinical Decision Support

Scheife, R. T., Hines, L. E., Boyce, R. D., Chung, S. P., Momper, J. D., Sommer, C. D., Abernethy, D. R., Horn, J. R., Sklar, S. J., Wong, S. K., Jones, G., Brown, M. L., Grizzle, A. J., Comes, S., Wilkins, T. L., Borst, C., Wittie, M. A. & Malone, D. C. 2015 In : Drug Safety. 38, 2, p. 197-206 10 p.

Research output: Research - peer-reviewArticle

Clinical Decision Support Systems
Drug Evaluation
Drug Interactions
Pharmaceutical Preparations
Drug interactions

Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome

Burkhart, K. K., Abernethy, D. & Jackson, D. Apr 15 2015 In : Journal of Medical Toxicology. 11, 2, p. 265-273 9 p.

Research output: Research - peer-reviewArticle

Stevens-Johnson Syndrome
Data Mining
Pharmaceutical Preparations
Data mining
Drug-Related Side Effects and Adverse Reactions

Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study

Gronich, N., Deftereos, S. N., Lavi, I., Persidis, A. S., Abernethy, D. R. & Rennert, G. Sep 1 2015 In : Diabetes Care. 38, 9, p. 1657-1664 8 p.

Research output: Research - peer-reviewArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypothyroidism
Cohort Studies
Diabetes Mellitus
Propensity Score

Logic-Based and cellular pharmacodynamic modeling of bortezomib responses in U266 human myeloma cellss

Chudasama, V. L., Ovacik, M. A., Abernethy, D. R. & Mager, D. E. Sep 1 2015 In : Journal of Pharmacology and Experimental Therapeutics. 354, 3, p. 448-458 11 p.

Research output: Research - peer-reviewArticle

Bortezomib
Proteins
Multiple Myeloma
Biological Models
Signal Transduction

Replication – why we need to publish our findings

Curtis, M. J. & Abernethy, D. R. Aug 1 2015 In : Pharmacology Research and Perspectives. 3, 4, e00164

Research output: Research - peer-reviewArticle

Research
Pharmacology
Publications
Publication Bias
Drug Discovery
2014

Drug burden index for international assessment of the functional burden of medications in older people

Hilmer, S. N., Gnjidic, D. & Abernethy, D. R. 2014 In : Journal of the American Geriatrics Society. 62, 4, p. 791-792 2 p.

Research output: Research - peer-reviewArticle

Cholinergic Antagonists
Hypnotics and Sedatives
Pharmaceutical Preparations

Use of internet search logs to evaluate potential drug adverse events

Sarntivijai, S. & Abernethy, D. R. 2014 In : Clinical Pharmacology and Therapeutics. 96, 2, p. 149-150 2 p.

Research output: Research - peer-reviewArticle

Drug-Related Side Effects and Adverse Reactions
Internet
Information Storage and Retrieval
United States Food and Drug Administration
Databases
2013
Drug-Related Side Effects and Adverse Reactions
Pharmacology
Pharmaceutical Preparations
Toxicity
Metabolomics

The utility of modeling and simulation in drug development and regulatory review

Huang, S. M., Abernethy, D. R., Wang, Y., Zhao, P. & Zineh, I. Sep 2013 In : Journal of Pharmaceutical Sciences. 102, 9, p. 2912-2923 12 p.

Research output: Research - peer-reviewArticle

Clinical Pharmacology
Public Sector
Drug and Narcotic Control
United States Food and Drug Administration
Pharmaceutical Preparations
2012

A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012)

He, Y., Toldo, L., Burns, G., Tao, C. & Abernethy, D. R. Dec 18 2012 In : Journal of Biomedical Semantics. 3, 1, 12

Research output: Research - peer-reviewArticle

Vaccines
Education
Pharmaceutical Preparations
Ontology
Biological Ontologies

Drug burden index and beers criteria: Impact on functional outcomes in older people living in self-care retirement villages

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N. 2012 In : Journal of Clinical Pharmacology. 52, 2, p. 258-265 8 p.

Research output: Research - peer-reviewArticle

Retirement
Self Care
Pharmaceutical Preparations
Potentially Inappropriate Medication List
Hand Strength

Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.

Zhao, P., Vieira, M. D. L. T., Grillo, J. A., Song, P., Wu, T. C., Zheng, J. H., Arya, V., Berglund, E. G., Atkinson, A. J., Sugiyama, Y., Pang, K. S., Reynolds, K. S., Abernethy, D. R., Zhang, L., Lesko, L. J. & Huang, S. M. Jan 2012 In : Journal of Clinical Pharmacology. 52, 1 Suppl

Research output: Research - peer-reviewArticle

Chronic Renal Insufficiency
Pharmacokinetics
Kidney
Pharmaceutical Preparations
Sildenafil Citrate

High-risk prescribing and incidence of frailty among older community-dwelling men

Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V., Cumming, R. G., Handelsman, D. J., McLachlan, A. J., Abernethy, D. R., Banks, E. & Le Couteur, D. G. Mar 2012 In : Clinical Pharmacology and Therapeutics. 91, 3, p. 521-528 8 p.

