Darrell R. Abernethy

Professor

1972 …2017
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Research Output 1972 2017

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Article
2017

Drug Burden and its Association with Falls Among Older Adults in New Zealand: A National Population Cross-Sectional Study

Jamieson, H. A., Nishtala, P. S., Scrase, R., Deely, J. M., Abey-Nesbit, R., Connolly, M. J., Hilmer, S. N., Abernethy, D. R. & Schluter, P. J., Dec 8 2017, (Accepted/In press) In : Drugs and Aging. p. 1-9 9 p.

Research output: Contribution to journalArticle

New Zealand
Cross-Sectional Studies
Pharmaceutical Preparations
Population
Independent Living

Improving Therapeutics to Better Care for Older Adults and the Young: Report From the American College of Clinical Pharmacology Workshop

Lau, S. W. J., Schlender, J. F., Abernethy, D. R., Burckart, G. J., Golden, A., Slattum, P. W., Stegemann, S. & Eissing, T., 2017, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Clinical Pharmacology
Young Adult
Education
Therapeutics

Improving the tools of clinical pharmacology: Goals for 2017 and beyond

Zineh, I., Abernethy, D., Hop, C. E. C. A., Bello, A., McClellan, M. B., Daniel, G. W. & Romine, M. H., Jan 1 2017, In : Clinical Pharmacology and Therapeutics. 101, 1, p. 22-24 3 p.

Research output: Contribution to journalArticle

Drug Evaluation
Clinical Pharmacology
Delivery of Health Care
Pharmaceutical Preparations

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Yoshida, K., Zhao, P., Zhang, L., Abernethy, D. R., Rekić, D., Reynolds, K. S., Galetin, A. & Huang, S. M., 2017, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Drug Interactions
Investigational Drugs
Pharmaceutical Preparations
Drug Evaluation
Complementary Therapies

Tyrosine kinase-targeting drugs-associated heart failure

Gronich, N., Lavi, I., Barnett-Griness, O., Saliba, W., Abernethy, D. R. & Rennert, G., Apr 11 2017, (Accepted/In press) In : British Journal of Cancer.

Research output: Contribution to journalArticle

Drug Delivery Systems
Protein-Tyrosine Kinases
Heart Failure
Odds Ratio
Confidence Intervals

Use of biomedical ontologies for integration of biological knowledge for learning and prediction of adverse drug reactions

Zaman, S., Sarntivijai, S. & Abernethy, D. R., Mar 15 2017, In : Gene Regulation and Systems Biology. 11, 1177625017696075

Research output: Contribution to journalArticle

Biological Ontologies
Drug-Related Side Effects and Adverse Reactions
Ontology
Toxicity
drug
2016

In Memoriam: David A. Flockhart, 1952-2015

Greenblatt, D. J. & Abernethy, D. R., Apr 1 2016, In : Journal of Clinical Pharmacology. 56, 4, p. 509-510 2 p.

Research output: Contribution to journalArticle

Medical Laboratory Personnel
Pharmacogenetics
Research Personnel

Linking MedDRA®-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors

Sarntivijai, S., Zhang, S., Jagannathan, D. G., Zaman, S., Burkhart, K. K., Omenn, G. S., He, Y., Athey, B. D. & Abernethy, D. R., Mar 22 2016, (Accepted/In press) In : Drug Safety. p. 1-11 11 p.

Research output: Contribution to journalArticle

Biological Ontologies
Protein-Tyrosine Kinases
Ontology
Phenotype
Monoclonal Antibodies

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5

Yoshida, K., Sun, B., Zhang, L., Zhao, P., Abernethy, D., Nolin, T., Rostami-Hodjegan, A., Zineh, I. & Huang, S. M., 2016, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
Chronic Renal Insufficiency
Pharmaceutical Preparations
Pharmacokinetics
2015

Adverse Event Detection and Labeling in Pediatric Drug Development: Antiretroviral Drugs

Momper, J. D., Chang, Y., Jackson, M., Schuette, P., Seo, S., Younis, I., Abernethy, D. R., Yao, L., Capparelli, E. V. & Burckart, G. J., Mar 15 2015, In : Therapeutic Innovation and Regulatory Science. 49, 2, p. 302-309 8 p.

