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Dan Arking

Professor

1995 …2024

Research activity per year

Search results

  • 2024

    Mitochondrial genetic variation and risk of chronic kidney disease and acute kidney injury in UK Biobank participants

    Jotwani, V., Yang, S. Y., Thiessen-Philbrook, H., Parikh, C. R., Katz, R., Tranah, G. J., Ix, J. H., Cummings, S., Waikar, S. S., Shlipak, M. G., Sarnak, M. J., Parikh, S. M. & Arking, D., Feb 2024, In: Human genetics. 143, 2, p. 151-157 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2023

    Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 27 2023, In: Nature. 616, 7958, p. 755-763 9 p.

    Research output: Contribution to journal › Article › peer-review

  • Association Between Whole Blood–Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk

    TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Oct 17 2023, In: Journal of the American Heart Association. 12, 20, e029090.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts

    Zhang, Y., Liu, X., Wiggins, K. L., Kurniansyah, N., Guo, X., Rodrigue, A. L., Zhao, W., Yanek, L. R., Ratliff, S. M., Pitsillides, A., Patiño, J. S. A., Sofer, T., Arking, D. E., Austin, T. R., Beiser, A. S., Blangero, J., Boerwinkle, E., Bressler, J., Curran, J. E., Hou, L., & 25 othersHughes, T. M., Kardia, S. L. R., Launer, L. J., Levy, D., Mosley, T. H., Nasrallah, I. M., Rich, S. S., Rotter, J. I., Seshadri, S., Tarraf, W., González, K. A., Ramachandran, V., Yaffe, K., Nyquist, P. A., Psaty, B. M., Decarli, C. S., Smith, J. A., Glahn, D. C., González, H. M., Bis, J. C., Fornage, M., Heckbert, S. R., Fitzpatrick, A. L., Liu, C. & Satizabal, C. L., May 2 2023, In: Neurology. 100, 18, p. E1930-E1943

    Research output: Contribution to journal › Article › peer-review

  • Author Correction: Clonal haematopoiesis and risk of chronic liver disease (Nature, (2023), 616, 7958, (747-754), 10.1038/s41586-023-05857-4)

    NHLBI TOPMed Hematology Working Group, Jul 20 2023, In: Nature. 619, 7970, p. E47

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access

  • Clonal haematopoiesis and risk of chronic liver disease

    NHLBI TOPMed Hematology Working Group, Apr 27 2023, In: Nature. 616, 7958, p. 747-754 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality

    Hong, Y. S., Battle, S. L., Shi, W., Puiu, D., Pillalamarri, V., Xie, J., Pankratz, N., Lake, N. J., Lek, M., Rotter, J. I., Rich, S. S., Kooperberg, C., Reiner, A. P., Auer, P. L., Heard-Costa, N., Liu, C., Lai, M., Murabito, J. M., Levy, D., Grove, M. L., & 6 othersAlonso, A., Gibbs, R., Dugan-Perez, S., Gondek, L. P., Guallar, E. & Arking, D. E., Dec 2023, In: Nature communications. 14, 1, 6113.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

    NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sep 2023, In: EBioMedicine. 95, 104758.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

    de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I., & 178 othersLim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F. C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L. P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y. D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C. K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W. P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X. O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y. X., Wei, W. B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J. M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C. T., Morrison, A. C., Rotter, J. I. & Fornage, M., 2023, In: Frontiers in Genetics. 14, 1235337.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

