D Wade Gibson

Professor Emeritus

1971 …2014
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Research Output 1971 2014

2014

Nelfinavir inhibits maturation and export of herpes simplex virus 1

Kalu, N. N., Desai, P., Shirley, C. M., Gibson, D. W., Dennis, P. A. & Ambinder, R. F., 2014, In : Journal of Virology. 88, 10, p. 5455-5461 7 p.

Research output: Contribution to journalArticle

Nelfinavir
Human herpesvirus 1
Human Herpesvirus 1
capsid
Capsid

Recovery of an HMWP/hmwBP (pUL48/pUL47) complex from virions of human cytomegalovirus: Subunit interactions, oligomer composition, and deubiquitylase activity

Tullman, J. A., Harmon, M. E., Delannoy, M. & Gibson, D. W., 2014, In : Journal of Virology. 88, 15, p. 8256-8267 12 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
virion
Virion
Amino Acids
2013

Cytomegalovirus Assemblin and Precursor

Gibson, D. W., 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 3. p. 3540-3545 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

assemblin
2011

Cytomegalovirus capsid protease: Biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (Assemblin)

Fernandes, S. M., Brignole, E. J., Taori, K. & Gibson, D. W., Aug 2011, In : Journal of Virology. 85, 15, p. 7951 1 p.

Research output: Contribution to journalArticle

Cytomegalovirus
capsid
active sites
proteinases
enzymes

Cytomegalovirus capsid protease: Biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)

Fernandes, S. M., Brignole, E. J. & Gibson, D. W., Apr 2011, In : Journal of Virology. 85, 7, p. 3526-3534 9 p.

Research output: Contribution to journalArticle

Cytomegalovirus
capsid
Capsid
active sites
Catalytic Domain
2009

Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells

Kim, E. T., Oh, S. E., Lee, Y. O., Gibson, D. W. & Ahn, J. H., Dec 2009, In : Journal of Virology. 83, 23, p. 12046-12056 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
active sites
cultured cells
Cultured Cells
Catalytic Domain
2008

Human Cytomegalovirus: Molecular Biology

Gibson, W., Jan 1 2008, Encyclopedia of Virology. Elsevier Ltd, p. 485-490 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytomegalovirus
Molecular Biology
Viruses
DNA Replication
Virion
Cytomegalovirus
nuclear localization signals
capsid
Capsid Proteins
Viruses

Structure and formation of the cytomegalovirus virion

Gibson, D. W., 2008, In : Current Topics in Microbiology and Immunology. 325, p. 187-204 18 p.

Research output: Contribution to journalArticle

Herpesviridae
Cytomegalovirus
Virion
Virus Assembly
Cell Nucleus Active Transport
2007
Human Activities
active sites
Peptide Hydrolases
proteinases
mutants

The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus production

Loveland, A. N., Nguyen, N. L., Brignole, E. J. & Gibson, D. W., Jan 2007, In : Journal of Virology. 81, 2, p. 620-628 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
capsid
Capsid
Cytomegalovirus
Viruses
Foreskin
Chemokine Receptors
Cytomegalovirus
Virion
Open Reading Frames
2006

High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: Mutant viruses altered in its active-site cysteine or histidine are viable

Wang, J., Loveland, A. N., Kattenhorn, L. M., Ploegh, H. L. & Gibson, D. W., Jun 2006, In : Journal of Virology. 80, 12, p. 6003-6012 10 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
histidine
Histidine
active sites
2005

Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a

McCartney, S. A., Brignole, E. J., Kolegraff, K. N., Loveland, A. N., Ussin, L. M. & Gibson, D. W., Sep 30 2005, In : Journal of Biological Chemistry. 280, 39, p. 33206-33212 7 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Peptide Hydrolases
Cells
Serine Proteases
Enzymes

Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity

Loveland, A. N., Chan, C. K., Brignole, E. J. & Gibson, D. W., Oct 2005, In : Journal of Virology. 79, 20, p. 12961-12968 8 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
proteinases
pathogenicity
Viruses
viruses
2004
Glycogen Synthase Kinase 3
Cytomegalovirus
Protein Precursors
Capsid Proteins
coat proteins
2003

Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid

Ogawa-Goto, K., Tanaka, K., Gibson, D. W., Moriishi, E., Miura, Y., Kurata, T., Irie, S. & Sata, T., Aug 2003, In : Journal of Virology. 77, 15, p. 8541-8547 7 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
capsid
Capsid
Cytomegalovirus
Microtubules
2002

Cytomegalovirus assemblin (pUL80a): Cleavage at internal site not essential for virus growth; proteinase absent from virions

Chan, C. K., Brignole, E. J. & Gibson, D. W., 2002, In : Journal of Virology. 76, 17, p. 8667-8674 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus
virion
Virion
Peptide Hydrolases
proteinases
2001

Action at the assemblin dimer interface

Gibson, D. W., 2001, In : Nature Structural Biology. 8, 9, p. 739-741 3 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Dimers
Peptide Hydrolases
Stabilization
Enzymes

Cytomegalovirus basic phosphoprotein (pUL32) binds to capsids in vitro through its amino one-third

Baxter, M. K. & Gibson, D. W., 2001, In : Journal of Virology. 75, 15, p. 6865-6873 9 p.

Research output: Contribution to journalArticle

Cytomegalovirus
phosphoproteins
capsid
Capsid
Phosphoproteins
1999

Capsid structure of simian cytomegalovirus from cryoelectron microscopy: Evidence for tegument attachment sites

Trus, B. L., Gibson, D. W., Cheng, N. & Steven, A. C., 1999, In : Journal of Virology. 73, 3, p. 2181-2192 12 p.

Research output: Contribution to journalArticle

Cryoelectron Microscopy
Cytomegalovirus
capsid
Capsid
Capsid Proteins
virology
Cytomegalovirus
capsid
cryo-electron microscopy
Casein Kinase II
Cytomegalovirus
Protein Precursors
consensus sequence
Consensus Sequence
1998
Cytomegalovirus
Nuclear Localization Signals
nuclear localization signals
Protein Precursors
Capsid Proteins
1997

Assemblin, an essential herpesvirus proteinase

Gibson, D. W. & Hall, M. R. T., 1997, In : Drug Design and Discovery. 15, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Virus Assembly
Endopeptidases
Herpesviridae
Cytomegalovirus

Assemblin homolog of herpes simplex virus type 1 retains proteolytic activity when expressed as a recombinant two-chain enzyme

Hall, M. R. T. & Gibson, D. W., Jan 6 1997, In : Virology. 227, 1, p. 160-167 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Cytomegalovirus
Enzymes
assemblin
Eukaryotic Cells

Human cytomegalovirus capsid assembly protein precursor (pUL80.5) Interacts with itself and with the major capsid protein (pUL86) through two different domains

Wood, L. J., Baxter, M. K., Plafker, S. M. & Gibson, D. W., 1997, In : Journal of Virology. 71, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Protein Precursors
capsid
Capsid Proteins
coat proteins
Cytomegalovirus
mutants
proteinases
Human herpesvirus 5
capsid
1996

A 'picture' is worth a thousand experiments

Gibson, D. W., Nov 1996, In : Nature Medicine. 2, 11, p. 1193-1194 2 p.

Research output: Contribution to journalArticle

Serine Endopeptidases
Endopeptidases
Molecular Models
X Ray Crystallography
Protein Folding
Cytomegalovirus
Eukaryotic Cells
eukaryotic cells
Peptide Hydrolases
proteinases

Cytomegalovirus 'missing' capsid protein identified as heat-aggregable product of human cytomegalovirus UL46

Gibson, D. W., Baxter, M. K. & Clopper, K. S., Nov 1996, In : Journal of Virology. 70, 11, p. 7454-7461 8 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
herpes simplex
Cytomegalovirus
Capsid Proteins
Simplexvirus

Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49

Gibson, D. W., Clopper, K. S., Britt, W. J. & Baxter, M. K., Aug 1996, In : Journal of Virology. 70, 8, p. 5680-5683 4 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Capsid Proteins
coat proteins
Cytomegalovirus
Open Reading Frames

Identification of the human cytomegalovirus G protein-coupled receptor homologue encoded by UL33 in infected cells and enveloped virus particles

Margulies, B. J., Browne, H. & Gibson, D. W., Nov 1 1996, In : Virology. 225, 1, p. 111-125 15 p.

Research output: Contribution to journalArticle

Forensic Anthropology
G-Protein-Coupled Receptors
Cytomegalovirus
Virion
Baculoviridae

Structure and assembly of the virion

Gibson, D. W., 1996, In : Intervirology. 39, 5-6, p. 389-400 12 p.

Research output: Contribution to journalArticle

Virion
Cytomegalovirus
Proteins
Capsid
Eukaryotic Cells

Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor

Beaudet-Miller, M., Zhang, R., Durkin, J., Gibson, D. W., Kwong, A. D. & Hong, Z., Nov 1996, In : Journal of Virology. 70, 11, p. 8081-8088 8 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
Protein Precursors
Human Herpesvirus 1
Protein C
1995

Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals

Gibson, D. W., Welch, A. R. & Hall, M. R. T., Jul 1995, In : Perspectives in Drug Discovery and Design. 2, 3, p. 413-426 14 p.

