Daniel Weinberger

Research output

Research output per year 1972 1990 1992 1993 1994 1995 1996 1997 1998 1999 2000 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2016 2017 2018 2019 2020 2023

• 877 Article
• 80 Review article
• 55 Letter
• 37 Comment/debate
• 34 More
  • 11 Editorial
  • 6 Chapter
  • 6 Short survey
  • 4 Conference contribution
  • 4 Foreword/postscript
  • 2 Paper
  • 1 Book

Research output per year

Research output per year

Search results

• 2023

  Associations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex

  Matosin, N., Arloth, J., Czamara, D., Edmond, K. Z., Maitra, M., Fröhlich, A. S., Martinelli, S., Kaul, D., Bartlett, R., Curry, A. R., Gassen, N. C., Hafner, K., Müller, N. S., Worf, K., Rehawi, G., Nagy, C., Halldorsdottir, T., Cruceanu, C., Gagliardi, M., Gerstner, N., & 16 othersKödel, M., Murek, V., Ziller, M. J., Scarr, E., Tao, R., Jaffe, A. E., Arzberger, T., Falkai, P., Kleinmann, J. E., Weinberger, D. R., Mechawar, N., Schmitt, A., Dean, B., Turecki, G., Hyde, T. M. & Binder, E. B., Apr 2023, In: Acta neuropathologica. 145, 4, p. 439-459 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neocortex 100%
  • Mental Disorders 72%
  • Neurons 55%
  • Messenger RNA 43%
  • RNA Sequence Analysis 42%

• Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia (Nature Neuroscience, (2021), 24, 2, (186-196), 10.1038/s41593-020-00767-4)

  Brain Somatic Mosaicism Network, Oct 2023, In: Nature neuroscience. 26, 10, p. 1833 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Mosaicism 100%
  • Machine Learning 91%
  • Neurosciences 86%
  • Neuroglia 71%
  • Neurons 50%

• Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing (Nature Neuroscience, (2021), 24, 2, (176-185), 10.1038/s41593-020-00765-6)

  Rodin, R. E., Dou, Y., Kwon, M., Sherman, M. A., D’Gama, A. M., Doan, R. N., Rento, L. M., Girskis, K. M., Bohrson, C. L., Kim, S. N., Nadig, A., Luquette, L. J., Gulhan, D. C., Walsh, C. A., Ganz, J., Woodworth, M. B., Li, P., Rodin, R. E., Hill, R. S., Bizzotto, S., & 86 othersZhou, Z., Lee, E. A., Barton, A. R., D’Gama, A. M., Galor, A., Bohrson, C. L., Kwon, D., Gulhan, D. C., Lim, E. T., Cortes, I. C., Luquette, L. J., Sherman, M. A., Coulter, M. E., Lodato, M. A., Park, P. J., Monroy, R. B., Kim, S. N., Dou, Y., Chess, A., Gulyás-Kovács, A., Rosenbluh, C., Akbarian, S., Ben Langmead, L., Thorpe, J., Pevsner, J., Cho, S., Jaffe, A. E., Paquola, A., Weinberger, D. R., Erwin, J. A., Shin, J. H., Straub, R. E., Narurkar, R., Abyzov, A. S., Bae, T., Addington, A., Panchision, D., Meinecke, D., Senthil, G., Bingaman, L., Dutka, T., Lehner, T., Saucedo-Cuevas, L., Conniff, T., Daily, K., Peters, M., Gage, F. H., Wang, M., Reed, P. J., Linker, S. B., Urban, A. E., Zhou, B., Zhu, X., Serres, A., Juan, D., Povolotskaya, I., Lobón, I., Solis-Moruno, M., García-Pérez, R., Marquès-Bonet, T., Mathern, G. W., Gu, J., Gleeson, J. G., Ball, L. L., George, R. D., Pramparo, T., Flasch, D. A., Frisbie, T. J., Kidd, J. M., Moldovan, J. B., Moran, J. V., Kwan, K. Y., Mills, R. E., Emery, S. B., Zhou, W., Wang, Y., Ratan, A., McConnell, M. J., Vaccarino, F. M., Coppola, G., Lennington, J. B., Fasching, L., Sestan, N., Pochareddy, S., Park, P. J. & Walsh, C. A., Oct 2023, In: Nature neuroscience. 26, 10, p. 1833 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Mosaicism 100%
  • Whole Genome Sequencing 94%
  • Neurosciences 86%
  • Cerebral Cortex 75%
  • Mutation 45%

