Cristian Tomasetti

Associate Professor

20102019
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Research Output 2010 2019

2019

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Molin, M. D., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., Klimstra, D. S., Schattner, M. A., Max Schmidt, C., Yip-Schneider, M., Simpson, R. E., Castillo, C. F. D., Mino-Kenudson, M., Brugge, W., Brand, R. E., Singhi, A. D. & 40 others, Scarpa, A., Lawlor, R., Salvia, R., Zamboni, G., Hong, S. M., Hwang, D. W., Jang, J. Y., Kwon, W., Swan, N., Geoghegan, J., Falconi, M., Crippa, S., Doglioni, C., Paulino, J., Schulick, R. D., Edil, B. H., Park, W., Yachida, S., Hijioka, S., Van Hooft, J., He, J., Weiss, M. J., Burkhart, R., Makary, M., Canto, M. I., Goggins, M. G., Ptak, J., Dobbyn, L., Schaefer, J., Sillman, N., Popoli, M., Klein, A. P., Tomasetti, C., Karchin, R., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Wolfgang, C. L., Hruban, R. H. & Lennon, A. M., Jul 17 2019, In : Science translational medicine. 11, 501, eaav4772.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cysts
Cyst Fluid
Practice Management
Standard of Care

Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

Tomasetti, C., Poling, J., Roberts, N., London, N., Pittman, M. E., Haffner, M. C., Rizzo, A., Baras, A., Karim, B., Kim, A., Heaphy, C. M., Meeker, A. K., Hruban, R. H., Iacobuzio-Donahue, C. A. & Vogelstein, B., Oct 8 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 41, p. 20482-20488 7 p.

Research output: Contribution to journalArticle

Open Access
Deceleration
Cell Division
Incidence
Neoplasms
Stem Cells

Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer

Tie, J., Cohen, J. D., Wang, Y., Christie, M., Simons, K., Lee, M., Wong, R., Kosmider, S., Ananda, S., McKendrick, J., Lee, B., Cho, J. H., Faragher, I., Jones, I. T., Ptak, J., Schaeffer, M. J., Silliman, N., Dobbyn, L., Li, L., Tomasetti, C. & 4 others, Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

Colonic Neoplasms
Recurrence
DNA
Neoplasms
Therapeutics

Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localized pancreatic cancer

Lee, B., Lipton, L., Cohen, J., Tie, J., Javed, A. A., Li, L., Goldstein, D., Burge, M., Cooray, P., Nagrial, A., Tebbutt, N. C., Thomson, B., Nikfarjam, M., Harris, M., Haydon, A., Lawrence, B., Tai, D. W. M., Simons, K., Lennon, A. M., Wolfgang, C. L. & 5 others, Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Sep 1 2019, In : Annals of Oncology. 30, 9, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Pancreatic Neoplasms
DNA
Neoplasms
gemcitabine

Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions

Wu, R. C., Wang, P., Lin, S. F., Zhang, M., Song, Q., Chu, T., Wang, B. G., Kurman, R. J., Vang, R. S., Kinzler, K. W., Tomasetti, C., Jiao, Y., Shih, I. M. & Wang, T-L., Jan 1 2019, In : Journal of Pathology.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma in Situ
Carcinoma
Mutation
History

Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma

Eich, M. L., Rodriguez Pena, M. D. C., Springer, S. U., Taheri, D., Tregnago, A. C., Salles, D. C., Bezerra, S. M., Cunha, I. W., Fujita, K., Ertoy, D., Bivalacqua, T., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J., Jan 1 2019, In : Modern Pathology.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Urinary Bladder
Papillary Carcinoma
Carcinoma
Incidence

Mutated clones are the new normal: Measuring and understanding the dynamics of clonal cell populations is key for cancer prevention

Tomasetti, C., Jun 7 2019, In : Science. 364, 6444, p. 938-939 2 p.

Research output: Contribution to journalShort survey

RNA Sequence Analysis
Diploidy
Clone Cells
Mutation
Population

Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer

Wang, Y., Li, L., Cohen, J. D., Kinde, I., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tie, J., Gibbs, P., Tomasetti, C., Kinzler, K. W., Papadopoulos, N., Vogelstein, B. & Olsson, L., Jan 1 2019, In : JAMA Oncology.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
Neoplasms
Recurrence
Triage

The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations

Wong, R., Tie, J., Lee, M., Cohen, J., Wang, Y., Li, L., Ma, S., Christie, M., Kosmider, S., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA
Neoplasms
Recurrence
Positron-Emission Tomography
2018

Cancer prevention: Molecular and epidemiologic consensus: Research in many fields emphasizes the value of prevention

Song, M., Vogelstein, B., Giovannucci, E. L., Willett, W. C. & Tomasetti, C., Sep 28 2018, In : Science. 361, 6409, p. 1317-1318 2 p.

