Daniel Laheru

Professor

1992 …2019
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Research Output 1992 2019

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2019

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer

Walsh, N., Zhang, H., Hyland, P. L., Yang, Q., Mocci, E., Zhang, M., Childs, E. J., Collins, I., Wang, Z., Arslan, A. A., Beane-Freeman, L., Bracci, P. M., Brennan, P., Canzian, F., Duell, E. J., Gallinger, S., Giles, G. G., Goggins, M., Goodman, G. E., Goodman, P. J. & 78 others, Hung, R. J., Kooperberg, C., Kurtz, R. C., Malats, N., Lemarchand, L., Neale, R. E., Olson, S. H., Scelo, G., Shu, X. O., Van Den Eeden, S. K., Visvanathan, K., White, E., Zheng, W., Albanes, D., Andreotti, G., Babic, A., Bamlet, W. R., Berndt, S. I., Borgida, A., Boutron-Ruault, M. C., Brais, L., Bueno-De-Mesquita, B., Buring, J., Chaffee, K. G., Chanock, S., Cleary, S., Cotterchio, M., Foretova, L., Fuchs, C., M Gaziano, J. M., Giovannucci, E., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Janout, V., Klein, E. A., Laheru, D., Lee, I. M., Lu, L., Mannisto, S., Milne, R. L., Oberg, A. L., Orlow, I., Patel, A. V., Peters, U., Porta, M., Real, F. X., Rothman, N., Sesso, H. D., Severi, G., Silverman, D., Strobel, O., Sund, M., Thornquist, M. D., Tobias, G. S., Wactawski-Wende, J., Wareham, N., Weiderpass, E., Wentzensen, N., Wheeler, W., Yu, H., Zeleniuch-Jacquotte, A., Kraft, P., Li, D., Jacobs, E. J., Petersen, G. M., Wolpin, B. M., Risch, H. A., Amundadottir, L. T., Yu, K., Klein, A. P. & Stolzenberg-Solomon, R. Z., Jun 1 2019, In : Journal of the National Cancer Institute. 111, 6, p. 557-567 11 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pancreatic Neoplasms
Genes
Single Nucleotide Polymorphism
Adenocarcinoma

Circulating tumor DNA as a clinical test in resected pancreatic cancer

Groot, V. P., Mosier, S., Javed, A. A., Teinor, J. A., Gemenetzis, G., Ding, D., Haley, L. M., Yu, J., Burkhart, R. A., Hasanain, A., Debeljak, M., Kamiyama, H., Narang, A., Laheru, D. A., Zheng, L., Lin, M. T., Gocke, C. D., Fishman, E. K., Hruban, R. H., Goggins, M. G. & 7 others, Quintus Molenaar, I., Cameron, J. L., Weiss, M. J., Velculescu, V. E., He, J., Wolfgang, C. L. & Eshleman, J. R., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 4973-4984 12 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA
Neoplasms
Adenocarcinoma
Recurrence

Effect of Gemcitabine and nab-Paclitaxel with or Without Hydroxychloroquine on Patients with Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial

Karasic, T. B., O'Hara, M. H., Loaiza-Bonilla, A., Reiss, K. A., Teitelbaum, U. R., Borazanci, E., De Jesus-Acosta, A., Redlinger, C., Burrell, J. A., Laheru, D., Von Hoff, D. D., Amaravadi, R. K., Drebin, J. A. & O'Dwyer, P. J., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

gemcitabine
Hydroxychloroquine
Pancreatic Neoplasms
Randomized Controlled Trials
Sulfates

Immune-related adverse events requiring hospitalization: Spectrum of toxicity, treatment, and outcomes

Balaji, A., Zhang, J., Wills, B., Marrone, K., Elmariah, H., Yarchoan, M., Zimmerman, J. W., Hajjir, K., Venkatraman, D., Armstrong, D. K., Laheru, D., Mehra, R., Ho, W. J., Reuss, J. E., Heng, J., Vellanki, P., Donehower, R. C., Holdhoff, M. & Naidoo, J., Jan 1 2019, In : Journal of oncology practice. 15, 9, p. E825-E834