Research output: Contribution to journalArticle

Serine Proteases
viruses
Viruses
Serine
Antiviral Agents

Cytomegalovirus protein substrates are not cleaved by the herpes simplex virus type 1 proteinase

Welch, A. R., Villarreal, E. C. & Gibson, D. W., Jan 1995, In : Journal of Virology. 69, 1, p. 341-347 7 p.

Research output: Contribution to journalArticle

Human herpesvirus 1
Cytomegalovirus
Human Herpesvirus 1
Peptide Hydrolases
proteinases

Human cytomegalovirus proteinase: Candidate glutamic acid identified as third member of putative active-site triad

Cox, G. A., Wakulchik, M., Sassmannshausen, L. M., Gibson, D. W. & Villarreal, E. C., 1995, In : Journal of Virology. 69, 7, p. 4524-4528 5 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
glutamic acid
active sites
Glutamic Acid
1994

Human cytomegalovirus maturational proteinase: Expression in Escherichia coli, purification, and enzymatic characterization by using peptide substrate mimics of natural cleavage sites

Burck, P. J., Berg, D. H., Luk, T. P., Sassmannshausen, L. M., Wakulchik, M., Smith, D. P., Hsiung, H. M., Becker, G. W., Gibson, D. W. & Villarreal, E. C., May 1994, In : Journal of Virology. 68, 5, p. 2937-2946 10 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
Peptide Hydrolases
proteinases
peptides

Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952

Greis, K. D., Gibson, D. W. & Hart, G. W., Dec 1994, In : Journal of Virology. 68, 12, p. 8339-8349 11 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
phosphoproteins
Phosphoproteins
glycosylation
Glycosylation

Transient transfection assay of the herpesvirus maturational proteinase, assemblin

Gibson, D. W., Welch, A. R. & Ludford, J. M., 1994, In : Methods in Enzymology. 244, p. 399-411 13 p.

Research output: Contribution to journalArticle

Assays
Peptide Hydrolases
Electrophoresis
Sodium Dodecyl Sulfate
Proteins
1993
Herpesviridae
site-directed mutagenesis
Site-Directed Mutagenesis
histidine
Histidine
1991
Herpesviridae
Catalytic Domain
Peptide Hydrolases
Genes
Proteins

Cytomegalovirus assembly protein nested gene family: Four 3′-coterminal transcripts encode four in-frame, overlapping proteins

Welch, A. R., McNally, L. M. & Gibson, D. W., Aug 1991, In : Journal of Virology. 65, 8, p. 4091-4100 10 p.

Research output: Contribution to journalArticle

Nested Genes
Cytomegalovirus
Protein Precursors
Initiator Codon
RNA 3' Polyadenylation Signals

Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed

Welch, A. R., Mcgregor, L. M. & Gibson, D. W., Jul 1991, In : Journal of Virology. 65, 7, p. 3915-3918 4 p.

Research output: Contribution to journalArticle

Human herpesvirus 5
Cytomegalovirus
G-Protein-Coupled Receptors
Human Genome
Infection

The 45-kilodalton protein of cytomegalovirus (colburn) B-capsids is an amino-terminal extension form of the assembly protein

Schenk, P., Woods, A. S. & Gibson, D. W., 1991, In : Journal of Virology. 65, 3, p. 1525-1529 5 p.

Research output: Contribution to journalArticle

Cytomegalovirus
capsid
Capsid
Proteins
proteins
1990

Evidence that HIV-1 gag precursor shares antigenic sites with the major capsid protein of human cytomegalovirus

Gibson, D. W., McNally, L. M., Benveniste, R. E. & Ward, J. M., 1990, In : Virology. 175, 2, p. 595-599 5 p.

Research output: Contribution to journalArticle

HIV-1
Cytomegalovirus
Viruses
Intranuclear Inclusion Bodies
Antibody Affinity

Identification of precursor to cytomegalovirus capsid assembly protein and evidence that processing results in loss of its carboxy-terminal end

Gibson, D. W., Marcy, A. I., Comolli, J. C. & Lee, J., 1990, In : Journal of Virology. 64, 3, p. 1241-1249 9 p.

Research output: Contribution to journalArticle

Cytomegalovirus
capsid
Capsid Proteins
Proteins
Protein Precursors
Human herpesvirus 5
Ganciclovir
Replication Origin
DNA replication
Cytomegalovirus