    Young, W. J., Haessler, J., Benjamins, J. W., Repetto, L., Yao, J., Isaacs, A., Harper, A. R., Ramirez, J., Garnier, S., van Duijvenboden, S., Baldassari, A. R., Concas, M. P., Duong, T. V., Foco, L., Isaksen, J. L., Mei, H., Noordam, R., Nursyifa, C., Richmond, A., Santolalla, M. L., & 74 othersSitlani, C. M., Soroush, N., Thériault, S., Trompet, S., Aeschbacher, S., Ahmadizar, F., Alonso, A., Brody, J. A., Campbell, A., Correa, A., Darbar, D., De Luca, A., Deleuze, J. F., Ellervik, C., Fuchsberger, C., Goel, A., Grace, C., Guo, X., Hansen, T., Heckbert, S. R., Jackson, R. D., Kors, J. A., Lima-Costa, M. F., Linneberg, A., Macfarlane, P. W., Morrison, A. C., Navarro, P., Porteous, D. J., Pramstaller, P. P., Reiner, A. P., Risch, L., Schotten, U., Shen, X., Sinagra, G., Soliman, E. Z., Stoll, M., Tarazona-Santos, E., Tinker, A., Trajanoska, K., Villard, E., Warren, H. R., Whitsel, E. A., Wiggins, K. L., Arking, D. E., Avery, C. L., Conen, D., Girotto, G., Grarup, N., Hayward, C., Jukema, J. W., Mook-Kanamori, D. O., Olesen, M. S., Padmanabhan, S., Psaty, B. M., Pattaro, C., Ribeiro, A. L. P., Rotter, J. I., Stricker, B. H., van der Harst, P., van Duijn, C. M., Verweij, N., Wilson, J. G., Orini, M., Charron, P., Watkins, H., Kooperberg, C., Lin, H. J., Wilson, J. F., Kanters, J. K., Sotoodehnia, N., Mifsud, B., Lambiase, P. D., Tereshchenko, L. G. & Munroe, P. B., Dec 2023, In: Nature communications. 14, 1, 1411.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic insights into resting heart rate and its role in cardiovascular disease

    the DCCT/EDIC Research Group, Dec 2023, In: Nature communications. 14, 1, 4646.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