Research output: Contribution to journalArticle

Hospitalization
Gastroenterology
Immunotherapy
Inpatients
Referral and Consultation

PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers

Yarchoan, M., Albacker, L. A., Hopkins, A. C., Montesion, M., Murugesan, K., Vithayathil, T. T., Zaidi, N., Azad, N., Laheru, D., Frampton, G. M. & Jaffee, E., Mar 21 2019, In : JCI Insight. 4, 6, 126908.

Research output: Contribution to journalArticle

Open Access
Tumor Burden
Biomarkers
Neoplasms
Therapeutics
Adenocarcinoma
Cell Death
Ligands
Survival
Biomarkers

Results from a phase IIb, randomized, multicenter study of GVAX pancreas and CRS-207 compared with chemotherapy in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE study)

Le, D., Picozzi, V. J., Ko, A. H., Wainberg, Z. A., Kindler, H., Wang-Gillam, A., Oberstein, P., Morse, M. A., Zeh, H. J., Weekes, C., Reid, T., Borazanci, E., Crocenzi, T., LoConte, N. K., Musher, B., Laheru, D., Murphy, A., Whiting, C., Nair, N., Enstrom, A. & 3 others, Ferber, S., Brockstedt, D. G. & Jaffee, E., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5493-5502 10 p.

Research output: Contribution to journalArticle

Multicenter Studies
Pancreas
Adenocarcinoma
Drug Therapy
Cyclophosphamide

Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection

Gemenetzis, G., Groot, V. P., Blair, A. B., Laheru, D. A., Zheng, L., Narang, A. K., Fishman, E. K., Hruban, R. H., Yu, J., Burkhart, R. A., Cameron, J. L., Weiss, M. J., Wolfgang, C. L. & He, J., Aug 1 2019, In : Annals of surgery. 270, 2, p. 340-347 8 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Pancreatic Neoplasms
Survival
gemcitabine
Neoplasms

The Significance of Ascites in Patients with Pancreatic Ductal Adenocarcinoma: A Case-Control Study

Baretti, M., Pulluri, B., Tsai, H. L., Blackford, A. L., Wolfgang, C., Laheru, D., Zheng, L., Herman, J., Le, D., Narang, A. & De Jesus-Acosta, A., Apr 1 2019, In : Pancreas. 48, 4, p. 585-589 5 p.

Research output: Contribution to journalArticle

Ascites
Case-Control Studies
Adenocarcinoma
Confidence Intervals
Survival
2018

A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan

Lee, V., Wang, J., Zahurak, M., Gootjes, E., Verheul, H. M., Parkinson, R., Kerner, Z., Sharma, A., Rosner, G., De Jesus-Acosta, A., Laheru, D., Le, D., Oganesian, A., Lilly, E., Brown, T., Jones, P., Baylin, S. B., Ahuja, N. & Azad, N., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6160-6167 8 p.

Research output: Contribution to journalArticle

irinotecan
Colorectal Neoplasms
Intercellular Signaling Peptides and Proteins
Fever
Gastrointestinal Neoplasms

