Daniel Weinberger

Professor

1972 …2020

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2020

Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation

Price, A. J., Hwang, T., Tao, R., Burke, E. E., Rajpurohit, A., Shin, J. H., Hyde, T. M., Kleinman, J. E., Jaffe, A. E. & Weinberger, D. R., Jan 1 2020, In : Genome research. 30, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Burke, E. E., Chenoweth, J. G., Shin, J. H., Collado-Torres, L., Kim, S. K., Micali, N., Wang, Y., Colantuoni, C., Straub, R. E., Hoeppner, D. J., Chen, H. Y., Sellers, A., Shibbani, K., Hamersky, G. R., Diaz Bustamante, M., Phan, B. D. N., Ulrich, W. S., Valencia, C., Jaishankar, A., Price, A. J. & 17 others, Rajpurohit, A., Semick, S. A., Bürli, R. W., Barrow, J. C., Hiler, D. J., Page, S. C., Martinowich, K., Hyde, T. M., Kleinman, J. E., Berman, K. F., Apud, J. A., Cross, A. J., Brandon, N. J., Weinberger, D. R., Maher, B. J., McKay, R. D. G. & Jaffe, A. E., Dec 1 2020, In : Nature communications. 11, 1, 462.

Research output: Contribution to journalArticle

Open Access

KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits

Ren, M., Hu, Z., Chen, Q., Jaffe, A., Li, Y., Sadashivaiah, V., Zhu, S., Rajpurohit, N., Heon Shin, J., Xia, W., Jia, Y., Wu, J., Lang Qin, S., Li, X., Zhu, J., Tian, Q., Paredes, D., Zhang, F., Wang, K. H., Mattay, V. S. & 4 others, Callicott, J. H., Berman, K. F., Weinberger, D. R. & Yang, F., Jan 1 2020, In : Molecular psychiatry. 25, 1, p. 206-229 24 p.

Research output: Contribution to journalArticle

Neural substrates of smoking and reward cue reactivity in smokers: a meta-analysis of fMRI studies

Lin, X., Deng, J., Shi, L., Wang, Q., Li, P., Li, H., Liu, J., Que, J., Chang, S., Bao, Y., Shi, J., Weinberger, D. R., Wu, P. & Lu, L., Dec 1 2020, In : Translational psychiatry. 10, 1, 97.

Research output: Contribution to journalArticle

Open Access

NurR1 and ERR1 modulate the expression of genes of a DRD2 coexpression network enriched for schizophrenia risk

Torretta, S., Rampino, A., Basso, M., Pergola, G., Carlo, P. D., Shin, J. H., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Masellis, R., Blasi, G., Pennuto, M. & Bertolino, A., Jan 22 2020, In : Journal of Neuroscience. 40, 4, p. 932-941 10 p.

Research output: Contribution to journalArticle

Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk

Jaffe, A. E., Hoeppner, D. J., Saito, T., Blanpain, L., Ukaigwe, J., Burke, E. E., Collado-Torres, L., Tao, R., Tajinda, K., Maynard, K. R., Tran, M. N., Martinowich, K., Deep-Soboslay, A., Shin, J. H., Kleinman, J. E., Weinberger, D. R., Matsumoto, M. & Hyde, T. M., Jan 1 2020, (Accepted/In press) In : Nature neuroscience.

Research output: Contribution to journalArticle

The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)-Genetics working group, Mar 20 2020, In : Science. 367, 6484, aay6690.

Research output: Contribution to journalArticle

2019

A Genetics Perspective on the Role of the (Neuro)Immune System in Schizophrenia

Birnbaum, R. & Weinberger, D., Jan 1 2019, In : Schizophrenia Research.