    Bakker, M. K., Kanning, J. P., Abraham, G., Martinsen, A. E., Winsvold, B. S., Zwart, J. A., Bourcier, R., Sawada, T., Koido, M., Kamatani, Y., Morel, S., Amouyel, P., Debette, S., Bijlenga, P., Berrandou, T., Ganesh, S. K., Bouatia-Naji, N., Jones, G., Bown, M., Rinkel, G. J. E., & 476 othersVeldink, J. H., Ruigrok, Y. M., Hege Aamodt, A., Heidi Skogholt, A., Brumpton, B. M., Willer, C. J., Sandset, E. C., Kristoffersen, E. S., Ellekjær, H., Heuch, I., Nielsen, J. B., Hagen, K., Hveem, K., Fritsche, L. G., Thomas, L. F., Pedersen, L. M., Gabrielsen, M. E., Holmen, O. L., Børte, S., Zhou, W., Abboud, S., Pandolfo, M., Thijs, V., Leys, D., Bodenant, M., Louillet, F., Touzé, E., Mas, J. L., Samson, Y., Leder, S., Léger, A., Deltour, S., Crozier, S., Méresse, I., Canaple, S., Godefroy, O., Giroud, M., Béjot, Y., Decavel, P., Medeiros, E., Montiel, P., Moulin, T., Vuillier, F., Dallongeville, J., Metso, A. J., Metso, T., Tatlisumak, T., Grond-Ginsbach, C., Lichy, C., Kloss, M., Werner, I., Arnold, M. L., Dos Santos, M., Grau, A., Dichgans, M., Thomas-Feles, C., Weber, R., Brandt, T., Pezzini, A., De Giuli, V., Caria, F., Poli, L., Padovani, A., Bersano, A., Lanfranconi, S., Beretta, S., Ferrarese, C., Giacolone, G., Paolucci, S., Lyrer, P., Engelter, S., Fluri, F., Hatz, F., Gisler, D., Bonati, L., Gensicke, H., Amort, M., Markus, H., Majersik, J., Worrall, B., Southerland, A., Cole, J., Kittner, S., Evangelou, E., Warren, H. R., Gao, H., Ntritsos, G., Dimou, N., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W. Y., Luan, J., Mangino, M., Oldmeadow, C., Peter Prins, B., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Zhao, J. H., Connell, J., De Mutsert, R., Doney, A. S. F., Farrall, M., Menni, C., Morris, A. D., Noordam, R., Paré, G., Poulter, N. R., Shields, D. C., Stanton, A., Thom, S., Abecasis, G., Amin, N., Arking, D. E., Ayers, K. L., Barbieri, C. M., Batini, C., Bis, J. C., Blake, T., Bochud, M., Boehnke, M., Boerwinkle, E., Boomsma, D. I., Bottinger, E. P., Braund, P. S., Brumat, M., Campbell, A., Campbell, H., Chakravarti, A., Chambers, J. C., Chauhan, G., Ciullo, M., Cocca, M., Collins, F., Cordell, H. J., Davies, G., De Borst, M. H., De Geus, E. J., Deary, I. J., Deelen, J., Del Greco M, F., Yusuf Demirkale, C., Dörr, M., Ehret, G. B., Elosua, R., Enroth, S., Mesut Erzurumluoglu, A., Ferreira, T., Frånberg, M., Franco, O. H., Gandin, I., Gasparini, P., Giedraitis, V., Gieger, C., Girotto, G., Goel, A., Gow, A. J., Gudnason, V., Guo, X., Gyllensten, U., Hamsten, A., Harris, T. B., Harris, S. E., Hartman, C. A., Havulinna, A. S., Hicks, A. A., Hofer, E., Hofman, A., Hottenga, J. J., Huffman, J. E., Hwang, S. J., Ingelsson, E., James, A., Jansen, R., Jarvelin, M. R., Joehanes, R., Johansson, Å., Johnson, A. D., Joshi, P. K., Jousilahti, P., Wouter Jukema, J., Jula, A., Kähönen, M., Kathiresan, S., Keavney, B. D., Khaw, K. T., Knekt, P., Knight, J., Kolcic, I., Kooner, J. S., Koskinen, S., Kristiansson, K., Kutalik, Z., Laan, M., Larson, M., Launer, L. J., Lehne, B., Lehtimäki, T., Liewald, D. C. M., Lin, L., Lind, L., Lindgren, C. M., Liu, Y. M., Loos, R. J. F., Lopez, L. M., Lu, Y., Lyytikäinen, L. P., Mahajan, A., Mamasoula, C., Marrugat, J., Marten, J., Milaneschi, Y., Morgan, A., Morris, A. P., Morrison, A. C., Munson, P. J., Nalls, M. A., Nandakumar, P., Nelson, C. P., Niiranen, T., Nolte, I. M., Nutile, T., Oldehinkel, A. J., Oostra, B. A., O'reilly, P. F., Org, E., Padmanabhan, S., Palmas, W., Palotie, A., Pattie, A., Wjh Penninx, B., Perola, M., Peters, A., Polasek, O., Pramstaller, P. P., Tri Nguyen, Q., Raitakari, O. T., Rettig, R., Rice, K., Ridker, P. M., Ried, J. S., Riese, H., Ripatti, S., Robino, A., Rose, L. M., Rotter, J. I., Rudan, I., Ruggiero, D., Saba, Y., Sala, C. F., Salomaa, V., Samani, N. J., Sarin, A. P., Schmidt, R., Schmidt, H., Shrine, N., Siscovick, D., Smith, A. V., Snieder, H., Sõber, S., Sorice, R., Starr, J. M., Stott, D. J., Strachan, D. P., Strawbridge, R. J., Sundström, J., Swertz, M. A., Taylor, K. D., Teumer, A., Tobin, M. D., Tomaszewski, M., Toniolo, D., Traglia, M., Trompet, S., Tuomilehto, J., Tzourio, C., Uitterlinden, A. G., Vaez, A., Van Der Most, P. J., Van Duijn, C. M., Verwoert, G. C., Vitart, V., Völker, U., Vollenweider, P., Vuckovic, D., Watkins, H., Wild, S. H., Willemsen, G., Wilson, J. F., Wright, A. F., Yao, J., Zemunik, T., Zhang, W., Attia, J. R., Butterworth, A. S., Chasman, D. I., Conen, D., Cucca, F., Danesh, J., Hayward, C., Howson, J. M. M., Laakso, M., Lakatta, E., Langenberg, C., Melander, O., Mook-Kanamori, D. O., Palmer, C. N. A., Risch, L., Scott, R. A., Scott, R. J., Sever, P., Spector, T. D., Van Der Harst, P., Wareham, N. J., Zeggini, E., Levy, D., Munroe, P. B., Newton-Cheh, C., Brown, M. J., Metspalu, A., Psaty, B. M., Wain, L. V., Elliott, P., Caulfield, M. J., Gormley, P., Anttila, V., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., Mcmahon, G., Ligthart, L., Terwindt, G. M., Kallela, M., Freilinger, T. M., Ran, C., Gordon, S. G., Stam, A. H., Steinberg, S., Borck, G., Koiranen, M., Quaye, L., Adams, H. H. H., Lehtimäki, T., Sarin, A. P., Wedenoja, J., Hinds, D. A., Buring, J. E., Schürks, M., Ridker, P. M., Gudlaug Hrafnsdottir, M., Stefansson, H., Ring, S. M., Hottenga, J. J., Penninx, B. W. J. H., Färkkilä, M., Artto, V., Kaunisto, M., Vepsäläinen, S., Malik, R., Heath, A. C., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Kurki, M. I., Kals, M., Mägi, R., Pärn, K., Hämäläinen, E., Huang, H., Byrnes, A. E., Franke, L., Huang, J., Stergiakouli, E., Lee, P. H., Sandor, C., Webber, C., Cader, Z., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Eriksson, J. G., Salomaa, V., Heikkilä, K., Loehrer, E., Uitterlinden, A. G., Van Duijn, C. M., Cherkas, L., Pedersen, L. M., Stubhaug, A., Nielsen, C. S., Männikkö, M., Mihailov, E., Milani, L., Göbel, H., Esserlind, A. L., Francke Christensen, A., Folkmann Hansen, T., Werge, T., Kaprio, J., Aromaa, A. J., Raitakari, O., Arfan Ikram, M., Spector, T., Järvelin, M. R., Metspalu, A., Kubisch, C., Strachan, D. P., Ferrari, M. D., Belin, A. C., Wessman, M., Van Den Maagdenberg, A. M. J. M., Davey Smith, G., Stefansson, K., Eriksson, N., Daly, M. J., Neale, B. M., Olesen, J., Chasman, D. I., Nyholt, D. R., Akiyama, M., Alg, V. S., Børte, S., Broderick, J. P., Dauvillier, J., Desal, H., Dina, C., Friedrich, C. M., Gaál-Paavola, E. I., Gentric, J. C., Hirsch, S., Hostettler, I. C., Houlden, H., Hveem, K., Jääskeläinen, J. E., Johnsen, M. B., Li, L., Lin, K., Lindgren, A., Martin, O., Matsuda, K., Millwood, I. Y., Naggara, O., Niemelä, M., Pera, J., Redon, R., Rouleau, G. A., Sandvei, M. S., Schilling, S., Shotar, E., Slowik, A., Terao, C., Verschuren, W. M. M., Walters, R. G., Werring, D. J., Willer, C. J., Woo, D., Worrall, B. B. & Zhou, S., Mar 1 2023, In: Stroke. 54, 3, p. 810-818 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genetic variant annotation scores in congenital long QT syndrome

    Younis, A., Bodurian, C., Arking, D. E., Bragazzi, N. L., Tabaja, C., Zareba, W., McNitt, S., Aktas, M. K., Polonsky, B., Lopes, C. M., Sotoodehnia, N., Kudenchuk, P. J. & Goldenberg, I., Sep 2023, In: Annals of Noninvasive Electrocardiology. 28, 5, e13080.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Long-Term Air Pollution Exposure and Mitochondrial DNA Copy Number: An Analysis of UK Biobank Data

    Hong, Y. S., Battle, S. L., Puiu, D., Shi, W., Pankratz, N., Zhao, D., Arking, D. E. & Guallar, E., May 2023, In: Environmental health perspectives. 131, 5, 057703.

    Research output: Contribution to journal › Letter › peer-review

    Open Access

  • Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

    Tewari, S. R., Kirk, G. D., Arking, D. E., Astemborski, J., Newcomb, C., Piggott, D. A., Mehta, S., Lucas, G. M. & Sun, J., Dec 2023, In: Scientific reports. 13, 1, 18406.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Priors, population sizes, and power in genome-wide hypothesis tests

    Cai, J., Zhan, J., Arking, D. E. & Bader, J. S., Dec 2023, In: BMC Bioinformatics. 24, 1, 170.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The functional impact of rare variation across the regulatory cascade

    Li, T., Ferraro, N., Strober, B. J., Aguet, F., Kasela, S., Arvanitis, M., Ni, B., Wiel, L., Hershberg, E., Ardlie, K., Arking, D. E., Beer, R. L., Brody, J., Blackwell, T. W., Clish, C., Gabriel, S., Gerszten, R., Guo, X., Gupta, N., Johnson, W. C., & 18 othersLappalainen, T., Lin, H. J., Liu, Y., Nickerson, D. A., Papanicolaou, G., Pritchard, J. K., Qasba, P., Shojaie, A., Smith, J., Sotoodehnia, N., Taylor, K. D., Tracy, R. P., Van Den Berg, D., Wheeler, M. T., Rich, S. S., Rotter, J. I., Battle, A. & Montgomery, S. B., Oct 11 2023, In: Cell Genomics. 3, 10, 100401.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

    Schlosser, P., Zhang, J., Liu, H., Surapaneni, A. L., Rhee, E. P., Arking, D. E., Yu, B., Boerwinkle, E., Welling, P. A., Chatterjee, N., Susztak, K., Coresh, J. & Grams, M. E., Dec 2023, In: Genome biology. 24, 1, 150.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy number

    Pillalamarri, V., Shi, W., Say, C., Yang, S., Lane, J., Guallar, E., Pankratz, N. & Arking, D. E., Jan 12 2023, In: Human Genetics and Genomics Advances. 4, 1, 100147.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2022

    A bioinformatics pipeline for estimating mitochondrial DNA copy number and heteroplasmy levels from whole genome sequencing data

    TOPMed mtDNA Working Group, Jun 1 2022, In: NAR Genomics and Bioinformatics. 4, 2, lqac034.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Dec 1 2022, In: Nature Methods.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • APOL1 Kidney Risk Variants and Proteomics

    Chen, T. K., Surapaneni, A. L., Arking, D. E., Ballantyne, C. M., Boerwinkle, E., Chen, J., Coresh, J., Köttgen, A., Susztak, K., Tin, A., Yu, B. & Grams, M. E., May 2022, In: Clinical Journal of the American Society of Nephrology. 17, 5, p. 684-692 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

    TOPMed Anthropometry Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mar 2022, In: Nature genetics. 54, 3, p. 263-273 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Association of Mitochondrial DNA Copy Number with Risk of Progression of Kidney Disease

    on behalf of the CRIC Study Investigators, Jul 2022, In: Clinical Journal of the American Society of Nephrology. 17, 7, p. 966-975 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Biological Life-Stage and the Burden of Cardiac Events in Women with Congenital Long QT Syndrome

    Younis, A., Zareba, W., Goldenberg, I., Kharsa, A., McNitt, S., Aktas, M. K., Bodurian, C., Farooq, S., Polonsky, B., Sotoodehnia, N., Kudenchuk, P. J., Rea, T. D., Arking, D. E., Luigi Bragazzi, N. & Goldenberg, I., Dec 1 2022, In: Circulation: Arrhythmia and Electrophysiology. 15, 12, p. E011247

    Research output: Contribution to journal › Letter › peer-review

    Open Access

  • Epigenome-wide association study of mitochondrial genome copy number

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Jan 15 2022, In: Human molecular genetics. 31, 2, p. 309-319 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Frequency of the PNPLA3 rs738409 polymorphism and other genetic loci for liver disease in a Guatemalan adult population

    Lazo, M., Xie, J., Alvarez, C. S., Parisi, D., Yang, S., Rivera-Andrade, A., Kroker-Lobos, M. F., Groopman, J. D., Guallar, E., Ramirez-Zea, M., Arking, D. E. & McGlynn, K. A., Jun 2022, In: Liver International. 42, 6, p. 1470-1474 5 p.