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Klein, A., Wolpin, B. M., Risch, H. A., Stolzenberg-Solomon, R. Z., Mocci, E., Zhang, M., Canzian, F., Childs, E. J., Hoskins, J. W., Jermusyk, A., Zhong, J., Chen, F., Albanes, D., Andreotti, G., Arslan, A. A., Babic, A., Bamlet, W. R., Beane-Freeman, L., Berndt, S. I., Blackford, A. & 103 others, Borges, M., Borgida, A., Bracci, P. M., Brais, L., Brennan, P., Brenner, H., Bueno-De-Mesquita, B., Buring, J., Campa, D., Capurso, G., Cavestro, G. M., Chaffee, K. G., Chung, C. C., Cleary, S., Cotterchio, M., Dijk, F., Duell, E. J., Foretova, L., Fuchs, C., Funel, N., Gallinger, S., Gaziano, J. M. M., Gazouli, M., Giles, G. G., Giovannucci, E., Goggins, M. S., Goodman, G. E., Goodman, P. J., Hackert, T., Haiman, C., Hartge, P., Hasan, M., Hegyi, P., Helzlsouer, K. J., Herman, J., Holcatova, I., Holly, E. A., Hoover, R., Hung, R. J., Jacobs, E. J., Jamroziak, K., Janout, V., Kaaks, R., Khaw, K. T., Klein, E. A., Kogevinas, M., Kooperberg, C., Kulke, M. H., Kupcinskas, J., Kurtz, R. J., Laheru, D., Landi, S., Lawlor, R. T., Lee, I. M., Lemarchand, L., Lu, L., Malats, N., Mambrini, A., Mannisto, S., Milne, R. L., Mohelníková-Duchoňová, B., Neale, R. E., Neoptolemos, J. P., Oberg, A. L., Olson, S. H., Orlow, I., Pasquali, C., Patel, A. V., Peters, U., Pezzilli, R., Porta, M., Real, F. X., Rothman, N., Scelo, G., Sesso, H. D., Severi, G., Shu, X. O., Silverman, D., Smith, J. P., Soucek, P., Sund, M., Talar-Wojnarowska, R., Tavano, F., Thornquist, M. D., Tobias, G. S., Van Den Eeden, S. K., Vashist, Y., Visvanathan, K., Vodicka, P., Wactawski-Wende, J., Wang, Z., Wentzensen, N., White, E., Yu, H., Yu, K., Zeleniuch-Jacquotte, A., Zheng, W., Kraft, P., Li, D., Chanock, S., Obazee, O., Petersen, G. M. & Amundadottir, L. T., Dec 1 2018, In : Nature Communications. 9, 1, 556.

Research output: Contribution to journalArticle

genome
loci
Pancreatic Neoplasms
Meta-Analysis
Genes

Is a Pathological Complete Response Following Neoadjuvant Chemoradiation Associated with Prolonged Survival in Patients with Pancreatic Cancer?

He, J., Blair, A. B., Groot, V. P., Javed, A. A., Burkhart, R., Gemenetzis, G., Hruban, R. H., Waters, K. M., Poling, J., Zheng, L., Laheru, D., Herman, J. M., Makary, M. A., Weiss, M. J., Cameron, J. L. & Wolfgang, C., Jul 1 2018, In : Annals of Surgery. 268, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Adenocarcinoma
Disease-Free Survival
Lymph Nodes

Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

Schunke, K. J., Rosati, L. M., Zahurak, M., Herman, J. M., Narang, A., Usach, I., Klein, A., Yeo, C. J., Korman, L. T., Hruban, R. H., Cameron, J. L., Laheru, D. & Abrams, R. A., Jan 1 2018, (Accepted/In press) In : Advances in Radiation Oncology.

Research output: Contribution to journalArticle

Mitomycin
Pancreatic Neoplasms
Fluorouracil
Prospective Studies
Survival

Outcome of Patients with Borderline Resectable Pancreatic Cancer in the Contemporary Era of Neoadjuvant Chemotherapy

Javed, A. A., Wright, M. J., Siddique, A., Blair, A. B., Ding, D., Burkhart, R., Makary, M. A., Cameron, J. L., Narang, A., Herman, J., Zheng, L., Laheru, D., Weiss, M. J., Wolfgang, C. & He, J., Jan 1 2018, (Accepted/In press) In : Journal of Gastrointestinal Surgery.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Therapy
Disease Progression
Comorbidity
Pancreas

Phase 1b investigation of the MEK inhibitor binimetinib in patients with advanced or metastatic biliary tract cancer

Finn, R. S., Ahn, D. H., Javle, M. M., Tan, B. R., Weekes, C. D., Bendell, J. C., Patnaik, A., Khan, G. N., Laheru, D., Chavira, R., Christy-Bittel, J., Barrett, E., Sawyer, M. B. & Bekaii-Saab, T. S., May 22 2018, (Accepted/In press) In : Investigational New Drugs. p. 1-7 7 p.