Research output: Contribution to journalArticle

Association of a Schizophrenia-Risk Nonsynonymous Variant with Putamen Volume in Adolescents: A Voxelwise and Genome-Wide Association Study

Luo, Q., Chen, Q., Wang, W., Desrivières, S., Quinlan, E. B., Jia, T., Macare, C., Robert, G. H., Cui, J., Guedj, M., Palaniyappan, L., Kherif, F., Banaschewski, T., Bokde, A. L. W., Büchel, C., Flor, H., Frouin, V., Garavan, H., Gowland, P., Heinz, A. & 24 others, Ittermann, B., Martinot, J. L., Artiges, E., Paillère-Martinot, M. L., Nees, F., Orfanos, D. P., Poustka, L., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Callicott, J. H., Mattay, V. S., Pausova, Z., Dartigues, J. F., Tzourio, C., Crivello, F., Berman, K. F., Li, F., Paus, T., Weinberger, D. R., Murray, R. M., Schumann, G. & Feng, J., Jan 1 2019, (Accepted/In press) In : JAMA psychiatry.

Research output: Contribution to journalArticle

Open Access

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq

The BrainSeq Consortium¶, Jun 2019, In : PloS one. 14, 6, e0217765.

Research output: Contribution to journalArticle

Open Access

Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods

Wright, C., Rajpurohit, A., Burke, E. E., Williams, C., Collado-Torres, L., Kimos, M., Brandon, N. J., Cross, A. J., Jaffe, A. E., Weinberger, D. R. & Shin, J. H., Jun 21 2019, In : BMC genomics. 20, 1, 513.

Research output: Contribution to journalArticle

Open Access

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation

Price, A. J., Collado-Torres, L., Ivanov, N. A., Xia, W., Burke, E. E., Shin, J. H., Tao, R., Ma, L., Jia, Y., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Sep 26 2019, In : Genome biology. 20, 1, 196.

Research output: Contribution to journalArticle

Open Access

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell–derived cortical interneurons from subjects with schizophrenia

Shao, Z., Noh, H., Bin Kim, W., Ni, P., Nguyen, C., Cote, S. E., Noyes, E., Zhao, J., Parsons, T., Park, J. M., Zheng, K., Park, J. J., Coyle, J. T., Weinberger, D., Straub, R. E., Berman, K. F., Apud, J., Ongur, D., Cohen, B. M., McPhie, D. L. & 17 others, Rapoport, J. L., Perlis, R. H., Lanz, T. A., Xi, H. S., Yin, C., Huang, W., Hirayama, T., Fukuda, E., Yagi, T., Ghosh, S., Eggan, K. C., Kim, H. Y., Eisenberg, L. M., Moghadam, A. A., Stanton, P. K., Cho, J. H. & Chung, S., Feb 1 2019, In : Nature neuroscience. 22, 2, p. 229-242 14 p.

Research output: Contribution to journalArticle

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

CommonMind Consortium, The Schizophrenia Working Group of the PsyUniversity of Copenhagenchiatric Genomics Consortium & iPSYCH-GEMS Schizophrenia Working Group, Apr 1 2019, In : Nature genetics. 51, 4, p. 659-674 16 p.

Research output: Contribution to journalArticle

Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., van der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 others, Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C. Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., de Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., van Eijk, K. R., Cavalleri, G. L., van der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B. C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J. J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., van Tol, M. J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J. L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., DeStefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., DeCarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., Nov 1 2019, In : Nature genetics. 51, 11, p. 1624-1636 13 p.

Research output: Contribution to journalArticle

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease

Semick, S. A., Bharadwaj, R. A., Collado-Torres, L., Tao, R., Shin, J. H., Deep-Soboslay, A., Weiss, J. R., Weinberger, D., Hyde, T., Kleinman, J., Jaffe, A. & Mattay, V., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function

Ni, P., Noh, H., Park, G. H., Shao, Z., Guan, Y., Park, J. M., Yu, S., Park, J. S., Coyle, J. T., Weinberger, D., Straub, R. E., Cohen, B. M., McPhie, D. L., Yin, C., Huang, W., Kim, H. Y. & Chung, S., Jan 1 2019, In : Molecular psychiatry.

