Cynthia Louise Sears

Professor

1983 …2020

Research output per year

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Research Output

2020

HIV, Sexual Orientation, and Gut Microbiome Interactions

Tuddenham, S., Koay, W. L. & Sears, C., Mar 1 2020, In : Digestive diseases and sciences. 65, 3, p. 800-817 18 p.

Research output: Contribution to journalReview article

Host responses to mucosal biofilms in the lung and gut

Domingue, J. C., Drewes, J. L., Merlo, C. A., Housseau, F. & Sears, C. L., May 1 2020, In : Mucosal Immunology. 13, 3, p. 413-422 10 p.

Research output: Contribution to journalReview article

Open Access

Human colon mucosal biofilms and murine host communicate via altered mRNA and microRNA expression during cancer

Tomkovich, S., Gharaibeh, R. Z., Dejea, C. M., Pope, J. L., Jiang, J., Winglee, K., Gauthier, J., Newsome, R. C., Yang, Y., Fodor, A. A., Schmittgen, T. D., Sears, C. L. & Jobin, C., Jan 1 2020, In : mSystems. 5, 1, e00451-19.

Research output: Contribution to journalArticle

Open Access

Microbial Diagnostics for Cancer: A Step Forward but Not Prime Time Yet

Sears, C. L. & Salzberg, S. L., May 11 2020, In : Cancer cell. 37, 5, p. 625-627 3 p.

Research output: Contribution to journalArticle

Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia

Iyadorai, T., Mariappan, V., Vellasamy, K. M., Wanyiri, J. W., Roslani, A. C., Lee, G. K., Sears, C. & Vadivelu, J., Jan 1 2020, In : PloS one. 15, 1, e0228217.

Research output: Contribution to journalArticle

Open Access

The Impact of Human Immunodeficiency Virus Infection on Gut Microbiota α-Diversity: An Individual-level Meta-analysis

Tuddenham, S. A., Koay, W. L. A., Zhao, N., White, J. R., Ghanem, K. G., Sears, C. L., Dillon, S., Wilson, C., Lozupone, C., Ward, H., Wanke, C., Dubourg, G., Raoult, D., Palmer, B., Monaco, C., Kwon, D., Mutlu, E., Landay, A., Paredes, R., Noguera-Julian, M. & 18 others, Sönnerborg, A., Neogi, U., Nowak, R., Ravel, J., Pérez-Santiago, J., Smith, D. M., Pinto-Cardoso, S., Reyes-Terán, G., Serrano-Villar, S., Gosalbes Soler, M. J., Vesterbacka, J., Nowak, P., Pérez-Matute, P., Oteo, J. A., D'Auria, G., Villar-García, J., Yu, G. & Goedert, J. J., Feb 3 2020, In : Clinical Infectious Diseases. 70, 4, p. 615-627 13 p.

Research output: Contribution to journalArticle

Yogurt consumption and colorectal polyps

Rifkin, S. B., Giardiello, F. M., Zhu, X., Hylind, L. M., Ness, R. M., Drewes, J. L., Murff, H. J., Spence, E. H., Smalley, W. E., Gills, J. J., Mullin, G. E., Kafonek, D., La Luna, L., Zheng, W., Sears, C. L. & Shrubsole, M. J., Jan 1 2020, (Accepted/In press) In : British Journal of Nutrition.

Research output: Contribution to journalArticle

Open Access
2019

A Summary of the Fight Colorectal Cancer Working Meeting: Exploring Risk Factors and Etiology of Sporadic Early-Age Onset Colorectal Cancer

Dwyer, A. J., Murphy, C. C., Boland, C. R., Garcia, R., Hampel, H., Limburg, P., Lowery, J., Zauber, A. G., Waring, S., Worrall, S., Perea, J., Siegel, R., Lee, J., Molmenti, C., Sears, C. L., Buckhaults, P., Hayes, R., Hussan, H., de Miranda, N., Palles, C. & 23 others, Diaz, L., Song, M., Cercek, A., Lieu, C. H., Patel, S. G., Karlitz, J. J., Cao, Y., Demb, J., Blatchford, P., Risendal, B., Weltzien, E., Wali, A., Daschner, P., Loomans-Kropp, H., Flores, R., Levell, C. L., Wehling, K., Martin, J., Pesmen, C., Kuchar, V., Soisson, R., Davis, A. & Ahnen, D., Aug 2019, In : Gastroenterology. 157, 2, p. 280-288 9 p.