Research output: Contribution to journalReview article

disease control
field method
molecular analysis
research work
epidemiology

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D., Li, L., Wang, Y., Thoburn, C., Afsari, B., Danilova, L. V., Douville, C., Javed, A. A., Wong, F., Mattox, A., Hruban, R. H., Wolfgang, C., Goggins, M. S., Molin, M. D., Wang, T-L., Roden, R. S., Klein, A., Ptak, J., Dobbyn, L., Schaefer, J. & 22 others, Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., O'Broin-Lennon, A. M. & Papadopoulos, N., Feb 23 2018, In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas

Erratum: Correction: Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy (eLife (2018) 7 PII: e43237)

Springer, S. U., Chen, C. H., Rodriguez Pena, M. D. C., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Nov 12 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

Aneuploidy
Chromosomes
Gene expression
Genes
Gene Expression

Evaluation of liquid from the papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Aug 1 2018, In : Obstetrical and Gynecological Survey. 73, 8, p. 463-464 2 p.

Research output: Contribution to journalComment/debate

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y., Li, L., Douville, C., Cohen, J. D., Yen, T. T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I. M., Wang, T-L., Kurman, R. J., Springer, S., Ptak, J., Popoli, M., Schaefer, J., Silliman, N., Dobbyn, L., Tanner, E. J., Angarita, A. & 17 others, Lycke, M., Jochumsen, K., Afsari, B., Danilova, L. V., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Nickles Fader, A. N., Gilbert, L. & Papadopoulos, N., Mar 21 2018, In : Science Translational Medicine. 10, 433, 8793.

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy
Confidence Intervals

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U., Chen, C. H., Del Carmen Rodriguez Pena, M., Li, L., Douville, C., Wang, Y., Cohen, J. D., Taheri, D., Silliman, N., Schaefer, J., Ptak, J., Dobbyn, L., Papoli, M., Kinde, I., Afsari, B., Tregnago, A. C., Bezerra, S. M., VandenBussche, C., Fujita, K., Ertoy, D. & 20 others, Cunha, I. W., Yu, L., Bivalacqua, T., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L. V., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J., Mar 20 2018, In : eLife. 7, e32143.

Research output: Contribution to journalArticle

Cytology
Aneuploidy
Urinary Bladder Neoplasms
Genes
Cell Biology

Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: A prospective biomarker study

Tie, J., Cohen, J. D., Wang, Y., Li, L., Christie, M., Simons, K., Elsaleh, H., Kosmider, S., Wong, R., Yip, D., Lee, M., Tran, B., Rangiah, D., Burge, M., Goldstein, D., Singh, M., Skinner, I., Faragher, I., Croxford, M., Bampton, C. & 14 others, Haydon, A., Jones, I. T., S Karapetis, C., Price, T., Schaefer, M. J., Ptak, J., Dobbyn, L., Silliman, N., Kinde, I., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Volgestein, B. & Gibbs, P., Feb 2 2018, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Rectal Neoplasms
Biomarkers
Prospective Studies
DNA
Neoplasms
2017

Cancer-associated mutations in endometriosis without cancer

Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R. C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F. & 20 others, Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, K. W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T-L., Vogelstein, B., Yong, P. J., Huntsman, D. G. & Shih, I. M., May 11 2017, In : New England Journal of Medicine. 376, 19, p. 1835-1848 14 p.

Research output: Contribution to journalArticle

Endometriosis
Mutation
Neoplasms
Epithelium
Exome

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D., Javed, A. A., Thoburn, C., Wong, F., Tie, J., Gibbs, P., Schmidt, C. M., Yip-Schneider, M. T., Allen, P. J., Schattner, M., Brand, R. E., Singhi, A. D., Petersen, G. M., Hong, S. M., Kim, S. C., Falconi, M., Doglioni, C., Weiss, M. J., Ahuja, N., He, J. & 20 others, Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. S., Hruban, R. H., Wolfgang, C., Klein, A., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & O'Broin-Lennon, A. M., Sep 19 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Early Detection of Cancer
Biomarkers
Biopsy
DNA
Stem cells
Cell Division
stem cells
cell division
Stem Cells

Role of stem-cell divisions in cancer risk

Tomasetti, C., Durrett, R., Kimmel, M., Lambert, A., Parmigiani, G., Zauber, A. & Vogelstein, B., Aug 9 2017, In : Nature. 548, 7666, p. E13-E14

Research output: Contribution to journalComment/debate

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Tomasetti, C., Li, L. & Vogelstein, B., Mar 24 2017, In : Science. 355, 6331, p. 1330-1334 5 p.