Research output: Contribution to journalArticle

Biliary Tract Neoplasms
Mitogen-Activated Protein Kinase Kinases
Mutation
MEK162
Pharmacokinetics

Smad4 Loss Correlates with Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation

Herman, J. M., Jabbour, S. K., Lin, S. H., Deek, M. P., Hsu, C. C., Fishman, E. K., Kim, S., Cameron, J. L., Chekmareva, M., Laheru, D., Narang, A., Pawlik, T. M., Hruban, R. H., Wolfgang, C. & Iacobuzio-Donahue, C. A., Feb 1 2018, In : Pancreas. 47, 2, p. 208-212 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Recurrence
Confidence Intervals
Survival
Tumor Suppressor Genes

Stereotactic body radiation therapy for palliative management of pancreatic adenocarcinoma in elderly and medically inoperable patients

Ryan, J. F., Rosati, L. M., Groot, V. P., Le, D., Zheng, L., Laheru, D., Shin, E., Jackson, J., Moore, J., Narang, A. & Herman, J. M., Jan 1 2018, In : Oncotarget. 9, 23, p. 16427-16436 10 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Radiotherapy
Disease-Free Survival
Induction Chemotherapy
Survival

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins, A. C., Yarchoan, M., Durham, J. N., Yusko, E. C., Rytlewski, J. A., Robins, H. S., Laheru, D., Le, D., Lutz, E. R. & Jaffee, E., Jul 12 2018, In : JCI insight. 3, 13

Research output: Contribution to journalArticle

Open Access
T-Cell Antigen Receptor
Immunotherapy
Adenocarcinoma
Survival
Pancreatic Neoplasms
2017

A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor

Bendell, J. C., Javle, M., Bekaii-Saab, T. S., Finn, R. S., Wainberg, Z. A., Laheru, D., Weekes, C. D., Tan, B. R., Khan, G. N., Zalupski, M. M., Infante, J. R., Jones, S., Papadopoulos, K. P., Tolcher, A. W., Chavira, R. E., Christy-Bittel, J. L., Barrett, E. & Patnaik, A., Feb 28 2017, In : British Journal of Cancer. 116, 5, p. 575-583 9 p.

Research output: Contribution to journalArticle

Maximum Tolerated Dose
Biliary Tract Neoplasms
Pharmacokinetics
Biopsy
Safety

BRCA2 secondary mutation-mediated resistance to platinum and PARP inhibitor-based therapy in pancreatic cancer

Pishvaian, M. J., Biankin, A. V., Bailey, P., Chang, D. K., Laheru, D., Wolfgang, C. & Brody, J. R., Apr 11 2017, In : British Journal of Cancer. 116, 8, p. 1021-1026 6 p.

Research output: Contribution to journalArticle

Platinum
Pancreatic Neoplasms
Mutation
Neoplasms
Therapeutics

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

Shrestha, B., Sun, Y., Faisal, F., Kim, V., Soares, K., Blair, A., Herman, J. M., Narang, A., Dholakia, A. S., Rosati, L., Hacker-Prietz, A., Chen, L., Laheru, D., De Jesus-Acosta, A., Le, D., Donehower, R. C., Azad, N., Diaz, L. A., Murphy, A., Lee, V. & 11 others, Fishman, E. K., Hruban, R. H., Liang, T., Cameron, J. L., Makary, M. A., Weiss, M. J., Ahuja, N., He, J., Wolfgang, C., Huang, C. Y. & Zheng, L., Jul 1 2017, In : Cancer Medicine. 6, 7, p. 1552-1562 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Therapy
Neoadjuvant Therapy
Survival
Adenocarcinoma

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D., Uram, J., Smith, K., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N., Rucki, A. A., Laheru, D., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F. & 26 others, Duffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L. V., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K., Nickles Fader, A. N., Taube, J. M., Housseau, F., Spetzler, D., Xiao, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In : Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journalArticle

Neoplasms
DNA Mismatch Repair
Disease-Free Survival
Turcot syndrome
Colorectal Neoplasms

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D., Liu, Y., von Eyben, R., Hsu, C. C., Hu, C., Rosati, L. M., Parekh, A., Ng, K., Hacker-Prietz, A., Zheng, L., Pawlik, T. M., Laheru, D., Jaffee, E., Weiss, M. J., Le, D., Hruban, R. H., De Jesus-Acosta, A., Wolfgang, C., Narang, A., Chang, D. T. & 2 others, Koong, A. C. & Herman, J. M., Jan 1 2017, (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Olaparib in combination with irinotecan, cisplatin, and mitomycin c in patients with advanced pancreatic cancer

Yarchoan, M., Myzak, M. C., Johnson, B. A., De Jesus-Acosta, A., Le, D., Jaffee, E., Azad, N., Donehower, R. C., Zheng, L., Oberstein, P. E., Fine, R. L., Laheru, D. & Goggins, M. S., 2017, In : Oncotarget. 8, 27, p. 44073-44081 9 p.

Research output: Contribution to journalArticle

irinotecan
Mitomycin
Pancreatic Neoplasms
Cisplatin
Adenocarcinoma

Stereotactic Body Radiation Therapy for Isolated Local Recurrence After Surgical Resection of Pancreatic Ductal Adenocarcinoma Appears to be Safe and Effective

Ryan, J. F., Groot, V. P., Rosati, L. M., Hacker-Prietz, A., Narang, A., McNutt, T., Jackson, J. F., Le, D., Jaffee, E., Zheng, L., Laheru, D., He, J., Pawlik, T. M., Weiss, M. J., Wolfgang, C. & Herman, J. M., Oct 23 2017, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Radiotherapy
Recurrence
Maintenance Chemotherapy
Disease-Free Survival

The effect of preservative and temperature on the analysis of circulating tumor DNA

Parpart-Li, S., Bartlett, B., Popoli, M., Adleff, V., Tucker, L., Steinberg, R., Georgiadis, A., Phallen, J., Brahmer, J., Azad, N., Browner, I., Laheru, D., Velculescu, V. E., Sausen, M. & Diaz, L. A., May 15 2017, In : Clinical Cancer Research. 23, 10, p. 2471-2477 7 p.

Research output: Contribution to journalArticle

Temperature
DNA
Neoplasms
Serum
Edetic Acid

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Begum, A., Ewachiw, T., Jung, C., Huang, A., Norberg, K. J., Marchionni, L., McMillan, R., Penchev, V., Rajeshkumar, N. V., Maitra, A., Wood, L. D., Wang, C., Wolfgang, C., De Jesus-Acosta, A., Laheru, D., Shapiro, I. M., Padval, M., Pachter, J. A., Weaver, D. T., Rasheed, Z. A. & 1 others, Matsui, W., Jul 1 2017, In : PLoS One. 12, 7, e0180181.

Research output: Contribution to journalArticle

non-specific protein-tyrosine kinase
Focal Adhesion Protein-Tyrosine Kinases
Neoplastic Stem Cells
adenocarcinoma
Stem cells

Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer

Beg, M. S., Huang, X., Silvers, M. A., Gerber, D. E., Bolluyt, J., Sarode, V., Fattah, F., Deberardinis, R. J., Merritt, M. E., Xie, X. J., Leff, R., Laheru, D. & Boothman, D. A., 2017, (Accepted/In press) In : Journal of Surgical Oncology.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Catalase
Pharmaceutical Preparations
Neoplasms
Substrate Cycling
2016

A new immunohistochemistry prognostic score (IPS) for recurrence and survival in resected pancreatic neuroendocrine tumors (PanNET)