Research output: Contribution to journalArticle

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain

Clark, M. B., Wrzesinski, T., Garcia, A. B., Hall, N. A. L., Kleinman, J. E., Hyde, T., Weinberger, D. R., Harrison, P. J., Haerty, W. & Tunbridge, E. M., Jan 1 2019, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex

Chronister, W. D., Burbulis, I. E., Wierman, M. B., Wolpert, M. J., Haakenson, M. F., Smith, A. C. B., Kleinman, J., Hyde, T., Weinberger, D., Bekiranov, S. & McConnell, M. J., Jan 22 2019, In : Cell Reports. 26, 4, p. 825-835.e7

Research output: Contribution to journalArticle

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

Lam, M., Hill, W. D., Trampush, J. W., Yu, J., Knowles, E., Davies, G., Stahl, E., Huckins, L., Liewald, D. C., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E. & 48 others, Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Hartmann, A. M., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T., Aug 1 2019, In : American journal of human genetics. 105, 2, p. 334-350 17 p.

Research output: Contribution to journalArticle

Polygenic risk score increases schizophrenia liability through cognition-relevant pathways

Toulopoulou, T., Zhang, X., Cherny, S., Dickinson, D., Berman, K. F., Straub, R. E., Sham, P. & Weinberger, D., Feb 1 2019, In : Brain. 142, 2, p. 471-485 15 p.

Research output: Contribution to journalArticle

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia

Wellcome Trust Case Control Consortium 2 & Schizophrenia Working Group of the Psychiatric Genomics Consortium, Apr 2019, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 180, 3, p. 223-231 9 p.

Research output: Contribution to journalArticle

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients

Pergola, G., Di Carlo, P., Jaffe, A., Papalino, M., Chen, Q., Hyde, T., Kleinman, J., Shin, J. H., Rampino, A., Blasi, G., Weinberger, D. & Bertolino, A., Jan 1 2019, In : Biological psychiatry.

Research output: Contribution to journalArticle

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia

BrainSeq Consortium, Jul 17 2019, In : Neuron. 103, 2, p. 203-216.e8

Research output: Contribution to journalArticle

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19)

The BrainSeq Consortium, Jan 1 2019, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

de Zwarte, S. M. C., Brouwer, R. M., Agartz, I., Alda, M., Aleman, A., Alpert, K. I., Bearden, C. E., Bertolino, A., Bois, C., Bonvino, A., Bramon, E., Buimer, E. E. L., Cahn, W., Cannon, D. M., Cannon, T. D., Caseras, X., Castro-Fornieles, J., Chen, Q., Chung, Y., De la Serna, E. & 71 others, Di Giorgio, A., Doucet, G. E., Eker, M. C., Erk, S., Fears, S. C., Foley, S. F., Frangou, S., Frankland, A., Fullerton, J. M., Glahn, D. C., Goghari, V. M., Goldman, A. L., Gonul, A. S., Gruber, O., de Haan, L., Hajek, T., Hawkins, E. L., Heinz, A., Hillegers, M. H. J., Hulshoff Pol, H. E., Hultman, C. M., Ingvar, M., Johansson, V., Jönsson, E. G., Kane, F., Kempton, M. J., Koenis, M. M. G., Kopecek, M., Krabbendam, L., Krämer, B., Lawrie, S. M., Lenroot, R. K., Marcelis, M., Marsman, J. B. C., Mattay, V. S., McDonald, C., Meyer-Lindenberg, A., Michielse, S., Mitchell, P. B., Moreno, D., Murray, R. M., Mwangi, B., Najt, P., Neilson, E., Newport, J., van Os, J., Overs, B., Ozerdem, A., Picchioni, M. M., Richter, A., Roberts, G., Aydogan, A. S., Schofield, P. R., Simsek, F., Soares, J. C., Sugranyes, G., Toulopoulou, T., Tronchin, G., Walter, H., Wang, L., Weinberger, D. R., Whalley, H. C., Yalin, N., Andreassen, O. A., Ching, C. R. K., van Erp, T. G. M., Turner, J. A., Jahanshad, N., Thompson, P. M., Kahn, R. S. & van Haren, N. E. M., Oct 1 2019, In : Biological psychiatry. 86, 7, p. 545-556 12 p.