Research output: Contribution to journalArticle

Open Access

Charting the Path Forward: Development, Goals and Initiatives of the 2019 Infectious Diseases of America Strategic Plan

Sears, C. L., File, T. M., Alexander, B. D., McQuillen, D. P., MacIntyre, A. T., Allen, U. D., Colasanti, J. A., Siddiqui, J., Reveles, K. R. & Busky, C., Nov 27 2019, In : Clinical Infectious Diseases. 69, 12, p. e1-e7

Research output: Contribution to journalArticle

Open Access

Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile

Chen, L., Hourigan, S. K., Grigoryan, Z., Gao, Z., Clemente, J. C., Rideout, J. R., Chirumamilla, S., Rabidazeh, S., Saeed, S., Elson, C. O., Oliva-Hemker, M., Blaser, M. J. & Sears, C. L., Apr 1 2019, In : Journal of pediatric gastroenterology and nutrition. 68, 4, p. 502-508 7 p.

Research output: Contribution to journalArticle

Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin

Metz, P., Tjan, M. J. H., Wu, S., Pervaiz, M., Hermans, S., Shettigar, A., Sears, C. L., Ritschel, T., Dutilh, B. E. & Boleij, A., Oct 25 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 364.

Research output: Contribution to journalArticle

Open Access

Epigenetic changes induced by bacteroides fragilis toxin

Allen, J., Hao, S., Sears, C. L. & Timp, W., Jan 1 2019, In : Infection and Immunity. 87, 6, e00447-18.

Research output: Contribution to journalArticle

Erratum to: High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia (npj Biofilms and Microbiomes, (2017), 3, 1, (34), 10.1038/s41522-017-0040-3)

Drewes, J., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., Thulasi, K., Gan, H. M., Goh, K. L., Chong, H. Y., Kumar, S., Wanyiri, J. W. & Sears, C. L., Dec 1 2019, In : npj Biofilms and Microbiomes. 5, 1, 2.

Research output: Contribution to journalComment/debate

Fecal Transplant in Children with Clostridioides difficile Gives Sustained Reduction in Antimicrobial Resistance and Potential Pathogen Burden

Hourigan, S. K., Ahn, M., Gibson, K. M., Pérez-Losada, M., Felix, G., Weidner, M., Leibowitz, I., Niederhuber, J. E., Sears, C. L., Crandall, K. A. & Oliva-Hemker, M., Oct 1 2019, In : Open Forum Infectious Diseases. 6, 10

Research output: Contribution to journalArticle

Open Access

Gut microbiome and its role in obesity and insulin resistance

Lee, C., Sears, C. L. & Maruthur, N., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journalReview article

Open Access

Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Tomkovich, S., Dejea, C. M., Winglee, K., Drewes, J., Chung, L., Housseau, F., Pope, J. L., Gauthier, J., Sun, X., Mühlbauer, M., Liu, X., Fathi, P., Anders, R. A., Besharati, S., Perez-Chanona, E., Yang, Y., Ding, H., Wu, X., Wu, S., White, J. R. & 6 others, Gharaibeh, R. Z., Fodor, A. A., Wang, H., Pardoll, A. M., Jobin, C. & Sears, C. L., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1699-1712 14 p.

Research output: Contribution to journalArticle

Open Access

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

Llosa, N. J., Luber, B., Siegel, N., Awan, A. H., Oke, T., Zhu, Q., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Jaffee, E. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., Pardoll, D. M., Wang, H., Housseau, F. & Anders, R. A., Jan 1 2019, In : Cancer Immunology Research. 7, 10, p. 1574-1579 6 p.

Research output: Contribution to journalArticle

Open Access

Impact of the microbiome on checkpoint inhibitor treatment in patients with non-small cell lung cancer and melanoma

Shaikh, F. Y., Gills, J. & Sears, C. L., Oct 1 2019, In : EBioMedicine. 48, p. 642-647 6 p.

Research output: Contribution to journalReview article

Open Access

Inclusion, Diversity, Access, and Equity: Perspectives for Infectious Diseases

Sears, C. L., Del Rio, C. & Malani, P., Aug 20 2019, In : Journal of Infectious Diseases. 220, p. S27-S29 jiz125.

Research output: Contribution to journalReview article

Open Access

Intratumoral adaptive immunosuppression and type 17 immunity in mismatch repair proficient colorectal tumors

Llosa, N. J., Luber, B., Tam, A. J., Smith, K. N., Siegel, N., Awan, A. H., Fan, H., Oke, T., Zhang, J., Domingue, J., Engle, E. L., Roberts, C. A., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Taube, J. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A. & 4 others, Pardoll, D. M., Wang, H., Anders, R. A. & Housseau, F., Sep 1 2019, In : Clinical Cancer Research. 25, 17, p. 5250-5259 10 p.

Research output: Contribution to journalArticle

Open Access

Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989-2012: A matched case-control study

Zhang, J., Haines, C., Watson, A. J. M., Hart, A. R., Platt, M. J., Pardoll, D. M., Cosgrove, S. E., Gebo, K. A. & Sears, C. L., Jan 1 2019, In : Gut. 68, 11, p. 1971-1978 8 p.