    Research output: Contribution to journal › Letter › peer-review

  • Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

    Young, W. J., Lahrouchi, N., Isaacs, A., Duong, T. V., Foco, L., Ahmed, F., Brody, J. A., Salman, R., Noordam, R., Benjamins, J. W., Haessler, J., Lyytikäinen, L. P., Repetto, L., Concas, M. P., van den Berg, M. E., Weiss, S., Baldassari, A. R., Bartz, T. M., Cook, J. P., Evans, D. S., & 146 othersFreudling, R., Hines, O., Isaksen, J. L., Lin, H., Mei, H., Moscati, A., Müller-Nurasyid, M., Nursyifa, C., Qian, Y., Richmond, A., Roselli, C., Ryan, K. A., Tarazona-Santos, E., Thériault, S., van Duijvenboden, S., Warren, H. R., Yao, J., Raza, D., Aeschbacher, S., Ahlberg, G., Alonso, A., Andreasen, L., Bis, J. C., Boerwinkle, E., Campbell, A., Catamo, E., Cocca, M., Cutler, M. J., Darbar, D., De Grandi, A., De Luca, A., Ding, J., Ellervik, C., Ellinor, P. T., Felix, S. B., Froguel, P., Fuchsberger, C., Gögele, M., Graff, C., Graff, M., Guo, X., Hansen, T., Heckbert, S. R., Huang, P. L., Huikuri, H. V., Hutri-Kähönen, N., Ikram, M. A., Jackson, R. D., Junttila, J., Kavousi, M., Kors, J. A., Leal, T. P., Lemaitre, R. N., Lin, H. J., Lind, L., Linneberg, A., Liu, S., MacFarlane, P. W., Mangino, M., Meitinger, T., Mezzavilla, M., Mishra, P. P., Mitchell, R. N., Mononen, N., Montasser, M. E., Morrison, A. C., Nauck, M., Nauffal, V., Navarro, P., Nikus, K., Pare, G., Patton, K. K., Pelliccione, G., Pittman, A., Porteous, D. J., Pramstaller, P. P., Preuss, M. H., Raitakari, O. T., Reiner, A. P., Ribeiro, A. L. P., Rice, K. M., Risch, L., Schlessinger, D., Schotten, U., Schurmann, C., Shen, X., Shoemaker, M. B., Sinagra, G., Sinner, M. F., Soliman, E. Z., Stoll, M., Strauch, K., Tarasov, K., Taylor, K. D., Tinker, A., Trompet, S., Uitterlinden, A., Völker, U., Völzke, H., Waldenberger, M., Weng, L. C., Whitsel, E. A., Wilson, J. G., Avery, C. L., Conen, D., Correa, A., Cucca, F., Dörr, M., Gharib, S. A., Girotto, G., Grarup, N., Hayward, C., Jamshidi, Y., Järvelin, M. R., Jukema, J. W., Kääb, S., Kähönen, M., Kanters, J. K., Kooperberg, C., Lehtimäki, T., Lima-Costa, M. F., Liu, Y., Loos, R. J. F., Lubitz, S. A., Mook-Kanamori, D. O., Morris, A. P., O’Connell, J. R., Olesen, M. S., Orini, M., Padmanabhan, S., Pattaro, C., Peters, A., Psaty, B. M., Rotter, J. I., Stricker, B., van der Harst, P., van Duijn, C. M., Verweij, N., Wilson, J. F., Arking, D. E., Ramirez, J., Lambiase, P. D., Sotoodehnia, N., Mifsud, B., Newton-Cheh, C. & Munroe, P. B., Dec 2022, In: Nature communications. 13, 1, 5144.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation

    Longchamps, R. J., Yang, S. Y., Castellani, C. A., Shi, W., Lane, J., Grove, M. L., Bartz, T. M., Sarnowski, C., Liu, C., Burrows, K., Guyatt, A. L., Gaunt, T. R., Kacprowski, T., Yang, J., De Jager, P. L., Yu, L., Bergman, A., Xia, R., Fornage, M., Feitosa, M. F., & 32 othersWojczynski, M. K., Kraja, A. T., Province, M. A., Amin, N., Rivadeneira, F., Tiemeier, H., Uitterlinden, A. G., Broer, L., Van Meurs, J. B. J., Van Duijn, C. M., Raffield, L. M., Lange, L., Rich, S. S., Lemaitre, R. N., Goodarzi, M. O., Sitlani, C. M., Mak, A. C. Y., Bennett, D. A., Rodriguez, S., Murabito, J. M., Lunetta, K. L., Sotoodehnia, N., Atzmon, G., Ye, K., Barzilai, N., Brody, J. A., Psaty, B. M., Taylor, K. D., Rotter, J. I., Boerwinkle, E., Pankratz, N. & Arking, D. E., Jan 2022, In: Human genetics. 141, 1, p. 127-146 20 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension

    Surapaneni, A., Schlosser, P., Zhou, L., Liu, C., Chatterjee, N., Arking, D. E., Dutta, D., Coresh, J., Rhee, E. P. & Grams, M. E., Nov 2022, In: Kidney international. 102, 5, p. 1167-1177 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Mitochondrial DNA copy number, metabolic syndrome, and insulin sensitivity: Insights from the Sugar, Hypertension, and Physical Exercise studies

    Yang, S. Y., Mirabal, C. S., Newcomb, C. E., Stewart, K. J. & Arking, D. E., Jul 2022, In: PloS one. 17, 7 July, e0270951.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Monogenic and Polygenic Contributions to QTc Prolongation in the Population

    National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Investigators, May 17 2022, In: Circulation. 145, 20, p. 1524-1533 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Rare Genetic Variants Associated With Myocardial Fibrosis: Multi-Ethnic Study of Atherosclerosis

    Shabani, M., Dutta, D., Ambale-Venkatesh, B., Post, W. S., Taylor, K. D., Rich, S. S., Wu, C. O., Pereira, N. L., Shah, S. J., Chatterjee, N., Rotter, J. I., Arking, D. E. & Lima, J. A. C., Feb 21 2022, In: Frontiers in Cardiovascular Medicine. 9, 804788.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium

    Siland, J. E., Geelhoed, B., Roselli, C., Wang, B., Lin, H. J., Weiss, S., Trompet, S., van den Berg, M. E., Soliman, E. Z., Chen, L. Y., Ford, I., Jukema, J. W., Macfarlane, P. W., Kornej, J., Lin, H., Lunetta, K. L., Kavousi, M., Kors, J. A., Ikram, M. A., Guo, X., & 14 othersYao, J., Dörr, M., Felix, S. B., Völker, U., Sotoodehnia, N., Arking, D. E., Stricker, B. H., Heckbert, S. R., Benjamin, E. J., Lubitz, S. A., Alonso, A., Ellinor, P. T., van der Harst, P. & Rienstra, M., May 2022, In: PloS one. 17, 5 May, e0268768.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Sex hormones and repolarization dynamics during the menstrual cycle in women with congenital long QT syndrome

    Bjelic, M., Zareba, W., Peterson, D. R., Younis, A., Aktas, M. K., Huang, D. T., Rosero, S., Cutter, K., McNitt, S., Xia, X., MacKecknie, B. D., Horn, R., Sotoodehnia, N., Kudenchuk, P. J., Rea, T. D., Arking, D. E., Wilde, A. A. M., Shimizu, W., Ackerman, M. J. & Goldenberg, I., Sep 2022, In: Heart Rhythm. 19, 9, p. 1532-1540 9 p.

    Research output: Contribution to journal › Article › peer-review

  • Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p

    iPSYCH Consortium, ASD Working Group of the Psychiatric Genomics Consortium & ADHD Working Group of the Psychiatric Genomics Consortium, Nov 2022, In: Nature genetics. 54, 11, p. 1630-1639 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study

    CKD Biomarkers Consortium and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Apr 2022, In: Kidney international. 101, 4, p. 814-823 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Use of oral contraceptives in women with congenital long QT syndrome

    Goldenberg, I., Younis, A., Huang, D. T., Yoruk, A., Rosero, S. Z., Cutter, K., Kutyifa, V., McNitt, S., Sotoodehnia, N., Kudenchuk, P. J., Rea, T. D., Arking, D. E., Polonski, B., Zareba, W. & Aktas, M. K., Jan 2022, In: Heart Rhythm. 19, 1, p. 41-48 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Whole genome sequence analysis of blood lipid levels in >66,000 individuals

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2022, In: Nature communications. 13, 1, 5995.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2021