Viúdez, A., Carvalho, F. L. F., Maleki, Z., Zahurak, M., Laheru, D., Stark, A., Azad, N., Wolfgang, C., Baylin, S. B., Herman, J. G. & De Jesus-Acosta, A., May 1 2016, In : Oncotarget. 7, 18, p. 24950-24961 12 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Immunohistochemistry
Recurrence
Survival
Methyltransferases

A polycythemia vera JAK2 mutation masquerading as a duodenal cancer mutation

Lee, J., Axilbund, J., Dalton, W., Laheru, D., Watkins, S., Chu, D., Cravero, K., Button, B., Kyker-Snowman, K., Waters, I., Gocke, C., Lauring, J. & Park, B. H., Dec 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 12, p. 1495-1498 4 p.

Research output: Contribution to journalArticle

Duodenal Neoplasms
Polycythemia Vera
Mutation
Cheek
Neoplasms

Assessing the Financial Burden Associated With Treatment Options for Resectable Pancreatic Cancer

Cerullo, M., Gani, F., Chen, S. Y., Canner, J. K., Herman, J. M., Laheru, D. & Pawlik, T. M., Oct 25 2016, (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
gemcitabine
Survival
Confidence Intervals
Episode of Care

Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma

Poruk, K. E., Valero, V., Saunders, T., Blackford, A. L., Griffin, J. F., Poling, J., Hruban, R. H., Anders, R. A., Herman, J., Zheng, L., Rasheed, Z. A., Laheru, D., Ahuja, N., Weiss, M. J., Cameron, J. L., Goggins, M. S., Iacobuzio-Donahue, C. A., Wood, L. D. & Wolfgang, C., Jan 7 2016, (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Adenocarcinoma
Phenotype
Recurrence
Survival

Longer course of induction chemotherapy followed by chemoradiation favors better survival outcomes for patients with locally advanced pancreatic cancer

Faisal, F., Tsai, H. L., Blackford, A., Olino, K., Xia, C., De Jesus-Acosta, A., Le, D., Cosgrove, D., Azad, N., Rasheed, Z., Diaz, L. A., Donehower, R. C., Laheru, D., Hruban, R. H., Fishman, E. K., Edil, B. H., Schulick, R., Wolfgang, C., Herman, J. & Zheng, L., 2016, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 39, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Pancreatic Neoplasms
Survival
Incidence
Drug Therapy

Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients with Unresectable Pancreatic Cancer

Wild, A. T., Herman, J. M., Dholakia, A. S., Moningi, S., Lu, Y., Rosati, L. M., Hacker-Prietz, A., Assadi, R. K., Saeed, A. M., Pawlik, T. M., Jaffee, E., Laheru, D., Tran, P. T., Weiss, M. J., Wolfgang, C., Ford, E., Grossman, S. A., Ye, X. & Ellsworth, S. G., 2016, In : International Journal of Radiation Oncology, Biology, Physics. 94, 3, p. 571-579 9 p.

Research output: Contribution to journalArticle

lymphocytes
Pancreatic Neoplasms
radiation therapy
Radiotherapy
cancer

Metastatic pancreatic adenocarcinoma associated with chronic calcific pancreatitis and a heterozygous SPINK1 N34S mutation

Moran, R. A., Klapheke, R., Jalaly, N. Y., Makary, M. A., Hirose, K., Goggins, M. S., Wood, L. D., Laheru, D., O'Broin-Lennon, A. M., Khashab, M. & Singh, V., Sep 1 2016, In : Pancreatology. 16, 5, p. 869-872 4 p.