Research output: Research - peer-reviewArticle

Independent Living
Incidence
Polypharmacy
Pharmaceutical Preparations
Odds Ratio

Methodological issues in the design of paediatric pharmacokinetic studies

Burckart, G. J., Estes, K. E., Leong, R., Mulugeta, Y., Tandon, V., Wang, J., Abernethy, D. R. & Jadhav, P. R. 2012 In : Pharmaceutical Medicine. 26, 1, p. 13-22 10 p.

Research output: Research - peer-reviewArticle

Pharmacokinetics
Pediatrics
Pharmaceutical Preparations
Population
Appointments and Schedules

Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms

Zhichkin, P. E., Athey, B. D., Avigan, M. I. & Abernethy, D. R. Jun 2012 In : Clinical Pharmacology and Therapeutics. 91, 6, p. 963-965 3 p.

Research output: Research - peer-reviewArticle

Systems Biology
Vocabulary
Computational Biology
Drug-Related Side Effects and Adverse Reactions
Safety
Pharmacoepidemiology
Safety
Pharmaceutical Preparations
Marketing
Geriatrics
2011

Geriatric drug evaluation: Where are we now and where should we be in the future?

Cho, S., Johnny Lau, S. W., Tandon, V., Kumi, K., Pfuma, E. & Abernethy, D. R. May 23 2011 In : Archives of Internal Medicine. 171, 10, p. 937-940 4 p.

Research output: Research - peer-reviewArticle

Drug Evaluation
Geriatrics
Pharmaceutical Preparations
Age Groups
Clinical Trials

Integration of diverse data sources for prediction of adverse drug events

Abernethy, D. R., Bai, J. P. F., Burkhart, K., Xie, H. G. & Zhichkin, P. Nov 2011 In : Clinical Pharmacology and Therapeutics. 90, 5, p. 645-646 2 p.

Research output: Research - peer-reviewArticle

Information Storage and Retrieval
Drug-Related Side Effects and Adverse Reactions
Pharmacology
Pharmaceutical Preparations
Chemical Databases

Pharmacological mechanism-based drug safety assessment and prediction

Abernethy, D. R., Woodcock, J. & Lesko, L. J. Jun 2011 In : Clinical Pharmacology and Therapeutics. 89, 6, p. 793-797 5 p.

Research output: Research - peer-reviewArticle

Pharmacology
Safety
Pharmaceutical Preparations
United States Food and Drug Administration
National Institutes of Health (U.S.)

Reducing drugs in older adults is more

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N. May 2011 In : Archives of Internal Medicine. 171, 9, p. 868-869 2 p.

Research output: Research - peer-reviewArticle

Physicians' Practice Patterns
Palliative Care
Drug Therapy
Pharmaceutical Preparations
2010

A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N. Nov 2010 In : Annals of Pharmacotherapy. 44, 11, p. 1725-1732 8 p.

Research output: Research - peer-reviewArticle

Cholinergic Antagonists
Hypnotics and Sedatives
Randomized Controlled Trials
Pharmaceutical Preparations
General Practitioners

Effect of obesity on the pharmacokinetics of drugs in humans

Hanley, M. J., Abernethy, D. R. & Greenblatt, D. J. 2010 In : Clinical Pharmacokinetics. 49, 2, p. 71-87 17 p.

Research output: Research - peer-reviewArticle

Pharmacokinetics
Obesity
Pharmaceutical Preparations
Body Composition
Kidney

Effects of the physical work environment on physiological measures of stress

Thayer, J. F., Verkuil, B., Brosschot, J. F., Kampschroer, K., West, A., Sterling, C., Christie, I. C., Abernethy, D. R., Sollers, J. J., Cizza, G., Marques, A. H. & Sternberg, E. M. Aug 2010 In : European Journal of Cardiovascular Prevention and Rehabilitation. 17, 4, p. 431-439 9 p.

Research output: Research - peer-reviewArticle

Physiological Stress
Lighting
Hydrocortisone
Heart Rate
Confidence Intervals

Metal impurities in food and drugs

Abernethy, D. R., DeStefano, A. J., Cecil, T. L., Zaidi, K. & Williams, R. L. May 2010 In : Pharmaceutical Research. 27, 5, p. 750-755 6 p.

Research output: Research - peer-reviewArticle

Metals
Impurities
Pharmaceutical Preparations
Food
Medicine

Pediatric dose selection

Abernethy, D. R. & Burckart, G. J. Mar 2010 In : Clinical Pharmacology and Therapeutics. 87, 3, p. 270-271 2 p.

Research output: Research - peer-reviewArticle

Pharmacokinetics
Pediatrics
Pharmaceutical Preparations
Therapeutics

Pharmacogenomics and adverse drug reactions

Amur, S., Zineh, I., Abernethy, D. R., Huang, S. M. & Lesko, L. J. Nov 2010 In : Personalized Medicine. 7, 6, p. 633-642 10 p.

Research output: Research - peer-reviewArticle

Pharmacogenetics
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Complementary Therapies
Marketing

Total protein methods and their potential utility to reduce the risk of food protein adulteration

Moore, J. C., DeVries, J. W., Lipp, M., Griffiths, J. C. & Abernethy, D. R. Aug 2010 In : Comprehensive Reviews in Food Science and Food Safety. 9, 4, p. 330-357 28 p.