Research output: Contribution to journalArticle

Open Access

The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia

The Schizophrenia Working Group of the Psychiatric Genomics Consortium 2, Aug 1 2019, In : Neuropsychopharmacology. 44, 9, p. 1562-1569 8 p.

Research output: Contribution to journalArticle

Open Access
2018

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

Schizophrenia and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Jun 25 2018, In : BMC genomics. 19, 1, 494.

Research output: Contribution to journalArticle

Age at first birth in women is genetically associated with increased risk of schizophrenia

Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F. & 281 others, Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., Dec 1 2018, In : Scientific reports. 8, 1, 10168.

Research output: Contribution to journalArticle

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes

Punzi, G., Ursini, G., Viscanti, G., Radulescu, E., Shin, J. H., Quarto, T., Catanesi, R., Blasi, G., Jaffe, A., Deep-Soboslay, A., Hyde, T., Kleinman, J., Bertolino, A. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups from Widely Available Symptom Data

Dickinson, D., Pratt, D. N., Giangrande, E. J., Grunnagle, M., Orel, J., Weinberger, D., Callicott, J. H. & Berman, K. F., Jan 1 2018, In : Schizophrenia Bulletin. 44, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

Convergence of placenta biology and genetic risk for schizophrenia article

Ursini, G., Punzi, G., Chen, Q., Marenco, S., Robinson, J. F., Porcelli, A., Hamilton, E. G., Mitjans, M., Maddalena, G., Begemann, M., Seidel, J., Yanamori, H., Jaffe, A., Berman, K. F., Egan, M. F., Straub, R. E., Colantuoni, C., Blasi, G., Hashimoto, R., Rujescu, D. & 3 others, Ehrenreich, H., Bertolino, A. & Weinberger, D., Jun 1 2018, In : Nature Medicine. 24, 6, p. 792-801 10 p.

Research output: Contribution to journalArticle

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

The BrainSeq Consortium, Aug 1 2018, In : Nature neuroscience. 21, 8, p. 1117-1125 9 p.

Research output: Contribution to journalArticle

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome

Semick, S. A., Collado-Torres, L., Markunas, C. A., Shin, J. H., Deep-Soboslay, A., Tao, R., Huestis, M. A., Bierut, L. J., Maher, B., Johnson, E. O., Hyde, T., Weinberger, D., Hancock, D. B., Kleinman, J. & Jaffe, A., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Effects of Schizophrenia Polygenic Risk Scores on Brain Activity and Performance during Working Memory Subprocesses in Healthy Young Adults

Miller, J. A., Scult, M. A., Conley, E. D., Chen, Q., Weinberger, D. R. & Hariri, A. R., Jun 6 2018, In : Schizophrenia bulletin. 44, 4, p. 844-853 10 p.

Research output: Contribution to journalArticle

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Wellcome Trust Case Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium, Jun 7 2018, In : American journal of human genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

Tao, R., Davis, K. N., Li, C., Shin, J. H., Gao, Y., Jaffe, A. E., Gondré-Lewis, M. C., Weinberger, D. R., Kleinman, J. E. & Hyde, T. M., Jun 1 2018, In : Molecular psychiatry. 23, 6, p. 1496-1505 10 p.

Research output: Contribution to journalArticle

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia

Boks, M. P., Houtepen, L. C., Xu, Z., He, Y., Ursini, G., Maihofer, A. X., Rajarajan, P., Yu, Q., Xu, H., Wu, Y., Wang, S., Shi, J. P., Hulshoff Pol, H. E., Strengman, E., Rutten, B. P. F., Jaffe, A. E., Kleinman, J. E., Baker, D. G., Hol, E. M., Akbarian, S. & 6 others, Nievergelt, C. M., De Witte, L. D., Vinkers, C. H., Weinberger, D. R., Yu, J. & Kahn, R. S., Dec 1 2018, In : npj Schizophrenia. 4, 1, 16.