• Changes in patterns of age-related network connectivity are associated with risk for schizophrenia

  Apulian Network On Risk For Psychosis, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 32, e2221533120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Siblings 42%
  • Magnetic Resonance Imaging 30%
  • Brain 15%
  • Direction compound 11%

• Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review

  Hoffman, G. E., Jaffe, A. E., Gandal, M. J., Collado-Torres, L., Sieberts, S. K., Devlin, B., Geschwind, D. H., Weinberger, D. R. & Roussos, P., Feb 2023, In: Molecular psychiatry. 28, 2, p. 523-525 3 p.

  Research output: Contribution to journal › Letter › peer-review

• Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

  Focal Cortical Dysplasia Neurogenetics Consortium & Brain Somatic Mosaicism Network, Feb 1 2023, In: Nature genetics. 55, 2, p. 209-220 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Malformations of Cortical Development 100%
  • Mutation 41%
  • Brain 36%
  • Genes 22%
  • Exome 22%

• Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions

  Pergola, G., Parihar, M., Sportelli, L., Bharadwaj, R., Borcuk, C., Radulescu, E., Bellantuono, L., Blasi, G., Chen, Q., Kleinman, J. E., Wang, Y., Sripathy, S. R., Maher, B., Monaco, A., Rossi, F., Shin, J. H., Hyde, T., Bertolino, A. & Weinberger, D., Apr 2023, In: Science Advances. 9, 15, eade2812.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Consensus 100%
  • Schizophrenia 85%
  • Brain 51%
  • Genes 42%
  • Neurodevelopmental Disorders 15%

• Control-independent mosaic single nucleotide variant detection with DeepMosaic

  NIMH Brain Somatic Mosaicism Network, Jun 2023, In: Nature biotechnology. 41, 6, p. 870-877 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Classifier 100%
  • Nucleotides 90%
  • Genomics 75%
  • Biological Property 70%
  • Nucleotide 60%

• Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance

  Managò, F., Scheggia, D., Pontillo, M., Mereu, M., Mastrogiacomo, R., Udayan, G., Valentini, P., Tata, M. C., Weinberger, D. R., Weickert, C. S., Pompa, P. P., De Luca, M. A., Vicari, S. & Papaleo, F., Oct 2023, In: British Journal of Pharmacology. 180, 19, p. 2514-2531 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Dysbindin 100%
  • DiGeorge Syndrome 80%
  • Dopamine 73%
  • Genetic Testing 60%
  • Behavioral Genetics 41%

• Erratum: A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan (Cell Stem Cell (2022) 29(11) (1594–1610.e8), (S1934590922004180), (10.1016/j.stem.2022.09.010))

  Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles-Cordon, M., Lu, L., Huh, S., Jimenez-Cyrus, D., Kennedy, B. C., Kessler, S. K., Viaene, A. N., Helbig, I., Gu, X., Kleinman, J. E., Hyde, T., Weinberger, D. R., Nauen, D. W., Song, H. & Ming, G. L., Jan 5 2023, In: Cell stem cell. 30, 1, p. 113 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Atlases 100%
  • Transcriptome 85%
  • Longevity 83%
  • Neuroglia 82%
  • Hippocampus 74%

• Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases

  Garrison, M. K. A., Jang, Y., Bae, T., Cherskov, A., Emery, S. B., Fasching, L., Jones, A., Moldovan, J. B., Molitor, C., Pochareddy, S., Peters, M. A., Shin, J. H., Wang, Y., Yang, X., Akbarian, S., Chess, A., Gage, F. H., Gleeson, J. G., Kidd, J. M., McConnell, M., & 75 othersMills, R. E., Moran, J. V., Park, P. J., Sestan, N., Urban, A. E., Vaccarino, F. M., Walsh, C. A., Weinberger, D. R., Wheelan, S. J., Abyzov, A., Amero, A. S., Antaki, D., Averbuj, D., Ball, L., Bizzotto, S., Bohrson, C., Borges-Monroy, R., Breuss, M., Cho, S., Chu, C., Chung, C., Cortes-Ciriano, I., Coulter, M., Daily, K., Dias, C., D’Gama, A., Dou, Y., Erwin, J., Flasch, D. A., Frisbie, T. J., Galor, A., Ganz, J., Gulhan, D., Hill, R., Huang, A. Y., Jaffe, A., Jourdon, A., Juan, D., Khoshkhoo, S., Kim, S., Kopera, H. C., Kwan, K. Y., Kwon, M., Langmead, B., Lee, E. A., Linker, S., Lobon, I., Lodato, M. A., Luquette, L. J., Mathern, G., Marques-Bonet, T., Maury, E. A., Miller, M., Moruno, M. S., Narurkar, R., Paquola, A., Pattni, R., Perez, R. G., Povolotskaya, I., Reed, P., Rodin, R., Rosenbluh, C., Scuderi, S., Sherman, M., Straub, R., Soriano, E., Sun, C., Thorpe, J., Viswanadham, V., Wang, M., Zhao, X., Zhou, B., Zhou, W., Zhou, Z. & Zhu, X., Dec 2023, In: Scientific Data. 10, 1, 813.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genomics 100%
  • Brain 92%
  • Resources 79%
  • brain 72%
  • Disorder 48%

• Investigating trait variability of gene coexpression network architecture in brain by controlling for genomic risk of schizophrenia

  Radulescu, E., Chen, Q., Pergola, G., Di Carlo, P., Han, S., Shin, J. H., Hyde, T. M., Kleinman, J. E. & Weinberger, D. R., Oct 13 2023, In: PLoS genetics. 19, 10, e1010989.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • gene regulatory networks 80%
  • Gene Regulatory Networks 78%
  • genomics 72%
  • brain 65%

• Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue

  Türker, F., Bharadwaj, R. A., Kleinman, J. E., Weinberger, D., Hyde, T. M., White, C. J., Williams, D. & Margolis, S. S., Jun 2023, In: Journal of Biological Chemistry. 299, 6, 104811.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteasome Endopeptidase Complex 100%
  • Brain 46%
  • Alzheimer Disease 14%
  • Macromolecular Substances 13%
  • Parahippocampal Gyrus 11%

• Prioritization of potential causative genes for schizophrenia in placenta

  Ursini, G., Di Carlo, P., Mukherjee, S., Chen, Q., Han, S., Kim, J., Deyssenroth, M., Marsit, C. J., Chen, J., Hao, K., Punzi, G. & Weinberger, D. R., Dec 2023, In: Nature communications. 14, 1, 2613.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • genes 68%
  • Placenta 54%
  • Disorder 50%
  • Schizophrenia 47%

• Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions

  Brain Somatic Mosaicism Network & Psychiatric Genomic Consortium Schizophrenia and CNV workgroup, Aug 9 2023, In: Cell Genomics. 3, 8, 100356.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antipsychotic 100%
  • Filtration 57%
  • Disorder 57%
  • Schizophrenia 54%
  • Exons 11%

• Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

  Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stanley Global Asia Initiatives, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium, May 19 2023, In: iScience. 26, 5, 106701.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Brain 60%
  • Proteins 45%
  • Genes 28%
  • Neurons 21%
• 2022

  A BIOLOGICALLY INTERPRETABLE GRAPH CONVOLUTIONAL NETWORK TO LINK GENETIC RISK PATHWAYS AND NEUROIMAGING MARKERS OF DISEASE

  Ghosal, S., Chen, Q., Pergola, G., Goldman, A. L., Ulrich, W., Weinberger, D. R. & Venkataraman, A., 2022.