Research output: Research - peer-reviewArticle

adulterated products
protein sources
proteins
methodology
Food Contamination
2009

Acceptable, equivalent, or better: Approaches for alternatives to official compendia! procedures

Hauck, W. W., DeStefano, A. J., Cecil, T. L., Abernethy, D. R., Koch, W. F. & Williams, R. L. May 2009 In : Pharmacopeial Forum. 35, 3, p. 772-778 7 p.

Research output: Research - peer-reviewArticle

Pharmacopoeias

Adulteration of drugs and foods: Compendial approaches to lowering risk

Abernethy, D. R., Sheehan, C., Griffiths, J. C. & Williams, R. L. Apr 2009 In : Clinical Pharmacology and Therapeutics. 85, 4, p. 444-447 4 p.

Research output: Research - peer-reviewArticle

Drug Contamination
Food Contamination
United States Food and Drug Administration
Food
Pharmaceutical Preparations

Aging and medications: Past, present, future

Schwartz, J. B. & Abernethy, D. R. Jan 2009 In : Clinical Pharmacology and Therapeutics. 85, 1, p. 3-10 8 p.

Research output: Research - peer-reviewArticle

Change in criteria for USP dissolution performance verification tests

Hauck, W. W., DeStefano, A. J., Brown, W. E., Stippler, E. S., Abernethy, D. R., Koch, W. F. & Williams, R. L. 2009 In : AAPS PharmSciTech. 10, 1, p. 21-26 6 p.

Research output: Research - peer-reviewArticle

Tablets
testing
Pharmacopoeias
Dosage Forms
administered dose

Description of the upcoming change in data analysis for USP dissolution performance verification tests

Hauck, W. W., DeStefano, A. J., Brown, W. E., Stippler, E., Abernethy, D. R., Williams, R. L., Foster, T. S., Polli, J. E., Burgess, D. J., Bryan Crist, G., Gonzalez, M. A., Gray, V. A., Kraemer, J., Leeson, L. J., Parr, A. F., Shargel, L., Shefter, E., Craig Simon, W., Tran, N. L. & Ueda, C. T. Feb 2009 In : Dissolution Technologies. 16, 1, p. 7-12 6 p.

Research output: Research - peer-reviewArticle

Tablets
Dissolution
Salicylic acid
Salicylic Acid
Biopharmaceutics

Drug Burden Index and physical function in older Australian men

Gnjidic, D., Cumming, R. G., Le Couteur, D. G., Handelsman, D. J., Naganathan, V., Abernethy, D. R. & Hilmer, S. N. Jul 2009 In : British Journal of Clinical Pharmacology. 68, 1, p. 97-105 9 p.

Research output: Research - peer-reviewArticle

Pharmaceutical Preparations
Cholinergic Antagonists
Hypnotics and Sedatives
Independent Living
Population

Drug Burden Index Score and Functional Decline in Older People

Hilmer, S. N., Mager, D. E., Simonsick, E. M., Ling, S. M., Windham, B. G., Harris, T. B., Shorr, R. I., Bauer, D. C. & Abernethy, D. R. Dec 2009 In : American Journal of Medicine. 122, 12

Research output: Research - peer-reviewArticle

Pharmaceutical Preparations
Area Under Curve
Independent Living
Cholinergic Antagonists
Hand Strength

Functional food ingredient quality: Opportunities to improve public health by compendial standardization

Griffiths, J. C., Abernethy, D. R., Schuber, S. & Williams, R. L. Jan 2009 In : Journal of Functional Foods. 1, 1, p. 128-130 3 p.

Research output: Research - peer-reviewArticle

standardization
functional foods
public health
ingredients
Food Quality

General chapter management in the 2010-2015 cycle

De Mars, S., Abernethy, D. R., Koch, W. F., Long, A. G., DeStefano, A. J., Williams, R. L., Walsh, P., Anderson, M. K., Caphart, M. E., Chung, C. C., Cimbala, K., Ghate, S. M., Gylys, S., Hickey, D., Lehmann, M. W., Lyon, F. S., Saulter, M. S., Raccasi, D., Sopirak, A. M. & Tscherne, R. J. Sep 2009 In : Pharmacopeial Forum. 35, 5, p. 1372-1379 8 p.

Research output: Research - peer-reviewArticle

Direction compound
Prescriptions

Heparin monographs further revised

Szajek, A. Y., Morris, T. S., Koch, W. F., Abernethy, D. R. & Williams, R. L. Mar 2009 In : Pharmaceutical Technology. 33, 3, p. 136-137 2 p.

Research output: Research - peer-reviewArticle

Heparin

Performance-based monographs

Cecil, T. L., Williams, R. L., Abernethy, D. R., Koch, W. F. & Hauck, W. W. May 2009 In : Pharmacopeial Forum. 35, 3, p. 765-771 7 p.

Research output: Research - peer-reviewArticle

Availability
Acoustic waves
Pharmacopoeias