Research output: Contribution to journalArticle

Cell Division
Stem Cells
Mutation
Neoplasms
DNA Replication
2016

Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer

Tie, J., Wang, Y., Tomasetti, C., Li, L., Springer, S., Kinde, I., Silliman, N., Tacey, M., Wong, H. L., Christie, M., Kosmider, S., Skinner, I., Wong, R., Steel, M., Tran, B., Desai, J., Jones, I., Haydon, A., Hayes, T., Price, T. J. & 6 others, Strausberg, R. L., Diaz, L. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Gibbs, P., Jul 6 2016, In : Science Translational Medicine. 8, 346, 346ra92.

Research output: Contribution to journalArticle

Residual Neoplasm
Colonic Neoplasms
Recurrence
DNA
Neoplasms

Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing

Hoang, M. L., Kinde, I., Tomasetti, C., McMahon, K. W., Rosenquist, T. A., Grollman, A. P., Kinzler, K. W., Vogelstein, B. & Papadopoulos, N., Aug 30 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. 9846-9851 6 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Genome
Mutation
Mitochondrial Genome
Biological Factors
2015

An argument for mechanism-based statistical inference in cancer

Geman, D., Ochs, M., Price, N. D., Tomasetti, C. & Younes, L., May 1 2015, In : Human Genetics. 134, 5, p. 479-495 17 p.

Research output: Contribution to journalArticle

Learning
Neoplasms
Systems Biology
Computational Biology
Uncertainty

Cancer risk: role of environment—response

Tomasetti, C. & Vogelstein, B., Feb 13 2015, In : Science. 347, 6223, p. 729-731 3 p.

Research output: Contribution to journalArticle

Cell Division
Stem Cells
Neoplasms

Drug resistance

Tomasetti, C., 2015, In : Advances in Experimental Medicine and Biology. 844, p. 303-316 14 p.

Research output: Contribution to journalArticle

Drug Resistance
Pharmaceutical Preparations
Neoplasms
Theoretical Models
Hematopoietic System
Colorectal Neoplasms
Lung Neoplasms
Mutation
Genes
Neoplasms

The (not so) immortal strand hypothesis

Tomasetti, C. & Bozic, I., Mar 1 2015, In : Stem Cell Research. 14, 2, p. 238-241 4 p.

Research output: Contribution to journalArticle

Stem Cells
DNA
Cell Lineage
Mutation Rate
DNA Replication

Variation in cancer risk among tissues can be explained by the number of stem cell divisions

Tomasetti, C. & Vogelstein, B., Jan 2 2015, In : Science. 347, 6217, p. 78-81 4 p.

Research output: Contribution to journalArticle

Cell Division
Stem Cells
Neoplasms
DNA Replication
Homeostasis
2013
Mutation
Neoplasms
Clonal Evolution
Mutation Rate
Theoretical Models

Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors

Tomasetti, C., Demetri, G. D. & Parmigiani, G., Jul 9 2013, In : F1000Research. 2, 152.v1.

Research output: Contribution to journalArticle

Gastrointestinal Stromal Tumors
Protein-Tyrosine Kinases
Tumors
Disease control
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
2012

On the Probability of Random Genetic Mutations for Various Types of Tumor Growth

Tomasetti, C., Jun 2012, In : Bulletin of Mathematical Biology. 74, 6, p. 1379-1395 17 p.

Research output: Contribution to journalArticle

Tumor Growth
tumor
Tumors
mutation
Tumor
Neoplastic Stem Cells
stem cells
mutation
cancer
stem
2011
Stem Cells
Imatinib Mesylate
2010

A mathematical model for microenvironmental control of tumor growth

Galante, A. R., Levy, D. & Tomasetti, C., 2010, IFMBE Proceedings. Vol. 32 IFMBE. p. 213-216 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tumors
Mathematical models
Cells
Ordinary differential equations

An elementary approach to modeling drug resistance in cancer

Tomasetti, C. & Levy, D., Oct 2010, In : Mathematical Biosciences and Engineering. 7, 4, p. 905-918 14 p.

Research output: Contribution to journalArticle

Drug Resistance
drug resistance
Ordinary differential equations
Cancer
Drugs

Drug resistance always depends on the turnover rate

Tomasetti, C. & Levy, D., 2010, IFMBE Proceedings. Vol. 32 IFMBE. p. 552-555 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Drug therapy
Pharmaceutical Preparations
Asymmetric Cell Division
Drug Resistance
Stem Cells
Neoplasms
Theoretical Models