  Research output: Contribution to conference › Paper › peer-review

  • Genetic Risk 100%
  • Neuroimaging 79%
  • Graph 62%
  • Imaging 62%
  • Pathway 54%

• Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways

  Zandi, P. P., Jaffe, A. E., Goes, F. S., Burke, E. E., Collado-Torres, L., Huuki-Myers, L., Seyedian, A., Lin, Y., Seifuddin, F., Pirooznia, M., Ross, C. A., Kleinman, J. E., Weinberger, D. R. & Hyde, T. M., Mar 2022, In: Nature neuroscience. 25, 3, p. 381-389 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gyrus Cinguli 100%
  • Amygdala 96%
  • Bipolar Disorder 93%
  • Transcriptome 89%
  • Down-Regulation 67%

• Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability

  Brain Somatic Mosaicism Network, Jul 9 2022, In: Science. 377, 6605, p. 511-517 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Autistic Disorder 89%
  • Brain 87%
  • Transcription Factors 44%
  • Virus Integration 40%

• Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes

  The BrainSeq Consortium, Nov 2022, In: Nature neuroscience. 25, 11, p. 1559-1568 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Caudate Nucleus 100%
  • Transcriptome 79%
  • Antipsychotic Agents 78%
  • Schizophrenia 70%
  • Genes 34%

• A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan

  Su, Y., Zhou, Y., Bennett, M. L., Li, S., Carceles-Cordon, M., Lu, L., Huh, S., Jimenez-Cyrus, D., Kennedy, B. C., Kessler, S. K., Viaene, A. N., Helbig, I., Gu, X., Kleinman, J. E., Hyde, T. M., Weinberger, D. R., Nauen, D. W., Song, H. & Ming, G. L., Nov 3 2022, In: Cell stem cell. 29, 11, p. 1594-1610.e8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atlases 100%
  • Transcriptome 85%
  • Longevity 83%
  • Neuroglia 82%
  • Hippocampus 74%

• Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders

  Zhou, J., Chen, Q., Braun, P. R., Perzel Mandell, K. A., Jaffe, A. E., Tan, H. Y., Hyde, T. M., Kleinman, J. E., Potash, J. B., Shinozaki, G., Weinberger, D. R. & Han, S., Aug 23 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 34, e2206069119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • DNA Methylation 71%
  • Inborn Genetic Diseases 67%
  • Mental Disorders 59%
  • Quantitative Trait Loci 45%

• Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

  Page, S. C., Sripathy, S. R., Farinelli, F., Ye, Z., Wang, Y., Hiler, D. J., Pattie, E. A., Nguyen, C. V., Tippani, M., Moses, R. L., Chen, H. Y., Tran, M. N., Eagles, N. J., Stolz, J. M., Catallini, J. L., Soudry, O. R., Dickinson, D., Berman, K. F., Apud, J. A., Weinberger, D. R., & 4 othersMartinowich, K., Jaffe, A. E., Straub, R. E. & Maher, B. J., Jan 18 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 3, e2109395119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Induced Pluripotent Stem Cells 92%
  • Neurons 75%
  • gamma-Aminobutyric Acid 39%
  • Synaptic Transmission 38%

• Genetics and Brain Transcriptomics of Completed Suicide

  Punzi, G., Ursini, G., Chen, Q., Radulescu, E., Tao, R., Huuki, L. A., Di Carlo, P., Collado-Torres, L., Heon Shin, J., Catanesi, R., Jaffe, A. E., Hyde, T. M., Kleinman, J. E., Mackay, T. F. C. & Weinberger, D. R., Mar 2022, In: American Journal of Psychiatry. 179, 3, p. 226-241 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Completed Suicide 100%
  • Suicide 64%
  • Brain 34%
  • Mental Disorders 21%
  • Metabolic Activation 10%

• Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

  Lahti, J., Tuominen, S., Yang, Q., Pergola, G., Ahmad, S., Amin, N., Armstrong, N. J., Beiser, A., Bey, K., Bis, J. C., Boerwinkle, E., Bressler, J., Campbell, A., Campbell, H., Chen, Q., Corley, J., Cox, S. R., Davies, G., De Jager, P. L., Derks, E. M., & 103 othersFaul, J. D., Fitzpatrick, A. L., Fohner, A. E., Ford, I., Fornage, M., Gerring, Z., Grabe, H. J., Grodstein, F., Gudnason, V., Simonsick, E., Holliday, E. G., Joshi, P. K., Kajantie, E., Kaprio, J., Karell, P., Kleineidam, L., Knol, M. J., Kochan, N. A., Kwok, J. B., Leber, M., Lam, M., Lee, T., Li, S., Loukola, A., Luck, T., Marioni, R. E., Mather, K. A., Medland, S., Mirza, S. S., Nalls, M. A., Nho, K., O’Donnell, A., Oldmeadow, C., Painter, J., Pattie, A., Reppermund, S., Risacher, S. L., Rose, R. J., Sadashivaiah, V., Scholz, M., Satizabal, C. L., Schofield, P. W., Schraut, K. E., Scott, R. J., Simino, J., Smith, A. V., Smith, J. A., Stott, D. J., Surakka, I., Teumer, A., Thalamuthu, A., Trompet, S., Turner, S. T., van der Lee, S. J., Villringer, A., Völker, U., Wilson, R. S., Wittfeld, K., Vuoksimaa, E., Xia, R., Yaffe, K., Yu, L., Zare, H., Zhao, W., Ames, D., Attia, J., Bennett, D. A., Brodaty, H., Chasman, D. I., Goldman, A. L., Hayward, C., Ikram, M. A., Jukema, J. W., Kardia, S. L. R., Lencz, T., Loeffler, M., Mattay, V. S., Palotie, A., Psaty, B. M., Ramirez, A., Ridker, P. M., Riedel-Heller, S. G., Sachdev, P. S., Saykin, A. J., Scherer, M., Schofield, P. R., Sidney, S., Starr, J. M., Trollor, J., Ulrich, W., Wagner, M., Weir, D. R., Wilson, J. F., Wright, M. J., Weinberger, D. R., Debette, S., Eriksson, J. G., Mosley, T. H., Launer, L. J., van Duijn, C. M., Deary, I. J., Seshadri, S. & Räikkönen, K., Nov 2022, In: Molecular psychiatry. 27, 11, p. 4419-4431 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Short-Term Memory 100%
  • Verbal Learning 93%
  • Meta-Analysis 79%
  • Learning 77%
  • Memory 77%

• Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

  de Zwarte, S. M. C., Brouwer, R. M., Agartz, I., Alda, M., Alonso-Lana, S., Bearden, C. E., Bertolino, A., Bonvino, A., Bramon, E., Buimer, E. E. L., Cahn, W., Canales-Rodríguez, E. J., Cannon, D. M., Cannon, T. D., Caseras, X., Castro-Fornieles, J., Chen, Q., Chung, Y., De la Serna, E., del Mar Bonnin, C., & 82 othersDemro, C., Di Giorgio, A., Doucet, G. E., Eker, M. C., Erk, S., Fatjó-Vilas, M., Fears, S. C., Foley, S. F., Frangou, S., Fullerton, J. M., Glahn, D. C., Goghari, V. M., Goikolea, J. M., Goldman, A. L., Gonul, A. S., Gruber, O., Hajek, T., Hawkins, E. L., Heinz, A., Hidiroglu Ongun, C., Hillegers, M. H. J., Houenou, J., Hulshoff Pol, H. E., Hultman, C. M., Ingvar, M., Johansson, V., Jönsson, E. G., Kane, F., Kempton, M. J., Koenis, M. M. G., Kopecek, M., Krämer, B., Lawrie, S. M., Lenroot, R. K., Marcelis, M., Mattay, V. S., McDonald, C., Meyer-Lindenberg, A., Michielse, S., Mitchell, P. B., Moreno, D., Murray, R. M., Mwangi, B., Nabulsi, L., Newport, J., Olman, C. A., van Os, J., Overs, B. J., Ozerdem, A., Pergola, G., Picchioni, M. M., Piguet, C., Pomarol-Clotet, E., Radua, J., Ramsay, I. S., Richter, A., Roberts, G., Salvador, R., Saricicek Aydogan, A., Sarró, S., Schofield, P. R., Simsek, E. M., Simsek, F., Soares, J. C., Sponheim, S. R., Sugranyes, G., Toulopoulou, T., Tronchin, G., Vieta, E., Walter, H., Weinberger, D. R., Whalley, H. C., Wu, M. J., Yalin, N., Andreassen, O. A., Ching, C. R. K., Thomopoulos, S. I., van Erp, T. G. M., Jahanshad, N., Thompson, P. M., Kahn, R. S. & van Haren, N. E. M., Jan 2022, In: Human Brain Mapping. 43, 1, p. 414-430 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intelligence 100%
  • Bipolar Disorder 91%
  • Schizophrenia 76%
  • Brain 46%
  • Cognitive Dysfunction 11%