Research output: Contribution to journalArticle

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., De Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H. & 97 others, Zabaneh, D., Hägg, S., Hansell, N. K., Karlsson, I. K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., Derosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., Van Der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J. & Posthuma, D., Jul 1 2018, In : Nature genetics. 50, 7, p. 912-919 8 p.

Research output: Contribution to journalArticle

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, Jun 14 2018, In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to journalArticle

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

Radulescu, E., Jaffe, A., Straub, R. E., Chen, Q., Shin, J. H., Hyde, T., Kleinman, J. & Weinberger, D., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

BrainSpan Consortium, PsychENCODE Consortium & PsychENCODE Developmental Subgroup, Dec 14 2018, In : Science. 362, 6420, 1264.

Research output: Contribution to journalArticle

Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)

Reed, J. L., D’Ambrosio, E., Marenco, S., Ursini, G., Zheutlin, A. B., Blasi, G., Spencer, B. E., Romano, R., Hochheiser, J., Reifman, A., Sturm, J., Berman, K. F., Bertolino, A., Weinberger, D. & Callicott, J. H., Apr 1 2018, In : PLoS One. 13, 4, e0195189.

Research output: Contribution to journalArticle

Investigating the neuroimmunogenic architecture of schizophrenia

Birnbaum, R., Jaffe, A. E., Chen, Q., Shin, J. H., Kleinman, J. E., Hyde, T. M. & Weinberger, D. R., May 1 2018, In : Molecular psychiatry. 23, 5, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F., Vermetten, E., Vinkers, C. H., Ursini, G., Daskalakis, N. P., Pishva, E., De Nijs, L., Houtepen, L. C., Eijssen, L., Jaffe, A. E., Kenis, G., Viechtbauer, W., Van Den Hove, D., Schraut, K. G., Lesch, K. P., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Schalkwyk, L., Lunnon, K. & 8 others, Mill, J., Cohen, H., Yehuda, R., Baker, D. G., Maihofer, A. X., Nievergelt, C. M., Geuze, E. & Boks, M. P. M., May 1 2018, In : Molecular psychiatry. 23, 5, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Multi-Trait analysis of gwas and biological insights into cognition: A response to hill (2018)

Lam, M., Trampush, J. W., Yu, J., Knowles, E., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., Derosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Roussos, P. & 41 others, Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Hellard, S. L., Keller, M. C., Andreassen, O. A., Glahn, D. C., Malhotra, A. K. & Lencz, T., Oct 1 2018, In : Twin Research and Human Genetics. 21, 5, p. 394-397 4 p.

Research output: Contribution to journalArticle

Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening

Bürli, R. W., Wei, H., Ernst, G., Mariga, A., Hardern, I. M., Herlihy, K., Cross, A. J., Wesolowski, S. S., Chen, H., McKay, R. D. G., Weinberger, D., Brandon, N. J. & Barrow, J., Oct 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 19, p. 3231-3235 5 p.

Research output: Contribution to journalArticle

Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition

Marenco, S., Meyer, C., van der Veen, J. W., Zhang, Y., Kelly, R., Shen, J., Weinberger, D., Dickinson, D. & Berman, K. F., Oct 1 2018, In : Neuropsychopharmacology. 43, 11, p. 2285-2291 7 p.

Research output: Contribution to journalArticle

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity

Chen, Q., Ursini, G., Romer, A. L., Knodt, A. R., Mezeivtch, K., Xiao, E., Pergola, G., Blasi, G., Straub, R. E., Callicott, J. H., Berman, K. F., Hariri, A. R., Bertolino, A., Mattay, V. & Weinberger, D., Apr 1 2018, In : Brain. 141, 4, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S. & 201 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2018, In : Nature communications. 9, 1, 2098.

Research output: Contribution to journalArticle