Research output: Contribution to journalArticle

Pediatrics
Pharmaceutical Preparations
Confidence Intervals
efavirenz
Safety

Bidirectional interactions between indomethacin and the murine intestinal microbiota

Liang, X., Bittinger, K., Xuanwen, L., Abernethy, D. R., Bushman, F. D. & Fitzgerald, G. A., Dec 23 2015, In : eLife. 4, DECEMBER2015, e08973

Research output: Contribution to journalArticle

Indomethacin
Cyclooxygenase 1
Microbiota
Cyclooxygenase 2
Metabolism

Consensus Recommendations for Systematic Evaluation of Drug–Drug Interaction Evidence for Clinical Decision Support

Scheife, R. T., Hines, L. E., Boyce, R. D., Chung, S. P., Momper, J. D., Sommer, C. D., Abernethy, D. R., Horn, J. R., Sklar, S. J., Wong, S. K., Jones, G., Brown, M. L., Grizzle, A. J., Comes, S., Wilkins, T. L., Borst, C., Wittie, M. A. & Malone, D. C., 2015, In : Drug Safety. 38, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

Clinical Decision Support Systems
Drug interactions
Drug Evaluation
Drug Interactions
Pharmaceutical Preparations

Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome

Burkhart, K. K., Abernethy, D. & Jackson, D., Apr 15 2015, In : Journal of Medical Toxicology. 11, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

Stevens-Johnson Syndrome
Data Mining
Data mining
Pharmaceutical Preparations
Drug-Related Side Effects and Adverse Reactions

Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology

Amemiya, T., Honma, M., Kariya, Y., Ghosh, S., Kitano, H., Kurachi, Y., Fujita, K. I., Sasaki, Y., Homma, Y., Abernethy, D. R., Kume, H. & Suzuki, H., Sep 28 2015, In : npj Systems Biology and Applications. 1, 15005

Research output: Contribution to journalArticle

Toxicology
Inhibitor
Phosphotransferases
Oxidative stress
Experiments

Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study

Gronich, N., Deftereos, S. N., Lavi, I., Persidis, A. S., Abernethy, D. R. & Rennert, G., Sep 1 2015, In : Diabetes Care. 38, 9, p. 1657-1664 8 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypothyroidism
Cohort Studies
Diabetes Mellitus
Propensity Score

Logic-Based and cellular pharmacodynamic modeling of bortezomib responses in U266 human myeloma cellss

Chudasama, V. L., Ovacik, M. A., Abernethy, D. R. & Mager, D. E., Sep 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 354, 3, p. 448-458 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Biological Models
Signal Transduction
Proteins
Cell Proliferation

Replication – why we need to publish our findings

Curtis, M. J. & Abernethy, D. R., Aug 1 2015, In : Pharmacology Research and Perspectives. 3, 4, e00164

Research output: Contribution to journalArticle

Pharmacology
Research
Publications
Publication Bias
Drug Discovery
2014

Drug burden index for international assessment of the functional burden of medications in older people

Hilmer, S. N., Gnjidic, D. & Abernethy, D. R., 2014, In : Journal of the American Geriatrics Society. 62, 4, p. 791-792 2 p.

Research output: Contribution to journalArticle

Cholinergic Antagonists
Hypnotics and Sedatives
Pharmaceutical Preparations

Use of internet search logs to evaluate potential drug adverse events

Sarntivijai, S. & Abernethy, D. R., 2014, In : Clinical Pharmacology and Therapeutics. 96, 2, p. 149-150 2 p.