Research output: Contribution to journalArticle

Serine Proteinase Inhibitors
Chronic Pancreatitis
Adenocarcinoma
Mutation
Pancreatic Neoplasms

Multidisciplinary management and the future of treatment in cholangiocarcinoma

Burkhart, R., Laheru, D., Herman, J. M. & Pawlik, T. M., Mar 3 2016, In : Expert Opinion on Orphan Drugs. 4, 3, p. 255-267 13 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Image-Guided Radiotherapy
Ampulla of Vater
Common Hepatic Duct
Interventional Radiology

Patient-reported outcomes of a multicenter phase 2 study investigating gemcitabine and stereotactic body radiation therapy in locally advanced pancreatic cancer

Rao, A. D., Sugar, E., Chang, D. T., Goodman, K. A., Hacker-Prietz, A., Rosati, L. M., Columbo, L., O'Reilly, E., Fisher, G. A., Zheng, L., Pai, J. S., Griffith, M. E., Laheru, D., Iacobuzio-Donahue, C. A., Wolfgang, C., Koong, A. & Herman, J. M., Nov 1 2016, In : Practical Radiation Oncology. 6, 6, p. 417-424 8 p.

Research output: Contribution to journalArticle

gemcitabine
Pancreatic Neoplasms
Radiotherapy
Quality of Life
Body Image

Phase 1 Study of ABT-751 in Combination With CAPIRI (Capecitabine and Irinotecan) and Bevacizumab in Patients With Advanced Colorectal Cancer

Rudek-Renaut, M., Dasari, A., Laheru, D., He, P., Jin, R., Walker, R., Taylor, G. E., Jimeno, A., Donehower, R. C., Hidalgo, M., Messersmith, W. A. & Purcell, W. T., 2016, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

irinotecan
Colorectal Neoplasms
Maximum Tolerated Dose
Pharmacokinetics
capecitabine-irinotecan combination

Reliable detection of somatic mutations in fine needle aspirates of pancreatic cancer with next-generation sequencing: Implications for surgical management

Valero, V., Saunders, T. J., He, J., Weiss, M. J., Cameron, J. L., Dholakia, A., Wild, A. T., Shin, E., Khashab, M., O'Broin-Lennon, A. M., Ali, S. Z., Laheru, D., Hruban, R. H., Iacobuzio-Donahue, C. A., Herman, J. M. & Wolfgang, C., 2016, In : Annals of Surgery. 263, 1, p. 153-161 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Needles
Mutation
Neoplasms
DNA

Using quantitative seroproteomics to identify antibody biomarkers in pancreatic cancer

Jhaveri, D. T., Kim, M. S., Thompson, E., Huang, L., Sharma, R., Klein, A., Zheng, L., Le, D., Laheru, D., Pandey, A., Jaffee, E. & Anders, R. A., Mar 1 2016, In : Cancer immunology research. 4, 3, p. 225-233 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Biomarkers
Immunoprecipitation
Antibodies
Cancer Vaccines
2015

A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours

Wilky, B. A., Rudek-Renaut, M., Ahmed, S., Laheru, D., Cosgrove, D., Donehower, R. C., Nelkin, B. D., Ball, D. W., Doyle, L. A., Chen, H., Ye, X., Bigley, G., Womack, C. & Azad, N., Jan 6 2015, In : British Journal of Cancer. 112, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Antibodies
Neoplasms
Maximum Tolerated Dose
Thyroid Neoplasms

CNS Involvement in Pancreatic Adenocarcinoma: a Report of Eight Cases from the Johns Hopkins Hospital and Review of Literature

Kumar, A., Dagar, M., Herman, J., Iacobuzio-Donahue, C. & Laheru, D., 2015, In : Journal of Gastrointestinal Cancer. 46, 1, p. 5-8 4 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
Pancreatic Neoplasms
Radiation
Nervous System

Correlation of clinical stage and performance status with quality of life in patients seen in a pancreas multidisciplinary clinic

Moningi, S., Walker, A., Hsu, C. C., Reese, J. B., Wang, J. Y., Fan, K. Y., Rosati, L. M., Laheru, D., Weiss, M. J., Wolfgang, C., Pawlik, T. M. & Herman, J. M., Mar 1 2015, In : Journal of Oncology Practice. 11, 2, p. e216-e221

Research output: Contribution to journalArticle

Pancreas
Quality of Life
Pancreatic Diseases
Cachexia
Ascites

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D., Jaffee, E., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. & Caturegli, P. P., Jan 1 2015, In : International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Thyroglobulin
Immunotherapy
Survival
Antibodies
Epitopes

Efficacy of platinum chemotherapy agents in the adjuvant setting for adenosquamous carcinoma of the pancreas

Wild, A. T., Dholakia, A. S., Fan, K. Y., Kumar, R., Moningi, S., Rosati, L. M., Laheru, D., Zheng, L., De Jesus-Acosta, A., Ellsworth, S. G., Hacker-Prietz, A., Voong, K., Tran, P. T., Hruban, R. H., Pawlik, T. M., Wolfgang, C. & Herman, J. M., 2015, In : Journal of Gastrointestinal Oncology. 6, 2, p. 115-125 11 p.

Research output: Contribution to journalArticle

Adenosquamous Carcinoma
Platinum
Pancreas
Drug Therapy
Survival

Family history as a marker of platinum sensitivity in pancreatic adenocarcinoma

Fogelman, D., Sugar, E., Oliver, G., Shah, N., Klein, A., Alewine, C., Wang, H., Javle, M., Shroff, R., Wolff, R. A., Abbruzzese, J. L., Laheru, D. & Diaz, L. A., Jul 1 2015, In : Cancer Chemotherapy and Pharmacology. 76, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

Platinum
Adenocarcinoma
Chemotherapy
Hazards
Survival

Immune therapy in GI malignancies: A review

Wang, J., Reiss, K. A., Khatri, R., Jaffee, E. & Laheru, D., Jun 1 2015, In : Journal of Clinical Oncology. 33, 16, p. 1745-1753 9 p.

Research output: Contribution to journalArticle

Neoplasms
Immunotherapy
Therapeutics
Oncogenes
Immune System

PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors

Soares, K. C., Rucki, A. A., Wu, A. A., Olino, K., Xiao, Q., Chai, Y., Wamwea, A., Bigelow, E., Lutz, E., Liu, L., Yao, S., Anders, R. A., Laheru, D., Wolfgang, C., Edil, B. H., Schulick, R. D., Jaffee, E. & Zheng, L., Jan 14 2015, In : Journal of Immunotherapy. 38, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle

Active Immunotherapy
Adenocarcinoma
T-Lymphocytes
CTLA-4 Antigen
Neoplasms

PD-1 blockade in tumors with mismatch-repair deficiency

Le, D., Uram, J., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N., Laheru, D., Biedrzycki, B., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Duffy, S. M., Goldberg, R. M., De La Chapelle, A., Koshiji, M. & 15 others, Bhaijee, F., Huebner, T., Hruban, R. H., Wood, L. D., Cuka, N., Pardoll, A. M., Papadopoulos, N., Kinzler, K. W., Zhou, S., Cornish, T. C., Taube, J. M., Anders, R. A., Eshleman, J., Vogelstein, B. & Diaz, L. A., Jun 25 2015, In : New England Journal of Medicine. 372, 26, p. 2509-2520 12 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
Colorectal Neoplasms
Neoplasms
Disease-Free Survival
Survival Rate

Phase 2 multi-institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma

Herman, J. M., Chang, D. T., Goodman, K. A., Dholakia, A. S., Raman, S. P., Hacker-Prietz, A., Iacobuzio-Donahue, C. A., Griffith, M. E., Pawlik, T. M., Pai, J. S., O'Reilly, E., Fisher, G. A., Wild, A. T., Rosati, L. M., Zheng, L., Wolfgang, C., Laheru, D., Columbo, L. A., Sugar, E. & Koong, A. C., Apr 1 2015, In : Cancer. 121, 7, p. 1128-1137 10 p.

Research output: Contribution to journalArticle

gemcitabine
Radiosurgery
Adenocarcinoma
Pancreatic Neoplasms
Quality of Life