Research output: Contribution to journalArticle

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L. & 21 others, Cope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In : Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journalArticle

Open Access

Transmission and clearance of potential procarcinogenic bacteria during fecal microbiota transplantation for recurrent Clostridioides difficile

Drewes, J. L., Corona, A., Sanchez, U., Fan, Y., Hourigan, S. K., Weidner, M., Sidhu, S. D., Simner, P. J., Wang, H., Timp, W., Oliva-Hemker, M. & Sears, C. L., Jan 1 2019, In : JCI Insight. 4, 19, e130848.

Research output: Contribution to journalArticle

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Riquelme, E., Zhang, Y., Zhang, L., Montiel, M., Zoltan, M., Dong, W., Quesada, P., Sahin, I., Chandra, V., San Lucas, A., Scheet, P., Xu, H., Hanash, S. M., Feng, L., Burks, J. K., Do, K. A., Peterson, C. B., Nejman, D., Tzeng, C. W. D., Kim, M. P. & 11 others, Sears, C. L., Ajami, N., Petrosino, J., Wood, L. D., Maitra, A., Straussman, R., Katz, M., White, J. R., Jenq, R., Wargo, J. & McAllister, F., Aug 8 2019, In : Cell. 178, 4, p. 795-806.e12

Research output: Contribution to journalArticle

2018

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., Shields, C. E. D. S., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F. M., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 others, Pardoll, A. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Jan 1 2018, (Accepted/In press) In : Cell Host and Microbe.

Research output: Contribution to journalArticle

Development and optimization of metagenomic next-generation sequencing methods for cerebrospinal fluid diagnostics

Simner, P. J., Miller, H. B., Breitwieser, F. P., Monsalve, G. P., Pardo, C. A., Salzberg, S. L., Sears, C. L., Thomas, D. L., Eberhart, C. G. & Carrolla, K. C., Sep 2018, In : Journal of clinical microbiology. 56, 9, e00472.

Research output: Contribution to journalArticle

Erratum: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells (Cell Host & Microbe (2018) 23(2) (203–214.e5) (S1931312818300428) (10.1016/j.chom.2018.01.007))

Chung, L., Orberg, E. T., Geis, A., Chan, J. L., Fu, K., DeStefano Shields, C. E., Dejea, C. M., Fathi, P., Chen, J., Finard, B. B., Tam, A. J., McAllister, F., Fan, H., Wu, X., Ganguly, S., Lebid, A., Metz, P., Van Meerbeke, S. W., Huso, D. L., Wick, E. C. & 5 others, Pardoll, D. M., Wan, F., Wu, S., Sears, C. L. & Housseau, F., Mar 14 2018, In : Cell Host and Microbe. 23, 3, 1 p.

Research output: Contribution to journalComment/debate

Gut Microbial-Related Choline Metabolite Trimethylamine-N-Oxide Is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection

Shan, Z., Clish, C. B., Hua, S., Scott, J. M., Hanna, D. B., Burk, R. D., Haberlen, S., Shah, S. J., Margolick, J. B., Sears, C. L., Post, W. S., Landay, A. L., Lazar, J. M., Hodis, H. N., Anastos, K., Kaplan, R. C. & Qi, Q., Sep 22 2018, In : The Journal of infectious diseases. 218, 9, p. 1474-1479 6 p.

Research output: Contribution to journalArticle

High-speed, ultrahigh-resolution distal scanning OCT endoscopy at 800 nm for in vivo imaging of colon tumorigenesis on murine models

Mavadia-Shukla, J., Fathi, P., Liang, W., Wu, S., Sears, C. & Li, X., Aug 1 2018, In : Biomedical Optics Express. 9, 8, p. 3731-3739 9 p., 335984.

Research output: Contribution to journalArticle

Malaria and the Microbiome: A Systematic Review

Ippolito, M., Denny, J. E., Langelier, C., Sears, C. L. & Schmidt, N. W., Nov 28 2018, In : Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 67, 12, p. 1831-1839 9 p.

Research output: Contribution to journalArticle

Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A

Chan, J. L., Wu, S., Geis, A., Chan, G. V., Gomes, T. A. M., Beck, S., Wu, X., Fan, H., Tam, A. J., Chung, L., Ding, H., Wang, H., Pardoll, A. M., Housseau, F. & Sears, C. L., Jan 1 2018, (Accepted/In press) In : Mucosal Immunology.

Research output: Contribution to journalArticle

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., Anders, R. A., Giardiello, F. M., Wick, E. C., Wang, H., Wu, S., Pardoll, A. M., Housseau, F. & Sears, C. L., Feb 2 2018, In : Science. 359, 6375, p. 592-597 6 p.

Research output: Contribution to journalArticle

Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer

Hurtado, C. G., Wan, F., Housseau, F. & Sears, C. L., Dec 1 2018, In : Gastroenterology. 155, 6, p. 1706-1715 10 p.