Research output: Contribution to journalArticle

Drug-Related Side Effects and Adverse Reactions
Internet
Information Storage and Retrieval
United States Food and Drug Administration
Databases
2013
Drug-Related Side Effects and Adverse Reactions
Toxicity
Pharmacology
Pharmaceutical Preparations
Metabolomics

The utility of modeling and simulation in drug development and regulatory review

Huang, S. M., Abernethy, D. R., Wang, Y., Zhao, P. & Zineh, I., Sep 2013, In : Journal of Pharmaceutical Sciences. 102, 9, p. 2912-2923 12 p.

Research output: Contribution to journalArticle

Clinical Pharmacology
Public Sector
Drug and Narcotic Control
United States Food and Drug Administration
Pharmaceutical Preparations
2012

A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012)

He, Y., Toldo, L., Burns, G., Tao, C. & Abernethy, D. R., Dec 18 2012, In : Journal of Biomedical Semantics. 3, 1, 12

Research output: Contribution to journalArticle

Vaccines
Ontology
Education
Pharmaceutical Preparations
Biological Ontologies

Drug burden index and beers criteria: Impact on functional outcomes in older people living in self-care retirement villages

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N., 2012, In : Journal of Clinical Pharmacology. 52, 2, p. 258-265 8 p.

Research output: Contribution to journalArticle

Retirement
Self Care
Pharmaceutical Preparations
Hand Strength
Potentially Inappropriate Medication List

Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.

Zhao, P., Vieira, M. D. L. T., Grillo, J. A., Song, P., Wu, T. C., Zheng, J. H., Arya, V., Berglund, E. G., Atkinson, A. J., Sugiyama, Y., Pang, K. S., Reynolds, K. S., Abernethy, D. R., Zhang, L., Lesko, L. J. & Huang, S. M., Jan 2012, In : Journal of Clinical Pharmacology. 52, 1 Suppl

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Pharmacokinetics
repaglinide
Kidney
Pharmaceutical Preparations

High-risk prescribing and incidence of frailty among older community-dwelling men

Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V., Cumming, R. G., Handelsman, D. J., McLachlan, A. J., Abernethy, D. R., Banks, E. & Le Couteur, D. G., Mar 2012, In : Clinical Pharmacology and Therapeutics. 91, 3, p. 521-528 8 p.

Research output: Contribution to journalArticle

Independent Living
Polypharmacy
Incidence
Odds Ratio
Pharmaceutical Preparations

Methodological issues in the design of paediatric pharmacokinetic studies

Burckart, G. J., Estes, K. E., Leong, R., Mulugeta, Y., Tandon, V., Wang, J., Abernethy, D. R. & Jadhav, P. R., 2012, In : Pharmaceutical Medicine. 26, 1, p. 13-22 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Pediatrics
Appointments and Schedules
Pharmaceutical Preparations
Population

Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms

Zhichkin, P. E., Athey, B. D., Avigan, M. I. & Abernethy, D. R., Jun 2012, In : Clinical Pharmacology and Therapeutics. 91, 6, p. 963-965 3 p.

Research output: Contribution to journalArticle

Systems Biology
Vocabulary
Computational Biology
Drug-Related Side Effects and Adverse Reactions
Safety
Pharmacoepidemiology
Safety
Marketing
Geriatrics
Pharmaceutical Preparations
2011

Geriatric drug evaluation: Where are we now and where should we be in the future?

Cho, S., Johnny Lau, S. W., Tandon, V., Kumi, K., Pfuma, E. & Abernethy, D. R., May 23 2011, In : Archives of Internal Medicine. 171, 10, p. 937-940 4 p.

Research output: Contribution to journalArticle

Drug Evaluation
Geriatrics
Pharmaceutical Preparations
Age Groups
Clinical Trials

Integration of diverse data sources for prediction of adverse drug events

Abernethy, D. R., Bai, J. P. F., Burkhart, K., Xie, H. G. & Zhichkin, P., Nov 2011, In : Clinical Pharmacology and Therapeutics. 90, 5, p. 645-646 2 p.

Research output: Contribution to journalArticle

Information Storage and Retrieval
Drug-Related Side Effects and Adverse Reactions
Chemical Databases
Biological Evolution
Pharmacology

Pharmacological mechanism-based drug safety assessment and prediction

Abernethy, D. R., Woodcock, J. & Lesko, L. J., Jun 2011, In : Clinical Pharmacology and Therapeutics. 89, 6, p. 793-797 5 p.

Research output: Contribution to journalArticle

Pharmacology
Safety
United States Food and Drug Administration
Pharmaceutical Preparations
National Institutes of Health (U.S.)

Reducing drugs in older adults is more

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N., May 2011, In : Archives of Internal Medicine. 171, 9, p. 868-869 2 p.

Research output: Contribution to journalArticle

Physicians' Practice Patterns
Palliative Care
Drug Therapy
Pharmaceutical Preparations
2010

A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people

Gnjidic, D., Le Couteur, D. G., Abernethy, D. R. & Hilmer, S. N., Nov 2010, In : Annals of Pharmacotherapy. 44, 11, p. 1725-1732 8 p.

Research output: Contribution to journalArticle

Cholinergic Antagonists
Hypnotics and Sedatives
Randomized Controlled Trials
General Practitioners
Pharmaceutical Preparations

Effect of obesity on the pharmacokinetics of drugs in humans

Hanley, M. J., Abernethy, D. R. & Greenblatt, D. J., 2010, In : Clinical Pharmacokinetics. 49, 2, p. 71-87 17 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Obesity
Pharmaceutical Preparations
Body Composition
Neuromuscular Blocking Agents

Effects of the physical work environment on physiological measures of stress

Thayer, J. F., Verkuil, B., Brosschot, J. F., Kampschroer, K., West, A., Sterling, C., Christie, I. C., Abernethy, D. R., Sollers, J. J., Cizza, G., Marques, A. H. & Sternberg, E. M., Aug 2010, In : European Journal of Cardiovascular Prevention and Rehabilitation. 17, 4, p. 431-439 9 p.

Research output: Contribution to journalArticle

Physiological Stress
Lighting
Hydrocortisone
Heart Rate
Confidence Intervals

Metal impurities in food and drugs

Abernethy, D. R., DeStefano, A. J., Cecil, T. L., Zaidi, K. & Williams, R. L., May 2010, In : Pharmaceutical Research. 27, 5, p. 750-755 6 p.

Research output: Contribution to journalArticle

Metals
Impurities
Food
Dietary supplements
Pharmaceutical Preparations

Pediatric dose selection

Abernethy, D. R. & Burckart, G. J., Mar 2010, In : Clinical Pharmacology and Therapeutics. 87, 3, p. 270-271 2 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Pediatrics
Pharmaceutical Preparations
Therapeutics

Pharmacogenomics and adverse drug reactions

Amur, S., Zineh, I., Abernethy, D. R., Huang, S. M. & Lesko, L. J., Nov 2010, In : Personalized Medicine. 7, 6, p. 633-642 10 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Complementary Therapies
Marketing

Total protein methods and their potential utility to reduce the risk of food protein adulteration

Moore, J. C., DeVries, J. W., Lipp, M., Griffiths, J. C. & Abernethy, D. R., Aug 2010, In : Comprehensive Reviews in Food Science and Food Safety. 9, 4, p. 330-357 28 p.

Research output: Contribution to journalArticle

Food Contamination
adulterated products
protein sources
Proteins
proteins
2009

Acceptable, equivalent, or better: Approaches for alternatives to official compendia! procedures

Hauck, W. W., DeStefano, A. J., Cecil, T. L., Abernethy, D. R., Koch, W. F. & Williams, R. L., May 2009, In : Pharmacopeial Forum. 35, 3, p. 772-778 7 p.

Research output: Contribution to journalArticle

Pharmacopoeias

Adulteration of drugs and foods: Compendial approaches to lowering risk

Abernethy, D. R., Sheehan, C., Griffiths, J. C. & Williams, R. L., Apr 2009, In : Clinical Pharmacology and Therapeutics. 85, 4, p. 444-447 4 p.

Research output: Contribution to journalArticle

Drug Contamination
Food Contamination
United States Food and Drug Administration
Food
Pharmaceutical Preparations

Aging and medications: Past, present, future

Schwartz, J. B. & Abernethy, D. R., Jan 2009, In : Clinical Pharmacology and Therapeutics. 85, 1, p. 3-10 8 p.

Research output: Contribution to journalArticle

Change in criteria for USP dissolution performance verification tests

Hauck, W. W., DeStefano, A. J., Brown, W. E., Stippler, E. S., Abernethy, D. R., Koch, W. F. & Williams, R. L., 2009, In : AAPS PharmSciTech. 10, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Tablets
Pharmacopoeias
Dosage Forms
testing
administered dose

Description of the upcoming change in data analysis for USP dissolution performance verification tests

Hauck, W. W., DeStefano, A. J., Brown, W. E., Stippler, E., Abernethy, D. R., Williams, R. L., Foster, T. S., Polli, J. E., Burgess, D. J., Bryan Crist, G., Gonzalez, M. A., Gray, V. A., Kraemer, J., Leeson, L. J., Parr, A. F., Shargel, L., Shefter, E., Craig Simon, W., Tran, N. L. & Ueda, C. T., Feb 2009, In : Dissolution Technologies. 16, 1, p. 7-12 6 p.

Research output: Contribution to journalArticle

Tablets
Dissolution
Salicylic acid
Biopharmaceutics
Salicylic Acid

Drug Burden Index and physical function in older Australian men

Gnjidic, D., Cumming, R. G., Le Couteur, D. G., Handelsman, D. J., Naganathan, V., Abernethy, D. R. & Hilmer, S. N., Jul 2009, In : British Journal of Clinical Pharmacology. 68, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Cholinergic Antagonists
Independent Living
Hypnotics and Sedatives
Hand Strength

Drug Burden Index Score and Functional Decline in Older People

Hilmer, S. N., Mager, D. E., Simonsick, E. M., Ling, S. M., Windham, B. G., Harris, T. B., Shorr, R. I., Bauer, D. C. & Abernethy, D. R., Dec 2009, In : American Journal of Medicine. 122, 12

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Area Under Curve
Independent Living
Cholinergic Antagonists
Hand Strength

Functional food ingredient quality: Opportunities to improve public health by compendial standardization

Griffiths, J. C., Abernethy, D. R., Schuber, S. & Williams, R. L., Jan 2009, In : Journal of Functional Foods. 1, 1, p. 128-130 3 p.

Research output: Contribution to journalArticle

Food Quality
Functional Food
standardization
functional foods
public health

General chapter management in the 2010-2015 cycle

De Mars, S., Abernethy, D. R., Koch, W. F., Long, A. G., DeStefano, A. J., Williams, R. L., Walsh, P., Anderson, M. K., Caphart, M. E., Chung, C. C., Cimbala, K., Ghate, S. M., Gylys, S., Hickey, D., Lehmann, M. W., Lyon, F. S., Saulter, M. S., Raccasi, D., Sopirak, A. M. & Tscherne, R. J., Sep 2009, In : Pharmacopeial Forum. 35, 5, p. 1372-1379 8 p.

Research output: Contribution to journalArticle

Prescriptions
Direction compound

Heparin monographs further revised

Szajek, A. Y., Morris, T. S., Koch, W. F., Abernethy, D. R. & Williams, R. L., Mar 2009, In : Pharmaceutical Technology. 33, 3, p. 136-137 2 p.

Research output: Contribution to journalArticle

Heparin

Performance-based monographs

Cecil, T. L., Williams, R. L., Abernethy, D. R., Koch, W. F. & Hauck, W. W., May 2009, In : Pharmacopeial Forum. 35, 3, p. 765-771 7 p.

Research output: Contribution to journalArticle

Pharmacopoeias
Availability
Acoustic waves