• It's Dopamine and Schizophrenia All Over Again

  Weinberger, D. R., Nov 15 2022, In: Biological psychiatry. 92, 10, p. 757-759 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Mapping genomic loci implicates genes and synaptic biology in schizophrenia

  PsychENCODE, Psychosis Endophenotypes International Consortium, The SynGO Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Indonesia Schizophrenia Consortium, Apr 21 2022, In: Nature. 604, 7906, p. 502-508 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Neurodevelopmental Disorders 57%
  • Genes 49%
  • Untranslated Regions 33%
  • Glutamate Receptors 27%

• Molecular landscapes of human hippocampal immature neurons across lifespan

  Zhou, Y., Su, Y., Li, S., Kennedy, B. C., Zhang, D. Y., Bond, A. M., Sun, Y., Jacob, F., Lu, L., Hu, P., Viaene, A. N., Helbig, I., Kessler, S. K., Lucas, T., Salinas, R. D., Gu, X., Chen, H. I., Wu, H., Kleinman, J. E., Hyde, T. M., & 4 othersNauen, D. W., Weinberger, D. R., Ming, G. L. & Song, H., Jul 21 2022, In: Nature. 607, 7919, p. 527-533 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Longevity 100%
  • Neurons 68%
  • Hippocampus 33%
  • Neurogenesis 29%
  • Alzheimer Disease 21%

• Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus

  Perzel Mandell, K. A., Eagles, N. J., Deep-Soboslay, A., Tao, R., Han, S., Wilton, R., Szalay, A. S., Hyde, T. M., Kleinman, J. E., Jaffe, A. E. & Weinberger, D. R., Apr 2022, In: Molecular psychiatry. 27, 4, p. 2061-2067 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Caudate Nucleus 100%
  • Antipsychotic Agents 78%
  • Phenotype 51%
  • Gene Expression 51%
  • DNA Methylation 34%

• Replicating G × E: The Devil and the Details

  Ursini, G. & Weinberger, D. R., Jan 1 2022, In: Schizophrenia bulletin. 48, 1, p. 4 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

  iPSYCH, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, Jan 1 2022, In: Biological psychiatry. 91, 1, p. 102-117 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psychotic Affective Disorders 100%
  • Schizophrenia 56%
  • Bipolar Disorder 45%
  • Genotype 41%
  • Genome 23%

• Somatic mosaicism reveals clonal distributions of neocortical development

  NIMH Brain Somatic Mosaicism Network, Apr 28 2022, In: Nature. 604, 7907, p. 689-696 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mosaicism 100%
  • Brain 39%
  • Clone Cells 32%
  • Neocortex 30%
  • Rhombencephalon 16%

• To Model Developmental Risk in a Dish

  Erwin, J. & Weinberger, D. R., May 2022, In: American Journal of Psychiatry. 179, 5, p. 319-321 3 p.

  Research output: Contribution to journal › Review article › peer-review

• Variation in TAF1 Expression in Female Carrier-Induced Pluripotent Stem Cells and Human Brain Ontogeny Has Implications for Adult Neostriatum Vulnerability in X-Linked Dystonia Parkinsonism

  D’ignazio, L., Jacomini, R. S., Qamar, B., Benjamin, K. J. M., Arora, R., Sawada, T., Evans, T. A., Diffenderfer, K. E., Pankonin, A. R., Hendriks, W. T., Hyde, T. M., Kleinman, J. E., Weinberger, D. R., Bragg, D. C., Paquola, A. C. M. & Erwin, J. A., Jul 1 2022, In: eNeuro. 9, 4, ENEURO.0129-22.2022.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dystonia 3, Torsion, X-Linked 100%
  • Neostriatum 72%
  • Induced Pluripotent Stem Cells 59%
  • Brain 25%
  • Short Interspersed Nucleotide Elements 21%
• 2021

  A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

  Schizophrenia Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Nov 1 2021, In: Biological psychiatry. 90, 9, p. 611-620 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mental Disorders 100%
  • Schizophrenia 42%
  • Genetic Models 39%
  • Statistics 27%
  • Genome-Wide Association Study 18%

• A generative-discriminative framework that integrates imaging, genetic, and diagnosis into coupled low dimensional space

  Ghosal, S., Chen, Q., Pergola, G., Goldman, A. L., Ulrich, W., Berman, K. F., Blasi, G., Fazio, L., Rampino, A., Bertolino, A., Weinberger, D. R., Mattay, V. S. & Venkataraman, A., Sep 2021, In: NeuroImage. 238, 118200.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biomarkers 100%
  • Schizophrenia 62%
  • Disease Vectors 56%
  • Genetic Vectors 50%
  • Support Vector Machine 46%

• Air pollution interacts with genetic risk to influence cortical networks implicated in depression

  Li, Z., Yan, H., Zhang, X., Shah, S., Yang, G., Chen, Q., Han, S., Zhang, D., Weinberger, D. R., Yue, W. & Tan, H. Y., Nov 16 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 46, e2109310118.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Air Pollution 100%
  • Brain 42%
  • Gene-Environment Interaction 21%
  • Particulate Matter 20%
  • Psychology Transfer 20%

• A polygenic resilience score moderates the genetic risk for schizophrenia

  The Schizophrenia Working Group of the Psychiatric Genomics Consortium & Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Mar 1 2021, In: Molecular psychiatry. 26, 3, p. 800-815 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Schizophrenia 100%
  • Disease Resistance 32%
  • Penetrance 28%
  • Genomics 24%
  • Psychiatry 18%
  6 Scopus citations

• Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing (Nature Neuroscience, (2021), 24, 2, (176-185), 10.1038/s41593-020-00765-6)

  Brain Somatic Mosaicism Network, Apr 1 2021, In: Nature neuroscience. 24, 4, p. 611 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • Whole Genome Sequencing 100%
  • Neurosciences 92%
  • Cerebral Cortex 79%
  • Mutation 48%
  • Reactive Oxygen Species 34%

• Childhood urbanicity interacts with polygenic risk for depression to affect stress-related medial prefrontal function

  Zhang, X., Yan, H., Yu, H., Zhao, X., Shah, S., Dong, Z., Yang, G., Zhang, X., Muse, T., Li, J., Jiang, S., Liao, J., Zhang, Y., Chen, Q., Weinberger, D. R., Yue, W., Zhang, D. & Tan, H. Y., Dec 2021, In: Translational psychiatry. 11, 1, 522.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prefrontal Cortex 86%
  • Behavioral Genetics 53%
  • Anxiety 27%
  • Magnetic Resonance Imaging 25%
  • Urbanization 24%

• Comprehensive identification of somatic nucleotide variants in human brain tissue

  Brain Somatic Mosaicism Network, Dec 2021, In: Genome biology. 22, 1, 92.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • brain 100%
  • DNA 90%
  • Nucleotides 88%
  • tissue 78%
  • nucleotides 77%

• Cortical cellular diversity and development in schizophrenia

  Price, A. J., Jaffe, A. E. & Weinberger, D. R., Jan 2021, In: Molecular psychiatry. 26, 1, p. 203-217 15 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Schizophrenia 100%
  • Brain 60%
  • Epigenome 38%
  • Transcriptome 28%
  • Genes 12%

• Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity

  Clifton, N. E., Collado-Torres, L., Burke, E. E., Pardiñas, A. F., Harwood, J. C., Di Florio, A., Walters, J. T. R., Owen, M. J., O'Donovan, M. C., Weinberger, D. R., Holmans, P. A., Jaffe, A. E. & Hall, J., Sep 15 2021, In: Biological psychiatry. 90, 6, p. 399-408 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cations 100%
  • Psychiatry 73%
  • Calcium Channels 64%
  • Bipolar Disorder 57%
  • Schizophrenia 48%

• Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium

  Schizophrenia Working Group of the Psychiatric Genomics Consortium, May 2021, In: Journal of Psychiatric Research. 137, p. 215-224 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Genomics 100%
  • Schizophrenia 80%
  • Psychiatry 73%
  • Smoking 71%
  • Genome 67%

• Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

  Perzel Mandell, K. A., Eagles, N. J., Wilton, R., Price, A. J., Semick, S. A., Collado-Torres, L., Ulrich, W. S., Tao, R., Han, S., Szalay, A. S., Hyde, T. M., Kleinman, J. E., Weinberger, D. R. & Jaffe, A. E., Dec 1 2021, In: Nature communications. 12, 1, 5251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • methylation 92%
  • sequencing 79%
  • genome 76%
  • Quantitative Trait Loci 73%

• G-MIND: An end-to-end multimodal imaging-genetics framework for biomarker identification and disease classification

  Ghosal, S., Chen, Q., Pergola, G., Goldman, A. L., Ulrich, W., Berman, K. F., Blasi, G., Fazio, L., Rampino, A., Bertolino, A., Weinberger, D. R., Mattay, V. S. & Venkataraman, A., 2021, Medical Imaging 2021: Image Processing. Isgum, I. & Landman, B. A. (eds.). SPIE, 115960C. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11596).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Genetics 100%
  • biomarkers 99%
  • Multimodal Imaging 98%
  • Biomarkers 92%
  • Classifier 67%

• Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

  Lam, M., Chen, C. Y., Ge, T., Xia, Y., Hill, D. W., Trampush, J. W., Yu, J., Knowles, E., Davies, G., Stahl, E. A., Huckins, L., Liewald, D. C., Djurovic, S., Melle, I., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., & 51 othersRäikkönen, K., Widen, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Hartmann, A. M., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Koltai, D. C., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Smyrnis, N., Bilder, R. M., Freimer, N. B., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Huang, H., Liu, C., Malhotra, A. K. & Lencz, T., Sep 2021, In: Neuropsychopharmacology. 46, 10, p. 1788-1801 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nootropic Agents 100%
  • Genome-Wide Association Study 74%
  • Cheminformatics 38%
  • Genes 28%
  • Cognition 18%

• Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective

  De Los Angeles, A., Fernando, M. B., Hall, N. A. L., Brennand, K. J., Harrison, P. J., Maher, B. J., Weinberger, D. R. & Tunbridge, E. M., Sep 15 2021, In: Biological psychiatry. 90, 6, p. 362-372 11 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Psychiatry 65%
  • Study Guides 21%
  • Research Personnel 20%
  • Phenotype 17%

• Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

  Brain Somatic Mosaicism Network, Feb 1 2021, In: Nature neuroscience. 24, 2, p. 186-196 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Machine Learning 100%
  • Neuroglia 78%
  • Neurons 54%
  • Brain 43%
  • Retroelements 29%
  1 Scopus citations