    Association of mitochondrial DNA copy number with cardiometabolic diseases

    TOPMed mtDNA Working Group in NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Oct 13 2021, In: Cell Genomics. 1, 1, 100006.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes (Nature, (2020), 586, 7831, (763-768), 10.1038/s41586-020-2819-2)

    NHLBI Trans-Omics for Precision Medicine Consortium, Mar 25 2021, In: Nature. 591, 7851, p. E27

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access

  • Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

    Yang, S. Y., Castellani, C. A., Longchamps, R. J., Pillalamarri, V. K., O'Rourke, B., Guallar, E. & Arking, D. E., Jan 2021, In: Genome research. 31, 3, p. 349-358 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

    NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & FinnGen, Dec 1 2021, In: Nature communications. 12, 1, 2182.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish

    Duong, T. V., Rose, R., Blazeski, A., Fine, N., Woods, C. E., Thole, J. F., Sotoodehnia, N., Soliman, E. Z., Tung, L., McCallion, A. S. & Arking, D. E., Aug 2021, In: DMM Disease Models and Mechanisms. 14, 8, dmm048827.

    Research output: Contribution to journal › Review article › peer-review

    Open Access

  • Epigenetic Age and the Risk of Incident Atrial Fibrillation

    Roberts, J. D., Vittinghoff, E., Lu, A. T., Alonso, A., Wang, B., Sitlani, C. M., Mohammadi-Shemirani, P., Fornage, M., Kornej, J., Brody, J. A., Arking, D. E., Lin, H., Heckbert, S. R., Prokic, I., Ghanbari, M., Skanes, A. C., Bartz, T. M., Perez, M. V., Taylor, K. D., Lubitz, S. A., & 8 othersEllinor, P. T., Lunetta, K. L., Pankow, J. S., Paré, G., Sotoodehnia, N., Benjamin, E. J., Horvath, S. & Marcus, G. M., Dec 14 2021, In: Circulation. 144, 24, p. 1899-1911 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    Lifelines Cohort Study, Jun 2021, In: Molecular psychiatry. 26, 6, p. 2111-2125 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

    NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), Dec 2021, In: Genome Medicine. 13, 1, 66.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome sequencing unveils a regulatory landscape of platelet reactivity

    NHLBI Trans-Omics for Precision (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3626.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension

    Luo, S., Feofanova, E. V., Tin, A., Tung, S., Rhee, E. P., Coresh, J., Arking, D. E., Surapaneni, A., Schlosser, P., Li, Y., Köttgen, A., Yu, B. & Grams, M. E., Aug 2021, In: Kidney international. 100, 2, p. 430-439 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

    Jones, G., Trajanoska, K., Santanasto, A. J., Stringa, N., Kuo, C. L., Atkins, J. L., Lewis, J. R., Duong, T. V., Hong, S., Biggs, M. L., Luan, J., Sarnowski, C., Lunetta, K. L., Tanaka, T., Wojczynski, M. K., Cvejkus, R., Nethander, M., Ghasemi, S., Yang, J., Zillikens, M. C., & 46 othersWalter, S., Sicinski, K., Kague, E., Ackert-Bicknell, C. L., Arking, D. E., Windham, B. G., Boerwinkle, E., Grove, M. L., Graff, M., Spira, D., Demuth, I., van der Velde, N., de Groot, L. C. P. G. M., Psaty, B. M., Odden, M. C., Fohner, A. E., Langenberg, C., Wareham, N. J., Bandinelli, S., van Schoor, N. M., Huisman, M., Tan, Q., Zmuda, J., Mellström, D., Karlsson, M., Bennett, D. A., Buchman, A. S., De Jager, P. L., Uitterlinden, A. G., Völker, U., Kocher, T., Teumer, A., Rodriguéz-Mañas, L., García, F. J., Carnicero, J. A., Herd, P., Bertram, L., Ohlsson, C., Murabito, J. M., Melzer, D., Kuchel, G. A., Ferrucci, L., Karasik, D., Rivadeneira, F., Kiel, D. P. & Pilling, L. C., Dec 1 2021, In: Nature communications. 12, 1, 654.

    Research output: Contribution to journal › Article › peer-review

    Open Access