Research output: Contribution to journalReview article

The contributions of physician-scientists within divisions of infectious diseases

Sears, C. L., Aug 14 2018, In : Journal of Infectious Diseases. 218, p. S16-S19

Research output: Contribution to journalArticle

The intestinal microbiome influences checkpoint blockade

Sears, C. L. & Pardoll, A. M., Mar 6 2018, In : Nature Medicine. 24, 3, p. 254-255 2 p.

Research output: Contribution to journalArticle

The who, where and how of fusobacteria and colon cancer

Sears, C. L., Mar 13 2018, In : eLife. 7, e28434.

Research output: Contribution to journalArticle

2017

A blueprint to advance colorectal cancer immunotherapies

Le, D. T., Hubbard-Lucey, V. M., Morse, M. A., Heery, C. R., Dwyer, A., Marsilje, T. H., Brodsky, A. N., Chan, E., Deming, D. A., Diaz, L. A., Fridman, W. H., Goldberg, R. M., Hamilton, S. R., Housseau, F., Jaffee, E. M., Kang, S. P., Krishnamurthi, S. S., Lieu, C. H., Messersmith, W., Sears, C. L. & 10 others, Segal, N. H., Yang, A., Moss, R. A., Cha, E., O'Donnell-Tormey, J., Roach, N., Davis, A. Q., McAbee, K., Worrall, S. & Benson, A. B., Nov 2017, In : Cancer Immunology Research. 5, 11, p. 942-949 8 p.

Research output: Contribution to journalArticle

High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia

Drewes, J., White, J. R., Dejea, C. M., Fathi, P., Iyadorai, T., Vadivelu, J., Roslani, A. C., Wick, E. C., Mongodin, E. F., Loke, M. F., Thulasi, K., Gan, H. M., Goh, K. L., Chong, H. Y., Kumar, S., Wanyiri, J. W. & Sears, C. L., Dec 1 2017, In : npj Biofilms and Microbiomes. 3, 1, 34.

Research output: Contribution to journalArticle

Microbiota dysbiosis in select human cancers: Evidence of association and causality

Chen, J., Domingue, J. C. & Sears, C. L., 2017, (Accepted/In press) In : Seminars in Immunology.

Research output: Contribution to journalArticle

Mismatch repair proteins initiate epigenetic alterations during inflammation-driven tumorigenesis

Maiuri, A. R., Peng, M., Sriramkumar, S., Kamplain, C. M., DeStefano Shields, C. E., Sears, C. L. & O'Hagan, H. M., Jul 1 2017, In : Cancer Research. 77, 13, p. 3467-3478 12 p.

Research output: Contribution to journalArticle

Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice

Muchenditsi, A., Yang, H., Hamilton, J., Koganti, L., Housseau, F., Aronov, L., Fan, H., Pierson, H., Bhattacharjee, A., Murphy, R., Sears, C. L., Potter, J. J., Wooton-Kee, C. R. & Lutsenko, S., 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 1, p. G39-G49

Research output: Contribution to journalArticle

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis

Thiele Orberg, E., Fan, H., Tam, A. J., Dejea, C. M., Destefano Shields, C. E., Wu, S., Chung, L., Finard, B. B., Wu, X., Fathi, P., Ganguly, S., Fu, J., Pardoll, A. M., Sears, C. L. & Housseau, F., Mar 1 2017, In : Mucosal Immunology. 10, 2, p. 421-433 13 p.

Research output: Contribution to journalArticle

2016

Clostridium difficile infection in pediatric inflammatory bowel disease

Hourigan, S. K., Sears, C. L. & Oliva-Hemker, M., Mar 9 2016, In : Inflammatory Bowel Diseases. 22, 4, p. 1020-1025 6 p.

Research output: Contribution to journalArticle

Do biofilms confer a pro-carcinogenic state?

Dejea, C. M. & Sears, C. L., Jan 2 2016, In : Gut Microbes. 7, 1, p. 54-57 4 p.

Research output: Contribution to journalArticle

Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus

Elliott Miller, P., Haberlen, S. A., Brown, T. T., Margolick, J. B., DiDonato, J. A., Hazen, S. L., Witt, M. D., Kingsley, L. A., Palella, F. J., Budoff, M., Jacobson, L. P., Post, W. S. & Sears, C. L., May 1 2016, In : Journal of Acquired Immune Deficiency Syndromes. 72, 1, p. 114-118 5 p.

Research output: Contribution to journalArticle

Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment

Destefano Shields, C. E., Van Meerbeke, S. W., Housseau, F., Wang, H., Huso, D. L., Casero, R. A., O'Hagan, H. M. & Sears, C. L., Jul 1 2016, In : Journal of Infectious Diseases. 214, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle